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Developing and implementing an effective and efficient gender capacity develo...ILRI
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A presentation by Respichius Mitti as part of the Practicalities of Cohort and Longitudinal Research panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
Developing and implementing an effective and efficient gender capacity develo...ILRI
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A presentation by Rachel Hinton as part of the Cohort Research for Programme and Policy panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
Setting the scene – Trends in programming Research and Innovation for Impact Francois Stepman
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Presentation by Paul Winter
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Setting the scene – Trends in programming Research and Innovation for Impact Francois Stepman
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What Makes a Good Performance Management Plan? A new tool for managersMEASURE Evaluation
Led by Tory M. Taylor, a monitoring and evaluation specialist with MEASURE Evaluation from Tulane University.
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Approaches to strengthen the capacity to integrate gender in agricultural res...ILRI
Presented by Annet A. Mulema at the EthioRice Gender Seminar: Gender and Rice Research, EIAR, Addis Ababa, 12 December 2017
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Planning the Evaluation
Impact models
Types of inference and choice of design
Defining the indicators and obtaining the data
Carrying out the evaluation
Disseminating evaluation findings
Working in large-scale evaluations
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Presentation by Jonathan Potter, OECD LEED Senior Policy Analyst, and Stuart Thompson, OECD LEED Policy Analys, tat the seminar organised by the OECD LEED Trento Centre for the Officers of the Autonomous Province of Trento on 13 November 2015.
https://www.trento.oecd.org
Whole systems change across a neighbourhood
How can we collaborate with people to help them build their resilience? Get under the skin of the culture and the lives people live. Identify people’s feelings and experiences of community and understand what people think is shaped by different values and by the environment and infrastructure around them. The future of collaboration could bring many opportunities but people find it more difficult to live and act together than before. How can we help people…and communities build their resilience? Understand people’s different situations and capabilities to develop pathways that help them build resilient relationships. Help people experience and practice change together. Help people grow everyday practices into sustainable projects. Turn people’s everyday motivations into design principles. Support infrastructure that connects different cultures of collaboration. Build relationships with people designing in collaboration for the future…now.
A presentation by Nalini Takeshwar as part of the Cohort Research for Programme and Policy panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
Introducing the Africa RISING research framework africa-rising
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Agriculture Public Expenditure Workshop organized by the Strengthening National Comprehensive Agricultural Public Expenditure in Sub-Saharan Africa Program
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The implementation 'black box' and evaluation as a driver for change. Presentation by Katie Burke and Claire Hickey of the Centre for Effective Services.
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Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The ASGCT Annual Meeting was packed with exciting progress in the field advan...
Seminar on Advisory and Knowledge Services: Evidence for What Works (Sept 17, 2014)
1. Advisory and Knowledge Services: Evidence for What Works
PIM Advisory Services Research Team 2014
PIM/IFPRI SEMINAR
17 September 2014, 12:00 – 2:00 pm
Washington, DC
2. How Did We Get Here?
IFPRI “Best Fit” Framework
GFRAS Evaluation Guide
PIM Research Area
3. Past Extension Work with PIM
•Building R4D learning platforms in Latin America, Africa Asia (CIAT)
•Evaluation of innovative extension approaches (ICRAF)
•Analyzing effects of decentralization and governance environment on policy processes and outcomes (IFPRI)
•Does agricultural training and female representation in extension foster investments among female farmers? Lessons from a policy experiment in Mozambique (IFPRI)
•Approaches for evaluating and increasing access to rural services by women and the poor (ILRI)
4. PIM’s “Advisory Services” Research
•October 2013 workshop
•2014 work plan under PIM
•IFPRI
•CIRAD
•GFRAS
•ICRAF
5. Overview of 2014 Work
Rationale
•Extension…advisory services…knowledge sharing…
•Critical institution for agricultural development
Goal
•Evidence & outreach to strengthen advisory services
Photo: Flickr, part of the image collection of the International Rice Research Institute (IRRI)
6. 2014 Activities
1.Framework to assess performance of pluralistic extension systems
2.Evaluation of impact of extension on ag productivity
3.Systematic collection of “global good practices”
4.Assessments in Central Asia, Brazil, North Africa
5.Knowledge sharing platform
6.Proposal for 2015-2016 work
7. Impact of Agricultural Extension
•AIM: Provide new set of evidence on impact of public investment
•Past meta-reviews on economic impact and ROR (Birkhaueser et al. 1991; Alston et al. 2000; Evenson 2001): generally positive, but results widely varied, averages misleading, too much noise, suffer econometric deficiencies
•Recent studies addressed some econometric deficiencies (Dercon et al. 2013; Owens et al. 2003; Gautam 2000; Benin et al. 2011; Davis et al. 2012)
•We will use existing datasets with components on extension to provide new empirical evidence on impact of agricultural extension
•We will further disaggregate analysis and unpack extension input to explain reasons for low or high marginal impact and suggest ways to move forward
8. Malawi Case
•What is differentiated impact across regions, zones and groups of access to extension services?
•Do different sources of information or service providers matter in explaining differences in productivity?
•Does access to other service providers or other sources of information a substitute or complementary to public extension services?
•Do different types of advice or information provided matter in explaining productivity?
•Does the gender of the receiver of information matter in explaining productivity?
IHS3 2010/11 covering 31 districts; 560 rural EAs; 10,038 rural HH; and follow-up panel in 2013/14 covering 150 EAs; 2,400 rural HH
9. Assessments and Evaluations
•How do we know RAS functions as supposed to?
•How to develop best-fit practices from wide range of contexts and policy regimes?
•Set of criteria for RAS program assessment and evaluations - Effectiveness, Efficiency, Relevance, Impact, Sustainability
•GFRAS evaluation indicators as starting point
•Currently engaged in applying methodology for Brazil, Central Asia, & North Africa
11. Which framework to assess the performance and impact of pluralistic extension systems ?
•Objective : design and test a framework to support national policy makers and top managers of service providers:
•Which extension programs suit which needs under what circumstances?
•How much public funding can be justified as a good investment?
•How performance and impact can be monitored?
12. Evaluations of Extension Performance: What do we have?
•Many evaluations of performance to assess the relevance of investments in extension (Neuchatel Initiative, World Bank, GFRAS, etc.)
•Mainly based on comparison between objectives of the project and achievements
•Using OECD criteria (relevance, efficiency, effectiveness, sustainability)
•Mix of surveys (SWOT, focus group, statistical surveys, etc.)
•More comprehensive studies about the evolution of RAS and the reforms undertaken:
•Labarthe et al. on EU advisory systems, Babu in India, etc.
13. Evaluation of Extension Impact: What do we have?
•A few research to assess change of farmers’ skills (Cameron in Australia, de Romemont in Benin, etc.)
•A large number of evaluations to assess extension programs (T&V, FFS, and other) (see GFRAS documents)
• Impacts on adoption of technologies, yields, and incomes,
•Some research to compare impacts of
•different methods (video, farmer to farmer, etc.)
•type of service provider (NGO, private provider)
•A few research to assess spill-over
14. Conclusions about Evaluations
•Positive impacts but variability and over-estimation with regards to the real evolution of agriculture
•Methodological questions (the quality of the data, the design of samples, the attribution)
•Such methods consider the service providers as a black box (not very useful to provide recommendations)
•There is no study about the impacts of an extension system (with a set of providers providing different type of advice) at territorial level/national level
15. Proposal to Assess Complex Pluralistic Extension Services
•Holistic approach based on IFPRI framework (Birner el al. 2009)
•Need to operationalize taking into account the national level and the local level
•Improving the impact pathway approach (Douthwaite 2003)
•Designing a mix of qualitative and quantitative methods
16. Context- ual factors
Policy,
farming systems, access to market)
Perfor- mance efficiency effectiveness inclusion sustainability
Impact
Economic
Social
Environmental
Governance structure (funding)
Advisory methods
Service provider capacities
Farm house- hold
Representation
Decision
Change of practices
17. Methodological Proposal
•Mapping of RAS at national level (governance, funding, capacities, methods)
•Case studies to represent the diversity of service providers and diversity of innovation processes
•Impact pathway linking key outputs (information, training, platform, etc.), outcomes (change at farm level) and impacts (economic, social, environmental, etc.)
•Two levels to assess impacts : direct impacts, indirect impacts
•Impact at national level = sum of impacts at case studies level
18. Tools to be Designed
•Timeline diagram describing actions undertaken by service provider and external events influencing advisory services
•Impact pathway diagram showing place where interactions advisors/farmers really take place, and changes at different levels
•Performance diagram is aiming to quantify an visualize the performances (effectiveness, efficiency, equity (targeting), sustainability)
•Impacts diagram to quantify and visualize different impacts
19. Key Methodological Questions to be Addressed
•How to select case studies to have relevant results?
•How to select performance indicators that make sense for actors and in line with national public policies on extension?
•How to calibrate a method to quantify the impacts (using existing surveys, carrying out specific surveys) (see Wellard 2014)?
•Next step : test the method in one or two countries
20. Global Best-fit Practices
The problem:
•Much available about how a particular practice works in a particular context: “case studies”
•But little synthetic material available - how a particular practice works in different contexts
•E.g. farmer to farmer extension: dozens of case studies available about a particular experience but only one study found that cuts across countries and facilitating organizations: Selener et al 1997 – covering only Latin America
21. •High demand from practitioners for simple materials that present how particular practices perform in different contexts and key lessons for implementation
•Our proposed solution:
•Commission preparation of syntheses of best-fit practices and produce reports and training materials useful for policy, rural advisory services managers and practitioners (different products likely needed for different target groups)
22. •Syntheses will be sought from 5 key dimensions of advisory services, using a structured framework for case selection:
•Governance structures (e.g., level and sources of financing)
•Policy (e.g., experiences with national advisory services policies)
•Capacity and management (e.g., staff numbers, expertise)
•Advisory methods (e.g., the use of ICTs)
•Cross cutting (e.g. gender, nutrition)
23. 5 Dimensions of extension
Theme
Case
Country Typology
Inter-country
Intra-country
Socio- economic
Political
Organiza- tional
Ecological
1.Governance
Decentrali- zed extension systems
Ethiopia
Agrarian
Federal
(decentrali- zed)
Government
providers
Low natural resource base, subsistence, medium density
2. Policies
3. Capacity & management
4. Methods
5. Cross-cutting
23
24. Implementation plan
•Fund raising. GIZ already on board
•Establish advisory committee composed mainly of potential users of the information
•The committee, in consultation with regional ag. advisory system networks, selects potential topics
•Issue call for proposals to conduct syntheses
•Award grants; develop and complete studies
•Develop informational materials and implement communication and capacity strengthening strategy to promote their use
25. Where Do We Go from Here?
•Team meetings, 18 Sep, 6-7 Nov
•Develop common framework and proposal
•Feedback from experts*
•Engage partners, find funding
*Mark Lundy (CIAT), Cheryl Doss (Yale), Arame Tall (CCAFS), Aden Aw-Hassan (ICARDA), Laurens Klerkx (Wageningen), Cathy Colverson (University of Florida), Ismail Moumouni (University of Parakou, Benin), Victor Manyong (IITA), Pierre Labarthe (INRA), Andrea Knierim (Hohenheim University), Evelyne Kiptot and Anne Degrande (ICRAF) and Katarina Kosec, David Spielman, Ephraim Nkonya, Tewodaj Mogues (IFPRI).
26. Response by the Panel
•Cheryl Doss, Yale
•David Spielman, IFPRI
•Valerie Mueller, IFPRI
•Pierre Labarthe, INRA