SEDEROBLASTIC ANEMIA FOR LAB.STUDENTS

1. 2-Sideroblastic anemia's (SA)
Developed by-Dr.Abdulrazzaq Othman Alagbare
M.D M.S.c C.P - Lecturer of Hematology and Immunohematology
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2. Mechanism:
The patient has adequate iron in his or her body, but is
unable to incorporate it into hemoglobin
The result is failure to produce RBC
The iron enters the developing red cells and accumulates
in the perinuclear.
Sideroblastic anemia's (SA)
6/8/2020
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3. Sideroblastic anemia's (SA)
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Causes
Hereditary Acquired
Drugs and toxins
Lead
Alcohol

4. Laboratory findings of SA
RBC WBC PLT
A-Hb, 8-10g/dl Normal Normal
B-RBC count  Low
C-MCV Normal
D-MCH  Normal
C-Rectic.Normal
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5. Laboratory findings of SA
PBS
 Typically the peripheral blood
smear shows two types of red cells
 Dimorphic RBC (some microcytes
and some normal cells, some
hypochromic and some
normochromic)
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Diagnostic Test of sideroblastic anaemia
 Specimen: bone marrow
 Stain: Perl`s stain
 Result: Bone marrow Iron staining show: Sideroblastic rings
Sideroblastic anaemia is diagnosed if ringed sideroblasts are ≥ 15% of
marrow erythroblasts

7. 6/8/2020Mini Introduction of
Hematology . ‫للطالب‬ ‫نسخة‬
‫فقط‬
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Detected with Perl's Prussian blue iron stain
Sideroblasts  are bone marrow nucleated red cells (normoblasts) that
contain small amounts of iron in the cytoplasm (normal).
• • diffusely spread throughout the red blood cell cytoplasm
• • found in normal individuals
Siderocytes Siderocytes are mature red blood cells that contain stainable
iron granules (abnormal,associated with iron overload
problems) .
“Ring”
Sideroblasts
• iron deposited in the mitochondria forms a ring around the
red blood cell nucleus
• large
• abnormal finding (abnormal,associated with iron overload
problems)

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‫رب‬ ‫هلل‬ ‫الحمد‬
‫العالمين‬....‫هذا‬
‫هللا‬ ‫مرضات‬ ‫ابتغاء‬