Iron deficiency anemia is a microcytic hypochromic anemia that results from insufficient iron intake or absorption. It is characterized by low hemoglobin and hematocrit levels, microcytic and hypochromic red blood cells, and low serum iron and ferritin levels with increased total iron binding capacity. The bone marrow shows erythroblastic hyperplasia and absent hemosiderin. Sideroblastic anemia is caused by an inability to incorporate iron into hemoglobin despite sufficient iron levels, resulting in increased hemosiderin deposition and serum iron.

1. 415 - PATH
PRACTICAL LECTURES

2. ANEMIA'S DUE TO DISORDERED IRON
METABOLISM OR HEME SYNTHESIS

3. Iron Deficiency Anemia (IDA)
Anemia is the condition of decrease in number of
circulating red blood cells (and hence
hemoglobin) below a normal range for age and
sex of the individual, resulting in decreased
oxygen supply to tissues. Iron deficiency anemia
is a type of microcytic hypochromic anemia,
which is the most common nutritional disorder.
Iron is an essential element in the synthesis of
hemoglobin.

4. Iron DeficiencyAnemia (IDA)
Laboratory finding :
• WBCs (not remarkable)
• Platelets (not remarkable)
• RBCs
1-Hb and Hct low
2-Microcytic / hypochromic anemia
3-Reticulocyte count normal to slightly increased.
4-RDW increased
5-Pencil or cigar shaped red blood cells.

5. Iron DeficiencyAnemia (IDA)
• Bone marrow :
1-Erythroblastic hyperplasia
2-Absent hemosiderin
• Chemistries :
1-Decreased serum iron level
2-Increased Total Iron Binding Capacity.
3-Decreased serum ferritin level

6. CBC OF IDA
http://library.med.utah.edu/WebPath/HEMEHTML/HEME024.html

7. Peripheral blood smear of IDA

9. Anemia of chronic disease (ACD)
Laboratory finding :
• WBCs (not consistent)
• Platelets (not consistent)
•RBCs
1-Hb and Hct low
2-Normocytic / normochromic anemia
3-Microcytic / hypochromic
4-Reticulocyte count normal to slightly increased

10. Anemia of chronic disease (ACD):
• Bone marrow :
1- Normal to increase hemosiderin
• Chemistries:
1- Decreased serum iron level
2- Normal to decrease TIBC
3- Normal to increase serum ferritin level

11. Lead Intoxication
• Laboratory finding:
• WBCs (not consistent finding)
• Platelets (not remarkable)
•RBCs
1- Microcytic / hypochromic anemia
2- Reticulocyte count normal to slightly increased
3- Basophilic stippling
• Chemistries:
1- Normal serum ferritin
2- Increased blood lead level

12. Peripheral blood smear

13. Sidroblastic anemia
The sideroblastic anemias are a group of blood disorders
in which the body has enough iron but is unable to use it
to make hemoglobin, which carries oxygen in the blood.
Laboratory finding :
• WBCs (not remarkable)
• Platelets (not remarkable)
• RBCs
1- Commonly Microcytic / hypochromic anemia
2- Reticulocyte count normal to slightly increased
3- RDW increased
4- Basophilic stippling
5- Dimorphism

14. • Chemistries :
A- Increased hemosidren
B- Increase serum iron
C- Normal to decreased TIBC
D- Increased serum ferritin level

15. Peripheral smear (dimorphism) Prussian blue stain