2. Qualitative defects of granular white cells
May be on
Morphologic changes
Functional changes
These changes are classified as
either
1. Inherited
2. Acquired. (greater seen)
Qualitative changes of the white cell take place
either in the cytoplasm or the nucleus
3. Acquired disorders in Neutrophils
Hypo segmentation
Nuclear Abnormalities
Pelger-Huet anomaly
benign congenital
abnormality
What changes in the
nucleus?
Bilobed and occasional
unsegmented neutrophils
don’t affect the cells
7. 4-Alder’s anomaly
This anomaly occurs in
1.Granulocytes (Neutrophils)
2.Monocytes
3.Lymphocytes
They contain granules
which stain purple with
Romanowsky stain
Neutrophils with granules Lymphocyte and Monocyte with granules
9. 5-Chediak-Higashi syndrome
This anomaly occurs in
1.Granulocytes (Neutrophils)
2.Monocytes
3.Lymphocytes
4.Platelets
They contain
Giant granules
Neutrophils in Chediak-Higashi
syndrome
Loss the Chemotaxis and
phagocytosis ability
Platelets lack dense granules and platelet function is abnormal
10. 6-Myeloperoxidase deficiency
(MPO)
MPO exist normally in
1-Neutrophils
2-Monocytes
What is MPO deficiency?
Inherited
Autosomal recessive
How present the deficiency?
Absence of the MPO
Result of this absence in the phagocyte
cells cannot kill the foreign substances
which engulfed
Negative MPO
Positive MPO