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Pharyngitis, a common inflammatory condition of the throat, presents a significant burden on healthcare systems globally. This comprehensive review explores the multifaceted aspects of pharyngitis, encompassing its etiology, clinical manifestations, diagnostic approaches, and therapeutic interventions. Pharyngitis, often referred to as sore throat, can stem from various infectious and non-infectious causes, including viral and bacterial pathogens, environmental irritants, and underlying medical conditions. Clinical presentation typically involves symptoms such as throat pain, difficulty swallowing, fever, and swollen lymph nodes. Differential diagnosis is crucial to distinguish between viral and bacterial etiologies, with streptococcal pharyngitis being a common bacterial cause requiring specific treatment. Diagnostic modalities include clinical evaluation, throat swabs for culture or rapid antigen testing, and, in some cases, imaging studies. Treatment strategies range from supportive measures, such as rest and hydration, to antimicrobial therapy for bacterial infections. Additionally, symptomatic relief can be achieved through analgesics, antipyretics, and throat lozenges. Prevention of pharyngitis involves practicing good hygiene, avoiding exposure to respiratory pathogens, and vaccination against specific bacterial pathogens. This review provides valuable insights into the epidemiology, pathophysiology, and management of pharyngitis, aiming to optimize patient care and outcomes. Keywords: Pharyngitis, sore throat, streptococcal pharyngitis, diagnosis, treatment, antimicrobial therapy, viral infections, bacterial infections

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