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Preparing a Search Strategy Step 1: What is the research question? Project Topic:  Research Question:  MicroRNA regulate protein production in a process known as base pairing – in which complementary codes found on microRNA bind to the corresponding mRNAs much like a lock and key. This process leads to inhibition of protein translation and, in some cases, to degradation of the mRNA itself. How do microRNAs interact with RNA to inhibit protein translation?
Preparing a Search Strategy Step 2: Identify main concepts and synonyms microRNAs translation Concept 1:  Concept 2:  Research Question:  small RNAs Synonyms:  gene regulation Synonyms:  How do microRNAs interact with RNA to inhibit protein translation?
microRNAs small RNAs Concept 1 & Synonym:  Concept 2 and Synonym:  translation gene regulation Preparing a Search Strategy Step 3: Prepare search statement Search statement:  OR OR AND Limits:  (microRNAs OR small RNAs) AND (translation OR gene regulation) Year (example: past 5 years only) Language (example: English only articles)
 

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Search strategy

  • 1. Preparing a Search Strategy Step 1: What is the research question? Project Topic: Research Question: MicroRNA regulate protein production in a process known as base pairing – in which complementary codes found on microRNA bind to the corresponding mRNAs much like a lock and key. This process leads to inhibition of protein translation and, in some cases, to degradation of the mRNA itself. How do microRNAs interact with RNA to inhibit protein translation?
  • 2. Preparing a Search Strategy Step 2: Identify main concepts and synonyms microRNAs translation Concept 1: Concept 2: Research Question: small RNAs Synonyms: gene regulation Synonyms: How do microRNAs interact with RNA to inhibit protein translation?
  • 3. microRNAs small RNAs Concept 1 & Synonym: Concept 2 and Synonym: translation gene regulation Preparing a Search Strategy Step 3: Prepare search statement Search statement: OR OR AND Limits: (microRNAs OR small RNAs) AND (translation OR gene regulation) Year (example: past 5 years only) Language (example: English only articles)
  • 4.