The document discusses some of the key challenges in scaling agile using SAFe (Scaled Agile Framework), including alignment, synchronization, and dependencies. It notes that alignment challenges can be addressed through value stream mapping, shared vision and goals, and roadmaps. Synchronization requires a common ART (Agile Release Train) cadence, continuous integration/delivery, a single backlog, and PI (Program Increment) goals. Managing dependencies involves using program boards, sequencing work using WSJF (Weighted Shortest Job First), having a single backlog and PI goals that cascade to team goals, and ART SOS (System of Systems) events.