The Wilton E. Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation’s and world’s energy challenges through research, strategic partnerships, public policy outreach and education.
The Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, strategic partnerships, public policy outreach and education.
Carnegie Mellon University Wilton E. Scott Institute for Energy Innovation Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University addresses the world’s most important energy-related challenges by enabling collaborative research, strategic partnerships, public policy outreach, entrepreneurship, and education. As one of CMU’s only university-wide institutes, we seek to optimize energy resources, reduce the environmental impacts of energy production and use, and develop breakthrough technologies and solutions that will have meaningful global impact.
Overcoming Pakistan's current crisis through energy efficiency and renewable energy was the topic of a seminar supported by USAID and organized by Senator (R) Rukhsana Zuberi, chairperson of the Pakistan Engineering Council and head of the non-government organization, South Asian Women in Energy.
The Alliance's Alexander Filippov was among the experts advising Pakistani representatives on energy efficiency implementation.
The Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, strategic partnerships, public policy outreach and education.
Carnegie Mellon University Wilton E. Scott Institute for Energy Innovation Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University addresses the world’s most important energy-related challenges by enabling collaborative research, strategic partnerships, public policy outreach, entrepreneurship, and education. As one of CMU’s only university-wide institutes, we seek to optimize energy resources, reduce the environmental impacts of energy production and use, and develop breakthrough technologies and solutions that will have meaningful global impact.
Overcoming Pakistan's current crisis through energy efficiency and renewable energy was the topic of a seminar supported by USAID and organized by Senator (R) Rukhsana Zuberi, chairperson of the Pakistan Engineering Council and head of the non-government organization, South Asian Women in Energy.
The Alliance's Alexander Filippov was among the experts advising Pakistani representatives on energy efficiency implementation.
ScottMadden's Energy Industry Update for the 2019 Utility Supply Chain Confer...ScottMadden, Inc.
As economic growth continues, and policies are increasingly driven by state and regional issues, utilities are placing bets, with large investments, on various growth strategies. They continue to face opposition and challenges from various stakeholders with disparate interests. Energy and utility companies will try to thread the needle of developing and upgrading much needed infrastructure, while satisfying those interests.
During the 2019 Utility Supply Chain Conference, Cristin Lyons reviewed the latest Energy Industry Update and shared key highlights for topics including:
- Electrification: A summary of increased electrification activities (ie: transportation/space heating) being promoted by electric industry stakeholders, and electrification’s pros and cons
- Wholesale energy infrastructure development: A discussion of proposed gas and power transmission projects, potential regulatory changes, and surrounding issues/implications
- Grid modernization: Noteworthy efforts around the nation, including both the programs and the common themes.
Learn more at www.scottmadden.com.
Dora Nakafuji from HECO describes plans to meet the renewable electricity generation goals set forth by the Renewable Portfolio Standard (RPS) and Hawaii Clean Energy Initiative (HCEI). Slides from the REIS seminar series at the University of Hawaii at Manoa on 2009-11-12.
Dr Callum Rae - A New Approach to Energy Centre Design
http://www.ktpscotland.org.uk/ViewArticle/tabid/4421/articleType/ArticleView/articleId/10338/Callum-Rae--Hurley-Palmer-Flatt.aspx
The route and how Japan has successfully implemented energy efficiency for better utilization of their energy resources and sustaining their economy to grow
Presentation from the New Mexico Regional Energy Storage and Grid Integration Workshop: Energy Storage Trends and Challenges, New Mexico's Numerous Contributions presented by Steve Willard, Electric Power Research Institute, August 23-24, 2016
Connecticut's ongoing renewable energy initiatives and best "green" practices for financing and operating affordable housing.
Presented at the 2015 Conn-NAHRO Convention by:
Kathy Dorgan, Dorgan Architecture & Planning
Colette Slover, CT Department of Housing
Marcus Smith, CT Housing Finance Authority
Kim Stevenson, CT Green Bank
Stephen Turner, Stephen Turner Inc.
Sciencewise Energy infrastructure webinarSciencewise
In this webinar we will present the findings of public views on the topic of energy infrastructure: how does the public feel about the technologies, drivers and trade-offs behind the complex and evolving area of energy infrastructure in the UK.
For our research we have reviewed findings from public engagement activities and relevant reports, exploring public views on the supply-side of national energy infrastructure in the UK.
We will present the key messages, trends and possible gaps in current knowledge about what the public think about energy infrastructure and why. You will also hear about good practice in engaging the public around climate change and energy.
We are also keen on hearing your views and experiences in engaging the public on these issues, and discuss what good quality (local) engagement with energy infrastructure looks like.
Many large-scale energy customers, from local governments to corporations, have set ambitious clean energy goals. Utility investments in renewables in the overall generation mix are important to achieving them. But there can be a number of barriers to the inclusion of solar and other renewables in utility long-term planning, including cost and technology assumptions, modeling approaches and scenario development. Large-scale energy customers and utilities have an opportunity and are increasingly taking action to update practices and address these barriers.
This presentation highlights ways that solar energy is currently considered and can be improved in utility long-term planning, and how customers are engaging in these plans to advance their clean energy goals.
Although the Hawaiian Islands are blessed with an abundance of renewable energy sources including excellent solar and wind resources, and have the nation’s most aggressive renewable energy standards, the state still relys heavily on fossil fuels for electricity generation. With isolated (unconnected) island grids and sparse systems on some islands, integration of the intermittent renewable generation systems has been challenging. In this talk, Richard discusses the approach used to identify strategic paths forward and describes several projects currently underway including the Maui Smart Grid Demonstration Project, the Smart Grid Inverter Project and several grid-scale battery energy storage projects.
Kaitiakitanga - Community owned and led enterpriseKaramea Insley
A paper I presented yesterday at Canterbury University on Community owned and led Enterprise profiling our kaitiakitanga (sustainable development) project at Omaio in the Eastern Bay of Plenty (New Zealand). Presented at the 2014 international Engineers Without Borders Conference. EWB have become valued partners to our project through especially the 2013 Odyssey Design Challenge and continue to play an important strategic partner role to the project.
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon Univer...Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University is focused on developing and demonstrating the technologies, systems and policies needed to accelerate the transition to a sustainable energy future.
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon Univer...Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, strategic partnerships, public policy outreach and education.
ScottMadden's Energy Industry Update for the 2019 Utility Supply Chain Confer...ScottMadden, Inc.
As economic growth continues, and policies are increasingly driven by state and regional issues, utilities are placing bets, with large investments, on various growth strategies. They continue to face opposition and challenges from various stakeholders with disparate interests. Energy and utility companies will try to thread the needle of developing and upgrading much needed infrastructure, while satisfying those interests.
During the 2019 Utility Supply Chain Conference, Cristin Lyons reviewed the latest Energy Industry Update and shared key highlights for topics including:
- Electrification: A summary of increased electrification activities (ie: transportation/space heating) being promoted by electric industry stakeholders, and electrification’s pros and cons
- Wholesale energy infrastructure development: A discussion of proposed gas and power transmission projects, potential regulatory changes, and surrounding issues/implications
- Grid modernization: Noteworthy efforts around the nation, including both the programs and the common themes.
Learn more at www.scottmadden.com.
Dora Nakafuji from HECO describes plans to meet the renewable electricity generation goals set forth by the Renewable Portfolio Standard (RPS) and Hawaii Clean Energy Initiative (HCEI). Slides from the REIS seminar series at the University of Hawaii at Manoa on 2009-11-12.
Dr Callum Rae - A New Approach to Energy Centre Design
http://www.ktpscotland.org.uk/ViewArticle/tabid/4421/articleType/ArticleView/articleId/10338/Callum-Rae--Hurley-Palmer-Flatt.aspx
The route and how Japan has successfully implemented energy efficiency for better utilization of their energy resources and sustaining their economy to grow
Presentation from the New Mexico Regional Energy Storage and Grid Integration Workshop: Energy Storage Trends and Challenges, New Mexico's Numerous Contributions presented by Steve Willard, Electric Power Research Institute, August 23-24, 2016
Connecticut's ongoing renewable energy initiatives and best "green" practices for financing and operating affordable housing.
Presented at the 2015 Conn-NAHRO Convention by:
Kathy Dorgan, Dorgan Architecture & Planning
Colette Slover, CT Department of Housing
Marcus Smith, CT Housing Finance Authority
Kim Stevenson, CT Green Bank
Stephen Turner, Stephen Turner Inc.
Sciencewise Energy infrastructure webinarSciencewise
In this webinar we will present the findings of public views on the topic of energy infrastructure: how does the public feel about the technologies, drivers and trade-offs behind the complex and evolving area of energy infrastructure in the UK.
For our research we have reviewed findings from public engagement activities and relevant reports, exploring public views on the supply-side of national energy infrastructure in the UK.
We will present the key messages, trends and possible gaps in current knowledge about what the public think about energy infrastructure and why. You will also hear about good practice in engaging the public around climate change and energy.
We are also keen on hearing your views and experiences in engaging the public on these issues, and discuss what good quality (local) engagement with energy infrastructure looks like.
Many large-scale energy customers, from local governments to corporations, have set ambitious clean energy goals. Utility investments in renewables in the overall generation mix are important to achieving them. But there can be a number of barriers to the inclusion of solar and other renewables in utility long-term planning, including cost and technology assumptions, modeling approaches and scenario development. Large-scale energy customers and utilities have an opportunity and are increasingly taking action to update practices and address these barriers.
This presentation highlights ways that solar energy is currently considered and can be improved in utility long-term planning, and how customers are engaging in these plans to advance their clean energy goals.
Although the Hawaiian Islands are blessed with an abundance of renewable energy sources including excellent solar and wind resources, and have the nation’s most aggressive renewable energy standards, the state still relys heavily on fossil fuels for electricity generation. With isolated (unconnected) island grids and sparse systems on some islands, integration of the intermittent renewable generation systems has been challenging. In this talk, Richard discusses the approach used to identify strategic paths forward and describes several projects currently underway including the Maui Smart Grid Demonstration Project, the Smart Grid Inverter Project and several grid-scale battery energy storage projects.
Kaitiakitanga - Community owned and led enterpriseKaramea Insley
A paper I presented yesterday at Canterbury University on Community owned and led Enterprise profiling our kaitiakitanga (sustainable development) project at Omaio in the Eastern Bay of Plenty (New Zealand). Presented at the 2014 international Engineers Without Borders Conference. EWB have become valued partners to our project through especially the 2013 Odyssey Design Challenge and continue to play an important strategic partner role to the project.
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon Univer...Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon University is focused on developing and demonstrating the technologies, systems and policies needed to accelerate the transition to a sustainable energy future.
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon Univer...Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, strategic partnerships, public policy outreach and education.
The Wilton E. Scott Institute for Energy Innovation at Carnegie Mellon Univer...Amanda Finkenbinder, MPM
The Wilton E. Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, strategic partnerships, public policy outreach and education
The Scott Institute for Energy Innovation works through the academic units of Carnegie Mellon University to find solutions for the nation's and the world's energy challenges including pathways to a low carbon future, smart grid, new materials for energy, shale gas, and building energy efficiency through research, education, and policymaker and public communication.
Strong growth in the global demand for electric power is projected for the next half-century and beyond. This growth will provide great opportunities for Western Pennsylvania (WPA) companies that are leaders in the chain of industries that generate, transmit and distribute electric power. While great opportunities await these companies, they are all preparing for the impact of workforce and technology development neglect that was dominant in their industries in the 1980s and 1990s. Representatives of these industries have indicated that up to half of their engineering workforce will be eligible for retirement within the next decade.
Don Shields, Executive Director for Center for Energy, Director of Corporate Relations, Co-Director of Swanson Institute for Technical Excellence, University of Pittsburgh (moderator)
Laura S. Fisher, Senior Vice President, Workplace and Special Projects, Allegheny Conference on Community Development
Kate Jackson, CTO, Westinghouse
James McCaffrey, Senior VP, CONSOL Energy
Clean Energy Overview - Pecan Street Project_BeceiroJohn Thornton
Austin’s Pecan Street Project: One model for integrating the Smart Grid into a comprehensive sustainable development strategy
Jose Beceiro, Board Member, Austin’s Pecan Street Project, and Director of Clean Energy Economic Development, Austin Chamber of Commerce
SGIP hosted an eMeeting focused on Stakeholder Category 14: R&D and Academia.
Leading experts presented on the impact of Smart Grid research on future products and services and how research contributes to new solutions for interoperability for the Smart Grid ecosystem. The panel was moderated by Steve Widergren, Pacific Northwest National Laboratory. Joining Steve as panelists were Don Von Dollen, Electrical Power Research Institute; Michael Cohen, MITRE; Jason Veneman, MITRE; and Dennis Ray, Power Systems Engineering Research Center.
An appraisal on the various SGIP technical activities was presented, including updates on transactive energy, cybersecurity and Smart Grid Testing and Certification Committee and Smart Grid Implementation Methods Committee activities. An update was also given on a new Catalog of Standards entry to be voted on by SGIP Participating member organizations.
- See more at: http://www.sgip.org/sgip-presents-how-todays-power-grid-integration-choices-impact-figure-smart-grid-deployments-emeeting-on-september-26-2013/#sthash.8fzknMkc.dpuf
Energy efficiency is often regarded as the fastest and most
accessible means to achieve sustainability and reduce energy
costs. Using a framework developed from semi-structured
interviews of business owners, staff and personnel, this
presentation will analyze the relevance of various barriers to
energy efficiency experienced by commercial and small
industrial businesses across 7 industrial parks in the Upper
Peninsula of Michigan.
Preliminary analysis indicates that high energy costs in the
region pose a significant barrier to business expansion and
workforce development. To address this, the presentation will
also make specific technical and policy recommendations for
regional planners, showing how advancing energy efficiency
helps support local economic development and business
retention.
Energy Industry Update Webcast: Don't Stop Believin'ScottMadden, Inc.
To coincide with the release of the latest Energy Industry Update, ScottMadden joined forces with Energy Central to present an interactive webinar, “ScottMadden’s Energy Industry Update: Don’t Stop Believin’.” During this session, our industry experts shared their views and fielded questions related to grid modernization efforts around the nation, evolving federal policy toward wholesale energy infrastructure development, and opportunities for and possible trade-offs with increased electrification.
The 90-minute webinar included four parts: (1) Karma Sawyer, Technology Manager at U.S. Department of Energy, gave an overview of R&D Directions and Opportunities at the Building Technologies Office of USDOE; (2) Jimmy Tran, Operations Manager of U.S.-China Clean Energy Research Center (CERC) on Building Energy Efficiency (BEE) Consortium, gave an overview of objectives, key research activities and outcomes from CERC-BEE 1.0 (2011-2016) Program and the upcoming CERC-BEE 2.0 (2016-2021) Program; (3) Tianzhen Hong, Staff Scientist, and Yixing Chen, Senior Scientific Engineering Associate of Building Technology and Urban Systems Division of LBNL , provided an overview of the occupant behavior research project under CERC-BEE 1.0, introduced and demonstrated the three occupant behavior modeling tools; and (4) Questions and Answers.
For more information, contact Tianzhen Hong at thong@lbl.gov or visit http://behavior.lbl.gov/?q=node/5
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
2. Scott Institute Leadership
Jay Whitacre,
Director
Professor of Materials Science
and Engineering and
Engineering and Public Policy
Andrew Gellman,
Co-Director
Lord Professor of Chemical
Engineering, Chemistry
(Courtesy), Materials Science
and Engineering (Courtesy)
2
Deborah Stine,
Associate Director for
Policy Outreach
Professor of the
Practice, Engineering
and Public Policy
Anna J. Siefken,
Associate Director for
Innovation and Strategic
Partnerships
3. Mission
3
The Scott Institute for Energy Innovation works through the
academic units of Carnegie Mellon University to find
solutions for the nation’s and world’s energy
challenges through research, strategic partnerships, public
policy outreach and education.
4. Scott Institute Activities
• Research
– Seed grants
– Presidential Fellowship matching for proposals
– Investments in strategic areas
• Industrial Partnerships and Technology
Commercialization
• Education
• Outreach
4
5. 2016-2017 Highlights
• 130 Faculty Affiliates
• 8 Seed grants supported with nearly $553K
• 2nd Annual Carnegie Mellon Energy Week
• Allegheny Region Cleantech University Prize Collegiate
Competition
• Public Radio Energy Bite Radio Program Turns 2
5
6. Strategic Investments
• Leverage CMU’s comparative advantages
• Choose important parts of the energy system
where we already have competitive advantage
Solar
Hydro
Nucl.
Wind
Geoth
Nat
Gas
26.0
Coal
17.4
Bio
Petro
34.7
0.24
8.05
2.69
1.36
0.23
4.32
Elect.
Gener.
38.1
Rejected
energy
58.1
Energy
Services
37.0
Resid.
10.6
Comm.
8.3
Indust.
23.9
Transp.
26.7
7. CMU’s Comparative Advantages
• Systems approach to problem-solving and design
• Unique energy policy expertise
• Interdisciplinary collaboration
• Innovative and entrepreneurial
• Location (Marcellus shale, industry, NETL)
7
8. Strategic Thrusts
• New Materials: Developing new chemistry for a photo-
rechargeable energy storage technology
• Energy Efficiency: Sensors, the Internet of Things,
Building design, Consumer Behavior, Utility and Grid
Design and Policy
• Pathways to a Low-Carbon Future
– Carbon Intensity Index
8
10. Seed Grants 2016-17:
8 funded of 22 submissions
10
Name College/School Project Title
Agarwal Computer Science Creating an Instrumented Scott Hall “Living Lab” Testbed
Severini Heinz
The Impact of Climate Change on Air Pollution: Evidence
from Ground-Level Ozone Concentration
Litster Engineering
Advanced Chemical Synthesis and Engineering to Enable
Low Cost Alkaline Membrane Fuel Cells
Viswanathan Engineering
Catalytic approaches to improvements in long-term
stability of Li-ion batteries
Karamalidis Engineering Critical Mineral Recovery from Energy-Related Fluids
Secomandi Tepper
Pathwise Optimization for Large Scale Energy Merchant
Operations Models
Whitacre Engineering Concurrent Assessment and Design of Systems (CADS)
Michalek Engineering
How Do Shared Mobility and Autonomous Taxis Affect
Energy Consumption, Vehicle Use, and Greenhouse Gas
and Criteria Air Pollutant Emissions?
11. Matching Fellowship Program
• For energy related proposals that will
support ≥2 PhD students, the SI will
provide funding for an additional student
for up to 3 years.
• Goal: incentivize writing of larger
proposals, increase odds of success
through CMU investment (cost matching),
increase productivity.
• Status: 14 submissions, 3 awards, 3
pending
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12. Visiting Faculty Fellows Program
• Provides support for senior visitors from
academia, industry or gov’t for 1-2 semesters.
• CMU has not traditionally been a sabbatical
destination, in part due to lack of resources.
Prof. Nicholas Muller
Economics, Middlebury College
(now CMU, EPP & Tepper)
Prof. Junho Song
Civil and Environ. Eng.,
Seoul National Univ.
12
13. Six ARPA-E Grants
• Innovative, predictive "InfoRich” vehicle dynamic and
powertrain technologies to improve energy efficiency.
• Rugged robotic system to measure characteristics of
sorghum in the field.
• Smart Wire power flow control devices to increase
overall grid transmission utilization by more than 30%
and reduce cost by 50%.
• Dendrite-blocking polymers in lithium-ion batteries to
reduce overheating and fires. Two different grants:
– Nano-composite protective layers in low-cost, high-energy
lithium batteries
– Optimize a new solid electrolyte made of polymer material
13
14. ARPA-E Grants (continued)
14
• New nanoscale magnetic material to
reduce the size, weight, and cost of utility-
scale PV solar power conversion systems.
• Advanced electrochemical process to
produce low-cost, low-weight titanium to
reduce fuel cost savings for military
vehicle and aircraft applications
16. Corporate and Industrial
Partnerships, Engagement
16
• Value proposition for corporations and industrial sectors
• Growing Brand awareness
• Amplifying faculty & specific research interests
• Deeping student recruitment opportunities
• Physical assets (Scott Hall, labs, clean room)
• Recruiting
• Relationship building and events
• Energy Week 2017 & 2018
• One-on-one sessions with corporate entities
• Speaking engagements & Distinguished Lectures
• Enhance Commercialization efforts
17. 2017 Distinguished Lectures - Industry
17
Itron Inc.
President & CEO
Philip Mezey
Chevron Appalachia
President Stacey
Olson
ComEd
SVP of
Customer
Operations
Val Jensen
18. Smart Cities: The Energy-Water Nexus
18
February 16, 2017
More than 450 guests + VIP reception for 150 including 30 faculty
Keynote speaker: Dr. Michael Webber, UT Austin
Panelists:
• Bill Peduto, Mayor - The City of Pittsburgh
• Rich Fitzgerald - Allegheny County Executive
• Rich Riazzi, CEO - Duquesne Light Company
• Morgan O’Brien, CEO - People’s Natural Gas
• Rick Stafford - CMU, Metro21/MetroLab Founder
• Phillip Mezey, CEO - Itron Inc.
Dr. Jared Cohon + Anna J. Siefken, moderators
Opportunity to bring city-related initiatives to campus and
demonstrate our leadership position in the energy space.
19. Company Snapshot
19
Arconic
BNY Mellon
Braskem
BuroHappold
Chevron Appalachia
Cisco
ComEd
Covestro
Direct Energy
Duke Energy
Duquesne Light
Encentiv
FedEx
GE Energy
Giant Eagle
Highmark
Honeywell
ICF International
JLL
Jones Day
Michael Baker
Orbital Engineering
Oxford Development
Pittsburgh Magazine
Platypus
PNC Financial
Rice Energy
Saint-Gobain
Shell
Siemens
Stantec
State Farm
The Southern Company
WGL Energy
21. Financial Support via CMU Center for
Technology Transfer and Enterprise Creation
(CTTEC)
• NSF I-Corps CMU Team Support (Regional
and National) for Costs Not Supported by NSF
(e.g,. Mentorship)
• Gap Funds (match with CTTEC gap funds)
• Small Business Innovation Research (SBIR)
Program Gap Funds
• Energy Knowledge Hub at CTTEC to Support
Analysis for CMU Spinouts (Interns; Database)
• Support for CTTEC Staff to Promote CMU
Energy Innovations at ARPA-E and NREL
Events
21
22. EEme, LLC processes smart meter interval data
using proprietary load disaggregation algorithms
to predict the technical and behavioral energy
efficiency (EE) potential by EE measure for
every residential user for a given service
territory.
Rapid Flow Technologies is an innovative
approach to traffic signal control, combining
research from artificial intelligence and traffic
theory to optimize the performance of signals
for the traffic that is actually on the road.
Lean FM Technologies is a lifecycle software
solution for economic, proactive and intelligent
Facilities Management.
Building Ideas is developing systems for data
collection, analytics and visualization on energy
usage to reveal actionable information for building
occupants, managers and owners.
23. D-PowerNet is developing software that
will enable dynamic, distributed, parallel
management of load balancing in electric
power distribution networks.
Gecko Robotics has developed robotic
systems to facilitate the inspection of boiler
tubes in power plants.
Platypus LLC manufactures small, low-cost
autonomous robotic boats with the ability to sense
environmental contaminants in large areas of calm
water along with other critical data such as water
depth, dissolved oxygen and pH.
SolePower is converting kinetic energy into
electrical energy. The technology is being
integrated into "Smart Boots" that have
embedded GPS trackers, temperature,
pressure sensors and other applications to
improve worker safety and
efficiency. Partners include the US Army,
NSF, and leading industrial boot
manufacturers.
28. Tri-State University Energy Alliance (TrUE)
• Four leading research universities
– Case Western Reserve University
– Carnegie Mellon University
– University of Pittsburgh
– West Virginia University
• Joined forces to accelerate innovations to address challenges and
opportunities facing the energy sector.
• Activities Thus Far:
– Two joint proposals to DOE (Energy Innovation; Energy and
Economic Development
– Joint TransTech Energy Innovation Competition
– Downstream Shale Gas Related Innovation
– Joint Meetings to Identify Potential for Research Collaboration
28
30. Energy Week 2017
• 1,010 Participants
• Speakers included:
– Mitsubishi Hitachi Power Systems President and
CEO Paul Browning (Engineering '90)
– Tesla's Special Projects Andrew Stevenson
– National Academy of Sciences President Marcia
McNutt
– U.S. Energy Information Administration Acting
Administrator and former CMU Professor Howard
Gruenspecht
– PA Public Utilities Chair Gladys Brown
– Federal Energy Regulatory Commissioner Colette
Honorable
– Columbia University’s Timothy Mitchell
– Eight CMU faculty members who gave “Andy
Talks” on Innovative Research (brief 20-minute
presentations)
30
31. Energy Week Continued
• Roundtables on:
– Regional Energy Innovation and Entrepreneurship
– The Energy Workforce
– Technical Innovation, Policy and Shale Gas Development
• Energy Career Fair
• Student Competitions
– Allegheny Cleantech University Prize Competition
– Low-Carbon Energy Innovation Talks
– Energy-Related Research Poster and Multimedia
• Policy and Law Forum
• Field Trips to Chatham U’s Eden Hall, Greenstar Recycling +
more
• An augmented reality tour of East Liberty’s history of electrical
infrastructure development (sponsored by CMU’s Center for the
Arts in Society and School of Drama)
• Contesting Energy Symposium with CMU’s English and History
Departments
• Thank you to our sponsors: Automated Logic, Duquesne Light
Company, Wells Fargo, The Southern Company, Philips, Itron,
WGL Energy, NRG Energy and NGH Energy.
31
32. 2016-2017 Distinguished Lectures and Seminars
Lectures
32
Seminars
Patricia Falcone,
Lawrence Livermore
National Laboratory
Deputy Director of
Science and Technology
(top) and George
Crabtree, Joint Center
for Energy Storage
Research Director (left)
33. For More Information
• Website: www.cmu.edu/energy
• Newsletter Signup: tinyurl.com/scottnews
• Funding Opportunities Newsletter Signup (CMU only):
tinyurl.com/ScottFundingNews
• Scott Institute Affiliate Signup (CMU only): http://bit.ly/scott-institute-affiliate
• Seed Grant Proposals: tinyurl.com/Scott-Seed-2016 (CMU only)
• Energy Week: cmuenergyweek.org
• CleanTech Competition: cleantechprize.org
• Energy Bite: energybite.org
• Jay Whitacre: whitacre@andrew.cmu.edu
• Andrew Gellman: gellman@cmu.edu
• Deborah Stine: dstine@andrew.cmu.edu
• Anna J. Siefken: asiefken@andrew.cmu.edu
33