This document provides an agenda for the NISMEC/I-STEM Talks conference with details of presentations on various science education topics. On Thursday, presentations will focus on student investigations of Galileo and the moons of Jupiter, using the high school modeling curriculum, and teacher developed extensions of the Indiana Science Initiative for grades 5-8. On Friday, topics will include the science process skills needed by middle schoolers, engaging students in science at all grades through object analysis, the impact of the Indiana Science Initiative on classrooms, teaching AP science, connecting literature to the lab, and the Next Generation Science Standards.