The Salud Mesoamerica Initiative (SMI) evaluation plan, dated March 21, 2023, aims to assess the project's impact on health systems through mixed methods, including quantitative and qualitative measurements. Key aspects include addressing the effects of COVID-19 on health service utilization and identifying the initiative's contributions to maternal and child health outcomes in the region. The evaluation emphasizes the importance of understanding sustainability, adaptation, and the mechanisms of change facilitated by SMI amidst global health challenges.