introduction and terminologies of preventive vet medicine, ,preventive medicine ,disinfection ,sterilization ,treatment principals ,disease control and eradication ,levels of disease prevention ,etiology and factor based disease types
Pathogenesis of microbial infections dr. ihsan alsaimarydr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Tuberculosis- International Perspectives on Epidemiology, diagnosis and ControlsRanjini Manuel
Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) that most often affect the lungs. Tuberculosis is curable and preventable.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
About one-quarter of the world's population has latent TB, which means people have been infected by TB bacteria but are not (yet) ill with the disease and cannot transmit the disease.
People infected with TB bacteria have a 5–15% lifetime risk of falling ill with TB. Persons with compromised immune systems, such as people living with HIV, malnutrition or diabetes, or people who use tobacco, have a higher risk of falling ill.
introduction and terminologies of preventive vet medicine, ,preventive medicine ,disinfection ,sterilization ,treatment principals ,disease control and eradication ,levels of disease prevention ,etiology and factor based disease types
Pathogenesis of microbial infections dr. ihsan alsaimarydr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Tuberculosis- International Perspectives on Epidemiology, diagnosis and ControlsRanjini Manuel
Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) that most often affect the lungs. Tuberculosis is curable and preventable.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
About one-quarter of the world's population has latent TB, which means people have been infected by TB bacteria but are not (yet) ill with the disease and cannot transmit the disease.
People infected with TB bacteria have a 5–15% lifetime risk of falling ill with TB. Persons with compromised immune systems, such as people living with HIV, malnutrition or diabetes, or people who use tobacco, have a higher risk of falling ill.
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
CBIC- Infection Prevention & Control training with Accrediation and with CME ...Deepika BL
About CIC Certification: is one of the current market hi in demand certification in the Health care Industry, which is Globally recognized at World class standard on INFECTION PREVENTION & CONTROLLING.
Certification Body
Certification Board of Infection control and Epidemiology Inc – (CBIC)
Name of the Training: Certification in Infection Control (CIC R ) with 20.5 CME POINTS Accredited
Course Contents
1. Identification of Infectious Disease Processes
2. Surveillance and Epidemiologic Investigation
3. Preventing/Controlling the Transmission of Infectious Agents
4. Employee/Occupational Health
5. Management and Communication
6. Education and Research
7. Environment of Care
8. Cleaning, Sterilization, Disinfection, Asepsis
Duration of the Training: 40 Hours / 5 Fridays
Exam Information
3Hrs
150 MCQs,
Online Exam Prometric Testing Centre
Exam Fee: 350 USD
Recertification
Valid for 5 Years
Training Information & Deliverable
40 Hours Lecture.
Course Completion Certificate with DHA Accrediation
20.5 CME Points
Study Materials
Training Kit
Consultant In charge Contact: Deepika , Email: deepika@transfedu.com
Looking forward for your positive reply.
For more details please contact us: Deepika- 0558978603
India is the highest TB burden country in the world & accounts for nearly 1/5th (20 per cent) of global burden of tuberculosis, 2/3rd of cases in SEAR. Every year approximately 1.8 million persons develop tuberculosis, of which about 0.8 million are new smear positive highly'- infectious cases.Annual risk of becoming infected with TB is 1.5 % and once infected there is 10 % life-time risk of developing TB disease
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
CBIC- Infection Prevention & Control training with Accrediation and with CME ...Deepika BL
About CIC Certification: is one of the current market hi in demand certification in the Health care Industry, which is Globally recognized at World class standard on INFECTION PREVENTION & CONTROLLING.
Certification Body
Certification Board of Infection control and Epidemiology Inc – (CBIC)
Name of the Training: Certification in Infection Control (CIC R ) with 20.5 CME POINTS Accredited
Course Contents
1. Identification of Infectious Disease Processes
2. Surveillance and Epidemiologic Investigation
3. Preventing/Controlling the Transmission of Infectious Agents
4. Employee/Occupational Health
5. Management and Communication
6. Education and Research
7. Environment of Care
8. Cleaning, Sterilization, Disinfection, Asepsis
Duration of the Training: 40 Hours / 5 Fridays
Exam Information
3Hrs
150 MCQs,
Online Exam Prometric Testing Centre
Exam Fee: 350 USD
Recertification
Valid for 5 Years
Training Information & Deliverable
40 Hours Lecture.
Course Completion Certificate with DHA Accrediation
20.5 CME Points
Study Materials
Training Kit
Consultant In charge Contact: Deepika , Email: deepika@transfedu.com
Looking forward for your positive reply.
For more details please contact us: Deepika- 0558978603
India is the highest TB burden country in the world & accounts for nearly 1/5th (20 per cent) of global burden of tuberculosis, 2/3rd of cases in SEAR. Every year approximately 1.8 million persons develop tuberculosis, of which about 0.8 million are new smear positive highly'- infectious cases.Annual risk of becoming infected with TB is 1.5 % and once infected there is 10 % life-time risk of developing TB disease
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Bio303 Lecture 2 Two Old Enemies, TB and LeprosyMark Pallen
In this lecture I will focusing on another of the most serious infectious threats to humanity, tuberculosis, outlining its evolutionary origins, impact on human health and wealth and the steps taken to control and treat this infection. I will also discuss a related mycobacterial infection, leprosy and recent progress in its control.
Definition of tuberculosis as scientific and practical problem.
Epidemiology of tuberculosis.
The etiology and pathogenesis of tuberculosis.
Immunity of tuberculosis.
Clinical classification of tuberculosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. History
Single cell microorganisms were the first forms of life to develop on
earth, approximately 3-4 billion years ago.
The existence of unseen microbiological life was postulated by
Jainism, which based on Mahavira’s teaching as early as 6th century
BCE (Nigods).
Roman scholar ‘Marus Terentius Varro’ in a 1st century BC book titled
on ‘Agriculture in which warns against locating a homes lead near
swamps‘ ‘…and because there are bred certain minute creature s that
can’t be seen be the eyes which float in the air and enter the body
through mouth and nose and they cause serious diseases .’
In the canon of medicine (1020), Abu Ali Ibh Sina (avicenna)
hypothesized that tuberculosis and other disease might be contagious.
In 1546 ,Girolamo Francostoro proposed that epidemic diseases were
caused by transferable seed like entities that could transmit infection
by direct or …
3. Contd…
Indirect contact or even without contact over long distances. All
these early claims about the existence of the micro-organisms
were not based on any data or science.
Antony van Leeuwenhoek , the first microbiologist and the
first to observe microorganisms using his own microscope.
Lazaro Spallanzani showed that boiling a broth stopped it
from decaying .
Oliver Wendell Holmes ,USA: story on Puerperal fever:
contagious.
Ignaz Philipp Semmelweis ,Hungarian physician; pioneer of
antisepsis policy and savour of mothers.
Joseph Lister , father of antiseptic surgery.
4. Contd...
Louis Pasteur showed that Spallanzani’s
finding held even if air could enter through a
filter that kept particles out .
Robert Koch showed that microorganisms
caused disease .
9/18/2014
5.
6. 9/18/2014
Joseph Lister, a British surgeon and a pioneer of antiseptic surgery.
Lister promoted the idea of sterile surgery while working at the
Glasgow Royal Infirmary
Carbolic steam spray used by
Joseph Lister
7. Problem statement
In May 1847 Jakob Kolletschka, a Viennese doctor, cut his
finger while doing an autopsy on a woman who had died of
puerperal fever in the hospital. A few days later Kolletschka
was died.
In the US Sulkin and Pike reported that 34 of 1342
laboratory infections occurring between 1930 and 1950
were due to mouth pipetting.
Ricketts and Karls Urbani died of rockey mountain fever
and SARS respectively while doing research on finding the
cause.
Cholera lab workers often died of the disease,
CDC annual data approxmately 12,000 HCWs become
accidently infected with Hepatitis B virus.
8. Common causes of death from lab acquired
infections Worldwide (except UK) 1969-89
Brucellosis-423
Q-fever-278
Typhoid fever-256
Hepatitis-234
Tularemia-225
TB-176
Dermatomycosis-161
Salmonellosis-48
Streptococcal infection-78
Leptospira-77
Shigellosis-58
Typhus-124
9. Occupationally acquired HIV;
CDC by 1992
Lab technician-25
Nurse-26
Physician-15
Paramedics-7
Dentist/technician-6
Health attendant-6
House keeper-6
10. “It may seem a strange principle to enunciate as the
very first requirement in a hospital that it should do
the sick no harm”
…”the acquired mortality in a hospital especially in
those of large crowded cities is very much higher
than any calculation founded on the mortality of the
same class of disease among patients treated out of
hospital would lead us to expect”…
-Florence Nightingale
11. Principles of bio safety
TO protect:
The patient
Health care workers
The environment
12. In 1996
• National Health and Medical Research Council
(NHMRC) and Australian National Council on
AIDS (ANCA) recommended adoption of the
terms
• “Standard Precautions” as an alternative to
Universal Precautions
• And “Additional Precautions”
13. Universal/standard precautions: these are the
measures that must be applied during
Patient care: mucosa, breached skin
Handling any potentially infected material: Blood
and body fluids or any other secretion
contaminated with blood
Components:
A. Hand washing.
B. Barrier precautions.
C. Sharp disposal.
D. Handling of contaminated material.
14. Additional Precautions
Used for patients with known or suspected of infection in which
standard precautions are not enough and which may be
transmitted by
• Respiratory secretions; TB, Measles, influenza
• By contact: MRSA, VRE
• Other diseases : Creutzfeldt-Jakob disease (CJD)
They may include:
• Isolation in single room (MRSA)
• separate toilet (VRE)
• Additional personal protective equipment
(e.g. particulate filter mask (N95) /powered air purifying
respirator for Influenza, TB)
16. Laboratory Bio safety
WHO describes this is as:
practices
containment principles
technologies
• Implemented to prevent unintentional exposure to
pathogens and toxins, or their accidental release
17. Good Microbiological Techniques(GMT)
GMT involves the use of aseptic techniques and other good
microbiological practices to achieve two objectives:
• Prevent handled organisms from contaminating the
laboratory, and
• Prevent organisms in a laboratory environment from
contaminating the work.
The principles of GMT should generally be applied
to all types of work involving microorganisms and
tissue cultures, regardless of containment level.
18.
19. Only authorized persons should be
allowed to enter the laboratory working
areas.
Lab doors should be kept closed.
Children should not be allowed to enter
working areas.
Access to animal houses should be
specially authorized.
No animals should be admitted other
than those involved in the work of the
Lab.
20.
21.
22.
23. Recommended vaccines for HCWS
Vaccines Recommendations in brief
1) Hep-B Not vaccinated/not immune to Hep-B i.e.no
serological evidence of immunity or prior to
vaccination then you should get 3 dose series.
2)Flu(Influenza) Get 1 dose of influenza vaccine annually
3)Measles, Mump
and Rubella(MMR)
If you are born in 1957 or later/not vaccinated/no
up to date serological evidence of Measles and
Mumps immunity/prior vaccination ;get 2 doses of
MMR.
4)Varicella(Chicken
pox)
Not Vaccinated/no serological evidence then you
should get 2 doses.
5)Tetanus
,Diphtheria
,Pertussis(Tdap)
Not received previously, get one time dose of
Tdap as soon as possible and then get booster
dose every 10 years. Pregnant HCWs need to a
dose during each pregnancy.
6)Meningococcal Those who are routinely exposed to isolate of N.
meningitidis should get one dose.
24. Categorization of biological agents and
containment(according to WHO)
Disease
Facility
Risk group 1 (no low individual and community risk) A microorganism that is
microorganism that is unlikely to cause human or animal disease.eg. Food
Food spoilage bacteria, common Mold , Yeast, Bacillus spp., non
diarrhoeagenic E. coli.
Basic
Biosafety
Level 1
Risk group 2(moderate individual risk, low community risk) A pathogen that
pathogen that can cause human or animal disease but unlikely to be a serious
a serious hazard to laboratory workers ,community, livestock or the
environment. E.g.Staphylococci,streptococci,Enterobacter except Salmonella
Salmonella Typhi, Clostridium ,Vibrios, Adenovirus ,Polio virus, Coxsackie
Coxsackie virus, Hepatitis virus, Blastomyces, Toxoplasma and Leishmania.
Basic
Biosafety
Level 2
Risk group 3(high individual risk and low community risk) It Causes serious
Causes serious disease and can be readily transmitted from one individual to
individual to another, directly or indirectly.eg. Brucella, Mycobaterium
Containment
25. Cond…
Risk group 4 (high individual and community
community risk) A pathogen that usually causes
causes serious disease and that can be readily
readily transmitted from one individual to
another, directly or indirectly. Effective
treatment and preventive measures are not
usually available.eg.Marburg , Ebola, Lyssa,
CFD, Equine encephalitis viruses, SARS virus
virus and certain Arboviruses.
Maximum
Containment
Biosafety Level 4
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36. Basics of Infection Control
Prevention of nosocomial infection is the
responsibility of all individuals and services
provided by healthcare setting.
A comprehensive, effective and supported
program is essential for reducing infection risk
and increasing hospital safety.
It should include surveillance, preventive
activities and staff training.
37. I. National program developed by Ministry of Health: to support
hospital programs. It sets national objectives, develops and
updates guidelines recommended for health care.
II. Hospital programs including:
1) major preventive efforts; keeping in mind
patients and staff.
2) It must be supported by senior management
And provided with sufficient resources.
3) It must develop a yearly work plan to
assess and promote all good health care
activities.
38.
39. Infection Control Committee
It is a multidisciplinary committee responsible for
monitoring program policies implementation and
recommend corrective actions.
It includes representatives from different concerned
hospital departments & management. They meet
bimonthly.
It establishes standards for patient care, it reviews
and assesses IC reports and identifies areas of
intervention.
40. Infection Control Team
The optimal structure varies with hospitals types,
needs and resources.
Hospital can appoint epidemiologist or infectious
disease specialist, microbiologist to work as infection
control physician.
Infection control nurse who is interested and
has experience in infection control issues.
41. Team should have authority to manage an effective
control program.
Team should have a direct reporting with senior
administration.
Infection control team members or are responsible for
day-to-day functions of IC and preparing they early
work plan.
They should be expert and creative in their job.
42. Infection Control Manual
Every Hospital should have a nosocomial infection
prevention manual compiling recommended instructions
and practices for patient care.
This manual should be developed and updated in a timely
manner by the infection control team.
It is to be reviewed and accepted by infection control
committee.
43. Infection Control Responsibility
Role of every hospital department and service units
must be identified, documented as manuals kept in
accessible place.
Job description of every hospital staff; defining details of
his duties must be discussed before employment.
Infection control precautions should be part of the routine
work and stressed for that.
45. Nosocomial Infection Surveillance
Nosocomial infection rate in a hospital is an indicator of
quality and safety of care.
Surveillance to monitor this rate is essential to identify
problems and evaluate control activities
The ultimate aim is the reduction of infection rate and
their costs.
The term surveillance implies that observational data are
regularly analyzed.
46. Key points in Surveillance
Active surveillance (Prevalence and incidence
studies)
Targeted surveillance (site, unit, priority-oriented)
Appropriately trained investigators
Standardized methodology
Risk- adjusted rates for comparisons
47. Organization for surveillance
Ward activity
devices or procedures
fever & inf. signs
antibiotics & charts
Laboratory reports
culture& sensitivity
resistance patterns
serologic tests
Data elements &analysis
patient data & infection
population & risks
computerization of data
Data collection and analysis
49. Staff health promotion and
education
1. HCW are at risk of acquiring infection, they can also transmit
infection to patients and other employee.
2. Employee health history must be reviewed, immunizations
recommendations to be considered.
3. Release from work if sick, occupation injury must be notified.
4. Continuous education to improve practice,
better performance of new techniques.
50. UNCETDG ICAO IATA
TRANSPORT OF
INFECTIOUS SUBSTANCES
Scientific background to the 13th revised edition of the UN Model
Regulations regarding the requirements for transporting infectious
substances
2003
Air transport of infectious substances
International Air Transportation Association (IATA)
Infectious Substances Shipping Guidelines
51.
52.
53. "Soap and water and common sense are the best disinfectants”
-Sir William Osler
54.
55. References
Topley and Wilson ‘ microbiology and microbial infection ,vol-
2,4 9th edition
Microbiology and infection control for health processionals-
Gary Lee and Penny Bishop,3rd edition.
Laboratory Biosafety Manual 3rd edition WHO 2004.
www.CDC.gov/biosafety
http//www.who.int/research/en/
http//en.Wikipedia.org/wiki/Biosafety
Handbook of bioterrorism and biodefense-Erik De Clercq and
Earl R Kern
Bailey and Scoot's Diagnostic Microbiology-13 ed
Monica Cheesbrough 2nd Updated part 1& 2.