Running head: CONGENITAL ANOMALIES 1 Congenital Anomalies Jillian Zucco Regis College, PMHNP CONGENITAL ANOMALIES 2 Congenital Anomalies The purpose of this assignment is to critique an article about a topic covered in this week’s reading material and discuss both the topic and the article with classmates. The topic I chose for this assignment is: congenital anomalies. Congenital anomalies are genetic or inherited disorders or developmental disorders that are present at birth. A congenital anomaly can be caused by a single-gene disorder, which is a mutation in one gene in the ova or sperm that is passed down to later generations. Mutations in body cells that are not reproductive cells can cause a disorder or dysfunction but cannot be passed down the way mutations in reproductive cells can (Vanmeter, 2014). Chromosomal defects can also be the cause congenital anomalies. During meiosis, DNA fragments can be displaced or lost. This kind of error is what usually causes chromosomal anomalies and is more common when the mother is older than age 35. Some congenital disorders happen at birth, but do not have a genetic component. These can occur from premature birth, exposure to teratogenic agents, or a traumatic labor or delivery. Teratogenic agents are those that can damage the embryo or fetus and its development. Some congenital anomalies are caused by multiple genes, making them polygenic disorders (Vanmeter, 2014). The article I chose to critique is entitled “Dietary glycemic index and glycemic load during pregnancy and offspring risk of congenital heart defects: a prospective cohort study.” It was authored by Amalie Schmidt, Marie Lund, Giulia Corn, Thorhallur Halldorsson, Nina Oyen, Jan Wohfahrt, Sjurdur Olsen, and Mads Melbye, all of whom are affiliated with reputable institutions, such as the University of Bergen Department of Global Public Health, Harvard TH Chan School of Public Health, and Stanford University School of Medicine. The article was published this year, 2020, in The American Journal of Clinical Nutrition. The purpose of this CONGENITAL ANOMALIES 3 article was research- to examine the relationship between mid-pregnancy dietary glycemic index, glycemic load, and the risk of congenital heart defects in the baby. The article does not include a formal literature review, but the introduction section provides information already published about the topic from previous studies, mostly in the discipline of medicine. The journals cited from are mostly medical journals on the topics of pediatrics, epidemiology, and diabetes. The authors identify a research gap by stating that only one other study exists that assesses the risks between glycemic index and heart defects. The first aim of the study was to investigate the association between glycemic index and glycemic load during pregnancy and offspring risk of congenital heart defects using a food-fre.