This document discusses trends in technology entrepreneurship and innovation. It argues that innovative companies, cultures, ecosystems, universities, individuals and societies are more important than innovation alone. True innovation requires creativity, entrepreneurship and commercialization. Historically, centers of innovation like Amsterdam and Silicon Valley benefited from diversity, openness, and access to global talent. For a region to be innovative, it needs strong corporate investment, scientific literacy, skilled labor markets, and new models for creating value from data. The document suggests Toronto could become a global center for health innovation startups due to its ecosystem of medical innovators and venture capital.