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D R W A S E E M M . N I Z A M A N I
M B B S , F C P S , E D I R ( E U R O P E A N B O A R D )
C O N S U L T A N T R A D I O L O G I S T
Z I A U D D I N U N I V E R S I T Y H O S P I T A L
K A R A C H I
Radiology in Pulmonary
Tuberculosis
ROLES
FOR
 INITIAL DIAGNOSIS
 FOLLOW UP
 TREATMENT RESPONSE
 COMPLICATIONS
 SEQUELAE
RADIOLOGICAL MODALITIES
 X-RAYS
WELL KNOWN
 ULTRASOUND
LIMITED ROLE
 CT SCAN
WELL ESTABLISHED
 MAGNETIC RESONANCE IMAGING(MRI)
LIMITED ROLE
 INTERVENTIONAL RADIOLOGY
LIMITED ROLE
 NUCLEAR IMAGING
LIMITED ROLE
Gallium-67 citrate, Indium-111–labeled white blood cell scintigraphy, and
fluorodeoxyglucose (FDG-PET)
EPIDEMIOLOGY
 There has also been an increase in global prevalence,
particularly in immuno-compromised patients, with
a rate of increase of approximately 1.1% per year.
 This increase has been seen not only in Africa and
Asia, but also in Europe.
 Early diagnosis promotes effective treatment and is,
therefore, essential.
CATEGORIES
 PRIMARY TUBERCULOSIS
 POST PRIMARY TUBERCULOSIS
Primary Tuberculosis
 Primary tuberculosis is seen in patients not
previously exposed to M tuberculosis.
 It is most common in infants and children and has
the highest prevalence in children under 5 years of
age.
Primary Tuberculosis
 At radiology, primary tuberculosis manifests as four
main entities:
1. Parenchymal disease,
2. Lymphadenopathy,
3. Miliary disease, and
4. Pleural effusion.
Parenchymal primary tuberculosis
in an adult. Radiograph of the left
lung demonstrates extensive upper lobe
and lingular consolidation.
Lymphadenopathy in a
patient with primary
tuberculosis. Chest
radiograph shows a
bulky left hilum and
a right paratracheal mass,
findings that are consistent
with lymphadenopathy
and are typical in
pediatric patients.
A radiologic scar pers-
ists that can calcify in
up to 15% of cases, an
entity that is known as a
Ghon focus.
Lymphadenopathy
Lymphadenopathy is seen in up to 96% of children
and 43% of adults.
Lymphadenopathy is typically unilateral and right
sided, involving the hilum and right paratracheal
region
Lymphadenopathy
It can be the sole radiographic feature, a
finding that is more common in infants
The combination of calcified hilar
nodes and a Ghon focus is called a Ranke complex
and is suggestive of previous tuberculosis,
Miliary Disease
It is usually seen in the elderly, infants, and
immunocompromised persons, manifesting within 6
months of initial exposure.
Chest radiography is usually normal at
the onset of symptoms
Miliary Disease
The classic radiographic findings
of evenly distributed diffuse small 2–3-mm
nodules, with a slight lower lobe predominance,
are seen in 85% of cases.
Pleural Effusion
The effusion is often the sole manifestation of
tuberculosis and usually manifests 3–7 months after
initial exposure.
The effusion is usually unilateral, and complications
(eg, empyema formation, fistulization, bone erosion)
are rare.
Post Primary TB
Postprimary tuberculosis is progressive,
with cavitation as its hallmark,
1. Predilection for the upper lobes
2. The absence of lymphadenopathy
3. Cavitation.
ULTRASOUND
Ultrasonography is considered as gold standard for the
diagnosis of pleural effusion
Blunting of CP angle is demonstrated on Xray after
collection of 175 mls on PA and 75 mls on Lateral
projection
On ultrasound 10 mls pleural effusion can be easily
diagnosed
(US) often demonstrates a complex septated effusion
in empyema and hemothorax
CT SCAN
CT is more sensitive than conventional radiography,
with nodules seen in a random distribution.
Any nodes greater than 2 cm in diameter generally
have a low-attenuation center secondary to
necrosis at CT and are highly suggestive of active
Disease. CT is more sensitive than chest radiography
for assessing lymphadenopathy.
PATTERNS
Tuberculous empyema. Computed tomographic scan showing
loculated pleural fluid and pleural thickening(arrow) in the right
chest with associated right lower lobe atelectasis.
 Some HRCT patterns.
 (A) Large nodule;
 (B) Micronodule;
 (C) Tree-in-bud pattern;
 (D) Centrilobular nodule.
ATYPICAL PRESENTATIONS
CASE 1:
Diabetic tuberculous patient
 LATERAL VIEW shows lesions and a cavity in the left lower
lung field.
In this patient, the cavity is easily missed on PA VIEW and
only observed over the lower vertebral shadows on the
LATERAL view
 In a number of published comparative studies
chest X-ray images from DM patients have been
described as ‘atypical’, mainly because they frequently
involve the lower lung fields, often with cavities.
 **Atypical radiological images of pulmonary tuberculosis in 192
diabetic patients.2001
 CASE 2
 Tuberculosis in 4-year-old girl.
 Patient presented with shortness of breath and
clinically suspected for foreign body in right
bronchus.
 Triangular opacity in right lower zone sillhouting
right hemidiaphragm suggestive of right lower-lobe
collapse.
 shift of upper mediastinum to right.
 CT scan showed right lower lobe collapse and
mediastinal lymphadenopathy. Patient responds well
with ATT
 Case 3
 Patient presented with atypical opacities on CXR.
 No occupational history
 No exposure
CONFUSIONS?
WHICH ONE IS TUBERCULOSIS????
Role of Radiology in Pulmonary Tuberculosis

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Role of Radiology in Pulmonary Tuberculosis

  • 1. D R W A S E E M M . N I Z A M A N I M B B S , F C P S , E D I R ( E U R O P E A N B O A R D ) C O N S U L T A N T R A D I O L O G I S T Z I A U D D I N U N I V E R S I T Y H O S P I T A L K A R A C H I Radiology in Pulmonary Tuberculosis
  • 2. ROLES FOR  INITIAL DIAGNOSIS  FOLLOW UP  TREATMENT RESPONSE  COMPLICATIONS  SEQUELAE
  • 3. RADIOLOGICAL MODALITIES  X-RAYS WELL KNOWN  ULTRASOUND LIMITED ROLE  CT SCAN WELL ESTABLISHED  MAGNETIC RESONANCE IMAGING(MRI) LIMITED ROLE
  • 4.  INTERVENTIONAL RADIOLOGY LIMITED ROLE  NUCLEAR IMAGING LIMITED ROLE Gallium-67 citrate, Indium-111–labeled white blood cell scintigraphy, and fluorodeoxyglucose (FDG-PET)
  • 5. EPIDEMIOLOGY  There has also been an increase in global prevalence, particularly in immuno-compromised patients, with a rate of increase of approximately 1.1% per year.  This increase has been seen not only in Africa and Asia, but also in Europe.  Early diagnosis promotes effective treatment and is, therefore, essential.
  • 6. CATEGORIES  PRIMARY TUBERCULOSIS  POST PRIMARY TUBERCULOSIS
  • 7. Primary Tuberculosis  Primary tuberculosis is seen in patients not previously exposed to M tuberculosis.  It is most common in infants and children and has the highest prevalence in children under 5 years of age.
  • 8. Primary Tuberculosis  At radiology, primary tuberculosis manifests as four main entities: 1. Parenchymal disease, 2. Lymphadenopathy, 3. Miliary disease, and 4. Pleural effusion.
  • 9.
  • 10.
  • 11. Parenchymal primary tuberculosis in an adult. Radiograph of the left lung demonstrates extensive upper lobe and lingular consolidation.
  • 12. Lymphadenopathy in a patient with primary tuberculosis. Chest radiograph shows a bulky left hilum and a right paratracheal mass, findings that are consistent with lymphadenopathy and are typical in pediatric patients.
  • 13.
  • 14.
  • 15. A radiologic scar pers- ists that can calcify in up to 15% of cases, an entity that is known as a Ghon focus.
  • 16. Lymphadenopathy Lymphadenopathy is seen in up to 96% of children and 43% of adults. Lymphadenopathy is typically unilateral and right sided, involving the hilum and right paratracheal region
  • 17. Lymphadenopathy It can be the sole radiographic feature, a finding that is more common in infants The combination of calcified hilar nodes and a Ghon focus is called a Ranke complex and is suggestive of previous tuberculosis,
  • 18. Miliary Disease It is usually seen in the elderly, infants, and immunocompromised persons, manifesting within 6 months of initial exposure. Chest radiography is usually normal at the onset of symptoms
  • 19. Miliary Disease The classic radiographic findings of evenly distributed diffuse small 2–3-mm nodules, with a slight lower lobe predominance, are seen in 85% of cases.
  • 20. Pleural Effusion The effusion is often the sole manifestation of tuberculosis and usually manifests 3–7 months after initial exposure. The effusion is usually unilateral, and complications (eg, empyema formation, fistulization, bone erosion) are rare.
  • 21. Post Primary TB Postprimary tuberculosis is progressive, with cavitation as its hallmark, 1. Predilection for the upper lobes 2. The absence of lymphadenopathy 3. Cavitation.
  • 22. ULTRASOUND Ultrasonography is considered as gold standard for the diagnosis of pleural effusion Blunting of CP angle is demonstrated on Xray after collection of 175 mls on PA and 75 mls on Lateral projection On ultrasound 10 mls pleural effusion can be easily diagnosed (US) often demonstrates a complex septated effusion in empyema and hemothorax
  • 23.
  • 24.
  • 25. CT SCAN CT is more sensitive than conventional radiography, with nodules seen in a random distribution. Any nodes greater than 2 cm in diameter generally have a low-attenuation center secondary to necrosis at CT and are highly suggestive of active Disease. CT is more sensitive than chest radiography for assessing lymphadenopathy.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35.
  • 36. Tuberculous empyema. Computed tomographic scan showing loculated pleural fluid and pleural thickening(arrow) in the right chest with associated right lower lobe atelectasis.
  • 37.
  • 38.  Some HRCT patterns.  (A) Large nodule;  (B) Micronodule;  (C) Tree-in-bud pattern;  (D) Centrilobular nodule.
  • 40.
  • 41.
  • 42.  LATERAL VIEW shows lesions and a cavity in the left lower lung field. In this patient, the cavity is easily missed on PA VIEW and only observed over the lower vertebral shadows on the LATERAL view
  • 43.  In a number of published comparative studies chest X-ray images from DM patients have been described as ‘atypical’, mainly because they frequently involve the lower lung fields, often with cavities.  **Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients.2001
  • 44.  CASE 2  Tuberculosis in 4-year-old girl.  Patient presented with shortness of breath and clinically suspected for foreign body in right bronchus.
  • 45.
  • 46.  Triangular opacity in right lower zone sillhouting right hemidiaphragm suggestive of right lower-lobe collapse.  shift of upper mediastinum to right.  CT scan showed right lower lobe collapse and mediastinal lymphadenopathy. Patient responds well with ATT
  • 47.  Case 3  Patient presented with atypical opacities on CXR.
  • 48.
  • 49.  No occupational history  No exposure
  • 50.
  • 51.
  • 52. CONFUSIONS? WHICH ONE IS TUBERCULOSIS????