This document outlines a proposed study on the prevalence and factors associated with road traffic accidents in Mekelle Town, Northern Ethiopia. The study will use a cross-sectional design involving a sample of 634 taxi drivers selected through systematic random sampling. Data will be collected through questionnaires on driver characteristics, vehicle condition, pedestrian factors, and environmental conditions. Descriptive statistics, bivariate and multivariate logistic regression will be used to analyze relationships between independent and dependent variables. Results will be disseminated to universities and transportation authorities to inform policies to reduce accidents. The proposal provides details on the introduction, objectives, methodology, variables, analysis plan, and ethics of the study.