This certificate of analysis provides information on a batch of Ritonavir impurity L, including: - The product name, chemical name, molecular formula, molecular weight, and batch number. - Results of tests for appearance, solubility, identification by NMR and mass spectrometry, and purity by HPLC. - The material was found to comply with specifications based on analytical test results. - Storage instructions are to preserve in an air tight container and protect from direct sunlight.

1. CERTIFICATE OF ANALYSIS
Ritonavir impurity L
Catlog code No
Product Name
Chemical Name
Mol. Formula
Mol. Weight
Batch No R1312YO Analysis Date
Quantity 25mg Retest Date
Storage
S.N. Test
1 Appearance
2 Solubility
3 Identification by 1H NMR
4 Identification by Mass
5 Purity by HPLC
Remarks:
Sign.
Date:
FRM/007-00
Complies
Complies
99.79%
Based on 1H NMR, Mass and HPLC data, material confirm
Prepared By
Preserve in Air tight container, protect from direct sunlig
Result
White solid
Freely Soluble in Me
O
NH
O
H
N
O
NH
N
O
S
N

2. 1181312
Ritonavir impurity L
(4S,5S)-4-benzyl-5-[(2S)-2-[[(2S)-3-methyl-2-[[methyl
[[2-(1-methylethyl)thiazol-4-yl]methyl]carbamoyl]amino]
butanoyl]amino]-3-phenylpropyl]oxazolidin-2-one
C33H43N5O4S
605.79 g/mol
4-Jun-15
Jun-17
Approved by
Quality Control Department
confirms to the above product.
sunlight and for longer storage store at 2-8 C.
in Methanol

3. CERTIFICATE OF ANALYSIS
Ritonavir impurity L
Product Name
Chemical Name
Mol. Formula
Mol. Weight
Batch No VSLS/RIT/IMP-L/15-16 Analysis Date
Quantity 25MG Retest Date
Storage
S.N. Test
1 Appearance
2 Solubility
3 Identification by 1H NMR
4 Identification by Mass
5 Purity by HPLC
Remarks:
Sign.
Date:
FRM/007-00
Preserve in Air tight container, protect from direct sunlig
Result
Off White solid
Freely Soluble in Me
Complies
Complies
98.89%
Based on 1H NMR, Mass and HPLC data, material confirm
Prepared By

4. Ritonavir impurity L
(2S)-3-Methyl-2-[[[methyl[[2-(1-methylethyl)-4-
thiazolyl]methyl]amiS)-2-oxo-4-(phenylmethyl)-5-
oxazolidinyl]methyl]-2-phenylethyl]-butanamide
C33H43N5O4S
605.79 g/mol
24-Nov-15
Nov-16
Approved by
Quality Control Department
sunlight and for longer storage store at 2-8 C.
in Methanol
confirms to the above product.