Talk given by prof. T.K. Prasad at the workshop on Semantics in Geospatial Architectures: Applications and Implementation. The workshop was held from October 28-29, 2013 at Pyle Center (702 Langdon Street, Madison, WI), University of Wisconsin-Madison.
These slides explain the basic meaning of text mining,its comparision with other data retrieval methods,its subtasks and applications, limitations, present and future of text mining. Also included is the topic data mining with its goals and applications.
Talk given by prof. T.K. Prasad at the workshop on Semantics in Geospatial Architectures: Applications and Implementation. The workshop was held from October 28-29, 2013 at Pyle Center (702 Langdon Street, Madison, WI), University of Wisconsin-Madison.
These slides explain the basic meaning of text mining,its comparision with other data retrieval methods,its subtasks and applications, limitations, present and future of text mining. Also included is the topic data mining with its goals and applications.
Text Mining is an Important part of data mining and it is used nowadays on a large scale. This mining technique is used to find patterns in text data collected from many online sources , and to gain some interestings insights from the patterns observed. Since text is basically everywhere on the internet, it becomes quite difficult to get the data in structured format, which is why text mining plays a huge role. It uses NLP(Natural Language Processing Techniques) to automate the text mining and this concept is used in Machine Learning.
An introduction to system-oriented evaluation in Information RetrievalMounia Lalmas-Roelleke
Slides for my lecture on IR evaluation, presented at 11th European Summer School in Information Retrieval (ESSIR 2017) at Universitat Pompeu Fabra, Barcelona.
These slides were based on
1. Evaluation lecture @ QMUL; Thomas Roelleke & Mounia Lalmas
3. Lecture 8: Evaluation @ Stanford University; Pandu Nayak & Prabhakar Raghavan
4. Retrieval Evaluation @ University of Virginia; Hongnig Wang
5. Lectures 11 and 12 on Evaluation @ Berkeley; Ray Larson
6. Evaluation of Information Retrieval Systems @ Penn State University; Lee Giles
Textbooks:
1. Information Retrieval, 2nd edition, C.J. van Rijsbergen (1979)
2. Introduction to Information Retrieval, C.D. Manning, P. Raghavan & H. Schuetze (2008)
3. Modern Information Retrieval: The Concepts and Technology behind Search, 2nd ed; R. Baeza-Yates & B. Ribeiro-Neto (2011)
This 2-hour lecture was held at Amsterdam University of Applied Sciences (HvA) on October 16th, 2013. It represents a basic overview over core technologies used by ICT companies such as Google, Twitter or Facebook. The lecture does not require a strong technical background and stays at conceptual level.
Amit Sheth with TK Prasad, "Semantic Technologies for Big Science and Astrophysics", Invited Plenary Presentation, at Earthcube Solar-Terrestrial End-User Workshop, NJIT, Newark, NJ, August 13, 2014.
Like many other fields of Big Science, Astrophysics and Solar Physics deal with the challenges of Big Data, including Volume, Variety, Velocity, and Veracity. There is already significant work on handling volume related challenges, including the use of high performance computing. In this talk, we will mainly focus on other challenges from the perspective of collaborative sharing and reuse of broad variety of data created by multiple stakeholders, large and small, along with tools that offer semantic variants of search, browsing, integration and discovery capabilities. We will borrow examples of tools and capabilities from state of the art work in supporting physicists (including astrophysicists) [1], life sciences [2], material sciences [3], and describe the role of semantics and semantic technologies that make these capabilities possible or easier to realize. This applied and practice oriented talk will complement more vision oriented counterparts [4].
[1] Science Web-based Interactive Semantic Environment: http://sciencewise.info/
[2] NCBO Bioportal: http://bioportal.bioontology.org/ , Kno.e.sis’s work on Semantic Web for Healthcare and Life Sciences: http://knoesis.org/amit/hcls
[3] MaterialWays (a Materials Genome Initiative related project): http://wiki.knoesis.org/index.php/MaterialWays
[4] From Big Data to Smart Data: http://wiki.knoesis.org/index.php/Smart_Data
Web Information Extraction for the Database Research DomainMichael Genkin
A presentation describing my final project for an engineering degree at the Hebrew University of Jerusalem - a system for extracting information from web sites into instances of an XML schema, utilizing machine learning, structural analysis of documents and a divide & conquer strategy.
This tutorial gives an overview of how search engines and machine learning techniques can be tightly coupled to address the need for building scalable recommender or other prediction based systems. Typically, most of them architect retrieval and prediction in two phases. In Phase I, a search engine returns the top-k results based on constraints expressed as a query. In Phase II, the top-k results are re-ranked in another system according to an optimization function that uses a supervised trained model. However this approach presents several issues, such as the possibility of returning sub-optimal results due to the top-k limits during query, as well as the prescence of some inefficiencies in the system due to the decoupling of retrieval and ranking.
To address this issue the authors created ML-Scoring, an open source framework that tightly integrates machine learning models into Elasticsearch, a popular search engine. ML-Scoring replaces the default information retrieval ranking function with a custom supervised model that is trained through Spark, Weka, or R that is loaded as a plugin in Elasticsearch. This tutorial will not only review basic methods in information retrieval and machine learning, but it will also walk through practical examples from loading a dataset into Elasticsearch to training a model in Spark, Weka, or R, to creating the ML-Scoring plugin for Elasticsearch. No prior experience is required in any system listed (Elasticsearch, Spark, Weka, R), though some programming experience is recommended.
RecSys 2015 Tutorial – Scalable Recommender Systems: Where Machine Learning...S. Diana Hu
Search engines have focused on solving the document retrieval problem, so their scoring functions do not handle naturally non-traditional IR data types, such as numerical or categorical. Therefore, on domains beyond traditional search, scores representing strengths of associations or matches may vary widely. As such, the original model doesn’t suffice, so relevance ranking is performed as a two-phase approach with 1) regular search 2) external model to re-rank the filtered items. Metrics such as click-through and conversion rates are associated with the users’ response to items served. The predicted selection rates that arise in real-time can be critical for optimal matching. For example, in recommender systems, predicted performance of a recommended item in a given context, also called response prediction, is often used in determining a set of recommendations to serve in relation to a given serving opportunity. Similar techniques are used in the advertising domain. To address this issue the authors have created ML-Scoring, an open source framework that tightly integrates machine learning models into a popular search engine (SOLR/Elasticsearch), replacing the default IR-based ranking function. A custom model is trained through either Weka or Spark and it is loaded as a plugin used at query time to compute custom scores.
Text Mining is an Important part of data mining and it is used nowadays on a large scale. This mining technique is used to find patterns in text data collected from many online sources , and to gain some interestings insights from the patterns observed. Since text is basically everywhere on the internet, it becomes quite difficult to get the data in structured format, which is why text mining plays a huge role. It uses NLP(Natural Language Processing Techniques) to automate the text mining and this concept is used in Machine Learning.
An introduction to system-oriented evaluation in Information RetrievalMounia Lalmas-Roelleke
Slides for my lecture on IR evaluation, presented at 11th European Summer School in Information Retrieval (ESSIR 2017) at Universitat Pompeu Fabra, Barcelona.
These slides were based on
1. Evaluation lecture @ QMUL; Thomas Roelleke & Mounia Lalmas
3. Lecture 8: Evaluation @ Stanford University; Pandu Nayak & Prabhakar Raghavan
4. Retrieval Evaluation @ University of Virginia; Hongnig Wang
5. Lectures 11 and 12 on Evaluation @ Berkeley; Ray Larson
6. Evaluation of Information Retrieval Systems @ Penn State University; Lee Giles
Textbooks:
1. Information Retrieval, 2nd edition, C.J. van Rijsbergen (1979)
2. Introduction to Information Retrieval, C.D. Manning, P. Raghavan & H. Schuetze (2008)
3. Modern Information Retrieval: The Concepts and Technology behind Search, 2nd ed; R. Baeza-Yates & B. Ribeiro-Neto (2011)
This 2-hour lecture was held at Amsterdam University of Applied Sciences (HvA) on October 16th, 2013. It represents a basic overview over core technologies used by ICT companies such as Google, Twitter or Facebook. The lecture does not require a strong technical background and stays at conceptual level.
Amit Sheth with TK Prasad, "Semantic Technologies for Big Science and Astrophysics", Invited Plenary Presentation, at Earthcube Solar-Terrestrial End-User Workshop, NJIT, Newark, NJ, August 13, 2014.
Like many other fields of Big Science, Astrophysics and Solar Physics deal with the challenges of Big Data, including Volume, Variety, Velocity, and Veracity. There is already significant work on handling volume related challenges, including the use of high performance computing. In this talk, we will mainly focus on other challenges from the perspective of collaborative sharing and reuse of broad variety of data created by multiple stakeholders, large and small, along with tools that offer semantic variants of search, browsing, integration and discovery capabilities. We will borrow examples of tools and capabilities from state of the art work in supporting physicists (including astrophysicists) [1], life sciences [2], material sciences [3], and describe the role of semantics and semantic technologies that make these capabilities possible or easier to realize. This applied and practice oriented talk will complement more vision oriented counterparts [4].
[1] Science Web-based Interactive Semantic Environment: http://sciencewise.info/
[2] NCBO Bioportal: http://bioportal.bioontology.org/ , Kno.e.sis’s work on Semantic Web for Healthcare and Life Sciences: http://knoesis.org/amit/hcls
[3] MaterialWays (a Materials Genome Initiative related project): http://wiki.knoesis.org/index.php/MaterialWays
[4] From Big Data to Smart Data: http://wiki.knoesis.org/index.php/Smart_Data
Web Information Extraction for the Database Research DomainMichael Genkin
A presentation describing my final project for an engineering degree at the Hebrew University of Jerusalem - a system for extracting information from web sites into instances of an XML schema, utilizing machine learning, structural analysis of documents and a divide & conquer strategy.
This tutorial gives an overview of how search engines and machine learning techniques can be tightly coupled to address the need for building scalable recommender or other prediction based systems. Typically, most of them architect retrieval and prediction in two phases. In Phase I, a search engine returns the top-k results based on constraints expressed as a query. In Phase II, the top-k results are re-ranked in another system according to an optimization function that uses a supervised trained model. However this approach presents several issues, such as the possibility of returning sub-optimal results due to the top-k limits during query, as well as the prescence of some inefficiencies in the system due to the decoupling of retrieval and ranking.
To address this issue the authors created ML-Scoring, an open source framework that tightly integrates machine learning models into Elasticsearch, a popular search engine. ML-Scoring replaces the default information retrieval ranking function with a custom supervised model that is trained through Spark, Weka, or R that is loaded as a plugin in Elasticsearch. This tutorial will not only review basic methods in information retrieval and machine learning, but it will also walk through practical examples from loading a dataset into Elasticsearch to training a model in Spark, Weka, or R, to creating the ML-Scoring plugin for Elasticsearch. No prior experience is required in any system listed (Elasticsearch, Spark, Weka, R), though some programming experience is recommended.
RecSys 2015 Tutorial – Scalable Recommender Systems: Where Machine Learning...S. Diana Hu
Search engines have focused on solving the document retrieval problem, so their scoring functions do not handle naturally non-traditional IR data types, such as numerical or categorical. Therefore, on domains beyond traditional search, scores representing strengths of associations or matches may vary widely. As such, the original model doesn’t suffice, so relevance ranking is performed as a two-phase approach with 1) regular search 2) external model to re-rank the filtered items. Metrics such as click-through and conversion rates are associated with the users’ response to items served. The predicted selection rates that arise in real-time can be critical for optimal matching. For example, in recommender systems, predicted performance of a recommended item in a given context, also called response prediction, is often used in determining a set of recommendations to serve in relation to a given serving opportunity. Similar techniques are used in the advertising domain. To address this issue the authors have created ML-Scoring, an open source framework that tightly integrates machine learning models into a popular search engine (SOLR/Elasticsearch), replacing the default IR-based ranking function. A custom model is trained through either Weka or Spark and it is loaded as a plugin used at query time to compute custom scores.
A Maturing Role of Workflows in the Presence of Heterogenous Computing Archit...Ilkay Altintas, Ph.D.
cientific workflows are used by many scientific communities to capture, automate and standardize computational and data practices in science. Workflow-based automation is often achieved through a craft that combines people, process, computational and Big Data platforms, application-specific purpose and programmability, leading to provenance-aware archival and publications of the results. This talk summarizes varying and changing requirements for distributed workflows influenced by Big Data and heterogeneous computing architectures and present a methodology for workflow-driven science based on these maturing requirements.
RDBMS gave us table schemas. A table schema, which is an essential metadata component, gave us the power to validate data types, and enforce constraints. In the age of varying data and schema-less data stores, how can we enforce these rules and how can we leverage metadata (even in RDBMS) to empower data validity, code checks, and automation.
This is a brief background into Big data (data lake) to put in context the importance of metadata from a governance perspective and more especially in todays heterogeneous big data platforms.
MUDROD - Mining and Utilizing Dataset Relevancy from Oceanographic Dataset Me...Yongyao Jiang
MUDROD - Mining and Utilizing Dataset Relevancy from Oceanographic Dataset Metadata, Usage Metrics, and User Feedback to Improve Data Discovery and Access
Lucene/Solr Revolution 2015: Where Search Meets Machine LearningJoaquin Delgado PhD.
Search engines have focused on solving the document retrieval problem, so their scoring functions do not handle naturally non-traditional IR data types, such as numerical or categorical. Therefore, on domains beyond traditional search, scores representing strengths of associations or matches may vary widely. As such, the original model doesn’t suffice, so relevance ranking is performed as a two-phase approach with 1) regular search 2) external model to re-rank the filtered items. Metrics such as click-through and conversion rates are associated with the users’ response to items served. The predicted selection rates that arise in real-time can be critical for optimal matching. For example, in recommender systems, predicted performance of a recommended item in a given context, also called response prediction, is often used in determining a set of recommendations to serve in relation to a given serving opportunity. Similar techniques are used in the advertising domain. To address this issue the authors have created ML-Scoring, an open source framework that tightly integrates machine learning models into a popular search engine (SOLR/Elasticsearch), replacing the default IR-based ranking function. A custom model is trained through either Weka or Spark and it is loaded as a plugin used at query time to compute custom scores.
Lucene/Solr Revolution 2015: Where Search Meets Machine LearningS. Diana Hu
Search engines have focused on solving the document retrieval problem, so their scoring functions do not handle naturally non-traditional IR data types, such as numerical or categorical. Therefore, on domains beyond traditional search, scores representing strengths of associations or matches may vary widely. As such, the original model doesn’t suffice, so relevance ranking is performed as a two-phase approach with 1) regular search 2) external model to re-rank the filtered items. Metrics such as click-through and conversion rates are associated with the users’ response to items served. The predicted selection rates that arise in real-time can be critical for optimal matching. For example, in recommender systems, predicted performance of a recommended item in a given context, also called response prediction, is often used in determining a set of recommendations to serve in relation to a given serving opportunity. Similar techniques are used in the advertising domain. To address this issue the authors have created ML-Scoring, an open source framework that tightly integrates machine learning models into a popular search engine (SOLR/Elasticsearch), replacing the default IR-based ranking function. A custom model is trained through either Weka or Spark and it is loaded as a plugin used at query time to compute custom scores.
The term "life cycle" refers to the series of stages or phases that an organism, system, or product goes through from its beginning to its end. It is a concept that can be applied to various contexts, such as biology, ecology, business, technology, and project management. Here are a few examples of life cycles:
Biological Life Cycle: In biology, the life cycle refers to the sequence of stages that an organism undergoes from birth to reproduction and eventually death. This can include processes like birth or germination, growth and development, reproduction, and death.
Product Life Cycle: The product life cycle describes the stages a product goes through from its introduction to the market until its eventual decline. These stages typically include introduction, growth, maturity, and decline. Companies monitor the product life cycle to make strategic decisions regarding marketing, production, and product development.
Project Life Cycle: The project life cycle outlines the stages involved in the management and execution of a project. These stages typically include initiation, planning, execution, monitoring and control, and closure. Each phase has specific activities and deliverables, ensuring that the project progresses in a structured and organized manner.
Ecological Life Cycle: Ecological life cycles refer to the stages that ecosystems or species go through over time. This can involve the growth and decline of populations, adaptation to environmental changes, and interactions within the ecosystem.
Human Life Cycle: The human life cycle encompasses the different stages of development and growth that individuals go through from birth to death. This includes infancy, childhood, adolescence, adulthood, and eventually old age.
Understanding life cycles is important as it provides insight into the processes and changes that occur within various systems. It allows for better planning, decision-making, and adaptation to ensure sustainable growth, effective management, and optimal utilization of resources throughout the life cycle.
Irving-TeraData: data and science driven big industry-nfdp13DataDryad
Presentation by Duncan Irving on TeraData's approach to data management and data publishing in science driven big industry given at the Now and Future of Data Publishing Symposium, 22 May 2013, Oxford, UK
Entity matching and entity resolution are becoming more important disciplines in data management over time, based on increasing number of data sources that should be addressed in economy that is undergoing digital transformation process, growing data volumes and increasing requirements related to data privacy. Data matching process is also called record linkage, entity matching or entity resolution in some published works. For long time research about the process was focused on matching entities from same dataset (i.e. deduplication) or from two datasets. Different algorithms used for matching different types of attributes were described in the literature, developed and implemented in data matching and data cleansing platforms. Entity resolution is element of larger entity integration process that include data acquisition, data profiling, data cleansing, schema alignment, data matching and data merge (fusion).
We can use motivating example of global pharmaceutical company with offices in more than 60 countries worldwide that migrated customer data from various legacy systems in different countries to new common CRM system in the cloud. Migration was phased by regions and countries, with new sources and data incrementally added and merged with data already migrated in previous phases. Entity integration in such case require deep understanding of data architectures, data content and each step of the process. Even with such deep understanding, design and implementation of the solution require many iterations in development process that consume human resources, time and financial resources. Reducing the number of iterations by automating and optimizing steps in the process can save vast amount of resources. There is a lot of available literature addressing any of the steps in the process, proposing different options for improvement of results or processing optimization, but the whole process still require a lot of human work and subject matter specific knowledge and many iterations to produce results that will have high F-measure (both high precision and recall). Most of the algorithms used in the various steps of the process are Human in the loop (HITL) algorithms that require human interaction. Human is always part of the simulation and consequently influences the outcome.
This paper is a part of the work in progress aimed to define conceptual framework that will try to automate and optimize some steps of entity integration process and try to reduce requirements for human influence in the process. In this paper focus will be on conceptual process definition, recommended data architecture and use of existing open source solutions for entity integration process automation and optimization.
Similar to Resource Classification as the Basis for a Visualization Pipeline in LOD Scenarios (20)
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Resource Classification as the Basis for a Visualization Pipeline in LOD Scenarios
1. Resource Classification as the
Basis for a Visualization Pipeline
in LOD Scenarios
Oscar Peña del Rio, Unai Aguilera
and Diego López de Ipiña
DeustoTech, University of Deusto
2. Motivation
• The Semantic Web is still waiting for massive traction
• The focus is set on ontology development, provenance
and supporting technological stack
• Little is known about the SW outside the research
community
• Potential benefits should be addressed to non-technical
user profiles
2
3. Data overview
• Need to get the whole picture of a dataset before
working with it
• Usually time/resource constraints and lack of expert
knowledge are present
• Based on Ben Shneiderman’s Overview task (from his
famous Visual Information Seeking Mantra)
• Diverse approaches perform basic statistics to fulfill this
task (counts, averages, min/max, etc.)
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4. Natural approaches to data exploration
• Takes some ideas from Tukey’s Exploratory Data Analysis
field (EDA)
• Proposes different approaches to get an overview of the
data
• Techniques lack the rigor of more formal methodologies,
is a more data-driven perspective
• Data discovery is more natural this way, in line with the
follow your nose principles
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5. Visualization Pipeline
raw data analysis operators
visual
transformations
recommender
engine
end user
visualizations
rdf, json-ld, …
statistical analysis,
datatype inference…
how to encode data
in visual elements
learned lessons, best
practices & fit models
Web browser accessible
visualization
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Defending visualization as the means
for a coherent, understandable Semantic
Web beneficial for all actors
6. Extract resource features
• We focus on the data itself to infer its structure and
relevance within the whole dataset
• The data is directly accessed through SPARQL queries
• Property usage: # unique class instances / # instance objects
• Completeness ratio: # values assigned to property / # instance objects
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dc:title -> 1 foaf:nick -> 3.4dc-terms:license -> 0.12
foaf:name -> 1 foaf:title -> 0.36
7. Primitive datatype inference
• Required to understand how each property may be interpreted, the operations it allows,
and how they relate to each other
• We define the following classification categories:
• Integer
• Float
• Boolean
• IRI
• String
• Geographical component
• Datetime component
• Categorical data
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9. Conclusions & future steps
• Common pitfalls addressed
• Missing property datatypes & ranges
• Incorrect typing / usage
• Redundancy
• Most instances typed as plain, literal strings
• Feed all the features to a classifier in order to create Entity Visualization
Templates (work in progress)
• Recommend coherent visual representations for each template
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