This document summarizes several components of the renin-angiotensin system and their roles in regulating blood pressure. It explains that renin is released by the kidneys and converts angiotensinogen to angiotensin I. Angiotensin I is then converted to angiotensin II by ACE, causing vasoconstriction and increased blood pressure. Angiotensin II stimulates the release of aldosterone and ADH, maintaining sodium and water levels in the blood. The atrial natriuretic peptide functions to lower blood pressure as a vasodilator that prevents sodium reabsorption.

1. Prepared by NSANZIMANA VEDASTE
UR-CMHS, BLS Department

3. Angiotensin
 Any of several polypeptides that narrow blood
vessels and thus regulate arterial pressure
Renin
 A circulating enzyme released by mammalian
kidneys that converts angiotensinogen to
angiotensin-I that plays a role in maintaining
blood pressure
Aquaporin
 Any of a class of proteins that form pores in the
membrane of biological cells

5.  Renin,
a hormone produced the
juxtaglomerular apparatus in the kidneys,
converts angiotensinogen (which is made in
the liver) to angiotensin I.
 Angiotensin I is then converted to angiotensin
II by the angiotensin converting enzyme
(ACE), increasing blood pressure by causing
vasoconstriction of the blood vessels.

6.  Angiotensin
II causes the release of aldosterone
which is produced by the adrenal cortex; it
functions to maintain both sodium and water
levels (osmotic balance) in the blood.
 Angiotensin II also causes the release of
antidiuretic hormone (ADH) which functions to
conserve water in the body when volume is low; it
does this by inserting aquaporins in the collecting
duct of the nephron to promote water
reabsorption.
.

7.  The
atrial natriuretic peptide (ANP) is another
hormone that is produced to function as a
vasodilator and lower blood pressure by
preventing sodium reabsorption

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you