Heartburn, also known as gastric reflux or GERD, affects many Americans and costs $10 billion annually to treat. GERD occurs when the lower esophageal sphincter opens spontaneously, allowing stomach contents to rise into the esophagus, causing heartburn and other symptoms. While antacids and proton pump inhibitors are commonly used to treat GERD symptoms, recent research suggests these drugs may actually aggravate conditions by interfering with acid production and nutrient absorption. Diet and supplements like Gastrazyme that heal the esophagus may be safer alternatives to medication for controlling heartburn.