Reactive attachment disorder (RAD) is characterized by inhibited or emotionally withdrawn behavior toward caregivers manifested as rarely seeking or responding to comfort when distressed. It results from extreme neglect such as lack of emotional nurturing or repeated changes in caregivers. Children with RAD show minimal social/emotional responsiveness, limited positive affect, and irritability. Treatment focuses on forming secure attachments through individual, family, and play therapy. RAD significantly impairs social relationships and is associated with developmental delays. It is differentiated from autism by histories of neglect rather than social communication deficits.