The document discusses rational use of drugs and strategies to promote rational use. Rational use means using the right drug, for the right indication, at the right dose and duration, for the right patient. Irrational use can lead to ineffective treatment, adverse drug events, increased resistance, and costs. Common causes of irrational use include lack of information, diagnostic uncertainty, patient demands, and promotional activities. Strategies to promote rational use include educational programs for providers, printed materials, media campaigns, essential drug lists, structured order forms, generic substitution, and regulating promotions. Rational prescribing involves defining the problem, setting objectives, selecting strategies, writing prescriptions, and monitoring treatment.