(1) The Quesungual Slash and Mulch Agroforestry System (QSMAS) was developed as a sustainable alternative to slash and burn agriculture for smallholder farmers in Honduras. (2) Initial acceptance of QSMAS was due to high levels of soil degradation, dependence on erratic rainfall, and the importance of agriculture for subsistence. (3) Adoption of QSMAS was facilitated by access to credit, markets, capacity building, and collective action by communities and institutions. (4) Validation and dissemination of QSMAS requires at least 3 years, and short-term positive effects on farmers are key to its diffusion in new areas.