As part of the Industrial Strategy the Government will invest in the “Commercialising quantum technologies” Industrial Strategy Challenge Fund (ISCF) to enable the UK to lead the global development and application of quantum technologies.
The aim of the competition is to advance the commercialisation of quantum technologies in the UK through the investment of up to £27m in innovation projects.
The webcast recording is now available. Click here to watch it: https://www.youtube.com/watch?v=8beNopMS7sw
Find out more about the Quantum Technologies Special Interest Group at https://ktn-uk.co.uk/interests/quantum-technologies
Join the Quantum Technologies Special Interest Group at https://www.linkedin.com/groups/8594516/
ISCF Robotics for a More Resilient Future: Competition BriefingKTN
Innovate UK is investing up to £6 million to support R&D projects to advance or develop solutions in service robotics for a more resilient future. During this briefing, the Robotics and AI team outlined the details of the competition, defining its scope and explaining the application process.
An Introduction to Eurostars - an Opportunity for SMEs to Collaborate Interna...KTN
This webinar highlighted opportunities within the EUREKA Eurostars programme and how Innovate UK KTN and partners can help your business to innovate and go international.
Prospering from the Energy Revolution: Six in Sixty - Technology and Infrastr...KTN
Hear about one of the key facets of PFER, a £104m programme focussed on the integration of power, heat and transport and the business models needed to enable Smart Local Energy Systems (SLES) to scale towards net zero.
This webinar was brought to you on 24 June 2021 by The GREAT UK Challenge Fund, The British High Commission in Canada, Department for International Trade, Global Affairs Canada, Midlands Engine, Society of Motor Manufacturers and Traders (SMMT), the Automotive Parts Manufacturers Association of Canada (APMA), and delivered by KTN Global Alliance. It focussed on enhancing business opportunities, visibility, and networking opportunities for UK and Canadian companies.
FluxSys was formed in 2013, from their base in Wellesbourne, Warwickshire they support their UK and international clients with the specification, design and prototyping of a wide range of electric machines and drives.
FluxSys uses its skills, experience and independence within customers’ projects to support their electrification journeys and skills development, utilising knowledge sharing in an open & collaborative manner with like-minded clients and technical experts.
ISCF Subsea Autonomous Systems: Next Generation Technologies - Competition Br...KTN
The Industrial Strategy Challenge Fund’s Robotics and AI challenge, through Innovate UK, (as part of UK Research and Innovation), is collaborating with The Royal Navy, Oil & Gas Technology Centre, BP, and the Oil & Gas Authority. Together they will invest up to £6 million, from a cross government and industry joint fund, in collaborative business led projects.
Individuals can apply to join a 5-day collaborative workshop to develop proposals for autonomous subsea systems that can significantly improve mission duration, sensing and communications.
Participants are sought to develop collaborative projects in next generation autonomous subsea systems which improve levels of autonomy, sensor miniaturisation, mission planning, monitoring, communications, navigation, data management, and operations together with improved endurance in the water column up to 3000 metres deep.
The challenge is to develop Next Generation Subsea Autonomous System technologies which are modular in design with common interfaces and open architectures that make trusted unmanned operations the standard approach in areas such as off-shore energy, aquafarming, deep sea mineral exploration and maritime defensive security operations.
Find out more: https://ktn-uk.co.uk/news/webcast-subsea-autonomous-systems-next-generation-technologies-iscf-competition-briefing-event
ISCF Robotics for a More Resilient Future: Competition BriefingKTN
Innovate UK is investing up to £6 million to support R&D projects to advance or develop solutions in service robotics for a more resilient future. During this briefing, the Robotics and AI team outlined the details of the competition, defining its scope and explaining the application process.
An Introduction to Eurostars - an Opportunity for SMEs to Collaborate Interna...KTN
This webinar highlighted opportunities within the EUREKA Eurostars programme and how Innovate UK KTN and partners can help your business to innovate and go international.
Prospering from the Energy Revolution: Six in Sixty - Technology and Infrastr...KTN
Hear about one of the key facets of PFER, a £104m programme focussed on the integration of power, heat and transport and the business models needed to enable Smart Local Energy Systems (SLES) to scale towards net zero.
This webinar was brought to you on 24 June 2021 by The GREAT UK Challenge Fund, The British High Commission in Canada, Department for International Trade, Global Affairs Canada, Midlands Engine, Society of Motor Manufacturers and Traders (SMMT), the Automotive Parts Manufacturers Association of Canada (APMA), and delivered by KTN Global Alliance. It focussed on enhancing business opportunities, visibility, and networking opportunities for UK and Canadian companies.
FluxSys was formed in 2013, from their base in Wellesbourne, Warwickshire they support their UK and international clients with the specification, design and prototyping of a wide range of electric machines and drives.
FluxSys uses its skills, experience and independence within customers’ projects to support their electrification journeys and skills development, utilising knowledge sharing in an open & collaborative manner with like-minded clients and technical experts.
ISCF Subsea Autonomous Systems: Next Generation Technologies - Competition Br...KTN
The Industrial Strategy Challenge Fund’s Robotics and AI challenge, through Innovate UK, (as part of UK Research and Innovation), is collaborating with The Royal Navy, Oil & Gas Technology Centre, BP, and the Oil & Gas Authority. Together they will invest up to £6 million, from a cross government and industry joint fund, in collaborative business led projects.
Individuals can apply to join a 5-day collaborative workshop to develop proposals for autonomous subsea systems that can significantly improve mission duration, sensing and communications.
Participants are sought to develop collaborative projects in next generation autonomous subsea systems which improve levels of autonomy, sensor miniaturisation, mission planning, monitoring, communications, navigation, data management, and operations together with improved endurance in the water column up to 3000 metres deep.
The challenge is to develop Next Generation Subsea Autonomous System technologies which are modular in design with common interfaces and open architectures that make trusted unmanned operations the standard approach in areas such as off-shore energy, aquafarming, deep sea mineral exploration and maritime defensive security operations.
Find out more: https://ktn-uk.co.uk/news/webcast-subsea-autonomous-systems-next-generation-technologies-iscf-competition-briefing-event
Performance Projects specialises in niche vehicle and motorsport innovation, designing, building and supplying complex subsystems through to whole vehicles.
Watch the recording of two SBRI competition briefings. £750k is being invested by Innovate UK, Crossrail and the Department for International Trade in digital innovation, operational efficiency, station security and more in Vietnam, Canada, Australia and India.
Watch our Consortia Building Workshop on replay to find out more about the Small R&D Partnership Projects funding competition, including pitches from organisations you could partner with.
Check out Tracxn's curated latest startup activity in Tech rebrand.ly/4hl9z
Subscribe for free https://rb.gy/3yuosu to access reports on your Geography of interest, every month!
The addition of AI or Machine Learning to embedded solutions will provide a powerful advance in the implementation of smart systems and support the advances in digitalisation that apply to all industry sectors. This webinar explored the potential impact of the addition of AI or Machine Learning to embedded solutions in the Digital industry.
UK Catalysis: Innovation opportunities for an enabling technologyKTN
Read about how accelerating innovations in catalysis will play a vital role in enabling the UK to meet its net zero targets in the areas of hydrogen production, Power-to-X, carbon dioxide utilisation and the use of alternative feedstocks.
Software Sustainability: preserving the future of research softwareNeil Chue Hong
Talk given at the National Science Foundation on the UK e-Science programme, the UK Software Sustainability Institute, and some of the challenges faced in ensuring long term development and maintenance of scientific software
Check out Tracxn's latest Geo Monthly Report on Tech rebrand.ly/ciqrk5b
For more free Monthly Startup Reports on geography of your interest , subscribe here: https://rb.gy/3yuosu
Research and innovation in Europe has to become more global and digital; EUREKA and especially the Clusters may act as frontrunners for this development. Through their flexibility and adaptability, the EUREKA Clusters are well equipped to consider more global approaches and the involvement of customers and end users.
This latest competition will award up to £30m to industry led projects aimed at addressing technological barriers to the commercial or industrial exploitation of quantum technologies in the UK. This in contrast to recent CR&D and FS competitions which focussed on developing products, services and components.
Projects should exploit second generation quantum techniques and focus on one or more of the challenge areas of:
- Connectivity
- Situation awareness
- Quantum computing
Projects must be collaborative, business led, and have eligible costs of £4m-£20m (with a maximum grant size of £10m).
Details from the competition scope will be posted on Innovate UK’s website during October. The EOI stage of the competition will open on 28th October 2019 and close on 27th November 2019.
Background: The Commercialising Quantum Technologies ISCF Challenge was launched in July 2019 by the Department of Business, Energy and Industrial Strategy as part of the Industrial Strategy Challenge Fund (ISCF). The ISCF provides funding and support to UK businesses and researchers. The fund is designed to ensure that research and innovation takes centre stage in the government’s Industrial Strategy.
The fund is being administered by UK Research and Innovation.
The Commercialising Quantum Technologies ISCF Challenge is an investment of £153m over 6 years.
Find out more about the Quantum Technologies Special Interest Group at https://ktn-uk.co.uk/interests/quantum-technologies
Presentation by Matt Chapman, Knowledge Transfer Manager, Knowledge Transfer Network at the Health Sector Business Breakfast, 16 March at Northwich Memorial Court
Performance Projects specialises in niche vehicle and motorsport innovation, designing, building and supplying complex subsystems through to whole vehicles.
Watch the recording of two SBRI competition briefings. £750k is being invested by Innovate UK, Crossrail and the Department for International Trade in digital innovation, operational efficiency, station security and more in Vietnam, Canada, Australia and India.
Watch our Consortia Building Workshop on replay to find out more about the Small R&D Partnership Projects funding competition, including pitches from organisations you could partner with.
Check out Tracxn's curated latest startup activity in Tech rebrand.ly/4hl9z
Subscribe for free https://rb.gy/3yuosu to access reports on your Geography of interest, every month!
The addition of AI or Machine Learning to embedded solutions will provide a powerful advance in the implementation of smart systems and support the advances in digitalisation that apply to all industry sectors. This webinar explored the potential impact of the addition of AI or Machine Learning to embedded solutions in the Digital industry.
UK Catalysis: Innovation opportunities for an enabling technologyKTN
Read about how accelerating innovations in catalysis will play a vital role in enabling the UK to meet its net zero targets in the areas of hydrogen production, Power-to-X, carbon dioxide utilisation and the use of alternative feedstocks.
Software Sustainability: preserving the future of research softwareNeil Chue Hong
Talk given at the National Science Foundation on the UK e-Science programme, the UK Software Sustainability Institute, and some of the challenges faced in ensuring long term development and maintenance of scientific software
Check out Tracxn's latest Geo Monthly Report on Tech rebrand.ly/ciqrk5b
For more free Monthly Startup Reports on geography of your interest , subscribe here: https://rb.gy/3yuosu
Research and innovation in Europe has to become more global and digital; EUREKA and especially the Clusters may act as frontrunners for this development. Through their flexibility and adaptability, the EUREKA Clusters are well equipped to consider more global approaches and the involvement of customers and end users.
This latest competition will award up to £30m to industry led projects aimed at addressing technological barriers to the commercial or industrial exploitation of quantum technologies in the UK. This in contrast to recent CR&D and FS competitions which focussed on developing products, services and components.
Projects should exploit second generation quantum techniques and focus on one or more of the challenge areas of:
- Connectivity
- Situation awareness
- Quantum computing
Projects must be collaborative, business led, and have eligible costs of £4m-£20m (with a maximum grant size of £10m).
Details from the competition scope will be posted on Innovate UK’s website during October. The EOI stage of the competition will open on 28th October 2019 and close on 27th November 2019.
Background: The Commercialising Quantum Technologies ISCF Challenge was launched in July 2019 by the Department of Business, Energy and Industrial Strategy as part of the Industrial Strategy Challenge Fund (ISCF). The ISCF provides funding and support to UK businesses and researchers. The fund is designed to ensure that research and innovation takes centre stage in the government’s Industrial Strategy.
The fund is being administered by UK Research and Innovation.
The Commercialising Quantum Technologies ISCF Challenge is an investment of £153m over 6 years.
Find out more about the Quantum Technologies Special Interest Group at https://ktn-uk.co.uk/interests/quantum-technologies
Presentation by Matt Chapman, Knowledge Transfer Manager, Knowledge Transfer Network at the Health Sector Business Breakfast, 16 March at Northwich Memorial Court
UKRI, in collaboration with the dept for Business Energy and Industrial Strategy, is seeking to invest up to £1 million to support collaborative projects to plan their route to cluster decarbonisation as part of the £170m Industrial Decarbonisation Challenge (IDC).
Background
As part of the UK’s Industrial Strategy Challenge Fund (ISCF), the IDC programme aims to accelerate the cost-effective decarbonisation of industry by developing and deploying low-carbon technologies. It aims to enable the deployment of infrastructure at scale by the mid-2020s.
It will support delivery of the Clean Growth Grand Challenge and the Industrial Clusters Mission, which has set an ambitious target to establish at least one low-carbon industrial cluster by 2030 and the world’s first net-zero carbon industrial cluster by 2040. The Mission, and this challenge, will help to place the UK at the forefront of the global shift to Clean Growth, by driving the technologies, services and markets to produce low carbon industrial products.
Find out more about the Industrial Strategy Challenge Fund at https://ktn-uk.co.uk/interests/iscf
Network Rail & Innovate UK Railways SBRI Competition Briefing: Innovation in ...KTN
Network Rail, through Innovate UK, are to invest £2.88 million in two SBRI competitions to improve the safety and efficiency of our railways. The competitions launch on Monday 2nd December and this briefing event is aimed at providing you with more information on the competitions and how to apply. It is also an opportunity to meet others, network and form collaborative partnerships.
Up to £1.08m (+VAT) is available to support the key challenges faced by Network Rail: trespass at platform ends and edges (e.g. fare evasion, shortcuts) and incursion over platform ends and edges to commit crime (e.g. cable theft, vandalism). Network Rail is seeking to demonstrate the capability of physical and/or technological solutions to combat these challenges. The solution must be scalable to suit a variety of station environments and will be tested through trials at multiple live station environments.
Find out more: https://ktn-uk.co.uk/news/live-now-webcast-network-rail-innovate-uk-railways-sbri-competition-briefing
Painel 5 - UK's Smart Grids Policy Landscape and Reflections for Brazil UKinBrazilNetwork
Apresentação ministrada pelo Sr. João Lampreia, Gerente de negócios da Carbon Trust no Brasil, exibida durante a Semana Brasil-Reino Unido de Baixo Carbono, realizada no Rio de Janeiro entre os dias 22 e 23 de março de 2016.
Building Talent for the Future 2 – Expression of Interest BriefingKTN
This competition briefing is supporting the creation, delivery, and growth of PEMD industry-focused course content, materials, and support for skills plus training.
During this UK National Robotics Proving Ground competition briefing, we outline how to apply for up to £500,000 of funding to develop your vision for the UK’s next-generation service robotics facilities.
Quantum Technologies Global Expert Mission Dissemination WorkshopKTN
The webinar presented the findings of the output report and gave delegates the opportunity to talk directly with representatives who went on the Mission in a Q&A Session. KTN hosted this event on behalf of Innovate UK and was presented by Mark Littlewood, Head of Emerging Technologies, KTN, Roger McKinlay, Challenge Director for Quantum Technologies at UK Research and Innovation, Dr Brendan Vickers, Head of International Trade Policy, Commonwealth Secretariat, Sir Peter Knight, Senior Research Investigator in the Physics Department at Imperial College, Dr Mike Short CBE, Department for International Trade (DIT).
Find out more: https://ktn-uk.co.uk/news/quantum-technologies-global-expert-dissemination-webinar-recording-and-slides-now-available
£10m funding support for Zero Emission Vehicle innovation.
The webinar will allow attendees to hear about the new funding opportunity. The top-level details are as follows:
- Application period opens 17 June and closes 29 July
- Single or up to two partner collaborations
- Focus around feasibility studies and R&D projects
- Projects delivery in six months
- Focused on ZEV innovation including battery and charging technologies
It is vital that businesses of all sizes, academics, RTOs and local authority representatives join to hear about the scope and details of this funding.
This will be your chance to hear about the funding scope, eligibility criteria and application process and also the chance to take part in a live Q&A with Innovate UK.
Find out more: https://ktn-uk.co.uk/news/catalysing-green-innovation-strand-2
Industrial Strategy Challenge Fund Next Generation Services CR&D Briefing SlidesKTN
UK Research and Innovation will invest up to £12 million in innovation projects to support the application of artificial intelligence (AI) and data technologies. Projects should aim to transform the 3 target sectors:
Accountancy
Insurance
Legal services
Find out more: https://ktn-uk.co.uk/funding/transforming-accountancy-insurance-and-legal-services-with-ai-and-data-small-projects-strand
Agri-Tech Catalyst Round 9 - Competition Briefing and Networking EventKTN
The Agri-Tech Catalyst offers funding for private sector/academic collaborative research and development projects, to deliver innovation in agriculture and food systems in Africa. All projects must include a partner from an eligible African country.
There is up to £5 million of funding available from the Department for International Development (DFID) and the Global Challenges Research Fund (GCRF) through Round 9 of this competition for early-stage feasibility studies, mid stage industrial research and late-stage experimental development. Projects must work on agri-tech and food chain innovations with partners in eligible African countries. The aim of this competition is to increase the pace of innovation in the development of agricultural and food systems in Africa. Your project must result in more use of innovations by farmers and food systems organisations such as manufacturers, processors, retailers, distributors and wholesalers.
Round 9 of funding from the Catalyst opened on 14th October 2019 and closes on 8th January 2020. The Knowledge Transfer Network (KTN) hosted a Competition Briefing and Networking Event for organisations developing projects for the Agri-Tech Catalyst on 24th October 2019 in Birmingham.
Find out more about the Agri-Food Main Interest at https://ktn-uk.co.uk/interests/agri-food
Competition Briefing - Open Digital Solutions for Net Zero Energy KTN
This briefing provided more information on the scope and application process for Innovate UK's Small Business Research Initiative (SBRI) competition to develop open software, hardware and data solutions that address the challenges of transforming to a net zero energy system in the UK.
Industrial Energy Transformational Fund Phase 2 Spring 2022 - Competition Bri...KTN
The Phase 2 competition for England, Wales and Northern Ireland opens on the 31st January 2022 and runs until 29th April 2022 and is worth up to £60 million in funding.
Horizon Europe ‘Culture, Creativity and Inclusive Society’ Consortia Building...KTN
This webinar highlights relevant call topics within Cluster 2 which focuses on challenges pertaining to democratic governance, cultural heritage and the creative economy, as well as social and economic transformations.
Horizon Europe ‘Culture, Creativity and Inclusive Society’ Consortia Building...KTN
This webinar highlights relevant call topics within Cluster 2 which focuses on challenges pertaining to democratic governance, cultural heritage and the creative economy, as well as social and economic transformations.
How to Create a Good Horizon Europe Proposal WebinarKTN
This webinar provides you with the essential hands-on knowledge and skills to transform your innovative project ideas into competitive project proposals in response to calls under Horizon Europe.
Horizon Europe Tackling Diseases and Antimicrobial Resistance (AMR) Webinar a...KTN
Innovate UK KTN Global Alliance in partnership with the Foreign, Commonwealth and Development Office (FCDO) the UK Science and Innovation Network in Ireland and the Nordics, and UK National Contact Points (NCPs) from Innovate UK (UKRI) hosted a workshop to help delegates form international collaborations and strategic partnerships.
Custom Interconnect Ltd (CIL) is a global provider of engineering solutions for mission critical applications. Based in Andover it has the most advanced electronic assembly facility in the UK, ranging from 6 SMT lines, 3D AOI, flying probe test, X-Ray/CT-Scan, laser depanelling, vacuum assisted vapour phase, 7 auto wire-bonders and 3 auto die bonders, and a scanning acoustic microscope.
ZF is a global technology company that supplies systems for passenger cars, commercial vehicles and industrial technology, enabling the next generation of mobility. ZF allows vehicles to see, think and act. In the four technology domains Vehicle Motion Control, Integrated Safety, Automated Driving, and Electric Mobility, ZF offers comprehensive solutions for established vehicle manufacturers and newly emerging transport and mobility service providers.
Made Smarter Innovation: Sustainable Smart Factory Competition BriefingKTN
This competition briefing outlines how this funding opportunity aims to support industrial research that addresses digital innovations to improve the sustainability of manufacturing processes.
Driving the Electric Revolution – PEMD Skills HubKTN
Watch this briefing webinar to find out more about this new competition which supports the development of the Skills Hub, a training platform to support the PEMD sector.
Medicines Manufacturing Challenge EDI Survey Briefing WebinarKTN
In anticipation of the Medicines Manufacturing Challenge sending out an EDI survey to those involved in any projects funded under the programme, this webinar provides more context behind the request, an overview of the Innovate UK Equality, Diversity and Inclusion (EDI) programmes, and an opportunity for attendees to ask questions and get involved.
Horizon Europe Clean Energy Webinar - Cluster 5 Destination 3 | PitchesKTN
This webinar highlights funding call topics within Cluster 5 / Destination 3 of the Horizon Europe Framework Programme and bring you plenty of networking opportunities.
Horizon Europe Clean Energy Webinar - Cluster 5 Destination 3 | SlidesKTN
This webinar highlights funding call topics within Cluster 5 / Destination 3 of the Horizon Europe Framework Programme and bring you plenty of networking opportunities.
Horizon Europe Quantum Webinar - Cluster 4 Destinations 4 and 5 | SlidesKTN
KTN Global Alliance in partnership with the Foreign, Commonwealth and Development Office (FCDO) in Germany, UK Science and Innovation Network and UK National Contact Points (NCPs) from Innovate UK as well as European NCPs focussed on pitching of project ideas and brokering partnerships for European Research and Innovation collaborations and networking.
Horizon Europe Quantum Webinar - Cluster 4 Destinations 4 and 5 | PitchesKTN
KTN Global Alliance in partnership with the Foreign, Commonwealth and Development Office (FCDO) in Germany, UK Science and Innovation Network and UK National Contact Points (NCPs) from Innovate UK as well as European NCPs focussed on pitching of project ideas and brokering partnerships for European Research and Innovation collaborations and networking.
Net Zero in Medicines Manufacturing: Measuring and Reporting Carbon FootprintKTN
On Friday 22nd October 2021, KTN hosted a webinar on Net Zero in Medicines Manufacturing, aimed at medicines manufacturers to learn about systems and tools for measuring and reporting on Scope 1, 2 and 3 carbon outputs. The webinar was hosted by the KTN Medicines Manufacturing Challenge Community in partnership with Innovate UK, Medicines Manufacturing Industry Partnership and Association of the British Pharmaceutical Industry, featuring presentations and discussion from GSK, AstraZeneca and Pfizer on reporting and science-based targets.
Horizon Europe Clean Transport Webinar - Cluster 5 Destination 5 | PitchesKTN
This webinar co-organised by KTN Global Alliance in partnership with the Foreign, Commonwealth and Development Office (FCDO) in Germany, UK Science and Innovation Network and UK National Contact Points (NCPs) from Innovate UK as well as European NCPs focussed on pitching of project ideas and brokering partnerships for European Research and Innovation collaborations and networking.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
3. Phase 1
Hubs and Capital
Training and Skills
NPL QMI
Dstl Demo
UKRI
EPSRC Science
~£400M
Phase 2 will bring UK quantum investment to £1bn
4. Pioneer funding for Quantum
A new set of products from
medical devices to sensors and
safer communication systems
may be possible using the
emerging physical science known
as quantum technology. The
potential is huge but still largely in
the lab environment. Pioneer
funding will bring new disruptive
companies together with existing
businesses to understand how
this emerging technology can be
turned into products that will
underpin industry in the future.
ISCF Wave 2 Quantum Pioneer - £20M funding
5. Progress to date - Projects
KAIROS
Pioneer Gravity
3QN
AquaSec
Miniature atomic clock
Gravity detection for survey
Quantum Key Distribution by Satellite
Agile Quantum safe Communications.
Quantum Key Distribution over Fibre
There are 4 ISCF Quantum projects which all kicked off in November 2018.
Led by
Teledyne e2v (UK) Limited
Led by
RSK Environment Limited
Led by
ArQit Limited
Led by
Toshiba Research Europe
Limited
6. AQuaSeC – A Consortium
Quantum Cryptography Post-Quantum Cryptography
National Facilities
System Integrators
End Users
Component Developers
TREL
Characterisation of components
High performance prototype
Security evaluation
User trials
KETS
QRNG
Low SWaP prototype
Security evaluation
User trials
IQE
Commercial growth of wafers
Uni. of Glasgow
Processing of Ge on Si APDs
Uni. of Sheffield
Growth of InGaAs/InP APDs and placed dot wafers
Uni. of Cambridge (Physics)
Processing of InGaAs/InP APDs and emitters
Heriot-Watt Uni.
Characterisation of APDs
Queen’s University Belfast
Hardware modules for QRA
Royal Holloway Uni. London
Security design
Software implementations of QRA
National Physical Laboratory
Security evaluation & certification
British Telecom
Demonstrations with end users
Senetas
Link encryption system and QKD integration
Uni. of Cambridge (Eng.)
Field trials in Cambridge and NDFIS
Dashboard
Integration with IoT system
TDS
Integration with tethered drone system
Radianz
Developing use-cases in financial sector
British Petroleum
Corporate network / Oil & Gas sectors
Ministry of Defence
Use cases in defence sector
CRUK - Cambridge Institute
Use cases in healthcare sector
7. Contingent upon
£205M of industry
investment
Current
Investment
Plan is
£153M over 6
years
Initial Budget
£70M over 3
years
ISCF Wave 3 - Commercialising Quantum
Products and Services: How Much?
Comms - Sensing - Imaging - Computing
11. Global investment in R&D comparisons
UK 2.4% Target
75% of Business R&D
carried out by just
400 businesses
(source: Industrial Strategy)
12.
13. Industrial Strategy Challenge Fund
• Delivers the science that business needs to transform
existing industries and create new ones
• Accelerates commercial exploitation of the most exciting
technologies the UK has to offer the world
• Ensures that scientific investment truly delivers economic
impact, jobs and growth right across the country
• Industry-led and powered by multi-disciplinary research
and business-academic collaboration
13
14. Industrial Strategy Challenge Fund objectives
• Increased UK business investment in R&D and improved R&D
capability and capacity
• Increased multi- and interdisciplinary research
• Increased business-academic engagement on innovation
activities
• Increased collaboration between younger, smaller companies
and larger more established companies, connecting up value
chains (or networks)
• Increased overseas investment in R&D in the UK
14
15. 15
Industrial Strategy
White Paper
Formation of UK Research
and Innovation
Budget 2018
Wave 1 challenge competitions Scaling wave 1 challenges
Announce wave 2 Wave 2 challenge competitions
Recruit Challenge Directors: (waves 1 and 2)
Scaling wave 1 challenges
Scaling wave 2 challenges
Recruit Challenge Directors (waves 2 and 3)
Wave 3 industry negotiations
Wave 3 delivery
Wave 2 challenge competitions
Wave 3 industry negotiations/outcomes
Wave 3 EOI process
Wave 3 challenge
development/shortlisting
16. Underpinning UKRI investments (Wave 1a) up to £283m
Leading-Edge
Healthcare
Challenge
(including
Medicines Mfg)
up to £188m
National
Satellite Test
Facility
up to £99m
Next Gen.
Affordable
Lightweight
Materials Mfg
(ATI projects) up
to £26m
Autonomous
Vehicles
(CCAV
projects)
up to £38m
Robotics and
AI in extreme
environments
Challenge
up to £93m
Faraday
Battery
Challenge
up to £246m
Wave 1 Challenges (c. £1bn)
16
17. Wave 2 Challenges (up to £729.5m)
17
Early diagnosis & precision
med (up to £196m)
Healthy ageing
(up to £98m)
Next generation
services (up to £20m)
Audience of the future
(up to £33m)
Quantum technology
(up to £20m)
Transforming construction
(up to £170m)
Transforming food
production (up to £90m)
Energy revolution
(up to £102.5m)
18. Wave 3 Challenge Shortlist
Subject to business case and successful negotiation
https://innovateuk.blog.gov.uk/2019/02/05/industrial-strategy-challenge-fund-wave-3-shortlist/
Industrial Strategy Grand Challenge ISCF wave 3 challenge
AI and data Commercialising quantum technologies (up to £70m*)
Digital security by design (up to £70m)
Ageing society Accelerating detection of disease (up to £79m)
Clean growth Industrial decarbonisation (up to £170m)
Manufacturing made smarter (up to £121m*)
Smart sustainable plastic packaging (up to £60m)
Transforming foundation industries (up to £66m)
Future of mobility Driving the electric revolution (up to £78m*)
Future flight (up to £125m)
* 3 year profiles were announced at Budget 2018 for these challenges as per current spending review period.
20. Theresa May praises UK sector as she opens London Tech Week
By Press Association
PUBLISHED: 12:59, 10 June 2019 | UPDATED: 13:00, 10 June 2019
Prime Minister Theresa May has urged the tech industry to work with the Government to
ensure Britain remains “one of the best places in the world to start and grow a tech
business”.
Mrs May used a speech at the opening of London Tech Week to announce Government
investment of more than £150 million in new technology such as quantum computing.
21. The Vision
Grow the UK’s leadership in Quantum Technologies,
delivering transformational products to a global market
and removing a range of technological barriers to UK
growth in productivity and competitiveness.
22. Exploiting Previous Investment
EPSRC Funded
Science
Commercialisation Industrialisation
Continued
Government Support
World Class Research
Four Hubs
Training and Skills
QMI
NQCC
NPL Programme
Dstl Programmes
Innovate UK EE and Quantum
Programmes
ISCF Wave 2
ISCF Wave 3
Other Missions
People and IP
Facilities, People and IP,
Industry-Academic Relationships,
Embryonic Supply Chain
Innovation centres
Mature consortia, demonstrators, early
products and services, industry
investment, finance, T&E. scale-up.
Future Initiatives
Quantum Computing Institute
Built on NQTP Phase 1 and ISCF
Wave 2 Pioneer
“The £1B NQTP.”
23. HOW MUCH INVESTMENT?
ISCF Wave 3
£153m
Industry matched funding
£205m
WHY ISCF WAVE 3?
System Failures (Market,
Coordination, Network.)
Investment Risk
Maintain Momentum
International
Competition
OBJECTIVES
• Products and Service
• s
2019/20 2021/22 2022/23 2023/24 2024/252020/21
CR&D
Feasibility
Studies
Technology
Projects
IA
WHAT WILL WE DELIVER?
WHAT ARE THE OUTCOMES
Increased skills & knowledge
Growth in export opportunities
New product lines & services
Increased R&D investment
SME involvement
Improved productivity & profitability
Summary
Sales of Products and
Services
R&D Investment
Focussed Research
Academic-Business
coordination
24. Increased sales of QT products and services
Increased UK business investment in R&D
Increased multi- & interdisciplinary research
Increased business-academic engagement
Objectives
25. Increased sales of QT products and services
Increased UK business investment in R&D
Increased multi- & interdisciplinary research
Increased business-academic engagement
Objectives
26. Industry Investment and Matched Funding
An important element in ISCF W3 has been an increased emphasis on
industry co-investment
• All W3 programmes have ambitious targets for industry matched
funding that exceeds that built into competitions
• Projects will need to identify non-competition matched funding
and co-investment and how this will be measured
• This will be an important part of the competition project
assessment and monitoring process.
28. Quantum Products and Services (CR&D)
• £83m over 3 rounds
• Industry led
• Aimed at delivering new quantum products and services with a
focus on the end user and a full supply chain.
• Similar to the ISCF W2 Pioneer programme in 2018 but quantum
computing IS in scope
• Collaborative projects £2m-£10m up to 36 months
• Expect to fund ~15 projects
29. Feasibility Studies (FS)
• £12m over 2 rounds
• Industry led
• Need an SME to lead or as a partner
• Smaller shorter projects, aimed at components and systems
integration
• Projects <£500k, up to 18 months
• Expect to fund ~40 projects
30. Technology Projects (Tech) – In Progress
• £46m over 2 rounds
• Industry led projects
• Aimed at allowing industry to work together on common
technology challenges facing quantum commercialisation
• May allow co-location at specialist facilities
• Primarily activities rather than facilities
• Expect to fund 5-8 large projects (grant size <£10m)
• RTO participation limited to 30%
• New buildings not eligible
31. Investment Accelerator (IA)
• £12m in one round
• Aimed at increasing VC investment into early stage quantum companies
• Identify 1-3 VC’s who will match a £12m investment to form a £12m
fund(s) – VC’s contract to procure at least another £36m in follow-on
funding
• Innovate UK runs open call for projects to be funded by the £12m fund
• VC’s agree investment terms with company recipients
32. Delivery Streams – Scope and Format
Delivery Strand Products & Services CR&D)
Quantum Technology
Development (Tech)
Components & Supply Chain
(FS)
Investment Accelerator
Technical Scope Whole of challenge initially – Later tuned to maximise impact and industry co-investment
Project Focus
End user led products and
services
Industry technology
challenges and co-location
Components, supply chain
elements
VC investment into early stage
high growth businesses
Lead Applicant Business
VC (investor stage), Business
(investee stage)
No. of participants 2 or more 1 or more n/a
RTO/academic participation Max 30% Max 50% n/a
Project Size
£2m-10m £4m- (max £10m grant) >£500k (<£50k for market
assessments)
tbd
Project Duration 18-36months <36 months <18 months n/a
Interview Assessment Stage Yes No Yes for investors
Lead Participation Limits
Companies can only lead on one project per stream per round Companies can lead on up to
3 projects
1-3 investors to be selected
36. Year 1 Delivery Plans
• CR&D Competition Round 1 (£27m) - Launch Date 5th August 2019
• FS Competition Round 1 (£6m) - Launch Date 5th August 2019
• Investment Accelerator (£12m) - Investor Stage Launch 17th August
2019
• Technology Projects (£30m) - Launch Nov/Dec 2019 tbd
Editor's Notes
As part of the White Paper, we announced additional funding was going to be available to tackle six more of the biggest challenges that are facing our economy, and look at two pioneer challenges that we’re looking to develop further so we can make sure we’re really answering the questions that business and academia have about what the future of these industries could mean
These latest announcements are the culmination of a substantial amount of engagement, deep-thought, debate, analysis and discussion with partners, experts and Government. But this is only the start of the process, there will be more challenges, and of course we need to make progress on those that we’ve already announced.
This is where we need businesses, researchers, investors to get behind these challenges, and start finding ways to solve them.