Qualitative and quantitative research methods differ in important ways. Qualitative research uses smaller sample sizes but collects more in-depth information from respondents through open-ended interviews. It aims to explore a topic rather than describe or establish causation. Quantitative research relies on larger sample sizes and standardized questionnaires to gather facts, opinions, and attitudes. It is more structured and able to establish relationships between variables but provides less detailed information per respondent. Both approaches have strengths and limitations depending on the research question.