This study examined synchrony in voice pitch between clinicians and suicidal patients during crisis interventions to quantify the process of empathy. Analysis of audio recordings found that patient and clinician voice pitch were moderately synchronized. Synchrony correlated with higher ratings of therapeutic alliance during interventions but not risk assessments. Regulation of patient emotion by the clinician also correlated with stronger alliances, depending on the phase of treatment. The results suggest empathy and alliance are related to the mutual influence between patients and clinicians on an interpersonal, moment-to-moment level.