This study examined characteristics of cancer patients interested in bibliotherapy and their motivation and adherence to a self-help program. The majority of participants were female, over 50 years old, and had education beyond high school. Participants had various cancer types and stages. They reported high autonomous motivation to engage in the program and over half had clinically significant psychological distress. Participants completed on average 80% of the workbook and spent 57 minutes weekly engaging with it. Those with more depressive symptoms spent less time reading. Motivation was unrelated to adherence measures but wanting responsibility for well-being related to seeking social support. The findings support bibliotherapy as an intervention option for a broad range of cancer patients.