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Sense amplifiers improve memory performance by quickly detecting small voltage changes on bit lines and amplifying them into full logic values. A 3-operand ISA has the advantage of preserving both inputs but the disadvantage of fewer bits per register input compared to a 2-operand ISA. Changing MIPS to use 6 bits for one operand would require taking an extra bit from another instruction field and adding special instructions to move values between registers 32-63, but this plan is a bad idea as it would result in a non-uniform ISA.
