A presentation I gave on Nov 18, 2021 for Mind Medicine's International Summit focused on how psychedelics are being used clinically and in research setting to treat eating disorders such as anorexia nervosa, bulimia, and binge eating disorder.
Assessment Of Fear Avoidance In Chronic Pain - Dr Johan W S Vlaeyenepicyclops
Lecture given to the North British Pain Association on 16th May 2008 by Dr Johan Vlaeyen. In this talk, Dr Vlaeyen discusses the mechanisms, assessment and treatment of fear avoidance in patients with chronic pain. Edinburgh, UK. www.nbpa.org.uk
Assessment Of Fear Avoidance In Chronic Pain - Dr Johan W S Vlaeyenepicyclops
Lecture given to the North British Pain Association on 16th May 2008 by Dr Johan Vlaeyen. In this talk, Dr Vlaeyen discusses the mechanisms, assessment and treatment of fear avoidance in patients with chronic pain. Edinburgh, UK. www.nbpa.org.uk
More info at: www.myndlift.com
This technique has generated a lot of buzz lately. But what is it really?
A short, fun and colorful way to explore neurofeedback, how it works, in addition to research and skepticism behind it.
Introduction to Mindfulness for Stress ReductionPhang Kar
Lecture at Watering the Seed of Mindfulness seminar organized by the Malaysia Association for Mindfulness Practice & Research (MMPR) on 30th September 2018.
This is a report made by Dr. Ramesh Manocha, who have used Sahaja Yoga Meditation for the improvement of symptoms and treatment of asthma, headache, menopause and depression.
Have a look, and feedback and comments are appreciated.
More information at: sahajayoga.org or at sahajayoga.dk
Treatments for Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a medical condition that affects a person’s thoughts, feelings and behaviors.
There are many treatments available; however, the most common treatments are psychotherapy and/or medication.
Psychotherapy, also known as talk therapy, is a treatment in which people work with trained behavorial health
providers to discuss their problems and learn new skills. While there are a variety of psychotherapies available to treat
PTSD, some have been proven to be more effective than others. There are also several medications that are effective
in treating PTSD. This handout provides basic information on treatments recommended as most effective by the VA/
DoD clinical practice guideline for PTSD.
More info at: www.myndlift.com
This technique has generated a lot of buzz lately. But what is it really?
A short, fun and colorful way to explore neurofeedback, how it works, in addition to research and skepticism behind it.
Introduction to Mindfulness for Stress ReductionPhang Kar
Lecture at Watering the Seed of Mindfulness seminar organized by the Malaysia Association for Mindfulness Practice & Research (MMPR) on 30th September 2018.
This is a report made by Dr. Ramesh Manocha, who have used Sahaja Yoga Meditation for the improvement of symptoms and treatment of asthma, headache, menopause and depression.
Have a look, and feedback and comments are appreciated.
More information at: sahajayoga.org or at sahajayoga.dk
Treatments for Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a medical condition that affects a person’s thoughts, feelings and behaviors.
There are many treatments available; however, the most common treatments are psychotherapy and/or medication.
Psychotherapy, also known as talk therapy, is a treatment in which people work with trained behavorial health
providers to discuss their problems and learn new skills. While there are a variety of psychotherapies available to treat
PTSD, some have been proven to be more effective than others. There are also several medications that are effective
in treating PTSD. This handout provides basic information on treatments recommended as most effective by the VA/
DoD clinical practice guideline for PTSD.
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
A Very Effective Depression Treatment Therapy: CBTAdam Smith
There are many kinds of therapeutic approaches to treat mental disorders, but research has shown that results demonstrated by Cognitive behavioral therapy is more effective and moreover permanent. Even the most mild cases of depression can be treated holistically with cognitive behavioral therapy centers.
Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive SymptomsA Randomized Clinical Trial
Zindel V. Segal, PhD1; Sona Dimidjian, PhD2; Arne Beck, PhD3; et alJennifer M. Boggs, PhD3; Rachel Vanderkruik, MA2; Christina A. Metcalf, MA2; Robert Gallop, PhD4; Jennifer N. Felder, PhD5; Joseph Levy, BA2
Author Affiliations
JAMA Psychiatry. Published online January 29, 2020. doi:10.1001/jamapsychiatry.2019.4693
Significance for fasd
Here\'s what we do at Brain State Technologies. Advanced neuro-technology to bring your brain into optimal balance and harmony. Life looks wonderfully different when you work from the inside out!
A synopsis of the book "Collaborative Therapeutic Neuropsychological Assessment". See website http://www.amazon.com/Collaborative-Therapeutic-Neuropsychological-Assessment-Gorske/dp/0387754253
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Mind Medicine | November 2021
"I’m tempted to say MDMA gave me ‘hope,’ but that word isn’t right: the
insight was more substantive than hope. I’d held the sensation in my
body; I understood, at a visceral level, what might someday be mine:
the sense of peace and joy within my body. For me, the therapeutic
process could unfurl from there.”
MDMA Study Participant
3. Mind Medicine | November 2021
Challenges in Eating Disorder Treatment
The Potential of Psychedelic Medicine for Eating Disorders
Ketamine/Esketamine (G-KAP, EF-KAP, IM Ketamine, Spravato)
MDMA-assisted Psychotherapy for AN & BED (with caregiver involvement)
Psilocybin + IFS for Eating Disorders
Presentation Outline
5. Mind Medicine | November 2021
Eating disorders are in desperate need of new treatments.
No FDA-approved medications exist for Anorexia.
We need a sense of urgency with screening/dx/tx—we often don’t act quickly enough:
“Ok you’ve missed one period, why don’t you come back if you’ve missed another period or two…” ←
We don’t do that in cancer treatment.
We’d never dream of saying: “Ok your cancer is a stage 1. Why don’t you come back when it’s stage 2
or 3.” And yet we do that with eating disorders.
These are serious conditions and sometimes immediate care is needed.
Don’t wait to treat until full medical workup is done and diagnosis is crystal clear:
“We’re still waiting for thyroid tests, celiac disease, etc., etc. But I need to be clear that the most
common reason that your child is having these symptoms is an eating disorder.”
Sometimes we need to think outside the box and venture into the unknown in search of new treatment options
for our clients.
Challenges in eating disorder treatment
6. Mind Medicine | November 2021
The potential to alleviate symptoms
that relate to serotonergic signaling
and cognitive inflexibility
The induction of desirable brain
states that might accelerate
therapeutic processes
01
02
How might psychedelics
help with eating
disorders?
9. Mind Medicine | November 2021
NMDA Receptor Blockade
Mechanism
Blocks NMDA
receptors, leading to
GABAergic inhibition
and a surge of
glutamate release.
Effect
Rapid
improvements in
mood by restoring
glutamatergic
signaling
Analogy
Wakes up dormant
neurons like jump starting
a car battery; lets them
communicate freely
10. Mind Medicine | November 2021
Lateral Habenular Burst Mode
Mechanism
Turns off “burst
mode” in the lateral
habenula (the “anti-
reward” center)
Effect
A break from
stress mode:
facilitates emotion
processing, reduces
avoidance of
negative affective
states
Analogy
Giving a dose of ketamine is
like extinguishing the “fire” of
stress in the brain
11. Mind Medicine | November 2021
BDNF & Neuroplasticity
Mechanism
Stimulates BDNF,
leading to
neurogenesis &
new connections
Effect
Neuron growth & a
window of opportunity
for deep therapeutic
work (neuroplasticity),
including: making new
connections and
strengthening
connections
Analogy
Ketamine is like a fertilizer
for neurons
*Ideally done during the 24-48 hour window of optimal
neuroplasticity after ketamine dosing
12. Mind Medicine | November 2021
Brain activity is
reduced in
depression.
Non-Depressed
A PET scan measures vital functions such as blood flow, oxygen
use, and blood sugar (glucose) metabolism.
Source: Mark George M.D. Biological Psychiatry Branch Division of Intramural
Research Programs, NIMH 1993
Depressed
13. Mind Medicine | November 2021
Limbic/Cortical Interruption
Mechanism
Interrupts
connection
between cortex &
limbic system
Effect
Time out from ordinary
mind (decreased
rumination), down
regulation of default
mode network (DMN),
increased cognitive
flexibility
Analogy
Rebooting your
computer
14. 3 ways we’re studying
ketamine/Spravato for eating
disorders…
15. Group-Based Ketamine-Assisted Psychotherapy
(G-KAP) for eating disorders in a residential
treatment setting
Novel group-based KAP protocol developed and tested out at a residential eating
disorder treatment center:
Groups of 4 adults per week, with group preparation, group processing/integration,
along with individual integration sessions
Collaborative care model with G-KAP integrated with multidisciplinary tx team
(including medical, dietary, specialized ED therapy, family therapy, etc.)
Study outcomes:
Improvements seen in depression and anxiety (PHQ-9 and GAD-7 scores)
G-KAP was well-tolerated and safe
Feasibility of implementing G-KAP for patients in residential treatment center
Cost reduction when using a group-based format
Paper submitted for publication – currently in review
16. Mind Medicine | November 2021
G-KAP for eating disorders:
Results
Figures: Mean pre-dose and 4-hour post dose PHQ-9 and GAD-7 scores for the 5 participants receiving IM ketamine treatment
across the 4-week study period
PHQ-9 = Depression score
GAD-7 = Anxiety score
Mean 4-hour post-dose survey scores
Mean pre-dose survey scores
17. Mind Medicine | November 2021
“Trying ketamine allowed me to see the possibility of a life I could have. While the effects did not last, my
very first experience snapped me out of a state of life-long, deep disconnection that I didn't even know I had
been experiencing. Suddenly, I was able to live in the world in the way people had always described it.
Though I am still trying to figure out how to attain that level of connection after catching a glimpse, that one
experience was so essential. I could finally feel hunger and fullness cues. I felt what it's like to live in a body,
instead of living a short distance from it. I felt connected to others and genuinely cared about their well-
being. I felt human for the first time in a long time.”
G-KAP Study: Participant Feedback
18. The development & feasibility study of a
treatment modality for Anorexia: EF-KAP
Focuses on developing of skill and confidence with emotion processing. This
increases self-efficacy with moving through stress/distress.
Also emphasizes the benefit of caregiver support and involvement.
REID TO ADD RATIONALE
Protocol
Preparation (2-3 session – with caregiver involvement if appropriate)
Ketamine dosing: Intention setting pre-ketamine, and processing post-ketamine
Caregiver skills development: Emotion coaching sessions provided to caregivers concurrently
Integration (1-2 session – with caregiver involvement if appropriate)
19. Mind Medicine | November 2021
Guiding Principles of Emotion-
Focused Ketamine-Assisted
Psychotherapy (EF-KAP)
This model aims to increase overall self-efficacy with emotion processing thus enabling lasting symptom relief. Every aspect of the
treatment is guided by two principles:
01
02
Leveraging the healing power of family
• By providing education and skills to a support person thereby:
• Strengthening meaningful relationships
• Creating a recovery-friendly environment outside of the therapy office
• Extending healing beyond the individual
Supporting the emotional health of the patient
• By focusing on the development of skill and confidence with emotion processing
• By focusing on transforming emotion with emotion
20. Mind Medicine | November 2021
EF-KAP 15-day (short-term) protocol
Visit 1 Monday Preparation session – Psychoeducation re: emotion focus and ketamine (+Caregiver)
Visit 2 Wednesday Dosing session #1 (similar to KAP)
Visit 3 Thursday Psychotherapeutic integration (with a focus on self-interruption or self-criticism)
Visit 4 Monday Dosing session #2 (similar to KAP) (+Caregiver, optional)
Visit 5 Tuesday Psychotherapeutic integration (with a focus on healthy anger/assertion)
Visit 6 Thursday Dosing session #3 (similar to KAP) (+Caregiver, recommended)
Visit 7 Friday Psychotherapeutic integration (with a focus on self-compassion)
Visit 8 Monday Closing session (+Caregiver, for full or half-session)
21. Mind Medicine | November 2021
Real-world data on ketamine /
esketamine & eating disorders
We conducted two separate real-world, retrospective analysis of clinical data from our Cedar Psychiatry clinics. Included 623 patients
receiving IM ketamine or Spravato nasal spray for depressive disorders.
Study measures:
Detailed demographic characteristics
Clinical characteristics
Treatment patterns (frequency, days between sessions, etc.)
Clinical outcomes: depression & anxiety scores (PHQ-9 and GAD-7)
Safety, tolerability, and adverse events
Cost of care
Esketamine study submitted for publication – currently being reviewed.
IM ketamine study to be submitted this month.
Cost-effectiveness analysis completed – manuscript draft underway.
22. IM ketamine & esketamine results
Neither population experienced significant safety or tolerability issues.
These populations had several physical and mental health comorbidities and high exposure to psychiatric medications.
In both retrospective analyses, we observed clinically meaningful improvements in depressive and anxiety symptoms as
measured by the PHQ-9 and GAD-7 survey instruments (p<.001).
Esketamine Mean Depression & Anxiety Scores at
Baseline and Last Treatment
0 10 20 30
Mean PHQ-9
Mean GAD-7
Last Treatment Baseline
IM Ketamine Depression & Anxiety Scores at Baseline
and Last Treatment
0 10 20
Mean PHQ-9
Mean GAD-7
Last Treatment Baseline
23. Depression scores in clients with eating
disorders before and after ketamine or
esketamine treatments
*Significant reduction in PHQ-9 scores on paired
samples t-test
**Eating disorders included: anorexia, bulimia,
binge-eating disorder, and a diagnosis of eating
disorder unspecified/not otherwise specified
25. Mind Medicine | November 2021
MED1: An Open-Label, Multi-Site Phase 2 Study of the Safety and Feasibility of MDMA-Assisted Psychotherapy for Eating Disorders
12 participants with Anorexia Nervosa
6 participants with Binge Eating Disorder
Protocol:
Weeks 1-3: three participant preparatory sessions (individual and with caregiver)
Weeks 4-12:
Three 8-hour experimental sessions
Six individual integration sessions
Three individual + caregiver integration sessions
MDMA-assisted psychotherapy for Anorexia
Nervosa & Binge Eating Disorder
26. Mind Medicine | November 2021
Why MDMA for eating
disorders?
TRUST: MDMA increases oxytocin levels, which
may strengthen the therapeutic alliance
FEAR REDUCTION: MDMA increases ventromedial
prefrontal activity and decreases amygdala activity, which may
improve emotional regulation and decrease avoidance
01
02
EMOTIONAL ENGAGEMENT: MDMA increases
norepinephrine release and circulating cortisol levels, which
may facilitate emotional engagement and enhance extinction of
learned fear association
03
28. Mind Medicine | November 2021
It’s not about the food
Disordered eating thoughts & behaviors are often ways to deal with the experiences in our life that overwhelm us with fear, grief,
shame and other emotional pain.
IFS is a form of psychotherapy developed by Richard Schwartz in his therapy sessions with individuals with eating disorders.
It acknowledges the innate multiplicity of the mind and starts from the premise that the mind is composed of relatively distinct
subpersonalities or "parts“, i.e. self critical voices, pessimism…
There are 3 categories of parts
Exiles: Hold onto the burdens of trauma
Managers: Take proactive measures to prevent activation of exiles and encounters with similar painful situations. ex parts that
"manage" food intake, sleep, public perceptions, self critical voices, pessimism etc.
Firefighters: Soothe exiles when they are activated. They use tools like food, drugs, meditation, exercise, sex etc. to sooth activated
or disrupted systems.
Rationale for IFS + Psilocybin
29. Planned feasibility study:
IFS + psilocybin for eating disorders
Outcome measures:
Safety and tolerability (vitals, ECG, adverse events)
Exploring preliminary eating disorders outcomes & changes in functioning
2 group therapy
preparation sessions
Group dosing session
2 group integration
sessions
3 follow-up group
therapy sessions
Study Design:
Group therapy preparation, dosing, integration, and follow-up
31. The potential of psychedelics for
eating disorders
Psychedelics, psychotherapy & psychotropics don’t need to be mutually exclusive in eating disorder treatment
Consider them adjunctive, to reduce fears related to recovery, increase flexibility and openness so that ED-specific
interventions are easier to receive
Though psychedelics may be generally safe from a medical perspective, careful medical and psychological screening and
monitoring is important
In my opinion, it’s a worthwhile pursuit:
I’ve witnessed first-hand the powerful healing that can occur for those suffering from mental health issues and for whom
conventional methods have not been effective
32. New possibilities along
the road to full recovery
I’ve witnessed time and time again the extent to which the field is made up of caring, compassionate and hardworking clinicians working hard on
behalf of those suffering and their families.
And one thing we can all agree on is that despite our best efforts, there remains a need for innovative treatment strategies to serve those for
whom conventional treatments have been insufficient, ineffective or even harmful.
Although much more research is needed to better understand the safety and efficacy of psychedelic medicines in eating disorders, we feel it
is a very worthwhile pursuit.
One thing is clear to us, however, and that is the importance of coordinating these efforts with conventional treatment approaches.
By doing so, we can build on the decades of research and clinical practice that have shaped treatment delivery across the spectrum of eating
disorders, including psychedelic psychotherapy as another treatment ingredient for those for whom it might be appropriate.
I have tremendous hope that psychedelic medicine can alleviate suffering for many along the continuum of recovery and their families and we look
forward to sharing the results of our studies as they become available.
- I'm Reid Robison, Chief Medical Officer at Novamind. thank you for having me.
- Honor to be attending this exciting and timely event.
Though theoretical mechanisms of action of psychedelic medicines are still being investigated, a growing body of research points towards the following ways psychedelics might help individuals with eating disorders in particular:
Classic psychedelics - like psilocybin, LSD and ayahuasca - are thought to interrupt what is called the default mode network (DMN), which is often considered the neurobiological seat of the “ego” in the brain. The DMN is a collection of pathways that govern our self image, our autobiographical memories, and our deeply ingrained beliefs and thought patterns. While results from brain imaging studies in eating disorders are diverse, findings seem to converge on a common theme of over-activity in the default-mode network, showing up in our clients as rumination over caloric intake and food rules, compulsive exercise or eating behavior patterns, body checking, etc. And, like a ski slope, the mind develops and strengthens pathways as we repeat patterns. Every time the thoughts and actions are engaged, the grooves get deeper and deeper, and before long, no matter where we start, we’re likely to slip into the same ruts, and end up following the same path down the mountain. When a psychedelic medicine is ingested, the default-mode network is down-regulated, and it’s like the mind benefits from a fresh coat of powder. This fresh coat of powder provides a blank slate - offering a welcome break from the eating disorder patterns, allowing for increased connectivity between other neuronal networks, and creating the potential to move beyond self-imposed limitations that can be so debilitating in those affected. In other words, the individual has the opportunity to travel down a new set of tracks, allowing them to consciously chart a course that isn’t governed entirely by eating disorder thoughts and urges.
The second theorized mechanism in support of psychedelics as a treatment tool for eating disorders involves the way in which psychedelics can help foster desirable brain states that might accelerate therapeutic processes. Specifically, the increased neuroplasticity observed with classic psychedelics and ketamine can also be leveraged in the context of psychotherapy. For example, when we use ketamine as a treatment for eating disorders, we schedule psychotherapy sessions within the 24-48 hour window of potential for neurogenesis to optimize outcomes. Also facilitative in the therapy setting, MDMA, while not a classic psychedelic, is unique among consciousness-altering substances in its ability to promote acceptance of and empathy for self and others. In addition to elevating oxytocin levels, MDMA stimulates the release of the monoamines serotonin, norepinephrine and dopamine, resulting in an improved mood and increased sociability. Brain imaging after administering MDMA shows decreased amygdala activation, and the reduced fear response that follows allows the client to emotionally engage in therapy without becoming overwhelmed by anxiety or negative affective states.
“[Ketamine] can enhance access to the psyche through enhanced self-awareness and a reduction of ego defenses. These medicines can help individuals break free of self-created barriers or access repressed traumas. In so doing our profession moves from a dose dependent daily suppression of the psyche (conventional psychiatric medications) to an episodic catalyst that tries to peer deeply into the psyche and allow it to be seen and more fully experienced (the psychedelic session). The medication opens the psyche to exploration by removing barriers. The use of evocative tools like ketamine and classic psychedelics run counter to all that conventional psychiatrists have been taught for decades. Medication can enhance access to the psyche instead of merely suppressing symptoms.” (Shannon, 2020)
The NMDA channel can be thought of as a gate for calcium ions, regulating the rate at which new thoughts are produced in the brain. At excessive rates of NMDA activity, thoughts and the rate at which new thoughts are generated (ideation) is slowed, thus reducing rumination. When the NMDA channel is blocked, thoughts are generated rapidly and, often incoherently, leading to hallucinations and psychosis (which is why there’s an upper limit to a ‘useful’ dose range in psychiatry).
The lateral habenula connects the limbic system (which processed emotions) and inhibits positive emotions (i.e. blocks pleasurable chemical messengers such as serotonin and dopamine).
Depression is like a kink in a hose, where the flow of pleasure and joy is blocked, but ketamine rapidly unkinks the hose, to let these chemical messengers flow
https://www.frontiersin.org/articles/10.3389/fncel.2020.00082/full
BDNF promotes neuron growth (neurogenesis; long term potentiation)
Neurotrophic hypothesis of depression:
Repeated stress prunes neuron
Ketamine can improve the abnormal plasticity of glutamate synapses
“When this promoted state of plasticity is combined with rehabilitation, plastic networks can reorganize so that impaired vision of one eye, due to developmental visual deprivation, can be fully restored (Castrén and Kojima, 2017).”
KAP is like doing this medication + rehabilitation, but for mental health.
Gene-environment interactions
Patients with the short (S) variant tri-allelic polymorphisms of the serotonin transporter gene (5-HTTLPR) promoter region were more likely than those with only one risk factor (genetic or environmental) to have smaller hippocampal volumes when experience childhood stress (Frodl et al., 2010).
When I conducted a pilot study of group-based KAP at an eating disorder treatment center here in utah a couple of years ago, it was easier than I though to integrate into conventional treatments.
It was also very well received by participants, AND personally and professionally meaningful to me. I learned a lot about both the power of the group format, AND how to do things better.
We’re working on writing up the manuscript for publication, but as a spoiler I’ll just say that we saw improvements in both depression and anxiety, in individuals with serious eating disorders, at a high level of care.
we’ve also done a pilot of group based KAP for PTSD,
And clinically, in addition to groups for psychotherapeutic integration, we’re working on the logistics of how to roll this out as an option for clients.
Unique healing properties in group-based psychotherapies
There are certain universal assumptions that underlie group therapy interventions
Group experience is universal and leads to reductions in stigma
Group therapy is used to bring about changes in attitude and behaviour
Groups produce change which is more permanent
Groups act as instruments for helping others
Through groups, people can grow together, treatment engagement is stronger
It is easier to support healing in people when in groups
Study of 5 participants receiving IM ketamine treatment across the 4-week study period
Significant reductions in GAD-7 and PHQ-9 scores as the study progressed.
Because eating disorders are so difficult to treat, Dr. Adele Lafrance and I designed this study specifically for patients with eating disorder. EF-KAP builds on the principles of Emotion-Focused Therapy (EFT) as well as ketamine-assisted psychotherapy (KAP).
A new development in the field of psychotherapy is the attention paid to the role of caregivers in the treatment of mental health issues across the lifespan. Caregivers, including parents and partners, represent an often-untapped resource for enhancing change in individuals who struggle with mental health issues. Aside from the fact that caregivers know their loved ones best, and love them the most, there are also a number of practical reasons for the involvement of caregivers. First, those who struggle with behavioral or mental health issues often live at home, with a spouse or partner, or are dependent on their families in some way. Therefore, it is sensible to equip these individuals with evidence-based support skills for use in day-to-day interactions. When caregivers can offer support in the real-world settings where their loved one is most likely to struggle, outcomes also improve. Providing the caregiver with an active role in the service of their loved one’s healing also decreases their feelings of powerlessness and paralysis, which can lead to burn-out, relationship strain, and the possible maintenance of their loved one’s symptoms. There is strong data relating to the cost-effectiveness and the efficacy of structured family involvement and yet the treatment offered to many is individually focused, especially among adolescent and adult populations.
This is also true in the context of psychedelic psychotherapies, where with few exceptions, research studies and treatment models focus on the “identified client”. This talk will introduce three models of family-based psychedelic medicine. The first model involves the recruitment of caregivers who learn specific skills to support their loved one throughout the course of psychedelic-assisted psychotherapy, creating an optimal home environment for healing and growth, and reducing the likelihood of problematic relational patterns that could interfere with treatment / outcomes. The second model involves the recruitment of caregivers who participate in medicine sessions alongside their loved one, thereby leveraging the neurobiological bond to deepen the process of healing and growth, including attending to relational patterns that may be reinforcing symptoms. The third model involves caregivers who participate in psychedelic-assisted psychotherapy on behalf of their loved one, who for medical or psychiatric reasons cannot participate themselves. Examples from research settings and anecdotal reports will be provided to illustrate each of these models. This focus on the engagement of caregivers as an extension of the therapist(s) can represent a departure from conventional methods, in particular when clients are adults. However, given the dearth of services available to those struggling – whether due to psychological or financial barriers, the model offers the possibility of filling important gaps in the mental health care system. More importantly, given that outcomes are improved for all involved in treatment efforts, family-based models of psychedelic-assisted psychotherapy offer the possibility of healing that extends far beyond the “identified client”, offering healing for broader systems and communities, and potentially interrupting intergenerational cycles of pain.
EF-KAP can be utilized as both a short-term intensive treatment and a long-term treatment.
For example, we recently delivered a family-based treatment in clinic out here in Utah, using this model #2 where all family members participated in medicine sessions With the goal of healing and growth for the entire family unit,
this was an incredibly rewarding process to participate in,
And was so touching to see caregivers not only supporting their loved one throughout the course of treatment, but also bravely participating with them, doing the work hand in hand,
This added a level of connection in the system that I have never seen before in treatment -- and.. We hope… reducing the likelihood of problematic relational patterns that could interfere with treatment goals and successful outcomes.
A new development in the field of psychotherapy is the attention paid to the role of caregivers in the treatment of mental health issues across the lifespan. Caregivers, including parents and partners, represent an often-untapped resource for enhancing change in individuals who struggle with mental health issues. Aside from the fact that caregivers know their loved ones best, and love them the most, there are also a number of practical reasons for the involvement of caregivers. First, those who struggle with behavioral or mental health issues often live at home, with a spouse or partner, or are dependent on their families in some way. Therefore, it is sensible to equip these individuals with evidence-based support skills for use in day-to-day interactions. When caregivers can offer support in the real-world settings where their loved one is most likely to struggle, outcomes also improve. Providing the caregiver with an active role in the service of their loved one’s healing also decreases their feelings of powerlessness and paralysis, which can lead to burn-out, relationship strain, and the possible maintenance of their loved one’s symptoms. There is strong data relating to the cost-effectiveness and the efficacy of structured family involvement and yet the treatment offered to many is individually focused, especially among adolescent and adult populations.
This is also true in the context of psychedelic psychotherapies, where with few exceptions, research studies and treatment models focus on the “identified client”. This talk will introduce three models of family-based psychedelic medicine. The first model involves the recruitment of caregivers who learn specific skills to support their loved one throughout the course of psychedelic-assisted psychotherapy, creating an optimal home environment for healing and growth, and reducing the likelihood of problematic relational patterns that could interfere with treatment / outcomes. The second model involves the recruitment of caregivers who participate in medicine sessions alongside their loved one, thereby leveraging the neurobiological bond to deepen the process of healing and growth, including attending to relational patterns that may be reinforcing symptoms. The third model involves caregivers who participate in psychedelic-assisted psychotherapy on behalf of their loved one, who for medical or psychiatric reasons cannot participate themselves. Examples from research settings and anecdotal reports will be provided to illustrate each of these models. This focus on the engagement of caregivers as an extension of the therapist(s) can represent a departure from conventional methods, in particular when clients are adults. However, given the dearth of services available to those struggling – whether due to psychological or financial barriers, the model offers the possibility of filling important gaps in the mental health care system. More importantly, given that outcomes are improved for all involved in treatment efforts, family-based models of psychedelic-assisted psychotherapy offer the possibility of healing that extends far beyond the “identified client”, offering healing for broader systems and communities, and potentially interrupting intergenerational cycles of pain.
there is currently limited real-world and long-term data for patients receiving IM (intramuscular) ketamine and esketamine nasal spray.
We took a look at detailed demographic/clinical characteristics, treatment patterns, clinical outcomes, adverse events, and cost of care of psychiatric patients receiving either IM ketamine therapy or esketamine therapy at private outpatient psychiatric clinics across Utah.
These retrospective data analyses were conducted with approval from the University of Utah IRB using de-identified data from the electronic health record system at Cedar Psychiatry clinics (Novamind).
In the IM ketamine data analysis, there are 452 adult (ages 18 and older) patients who received ketamine treatment by IM administration from January 2018 to June 2021. The esketamine data analysis includes 171 adults (18 years or older) with TRD and a prescription order for esketamine from July 2019 to June 2020.
For IM ketamine, average PHQ-9 and GAD-7 scores at baseline (PHQ-9: mean=15.5, SD=6.7; SI: mean=1.06, SD=1.09; GAD-7: mean=12.4, SD=5.7) were significantly reduced at the last IM ketamine treatment (PHQ-9: mean=11.6, SD=6.3; SI: mean=0.65, SD=0.84; GAD-7: mean=8.9, SD=5.8). For intranasal esketamine, the same measurements (PHQ-9: mean=16.7, SD=5.8; GAD-7: mean=12.0, SD=5.8) were found to be significantly lower at the last available treatment (PHQ-9: mean=12.0, SD=6.4; GAD-7: mean=8.7, SD=5.6).
In both retrospective analyses, we observed clinically meaningful improvements in depressive and anxiety symptoms as measured by the PHQ-9 and GAD-7 survey instruments (p<.001).
Esketamine and IM ketamine:
All EDs = 28 pts
Anorexia = 8 pts
Bulimia = 4 pts
BED = 7 pts
AN-R and BED will be the focus of this pilot study due to the great need for effective treatments. Anorexia nervosa (AN) among adults with more chronic symptomology is often resistant to recommended treatments and associated with poor outcomes [1]. Furthermore, completion rates for existing AN treatments are often low. Among adults with BED, approximately 41 to 60% of individuals who receive treatment for BED continue to experience binge-eating symptoms after treatment [3].
While new and innovative treatments are also needed for Anorexia Nervosa binge-purge subtype and Bulimia Nervosa, medical complications related to serious patterns of purging may increase the risk of interaction with the drug and therefore this study will first explore the safety and feasibility of a MDMA-assisted psychotherapy protocol with AN-R and BED.
A couple main categories:
Helps your brain – DMN, cognitive flexibility, neuroplasticity
Helps the therapy process - approaching previously unmanageable emotions — therapeutic alliance — inner critic / increased self-compassion
MDMA, while not a classic psychedelic, is unique among consciousness-altering substances in its ability to promote acceptance of and empathy for self and others.
In addition to elevating oxytocin levels, MDMA stimulates the release of the monoamines serotonin, norepinephrine and dopamine, resulting in an improved mood and increased sociability.
Brain imaging after administering MDMA shows decreased amygdala activation, and the reduced fear response that follows allows the client to emotionally engage in therapy without becoming overwhelmed by anxiety or negative affective states.
Thank you for listening.
The “problem” in eating disorders is not just about food, eating habits, or weight. It’s a coping response we have to past trauma, shame and anxiety. We develop these harmful habits — such as eating in a disordered way — to deal with the experiences in our life that overwhelm us with fear, grief, shame and other emotional pain.
Internal Family Systems (IFS) revolves around the idea that all of us have many “parts” or inner personalities, and that each part has its own individual way of handling various situations to manage the system (ourselves) as a whole.
The three main roles of the “parts” that exist within us from an IFS perspective are managers, firefighters, and exiles:
The managers create stability and run our day-to-day lives. These parts are proactive and encourage forward movement, striving and want us to improve. They try to maintain control of each situation and relationship we encounter through behaviors such as perfectionism, people pleasing, controlling, judging, and criticizing. (If I do everything right, I’m not a horrible person.)
The firefighters or distractors are reactive and try to make us shift gears and balance other parts in the system. These parts protect us by “extinguishing” our harmful feelings, through unhealthy behaviors, including disordered eating, self-harm, and drug abuse. (I’m getting relief now before I lose it.)
The exiles are the parts of us that have experienced trauma and carry burdens, and often become isolated within the system in order to protect us from feeling pain, fear, shame and other negative emotions.
In addition to these three parts is the Self (with a capital “S”), which resides within each of us. Our Self is our true, unburdened, and self-assured soul, and cannot be damaged by experience. According to IFS founder Richard Schwartz, the Self has “8 C’s”: calmness, curiosity, clarity, compassion, confidence, creativity, courage, and connectedness.
IFS and Psilocybin are a promising pair because IFS offers a great tool for preparation and integration of Psychedelic experiences. People often experience a de-polarization of their inner systems and a recovery of a connection to Self often that is permanent. By giving people the language and tools of IFS they can get more out of their psychedelic experiences and heal more comprehensively.