This document provides information on evaluating patients presenting with psychiatric complaints. It discusses that medical illnesses are missed in 4% of cases due to deficiencies in history and physical exams. Common missed illnesses include infections, pulmonary, thyroid, and neurological disorders. Hypoglycemia and hypoxia should be considered in all new psychiatric presentations. A thorough history, physical exam, and lab work is important to identify any underlying medical conditions.
Alcohol withdrawal syndrome is a set of symptoms that people who have a history of alcoholism experience when they stop drinking. People who are casual drinkers rarely have withdrawal symptoms.
People who have gone through withdrawal before are more likely to have withdrawal symptoms each time they quit drinking.
Symptoms of alcohol withdrawal can range from severe to mild, and can include:
-- Insomnia
-- Nightmares
-- Irritability
-- Fatigue
-- Shakes
-- Sweats
-- Anxiety
-- Depression
-- Headaches
-- Decreased appetite
Severe withdrawal symptoms include fever, convulsions and delirium tremens (DTs). Those who experience DTs may become confused, anxious and even have hallucinations. DTs can be very serious if they are not treated by a doctor.
Alcohol withdrawal syndrome is a set of symptoms that people who have a history of alcoholism experience when they stop drinking. People who are casual drinkers rarely have withdrawal symptoms.
People who have gone through withdrawal before are more likely to have withdrawal symptoms each time they quit drinking.
Symptoms of alcohol withdrawal can range from severe to mild, and can include:
-- Insomnia
-- Nightmares
-- Irritability
-- Fatigue
-- Shakes
-- Sweats
-- Anxiety
-- Depression
-- Headaches
-- Decreased appetite
Severe withdrawal symptoms include fever, convulsions and delirium tremens (DTs). Those who experience DTs may become confused, anxious and even have hallucinations. DTs can be very serious if they are not treated by a doctor.
common problem faced by medical faternity .
It is a systemic effort made to assess a case and identify sinister signs of illness. draw an outline of management
The proportion of the elderly in America is greater today than ever before and is growing even larger. What’s more, the elderly tend to be our sickest and most challenging patients. What signs and symptoms may indicate common disease processes, the normal signs of aging or special needs of the geriatric patient? How do you deal with the special needs of the geriatric patient? With a focus on every aspect of caring for your patient, this presentation answers your questions so that you’ll love what you learn.
Find more at www.romduckworth.com
pediatric hypertension workup and evaluation Balqees Majali
pediatric rotation seminar
hypertension in pediatrics workup and evaluation
ps: obtain renal US in all children with HTN as a part of your evaluation whether they have risk factors or not and whatever the age.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
2. 8th leading cause of death for all ages
3rd leading cause of death in adolescents
In the past 20 years suicide killed more
people than HIV and AIDS
90% of patients who commit suicide suffer
from a diagnosable mental illness
About 40-60% of those who die by suicide
are intoxicated at the time of death
10% of patients who attempt suicide will re
attempt within one year
3. Current suicidal ideation
Intent/ Plan
Hx of Suicide Attempts
◦ Date, circumstances, and method
Hx of Mental illness
◦ Intensity of current depressive symptoms
◦ Current treatment
◦ Psychotic Symptoms
Auditory command hallucinations, external control, and religious pre
occupation
Drug and alcohol use
Concurrent medical illness
Past or Present hx of Violence/Aggression
Recent life stressors
Current living situation
4. Make sure patient is fully undressed prior to
entering room
Patients belonging should be taken and stored
He/She should be checked for any pills, drugs,
weapons, sharp objects ect.
Observe patient from doorway or discuss with
nursing interaction, ensure that patient is not
threatening
Pt should have sitter at bedside if he/she has
active SI complaint or are a danger to themselves
5. Only 13% of surveyed psychiatrists perform a physical
exam on their inpatients
Inspect head for trauma or prior neurosurgery
◦ Signs of basilar skull fracture
Ocular exam
◦ Pinpoint pupils – narcotics, organophosphates or clonidine
◦ Dilated pupils – stimulant or anticholinergics, withdrawal from
sedatives, narcotics or post anoxic injury
◦ EOMS- impairment seen with Wernicke’s encephalopathy or space
occupying lesions
◦ Nystagmus-
Vertical (brain stem lesion), Wernicke’s encephalopathy or congenital
Horizontal or rotatory nystagmus suggests drug or more commonly
alcohol toxicity
PCP intoxication – blank open eye stair with roving gas, nystagmus and
dilated pupils
6. Neck exam- meningeal signs or thyroid
enlargement
Chest exam – auscultate for PNA, PTX, CHF,
COPD, Heart Murmur – valvular heart disease
(endocarditis)
Abdominal exam – obstruction, perforation,
hemorrhage, or infection in the abdominal cavity,
enlarged liver (jaundice or asterixis)
Inspect skin for rashes, Kaposi sarcoma or
petechiae, Track marks
Neuro exam is most frequent deficiency in
charts, perform basic neuro exam depending on
suspicion of medical diagnosis
7. Fever in combination with psychiatric
complaint is concerning for intracranial
infection of systemic illness
Hypoglycemia and hypoxia are common
causes of agitation and AMS
8. Hypoglycemia may be responsible for up to
10% of altered behavior in ED patients
UDS is unlikely to change managements,
patients typically will admit to drug or etoh
use if being seen for a psychiatric complaint
Labs including blood chemistries, CBC, UA,
toxicology and alcohol have only a 20%
sensitivity of detecting a medical disorder
History alone has 95% sensitivity
9. CXR – unnecessary in most patients unless hx
of cough, tachypnea or low pulse ox, more
liberal use in the elderly
CT Head – worrisome headache, focal neuro
exam, at risk for chronic subdural (dialysis,
anticoagulated, alcoholic, seizures, falls)
LP – Patients with fever, meningismus or
immunocompromised
10. Points
•Sex
•Age (<19 or > 45)
•Depression or Hopelessness
•Previous suicide attempts or psychiatric care
•Excessive alcohol or drug use
•Rational thinking loss
•Separated, divorced or widowed
•Organized or serious attempt
•No Social Supports
•Stated future intent
Score 6-8: Full Emergency Psychiatric Eval/Treatment
Score 9 or greater: Immediate Psychiatric Hospitalization
1
1
2
1
1
2
1
2
1
2
11. Compliance with psychiatric medications
Social Support
Involvement in a religious group
Being a parent
Positive coping skills
Adequate treatment of chronic pain or
substance abuse
Adequate followup
12. Patient and Complaint Dependent
Attempted Suicide
◦ CBC, BMP
◦ Etoh, UDS, APAP, Salicylate level
◦ EKG
◦ Preg
At a minimum
◦ Most will require Istat8, UDS, etoh, preg
13. PERS- Consult for voluntary admissions, ED
Consults
CSB- Social Worker who will find placement
for ECO/TDO patients
ECO- Emergency Custody Order
TDO- Temporary Detention Order
◦ Medical- Patients who are deemed not able to
refuse treatment or lab work because of medical
condition
14. 4% of the time a medical diagnosis is missed
Deficiencies in history and physical examination accounted
for the vast majority of illness
Most common are infection, pulmonary, thyroid, diabetic,
hematopoietic, hepatic and CNS disease
Hypoglycemia, Hypoxia and Thyroid disease should be
considered in all patients with new onset psychiatric
disease
Serum Sodium > 160 mEq/L is associated with AMS
Serum Sodium < 115 mEq/L produces confusion, coma
and even seizures
Hypercalcemia < 14 mg/dl can cause lethargy and mental
status change
◦ Malignant neoplasms and hyperparathyroidism account for the
vast majority of hypercalcemia
15. Disturbance of consciousness occurring over a
short time and affecting attention, with
impairment in other cognitive function
May be disoriented to time or place but not to
person
Perceptual disturbances including
misinterpretations, illusions or hallucinations
Disturbances develop abruptly and fluctuate
Drug toxicity or withdrawal accounts for up to
30% of all cases of delirium
UTI is one of the most common causes of
delirium in the elderly
16. Effective loss of reality testing, a disturbance
of thought processes and consequently,
changes in behavior
Disrupts perception and disorganizes
thinking to a degree that interferes with
social interactions
Suspect medial etiology in new cases of
psychosis, especially if patient in > 40 y.o
17. Major depression diagnosis requires
alterations in mood, psychomotor activity,
and cognition
15% of patients with major depression
commit suicide
18. Persistently elevated, expansive or irritable
mood
At least three of the following: inflated self
esteem or grandiosity, decreased need for
sleep, increased talkativeness, flight of ideas,
easy distractibility, increased activity or an
excessive quest for pleasure
Mood disturbance is severe enough to
markedly interfere with job performance and
personal relations
19. Complaints of anxiety, nervousness, panic or
stress
Sleep disturbance, irritability, difficulty
concentration, easy fatigue, restlessness, and
muscle tension
If a patient has a panic attack after age 35
and there is no clear cut psychologic
precipitant, suspect a medical cause,
hyperthyroidism, hypoxia, hypoglycemia, or
drug toxicity.
20. Sensation of bugs crawling under skin-
associated with cocaine or speed use
Bugs on the walls – alcohol withdrawal
Visual Hallucinations are strongly associated with
a medical pathology
Seizure prior to presentation suggests postictal
sate or nonconvulsive status epilepticus
Palpitations, tremor and weight loss suggests
hyperthyroidism
Headache suggests CNS tumor, meningitis or
chronic subdural hematoma
21. Late age (over 40) of onset of a new behavioral
symptom
No past medical history of psychiatric illness
Sudden onset of altered behavior
Presence of a toxidrome
Visual Hallucinations
Known systemic disease with new onset behavior
change
New Medication
Altered behavior temporally related to a convulsive
seizure
Abnormal vitals
Disorientation
Clouded consciousness
22. Very Uncooperative patient
◦ 5 MG IM Haldol + 2 MG IM Ativan + 50 MG IM
Benadryl, one syringe
◦ OR 10mg Geodon IM
Somewhat cooperative
◦ PO dosing of above Rx
23. Acute behavior changes in elderly are at risk
for adverse outcomes
Common sequela to infection or other
disease
Nearly 20% of elderly patients brought for
emergency psychiatric eval may be suffering
from a drug reaction
◦ Review BEERS Criteria
http://chpw.org/resources/Providers/Beers_Criteria.pdf