Prolia 60mg is a monoclonal antibody used to treat osteoporosis and bone metastases. It works by inhibiting RANKL and reducing bone resorption. Prolia is administered as a subcutaneous injection once every 6 months for osteoporosis or bone metastases from breast cancer in men. It is contraindicated in hypocalcemia and pregnancy. Common side effects include nausea, fatigue, and muscle weakness.

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2.  Prolia 60mg is a human monoclonal antibody for the
treatment of osteoporosis, treatment-persuaded bone
loss, metastases to bone, and giant cell tumor of bone.
 Prolia 60mg contraindicated in people with low blood
calcium levels.
 Prolia 60mg injection is prescription drug which is
used under the guidance of medical oncologist.

3.  • Prolia 60mg injectionIndicated for treatment of
osteoporosis at high risk postmenopausal women with
(end of menopause/ change of life), whose have serious
problem of fractures raised or who failed to other
medication of osteoporosis.
 • Prolia 60mg Indicated for treatment of Breast cancer in
women whose taking certain treatment which make severe
their risk of fractures and bone loss in men with prostate
cancer.
 • Indicated for treatment in adults and some adolescents
with giant cell tumor of bone which cannot treat with
surgery / surgery is not possible is treated with Prolia 60mg
injection.

4.  Denosumab (Prolia 60mg injection )mechanism by
aiming a protein called RANKL, which is required for
new osteoclasts to be made and to function. This
promote to inhibit further breakdown of bone and
reduces the risk of problems caused by secondary bone
cancer, such as fractures. It can also promote to
decreased pain caused by secondary bone cancer.

5. PRODUCT
DETAILS
Brand :Prolia
Ingredients :
Denosumab
Strength : 60mg
Manufactured : Dr.
Reddy’s laboratories
Package : 1 injection
in a prefilled syringe
Price : prolia 60mg
price in India

6.  • Peak plasma concentration: 6.75mcg/mL
 • Tmax: 10days
 • Without aggregation in Prolia 60mg injection
pharmacokinetics with duration was noticed upon
multiple dosing of 60 mg SC administered once every
6 months.
 • Pharmacokinetics of Prolia 60mg will not affected by
the binding antibodies formation.
 • Half-life is 25.4 days.

7.  For adult :
 The prescribed dose for Osteoporosis is Prolia 60mg injection SC
(subcutaneously) once every 6 months
 Administer injection in upper arm, upper thigh or abdomen
 The prescribed dose for Androgen Deprivation induced bone loss is
Prolia 60mg SC q6months.
 The prescribed dose is Glucocorticoid induced osteoporosis Prolia
60mg injection q6months.
 The prescribed dose is Aromatase inhibitor induced bone loss Prolia
60mg SC q6months
 For pediatric :
 The prescribed dose is 13 years and older and 45kg or more for Giant
Cell Tumor of bone: The recommended dose is of 120mg Prolia 60mg
injection tablet given SC, with additional 120mg doses on days 8 and 15
of the 1st month treatment every 4 weeks

8.  No experienced with Prolia 60mg injection overdose.
If occurs take the patient to emergency department
and call poison control

9.  • Before starting denosumab should be corrected. Hypocalcemia
may worsen, specifically in patients with renal impairment.
Sufficiently supplement patients with calcium and vitamin D.
 • Prolia 60mg injection has negative effects of immuno-
suppressants may improve. Especially the harm for severe
infections may be raised. Discuss with your doctor of any
immuno-suppressive drugs you early consume.
 • While treatment with Prolia 60mg have Osteonecrosis of the
jaw (ONJ) has been reported with denosumab – check for
symptoms.
 • Prolia 60mg injection Planning to become pregnant before to
starting this therapy, consult with doctor before the treatment
because use in pregnancy only if benefit to mother outweighs
risk to fetus).

10.  Common side effects for the patient taking Prolia
60mg injection :
 • Nausea
 • Fatigue
 • Muscle weakness
 • Hypophosphatemia.

11.  Less common side effects for patients taking Prolia 60mg :
 • Diarrhae
 • Shortness of breath
 • Hypocalcemia
 • Joint pain
 • Hypocalcemia
 • Cough
 • Arthralgia
 • Limb pain
 • Eczema
 • Headache
 • Eczema
 • Rash

12.  No formal drug-drug interaction with denosumab
(Prolia 60mg injection )during trials.
 When concomitant use with some anticancer drug,
orthopedic drugs, vaccines will lead to risk of adverse
effects can be increased
 CONTRAINDICATION
 Prolia 60mg injection is contraindicated in
 Hypocalcemia
 Pregnancy
 Hypersensitivity

13.  Pregnancy category C
 The Prolia 60mg which has no enough data in
pregnant women to convey any drug analog risk for
adverse development outcomes the drug in pregnant
women is contraindicated for use because it may cause
serious risk to the fetus.
 LACTATION
 Prolia 60mg injection is excreted into human milk is
not known. Since possible for severe side effects occurs
in nursing infants from Prolia 60mg injection. Avoid
breastfeeding during treatment of Denosumab.

14.  Store at 2°C to 8°C in the original container.
 Avoid freeze.
 Before to administration keep at room temperature.
 Prolia 60mg injection protect from direct light and heat.
 MISSED DOSE
 If Prolia 60mg dose is missed then have the dose
immediately before next dose duration. Next dose time
reaches then left off the missed dose and follows regular
schedule.
 Avoid taking double dose at same time.
 Please consult the doctor for further information.

15.  PHONE NO : +91-9940472902
 EMAIL : millionhealthpharmaceuticals@gmail.com
 WEBSITE URL: https://millionpharma.com/prolia-
60mg.php
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