This document summarizes a proposed study on the effect of phototherapy on hematological and biochemical parameters in neonatal jaundice. The study will be conducted at Chirayu Medical College and Hospital in Bhopal, India over 18 months. 50 newborns receiving phototherapy for jaundice will be enrolled. Blood samples will be collected before and after phototherapy to analyze total and direct bilirubin, electrolytes, blood counts, and kidney function. The aim is to assess if phototherapy impacts these parameters. This may help optimize phototherapy and identify neonates needing early intervention.
Incidence of significant jaundice in healthy term newborns and the ability of...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This study examined neurological outcomes in 35 neonates who underwent exchange transfusion for hyperbilirubinemia. The most common causes for exchange transfusion were ABO incompatibility (42.86% of cases) and Rh incompatibility (22.85% of cases). The neonates were followed for 12 months, with assessments at 3, 6, and 12 months. At 3-month follow-up, 4 cases (11.43%) showed abnormal brainstem evoked response audiometry results, and all 4 of these cases exhibited abnormal development. At 6-month follow-up, 4 cases (11.76%) showed delays in gross and fine motor development, while 2 cases (5.88%) and 3 cases
Bind neuro neocon 2018 - Dr Karthik Nageshkarthiknagesh
This document discusses bilirubin-induced neurologic dysfunction (BIND) and chronic bilirubin encephalopathy. It covers the diagnosis and outcomes of these conditions, as well as prevention strategies. Some key points:
- BIND represents a spectrum of minor neurologic manifestations that can occur with moderate hyperbilirubinemia exposure. It includes subtle processing disorders, disturbances in visual-motor skills, and speech/language abnormalities.
- Risk factors for BIND/encephalopathy include prematurity, hemolysis, complications, and individual infant vulnerability. Diagnosis involves assessments of neuromotor signs, muscle tone, reflexes, and neurobehavior over time.
- Prevention strategies include promoting
Yasser's covid 19 discrepancy phenomenon-dr. yasser mohammed hassanain elsayedYasserMohammedHassan1
Yasser’s COVID-19 Discrepancy phenomenon is a novel descriptive phenomenon that is always seen in all COVID-19 pneumonia. Initial dramatic improvement of the clinical status of COVID-19 pneumonic patient, not a simultaneously after the management, not a coincide with laboratory, radiological, and electrocardiographic workup. Further larger studies for the study medical regimen with considering of “Yasser’s COVID-19 Discrepancy phenomenon” is recommended.
This research article examines alterations in reproductive hormones during pregnancy and the risk of preeclampsia. The study followed 79 preeclamptic women and 80 healthy pregnant controls longitudinally from the third trimester through 6 weeks postpartum. Blood samples were taken at each visit and analyzed for beta-hCG, oestriol, progesterone and prolactin levels. Results showed beta-hCG and oestriol levels were significantly altered in the preeclamptic group compared to controls in the first and third trimesters respectively, indicating these hormones may help identify risk of preeclampsia earlier in pregnancy. The study aims to determine the gestational age at which hormonal changes occur that are associated with developing preecl
This document discusses various study designs used in medical research. It describes descriptive study designs like case reports, case series, ecological studies, and cross-sectional studies which are used to describe characteristics of subjects. It also describes analytical study designs like case-control studies and cohort studies which are used to analyze associations between exposures and outcomes. Experimental study designs like randomized controlled trials are also discussed which are used to evaluate interventions. Key aspects of each study design like their strengths, weaknesses and steps are highlighted.
PET imaging can play important roles in drug development. In pre-clinical development, PET can be used to assess target expression levels in disease models and evaluate candidate drugs' ability to reach targets. Small animal PET allows studying drug pharmacokinetics and target engagement in living subjects. In clinical development, PET provides quantitative measures of target occupancy to guide dose selection and allows monitoring treatment effects. Overall, molecular imaging techniques like PET can help accelerate drug development by aiding candidate selection and optimization of dosing.
Title: "DNB Exam: Past Papers and Answers - Your Comprehensive Guide"Raju678948
Welcome to your one-stop destination for DNB (Diplomate of National Board) exam preparation! In this curated collection, we bring you a comprehensive set of past papers along with detailed answers, all conveniently hosted on SlideShare. Whether you're gearing up for your upcoming DNB exam or looking to sharpen your skills, these resources are tailored to suit your needs.
Each slide is meticulously crafted to present a challenging yet rewarding experience, mirroring the format and difficulty level of the actual DNB exam. With a diverse range of topics covered, including medicine, surgery, obstetrics, gynecology, pediatrics, and more, you'll find ample opportunities to test your knowledge and enhance your understanding.
Our team of experts has meticulously curated these past papers and answers to ensure accuracy and relevance. We understand the importance of rigorous preparation in achieving success, which is why we've gone the extra mile to provide detailed explanations for each question. Whether you're reviewing core concepts or tackling complex scenarios, you'll find invaluable insights to guide you every step of the way.
Take advantage of this invaluable resource to streamline your DNB exam preparation journey. Whether you're studying solo or collaborating with peers, these past papers and answers are designed to empower you with the confidence and proficiency needed to excel on exam day.
Don't leave your success to chance – equip yourself with the tools and knowledge necessary to achieve your goals. Dive into our collection of DNB past papers and answers today and embark on a journey towards professional excellence. Your success awaits!
Incidence of significant jaundice in healthy term newborns and the ability of...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This study examined neurological outcomes in 35 neonates who underwent exchange transfusion for hyperbilirubinemia. The most common causes for exchange transfusion were ABO incompatibility (42.86% of cases) and Rh incompatibility (22.85% of cases). The neonates were followed for 12 months, with assessments at 3, 6, and 12 months. At 3-month follow-up, 4 cases (11.43%) showed abnormal brainstem evoked response audiometry results, and all 4 of these cases exhibited abnormal development. At 6-month follow-up, 4 cases (11.76%) showed delays in gross and fine motor development, while 2 cases (5.88%) and 3 cases
Bind neuro neocon 2018 - Dr Karthik Nageshkarthiknagesh
This document discusses bilirubin-induced neurologic dysfunction (BIND) and chronic bilirubin encephalopathy. It covers the diagnosis and outcomes of these conditions, as well as prevention strategies. Some key points:
- BIND represents a spectrum of minor neurologic manifestations that can occur with moderate hyperbilirubinemia exposure. It includes subtle processing disorders, disturbances in visual-motor skills, and speech/language abnormalities.
- Risk factors for BIND/encephalopathy include prematurity, hemolysis, complications, and individual infant vulnerability. Diagnosis involves assessments of neuromotor signs, muscle tone, reflexes, and neurobehavior over time.
- Prevention strategies include promoting
Yasser's covid 19 discrepancy phenomenon-dr. yasser mohammed hassanain elsayedYasserMohammedHassan1
Yasser’s COVID-19 Discrepancy phenomenon is a novel descriptive phenomenon that is always seen in all COVID-19 pneumonia. Initial dramatic improvement of the clinical status of COVID-19 pneumonic patient, not a simultaneously after the management, not a coincide with laboratory, radiological, and electrocardiographic workup. Further larger studies for the study medical regimen with considering of “Yasser’s COVID-19 Discrepancy phenomenon” is recommended.
This research article examines alterations in reproductive hormones during pregnancy and the risk of preeclampsia. The study followed 79 preeclamptic women and 80 healthy pregnant controls longitudinally from the third trimester through 6 weeks postpartum. Blood samples were taken at each visit and analyzed for beta-hCG, oestriol, progesterone and prolactin levels. Results showed beta-hCG and oestriol levels were significantly altered in the preeclamptic group compared to controls in the first and third trimesters respectively, indicating these hormones may help identify risk of preeclampsia earlier in pregnancy. The study aims to determine the gestational age at which hormonal changes occur that are associated with developing preecl
This document discusses various study designs used in medical research. It describes descriptive study designs like case reports, case series, ecological studies, and cross-sectional studies which are used to describe characteristics of subjects. It also describes analytical study designs like case-control studies and cohort studies which are used to analyze associations between exposures and outcomes. Experimental study designs like randomized controlled trials are also discussed which are used to evaluate interventions. Key aspects of each study design like their strengths, weaknesses and steps are highlighted.
PET imaging can play important roles in drug development. In pre-clinical development, PET can be used to assess target expression levels in disease models and evaluate candidate drugs' ability to reach targets. Small animal PET allows studying drug pharmacokinetics and target engagement in living subjects. In clinical development, PET provides quantitative measures of target occupancy to guide dose selection and allows monitoring treatment effects. Overall, molecular imaging techniques like PET can help accelerate drug development by aiding candidate selection and optimization of dosing.
Title: "DNB Exam: Past Papers and Answers - Your Comprehensive Guide"Raju678948
Welcome to your one-stop destination for DNB (Diplomate of National Board) exam preparation! In this curated collection, we bring you a comprehensive set of past papers along with detailed answers, all conveniently hosted on SlideShare. Whether you're gearing up for your upcoming DNB exam or looking to sharpen your skills, these resources are tailored to suit your needs.
Each slide is meticulously crafted to present a challenging yet rewarding experience, mirroring the format and difficulty level of the actual DNB exam. With a diverse range of topics covered, including medicine, surgery, obstetrics, gynecology, pediatrics, and more, you'll find ample opportunities to test your knowledge and enhance your understanding.
Our team of experts has meticulously curated these past papers and answers to ensure accuracy and relevance. We understand the importance of rigorous preparation in achieving success, which is why we've gone the extra mile to provide detailed explanations for each question. Whether you're reviewing core concepts or tackling complex scenarios, you'll find invaluable insights to guide you every step of the way.
Take advantage of this invaluable resource to streamline your DNB exam preparation journey. Whether you're studying solo or collaborating with peers, these past papers and answers are designed to empower you with the confidence and proficiency needed to excel on exam day.
Don't leave your success to chance – equip yourself with the tools and knowledge necessary to achieve your goals. Dive into our collection of DNB past papers and answers today and embark on a journey towards professional excellence. Your success awaits!
This bulletin is a publication of the CRC networks in Perak (Hospital Raja Permaisuri Bainun Ipoh, Hospital Seri Manjung and Hospital Taiping).
This issue emcompasses various research articles written by CRC staff, a research scope write-up to emphasize on the research focus this coming year, programmes conducted in 2021 as well as upcoming events across the CRC Perak Network this year.
(e-ISSN Number: 2682-7867).
A COMPARATIVE ANALYSIS OF HEMATOLOGICAL INDICES IN PREGNANT WOMEN AND NON PR...FidelityP
Red blood cell (RBC) indices are individual components of a routine blood test called the complete blood count (CBC). The CBC is used to measure the quantity and physical characteristics of different types of cells found in your blood. Blood consists of RBCs, white blood cells (WBCs), and platelets that are suspended in your plasma. Platelets are cells that enable clot formation. RBCs contain hemoglobin, which carries oxygen throughout your body to all of your tissues and organs. An RBC is pale red and gets its color from hemoglobin. It’s shaped like a doughnut, but it has a thinner area in the middle instead of a hole. Your RBCs are normally all the same color, size, and shape. However, certain conditions can cause variations that impair their ability to function properly. The RBC indices measure the size, shape, and physical characteristics of the RBCs. Your doctor can use RBC indices to help diagnose the cause of anemia. Anemia is a common blood disorder in which you have too few, misshapen, or poorly functional RBCs123
Clinical, ethical and legal considerations in the treatment of newborns 2008Dominique Gross
Non-ketotic hyperglycinaemia (NKH) is a devastating neurometabolic disorder leading, in its classical form, to early death or severe disability and poor quality of life in survivors. Affected neonates may need ventilatory support during a short period of respiratory depression. The transient dependence on ventilation dictates urgency in decision-making regarding withdrawal of therapy.
The occurrence of patients with apparent transient forms of the disease, albeit rare, adds uncertainty to the prediction of clinical outcome and dictates that the current practice of withholding or withdrawing therapy in these neonates be reviewed. Both bioethics and law take the view that treatment decisions should be based on the best interests of the patient.
The medical-ethics approach is based on the principles of non-maleficence, beneficence, autonomy and justice. The law relating to withholding or withdrawing life-sustaining treatment is complex and varies between jurisdictions. Physicians treating newborns with NKH need to provide families with accurate and complete information regarding the disease and the relative probability of possible outcomes of the neonatal presentation and to explore the extent to which family members are willing to take part in the decision making process. Cultural and religious attitudes, which may potentially clash with bioethical and juridical principles, need to be considered.
2008 Elsevier Inc
This document proposes a study to determine the prevalence and risk factors of jaundice among newborn babies in Plateau State, Nigeria. Jaundice is common in newborns worldwide and an estimated 60-80% of babies develop jaundice in their first week. However, there is a lack of local data on jaundice incidence and risks in Plateau State. The study aims to measure jaundice prevalence at two hospitals and identify associated risk factors. A cross-sectional survey of 100 mothers will collect data on demographics, pregnancies, babies, and healthcare practices. Findings will help develop better prevention and management of newborn jaundice in the state.
“A Study on Coagulation Profile in Pregnancy Induced Hypertension Cases”iosrjce
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB) covers studies of the chemical processes in living organisms, structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules, chemical properties of important biological molecules, like proteins, in particular the chemistry of enzyme-catalyzed reactions, genetic code (DNA, RNA), protein synthesis, cell membrane transport, and signal transduction. IOSR-JBB is privileged to focus on a wide range of biotechnology as well as high quality articles on genetic engineering, cell and tissue culture technologies, genetics, microbiology, molecular biology, biochemistry, embryology, cell biology, chemical engineering, bioprocess engineering, information technology, biorobotics.
CANDIDATES FOR HIPPOCAMPAL SPARING14MethodologyTo evaluate .docxhumphrieskalyn
CANDIDATES FOR HIPPOCAMPAL SPARING 14
Methodology
To evaluate which patients would be higher priority candidates for hippocampal sparing, 3,000 participant treatment plans were evaluated via a cross-sectional differential research method. The method of research used in this study is considered differential and cross-sectional because groups of participants are different ages are compared on a set of variables and because participates of this study were assigned to groups based on preexisting factors.
Patients over the age of 18 and parents of participants under the age of 18 were asked to take part in the research. The aim of research was explained to them and informed consent was obtained by all participants prior to participating in the study. It was explained to participants, or parents of the participants, that data was going to be collected based on the treatment they received and that no additional experimentation with radiation was to be added to their treatment for the benefit of the research study, therefore, there was no additional risk to their treatment plan implemented by this differential research study. The study was subject to external review several credible institutions including the American Society for Therapeutic Radiology and Oncology (ASTRO).
Participants. Participants of this study were subjects who required WBRT and were evaluated in two categories. The two categories were based on treatment intent and will be separated into preexisting palliative and prophylactic categories. With age thought to be the most influential variable, participants in each category were further categorized into two subcategories based on age. Subjects of this study included subcategory A participates who were required to be 25 years of age and younger and subcategory B participants who were required to be 26 years old age and older based on prior research on brain development studies done by Giedd & Rapoport.
The cumulative sample size for the research study was 2,000 participants. 500 subcategory A and 500 subcategory B participants were included in each intent category. Subject exclusions included patients who were on hospice care, those on a concurrent chemotherapy regimen during their radiation therapy treatment and patients who had a treatment plan change after beginning their initially recommended treatment.
Treatment Intent
Total Number of Participants
A: Under 25
B: Over 25
Prophylactic
500
500
Palliative
500
500
Table 1. Visual representation of participants.
Data Collection Method. Data was collected from 20 Radiation Oncologist between 21 different cancer centers over a course of 18 months between January 2014 and June 2015. Two Oncologists at each cancer center participated in the study by collecting research and all had an average of 3 new WBRT patients per month. Each cancer center then treated an average of 6 new WBRT patients per month, 2,000 of which agreed to participate in the study. Data was collected from each ph ...
Over the past few decades, the prognosis of neonatal seizures has experienced considerable enhancement due to the improvement in neonatal and infant care. The mortality rate of neonatal seizures has fallen from 40% to 20%, and the relationship between electro encephalogram (EEG) and prognosis has become quite clear. The underlying cause of seizures is a major determinant of the outcome of the disease. For example, patients with secondary seizures and hypoxic-ischemic encephalopathy have only 50% chance of normal development and total recovery, while newborns with secondary seizures and subarachnoid hemorrhage or better hypocalcemia have higher chances of recovery. Searches were conducted by two independent researchers in international (PubMed, Web of Science, Scopus, and Google Scholar) and national (SID and Magiran) databases for related studies from the inception of the databases to September 2017 (without time limitation) in English and Persian languages. It is possible to achieve accurate diagnosis through checking the history before birth and performing a thorough physical examination in some rare cases. Depending on the case, tests or additional actions can be done. EEG is the primary means for diagnosis and may exhibit paroxysmal activity in the difference between seizures or may produce electrographic seizures in cases where seizure is hidden or latent. One of the most important points in the treatment of neonatal seizures is the diagnosis of underlying cause (such as hypoglycemia, meningitis, drug deprivation, and trauma) because such diagnosis facilitates different approaches to control neonatal seizures. Most experts agree to control all clinical and electrographic seizures. Some others focus merely on clinical seizures. Most centers prefer the first approach. An important point before starting an anticonvulsant drug is to decide if the patient needs intravenous and luteinizing treatment with an initial bolus dose, or it can be easy to start treatment with a prescription for a long-acting medication based on the severity of seizure, duration, and frequency.
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
The document summarizes a study on the effects of maternal anemia on the placenta and fetal outcomes. 120 placentas were examined from anemic and non-anemic mothers. Results showed placentas from anemic mothers had lower weight, volume, and number of cotyledons. Histological examination revealed increased syncytial knots, cyto trophoblastic proliferation, and stromal fibrosis in placentas from anemic mothers. Babies born to anemic mothers were more likely to be premature, have low birth weight, or experience intrauterine death. Maternal anemia can have medicolegal importance due to increased risks of perinatal morbidity and mortality.
Point of Care Testing (POCT) refers to medical testing that is conducted outside of a laboratory setting, typically near or at the location of a patient. This can include testing in a physician's office, at home, in the field, or in a hospital room. POCT is usually performed using portable, handheld, or small benchtop devices. Here are some main features and advantages of POCT:
Convenience and Speed: Since POCT can be done at or near the patient's location, it eliminates the need to send samples to a lab and wait for the results. This can result in quicker diagnosis and treatment.
Immediate Decision Making: With instant results, healthcare providers can make immediate decisions about a patient's care, leading to improved patient outcomes.
Reduced Costs: While some POCT devices can be expensive, they may reduce overall healthcare costs by shortening hospital stays, reducing the number of follow-up visits, and preventing complications.
Simplicity: Many POCT devices are designed to be user-friendly, allowing non-laboratory personnel or even patients themselves to conduct tests.
Connectivity: Modern POCT devices often come with connectivity options, enabling the integration of test results into electronic health records.
Versatility: There's a wide range of tests available for POCT, from blood glucose testing to rapid strep tests and coagulation tests.
However, it's also important to note some challenges with POCT:
Quality Control: Ensuring the accuracy and reliability of POCT results can be challenging, especially if tests are being conducted by non-laboratory personnel.
Cost: Some advanced POCT devices can be costly, and there may be additional costs associated with training and quality control.
Regulation and Oversight: Because POCT is performed outside of the traditional lab setting, there can be challenges related to oversight, regulation, and ensuring that tests meet necessary standards.
In summary, while POCT offers many advantages in terms of speed and convenience, it's essential to ensure that tests are accurate, reliable, and meet necessary standards.
Rapid diagnostic tests (RDTs) in India play a crucial role in the detection and management of various diseases, including infectious diseases like malaria, dengue, and more recently, COVID-19. Here's an overview of RDTs in India:
Importance in Disease Management: In a vast and diverse country like India, with varied healthcare infrastructure across its regions, RDTs provide a quick and effective way to diagnose diseases, especially in remote areas where sophisticated laboratory setups might not be available.
Malaria and Dengue Detection: RDTs for malaria (based on the detection of antigens produced by malaria parasites) and dengue (based on the detection of dengue NS1 antigen and anti-dengue antibodies) are widely used. They offer results in less than
Rapid Diagnostic Tests (RDTs) in India play a crucial role in the quick detection and diagnosis of various diseases. They are espec
bevacizumab chemotherapy treatment of metastastic colorectal cancer metasta...Мандухай Г.
Bevacizumab is one of the chemotherapy for metastatic colorectal cancer. It is effective with Irinotecan, fluorouracil,, and Leucovorin for metastatic colorectal cancer.
This document outlines a prospective study on the effect of pandemic restrictions on quality of life and medication adherence in diabetes patients. It discusses the introduction, aims and objectives, methodology, results and conclusion of the study. The study aims to assess the impact of COVID-19 pandemic restrictions on quality of life and medication adherence in 110 diabetes patients in Bangalore, India over 6 months. Preliminary results show that quality of life was reduced for most patients due to restrictions, while medication adherence decreased initially but increased after counselling. New diabetes cases and complications were also observed due to reduced activity and increased weight during the pandemic. The study concludes that the prevalence of diabetes has increased overall due to pandemic restrictions.
This document discusses newborn screening programs, which screen babies for treatable genetic and metabolic conditions. It outlines the seven components of newborn screening, including education, screening, diagnosis, conveying results, follow up, management, and evaluation. The document discusses the history and development of newborn screening, beginning with Robert Guthrie's work developing a test for phenylketonuria in the 1960s. It also reviews current screening methods, conditions screened for, and challenges to implementing nationwide newborn screening in India.
This document summarizes research on CLN3-Batten disease, a rare neurodegenerative lysosomal storage disorder. It describes a natural history study and biorepository at the National Institutes of Health to gather clinical data and biosamples from well-characterized patients over time and across institutions. The study aims to identify blood-based biomarkers for diagnosis and disease monitoring, clinically meaningful outcomes measures, and advance collaborative research efforts between patients, clinicians, and researchers to develop therapies for this currently untreatable disease.
This study assessed the effectiveness of a health education program for type 2 diabetes patients in Egypt. It found that most patients had low baseline knowledge about diabetes. After the education program, patients had significant improvements in their knowledge, attitudes, blood sugar levels, and HbA1c. The program involved 3 sessions over 3 months that provided information on diabetes symptoms, treatment, complications, diet, exercise, and self-management. The study demonstrated that health education can positively impact diabetes outcomes and is an important part of diabetes care.
This document summarizes evidence and guidelines around the evaluation and management of possible early-onset neonatal sepsis. It finds that restricting unnecessary evaluation and antibiotics is important. Clinical monitoring can identify red flags and is often sufficient for well-appearing late preterm and term infants, especially with serial exams over 12 hours. While tests have limited predictive value, stopping antibiotics by 36 hours for reassuring infants is recommended. Several adjuvant therapies like exchange transfusions, immunoglobulins, and colony stimulating factors show promise but require more research before routine use.
The document provides an overview of clinical research at the Rett Clinic, including several ongoing and planned clinical trials. It summarizes:
1) Clinical trials in Rett syndrome testing ketamine, cannabidiol, trofinetide, and Anavex2-73, as well as planned gene therapy trials.
2) Clinical trials in CDKL5 Deficiency Disorder testing ganaxalone and TAK-935, with goals of reducing seizures.
3) Planned deliverables from the NIH-funded Natural History Study of Rett and related disorders, which has followed over 1000 patients.
This document provides details of a proposed research study on the nutritional status of people living with AIDS receiving antiretroviral therapy (ART) at B.P. Koirala Institute of Health Sciences in Dharan, Nepal. The principal investigator is a nursing officer in the medical-surgical nursing department. The study will use a descriptive cross-sectional design to assess the nutritional status of approximately 200 ART patients through measurements of weight, BMI, serum proteins, micronutrients, and fat distribution over the course of one year with a budget of 25,000 Nepali rupees. A literature review establishes that malnutrition is common in HIV/AIDS and predicts health outcomes, so this study aims to identify nutritional deficiencies and
Presentation blood supply on bone. .pptxNamanSharda2
The document discusses the anatomy and blood supply of long bones. It notes that long bones receive blood supply from three main sources: nutrient arteries, metaphyseal arteries, and periosteal arteries. Nutrient arteries enter through the medullary canal and branch longitudinally and radially. Metaphyseal arteries supply the ends of bones, and periosteal arteries on the outer surface supply the outer third of the cortex. The blood supply supports bone growth and healing after fractures. Certain bones like the scaphoid and talus have a more tenuous blood supply.
median nerve power point presentation.pptxNamanSharda2
This document discusses the anatomy and injuries of the median nerve. It begins with the anatomy of the median nerve as it travels from the axilla to the forearm. It then discusses high and low injuries to the median nerve and their associated motor and sensory deficits. Examination techniques like the pronator teres assessment and Kleinert test are described. Median nerve compression syndromes like carpal tunnel syndrome are also covered. The document concludes with discussing indications for median nerve surgery, timing of surgery, and critical limits for delayed repair.
This bulletin is a publication of the CRC networks in Perak (Hospital Raja Permaisuri Bainun Ipoh, Hospital Seri Manjung and Hospital Taiping).
This issue emcompasses various research articles written by CRC staff, a research scope write-up to emphasize on the research focus this coming year, programmes conducted in 2021 as well as upcoming events across the CRC Perak Network this year.
(e-ISSN Number: 2682-7867).
A COMPARATIVE ANALYSIS OF HEMATOLOGICAL INDICES IN PREGNANT WOMEN AND NON PR...FidelityP
Red blood cell (RBC) indices are individual components of a routine blood test called the complete blood count (CBC). The CBC is used to measure the quantity and physical characteristics of different types of cells found in your blood. Blood consists of RBCs, white blood cells (WBCs), and platelets that are suspended in your plasma. Platelets are cells that enable clot formation. RBCs contain hemoglobin, which carries oxygen throughout your body to all of your tissues and organs. An RBC is pale red and gets its color from hemoglobin. It’s shaped like a doughnut, but it has a thinner area in the middle instead of a hole. Your RBCs are normally all the same color, size, and shape. However, certain conditions can cause variations that impair their ability to function properly. The RBC indices measure the size, shape, and physical characteristics of the RBCs. Your doctor can use RBC indices to help diagnose the cause of anemia. Anemia is a common blood disorder in which you have too few, misshapen, or poorly functional RBCs123
Clinical, ethical and legal considerations in the treatment of newborns 2008Dominique Gross
Non-ketotic hyperglycinaemia (NKH) is a devastating neurometabolic disorder leading, in its classical form, to early death or severe disability and poor quality of life in survivors. Affected neonates may need ventilatory support during a short period of respiratory depression. The transient dependence on ventilation dictates urgency in decision-making regarding withdrawal of therapy.
The occurrence of patients with apparent transient forms of the disease, albeit rare, adds uncertainty to the prediction of clinical outcome and dictates that the current practice of withholding or withdrawing therapy in these neonates be reviewed. Both bioethics and law take the view that treatment decisions should be based on the best interests of the patient.
The medical-ethics approach is based on the principles of non-maleficence, beneficence, autonomy and justice. The law relating to withholding or withdrawing life-sustaining treatment is complex and varies between jurisdictions. Physicians treating newborns with NKH need to provide families with accurate and complete information regarding the disease and the relative probability of possible outcomes of the neonatal presentation and to explore the extent to which family members are willing to take part in the decision making process. Cultural and religious attitudes, which may potentially clash with bioethical and juridical principles, need to be considered.
2008 Elsevier Inc
This document proposes a study to determine the prevalence and risk factors of jaundice among newborn babies in Plateau State, Nigeria. Jaundice is common in newborns worldwide and an estimated 60-80% of babies develop jaundice in their first week. However, there is a lack of local data on jaundice incidence and risks in Plateau State. The study aims to measure jaundice prevalence at two hospitals and identify associated risk factors. A cross-sectional survey of 100 mothers will collect data on demographics, pregnancies, babies, and healthcare practices. Findings will help develop better prevention and management of newborn jaundice in the state.
“A Study on Coagulation Profile in Pregnancy Induced Hypertension Cases”iosrjce
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB) covers studies of the chemical processes in living organisms, structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules, chemical properties of important biological molecules, like proteins, in particular the chemistry of enzyme-catalyzed reactions, genetic code (DNA, RNA), protein synthesis, cell membrane transport, and signal transduction. IOSR-JBB is privileged to focus on a wide range of biotechnology as well as high quality articles on genetic engineering, cell and tissue culture technologies, genetics, microbiology, molecular biology, biochemistry, embryology, cell biology, chemical engineering, bioprocess engineering, information technology, biorobotics.
CANDIDATES FOR HIPPOCAMPAL SPARING14MethodologyTo evaluate .docxhumphrieskalyn
CANDIDATES FOR HIPPOCAMPAL SPARING 14
Methodology
To evaluate which patients would be higher priority candidates for hippocampal sparing, 3,000 participant treatment plans were evaluated via a cross-sectional differential research method. The method of research used in this study is considered differential and cross-sectional because groups of participants are different ages are compared on a set of variables and because participates of this study were assigned to groups based on preexisting factors.
Patients over the age of 18 and parents of participants under the age of 18 were asked to take part in the research. The aim of research was explained to them and informed consent was obtained by all participants prior to participating in the study. It was explained to participants, or parents of the participants, that data was going to be collected based on the treatment they received and that no additional experimentation with radiation was to be added to their treatment for the benefit of the research study, therefore, there was no additional risk to their treatment plan implemented by this differential research study. The study was subject to external review several credible institutions including the American Society for Therapeutic Radiology and Oncology (ASTRO).
Participants. Participants of this study were subjects who required WBRT and were evaluated in two categories. The two categories were based on treatment intent and will be separated into preexisting palliative and prophylactic categories. With age thought to be the most influential variable, participants in each category were further categorized into two subcategories based on age. Subjects of this study included subcategory A participates who were required to be 25 years of age and younger and subcategory B participants who were required to be 26 years old age and older based on prior research on brain development studies done by Giedd & Rapoport.
The cumulative sample size for the research study was 2,000 participants. 500 subcategory A and 500 subcategory B participants were included in each intent category. Subject exclusions included patients who were on hospice care, those on a concurrent chemotherapy regimen during their radiation therapy treatment and patients who had a treatment plan change after beginning their initially recommended treatment.
Treatment Intent
Total Number of Participants
A: Under 25
B: Over 25
Prophylactic
500
500
Palliative
500
500
Table 1. Visual representation of participants.
Data Collection Method. Data was collected from 20 Radiation Oncologist between 21 different cancer centers over a course of 18 months between January 2014 and June 2015. Two Oncologists at each cancer center participated in the study by collecting research and all had an average of 3 new WBRT patients per month. Each cancer center then treated an average of 6 new WBRT patients per month, 2,000 of which agreed to participate in the study. Data was collected from each ph ...
Over the past few decades, the prognosis of neonatal seizures has experienced considerable enhancement due to the improvement in neonatal and infant care. The mortality rate of neonatal seizures has fallen from 40% to 20%, and the relationship between electro encephalogram (EEG) and prognosis has become quite clear. The underlying cause of seizures is a major determinant of the outcome of the disease. For example, patients with secondary seizures and hypoxic-ischemic encephalopathy have only 50% chance of normal development and total recovery, while newborns with secondary seizures and subarachnoid hemorrhage or better hypocalcemia have higher chances of recovery. Searches were conducted by two independent researchers in international (PubMed, Web of Science, Scopus, and Google Scholar) and national (SID and Magiran) databases for related studies from the inception of the databases to September 2017 (without time limitation) in English and Persian languages. It is possible to achieve accurate diagnosis through checking the history before birth and performing a thorough physical examination in some rare cases. Depending on the case, tests or additional actions can be done. EEG is the primary means for diagnosis and may exhibit paroxysmal activity in the difference between seizures or may produce electrographic seizures in cases where seizure is hidden or latent. One of the most important points in the treatment of neonatal seizures is the diagnosis of underlying cause (such as hypoglycemia, meningitis, drug deprivation, and trauma) because such diagnosis facilitates different approaches to control neonatal seizures. Most experts agree to control all clinical and electrographic seizures. Some others focus merely on clinical seizures. Most centers prefer the first approach. An important point before starting an anticonvulsant drug is to decide if the patient needs intravenous and luteinizing treatment with an initial bolus dose, or it can be easy to start treatment with a prescription for a long-acting medication based on the severity of seizure, duration, and frequency.
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
The document summarizes a study on the effects of maternal anemia on the placenta and fetal outcomes. 120 placentas were examined from anemic and non-anemic mothers. Results showed placentas from anemic mothers had lower weight, volume, and number of cotyledons. Histological examination revealed increased syncytial knots, cyto trophoblastic proliferation, and stromal fibrosis in placentas from anemic mothers. Babies born to anemic mothers were more likely to be premature, have low birth weight, or experience intrauterine death. Maternal anemia can have medicolegal importance due to increased risks of perinatal morbidity and mortality.
Point of Care Testing (POCT) refers to medical testing that is conducted outside of a laboratory setting, typically near or at the location of a patient. This can include testing in a physician's office, at home, in the field, or in a hospital room. POCT is usually performed using portable, handheld, or small benchtop devices. Here are some main features and advantages of POCT:
Convenience and Speed: Since POCT can be done at or near the patient's location, it eliminates the need to send samples to a lab and wait for the results. This can result in quicker diagnosis and treatment.
Immediate Decision Making: With instant results, healthcare providers can make immediate decisions about a patient's care, leading to improved patient outcomes.
Reduced Costs: While some POCT devices can be expensive, they may reduce overall healthcare costs by shortening hospital stays, reducing the number of follow-up visits, and preventing complications.
Simplicity: Many POCT devices are designed to be user-friendly, allowing non-laboratory personnel or even patients themselves to conduct tests.
Connectivity: Modern POCT devices often come with connectivity options, enabling the integration of test results into electronic health records.
Versatility: There's a wide range of tests available for POCT, from blood glucose testing to rapid strep tests and coagulation tests.
However, it's also important to note some challenges with POCT:
Quality Control: Ensuring the accuracy and reliability of POCT results can be challenging, especially if tests are being conducted by non-laboratory personnel.
Cost: Some advanced POCT devices can be costly, and there may be additional costs associated with training and quality control.
Regulation and Oversight: Because POCT is performed outside of the traditional lab setting, there can be challenges related to oversight, regulation, and ensuring that tests meet necessary standards.
In summary, while POCT offers many advantages in terms of speed and convenience, it's essential to ensure that tests are accurate, reliable, and meet necessary standards.
Rapid diagnostic tests (RDTs) in India play a crucial role in the detection and management of various diseases, including infectious diseases like malaria, dengue, and more recently, COVID-19. Here's an overview of RDTs in India:
Importance in Disease Management: In a vast and diverse country like India, with varied healthcare infrastructure across its regions, RDTs provide a quick and effective way to diagnose diseases, especially in remote areas where sophisticated laboratory setups might not be available.
Malaria and Dengue Detection: RDTs for malaria (based on the detection of antigens produced by malaria parasites) and dengue (based on the detection of dengue NS1 antigen and anti-dengue antibodies) are widely used. They offer results in less than
Rapid Diagnostic Tests (RDTs) in India play a crucial role in the quick detection and diagnosis of various diseases. They are espec
bevacizumab chemotherapy treatment of metastastic colorectal cancer metasta...Мандухай Г.
Bevacizumab is one of the chemotherapy for metastatic colorectal cancer. It is effective with Irinotecan, fluorouracil,, and Leucovorin for metastatic colorectal cancer.
This document outlines a prospective study on the effect of pandemic restrictions on quality of life and medication adherence in diabetes patients. It discusses the introduction, aims and objectives, methodology, results and conclusion of the study. The study aims to assess the impact of COVID-19 pandemic restrictions on quality of life and medication adherence in 110 diabetes patients in Bangalore, India over 6 months. Preliminary results show that quality of life was reduced for most patients due to restrictions, while medication adherence decreased initially but increased after counselling. New diabetes cases and complications were also observed due to reduced activity and increased weight during the pandemic. The study concludes that the prevalence of diabetes has increased overall due to pandemic restrictions.
This document discusses newborn screening programs, which screen babies for treatable genetic and metabolic conditions. It outlines the seven components of newborn screening, including education, screening, diagnosis, conveying results, follow up, management, and evaluation. The document discusses the history and development of newborn screening, beginning with Robert Guthrie's work developing a test for phenylketonuria in the 1960s. It also reviews current screening methods, conditions screened for, and challenges to implementing nationwide newborn screening in India.
This document summarizes research on CLN3-Batten disease, a rare neurodegenerative lysosomal storage disorder. It describes a natural history study and biorepository at the National Institutes of Health to gather clinical data and biosamples from well-characterized patients over time and across institutions. The study aims to identify blood-based biomarkers for diagnosis and disease monitoring, clinically meaningful outcomes measures, and advance collaborative research efforts between patients, clinicians, and researchers to develop therapies for this currently untreatable disease.
This study assessed the effectiveness of a health education program for type 2 diabetes patients in Egypt. It found that most patients had low baseline knowledge about diabetes. After the education program, patients had significant improvements in their knowledge, attitudes, blood sugar levels, and HbA1c. The program involved 3 sessions over 3 months that provided information on diabetes symptoms, treatment, complications, diet, exercise, and self-management. The study demonstrated that health education can positively impact diabetes outcomes and is an important part of diabetes care.
This document summarizes evidence and guidelines around the evaluation and management of possible early-onset neonatal sepsis. It finds that restricting unnecessary evaluation and antibiotics is important. Clinical monitoring can identify red flags and is often sufficient for well-appearing late preterm and term infants, especially with serial exams over 12 hours. While tests have limited predictive value, stopping antibiotics by 36 hours for reassuring infants is recommended. Several adjuvant therapies like exchange transfusions, immunoglobulins, and colony stimulating factors show promise but require more research before routine use.
The document provides an overview of clinical research at the Rett Clinic, including several ongoing and planned clinical trials. It summarizes:
1) Clinical trials in Rett syndrome testing ketamine, cannabidiol, trofinetide, and Anavex2-73, as well as planned gene therapy trials.
2) Clinical trials in CDKL5 Deficiency Disorder testing ganaxalone and TAK-935, with goals of reducing seizures.
3) Planned deliverables from the NIH-funded Natural History Study of Rett and related disorders, which has followed over 1000 patients.
This document provides details of a proposed research study on the nutritional status of people living with AIDS receiving antiretroviral therapy (ART) at B.P. Koirala Institute of Health Sciences in Dharan, Nepal. The principal investigator is a nursing officer in the medical-surgical nursing department. The study will use a descriptive cross-sectional design to assess the nutritional status of approximately 200 ART patients through measurements of weight, BMI, serum proteins, micronutrients, and fat distribution over the course of one year with a budget of 25,000 Nepali rupees. A literature review establishes that malnutrition is common in HIV/AIDS and predicts health outcomes, so this study aims to identify nutritional deficiencies and
Similar to PRESENTATION OF MY SYNOPSIS 2023.pptx (20)
Presentation blood supply on bone. .pptxNamanSharda2
The document discusses the anatomy and blood supply of long bones. It notes that long bones receive blood supply from three main sources: nutrient arteries, metaphyseal arteries, and periosteal arteries. Nutrient arteries enter through the medullary canal and branch longitudinally and radially. Metaphyseal arteries supply the ends of bones, and periosteal arteries on the outer surface supply the outer third of the cortex. The blood supply supports bone growth and healing after fractures. Certain bones like the scaphoid and talus have a more tenuous blood supply.
median nerve power point presentation.pptxNamanSharda2
This document discusses the anatomy and injuries of the median nerve. It begins with the anatomy of the median nerve as it travels from the axilla to the forearm. It then discusses high and low injuries to the median nerve and their associated motor and sensory deficits. Examination techniques like the pronator teres assessment and Kleinert test are described. Median nerve compression syndromes like carpal tunnel syndrome are also covered. The document concludes with discussing indications for median nerve surgery, timing of surgery, and critical limits for delayed repair.
Teriparatide in Avascular Necrosis .pptxNamanSharda2
Teriparatide, a parathyroid hormone analogue, shows promise in treating avascular necrosis (AVN). A retrospective study found teriparatide treatment led to less collapse of the femoral head compared to alendronate over 18 months. Case reports also found teriparatide improved pain and mobility in a patient with severe AVN, and promoted healing of an osteoporosis-induced mandible fracture. While evidence is limited, teriparatide may reduce progression of AVN and promote bone regeneration through its anabolic effects on bone.
Mr. Arthur, a 52-year-old man, presented with a hot, swollen, and painful right knee for 24 hours. Physical examination found a warm knee with a large effusion and reduced range of motion. Blood tests showed elevated white blood cell count and C-reactive protein. Arthrocentesis of the knee joint found urate crystals in the synovial fluid analysis, with a white blood cell count of 15,000 and 60% polymorphonuclear cells. This confirms the diagnosis of acute gouty arthritis as the cause of Mr. Arthur's knee pain and swelling.
Dr. Naman Sharda is a postgraduate resident at CMCH in Bhopal under the mentorship of Dr. Pawan Mishra. The document provides brief information on Dr. Naman Sharda's position and affiliation as well as the name of his mentor at CMCH, Bhopal.
Rotator Cuff Injuries present at Chirayu Medical College.pptxNamanSharda2
The document discusses rotator cuff injuries, including the anatomy of the rotator cuff, classification of tears, symptoms, physical examinations, investigations like X-rays and MRI, and treatment options like conservative management, open repair, arthroscopic repair, and rehabilitation protocols. It also covers irreparable rotator cuff tears and treatment options for those, which can include conservative care, decompression, tendon transfers, graft interposition, balloon spacers, capsular reconstruction, or reverse shoulder arthroplasty.
Preventive and Social Medicine in Images.pptxNamanSharda2
This document contains information about various scientists and their contributions, health organizations and their logos, disease vectors, epidemiological diagrams, contraceptive methods, study designs, and medical equipment. It provides descriptions and identifies the discoveries, concepts, agencies, diseases, populations, devices, and measurements associated with each item. The document acts as a review of important people, organizations, concepts and tools in public health and epidemiology.
This document discusses various types of splints and tractions used in orthopedics. It begins by defining a splint and its functions, which include immobilization, pain control, and prevention of further injury. It describes different types of splints like the Thomas splint and Bohler-Braun splint. Traction is defined as a method of restoring bone alignment through gradual neutralization of muscles. Different traction types include skin, skeletal, and pelvic traction. Complications of splinting and traction are also outlined. The document provides detailed information on preparation, applications, and care for a variety of splints and traction techniques.
This document provides a synopsis for a study comparing the use of temporalis fascia with and without platelet rich fibrin (PRF) for myringoplasty. The study aims to evaluate the success rates and benefits of PRF in improving hearing outcomes when applied to the temporalis fascia graft. It is a prospective study that will recruit 100 patients with inactive chronic otitis media requiring myringoplasty, who will be divided into two groups: one receiving temporalis fascia alone and the other receiving PRF applied to the fascia graft. Patients will be followed for 12 weeks to assess graft healing and post-operative hearing.
Clavicle fractures are common injuries, especially in young active individuals. The majority occur in the midshaft region due to its thin bone and lack of muscle protection. Treatment depends on the location and degree of displacement/shortening. Nondisplaced fractures are usually treated nonsurgically with slings or strapping. Displaced fractures may require plate fixation, intramedullary nails, or coracoclavicular ligament repair/reconstruction to achieve union and restore function. Complications can include nonunion, malunion, hardware irritation, and neurovascular injury.
This document lists various terms related to forensic science including:
- Methods of injury analysis such as Puppe's Rule, diastatic fracture, bevelling of skull, and contact shot.
- Types of injuries like whiplash, depressed fracture, and filigree burn.
- Poisons and toxic substances like datura, strychnos nux-vomica, phosphorus, arsenic, and mercury.
- Methods of examination like the Hepburn osteometric board and forensic entomology.
- Causes of death like partial hanging, smothering, and garotting.
- Snakes and other animals that can cause harm such as cobra, saw scaled viper
This document contains information about various scientists and their contributions, health organizations and their logos, disease vectors, epidemiological diagrams, contraceptive methods, study designs, and medical equipment. It provides descriptions and identifies the discoveries, concepts, agencies, diseases, populations, devices, and measurements associated with each item. The document acts as a review of important people, organizations, concepts, and tools in public health and epidemiology.
Research, Monitoring and Evaluation, in Public Healthaghedogodday
This is a presentation on the overview of the role of monitoring and evaluation in public health. It describes the various components and how a robust M&E system can possitively impact the results or effectiveness of a public health intervention.
The Ultimate Guide in Setting Up Market Research System in Health-TechGokul Rangarajan
How to effectively start market research in the health tech industry by defining objectives, crafting problem statements, selecting methods, identifying data collection sources, and setting clear timelines. This guide covers all the preliminary steps needed to lay a strong foundation for your research.
"Market Research it too text-booky, I am in the market for a decade, I am living research book" this is what the founder I met on the event claimed, few of my colleagues rolled their eyes. Its true that one cannot over look the real life experience, but one cannot out beat structured gold mine of market research.
Many 0 to 1 startup founders often overlook market research, but this critical step can make or break a venture, especially in health tech.
But Why do they skip it?
Limited resources—time, money, and manpower—are common culprits.
"In fact, a survey by CB Insights found that 42% of startups fail due to no market need, which is like building a spaceship to Mars only to realise you forgot the fuel."
Sudharsan Srinivasan
Operational Partner Pitchworks VC Studio
Overconfidence in their product’s success leads founders to assume it will naturally find its market, especially in health tech where patient needs, entire system issues and regulatory requirements are as complex as trying to perform brain surgery with a butter knife. Additionally, the pressure to launch quickly and the belief in their own intuition further contribute to this oversight. Yet, thorough market research in health tech could be the key to transforming a startup's vision into a life-saving reality, instead of a medical mishap waiting to happen.
Example of Market Research working
Innovaccer, founded by Abhinav Shashank in 2014, focuses on improving healthcare delivery through data-driven insights and interoperability solutions. Before launching their platform, Innovaccer conducted extensive market research to understand the challenges faced by healthcare organizations and the potential for innovation in healthcare IT.
Identifying Pain Points: Innovaccer surveyed healthcare providers to understand their difficulties with data integration, care coordination, and patient engagement. They found widespread frustration with siloed systems and inefficient workflows.
Competitive Analysis: Analyzed competitors offering similar solutions in healthcare analytics and interoperability. Identified gaps in comprehensive data aggregation, real-time analytics, and actionable insights.
Regulatory Compliance: Ensured their platform complied with HIPAA and other healthcare data privacy regulations. This compliance was crucial to gaining trust from healthcare providers wary of data security issues.
Customer Validation: Conducted pilot programs with several healthcare organizations to validate the platform's effectiveness in improving care outcomes and operational efficiency. Gathered feedback to refine features and user interface.
R3 Stem Cell Therapy: A New Hope for Women with Ovarian FailureR3 Stem Cell
Discover the groundbreaking advancements in stem cell therapy by R3 Stem Cell, offering new hope for women with ovarian failure. This innovative treatment aims to restore ovarian function, improve fertility, and enhance overall well-being, revolutionizing reproductive health for women worldwide.
Digital Health in India_Health Informatics Trained Manpower _DrDevTaneja_15.0...DrDevTaneja1
Digital India will need a big trained army of Health Informatics educated & trained manpower in India.
Presently, generalist IT manpower does most of the work in the healthcare industry in India. Academic Health Informatics education is not readily available at school & health university level or IT education institutions in India.
We look into the evolution of health informatics and its applications in the healthcare industry.
HIMMS TIGER resources are available to assist Health Informatics education.
Indian Health universities, IT Education institutions, and the healthcare industry must proactively collaborate to start health informatics courses on a big scale. An advocacy push from various stakeholders is also needed for this goal.
Health informatics has huge employment potential and provides a big business opportunity for the healthcare industry. A big pool of trained health informatics manpower can lead to product & service innovations on a global scale in India.
Fit to Fly PCR Covid Testing at our Clinic Near YouNX Healthcare
A Fit-to-Fly PCR Test is a crucial service for travelers needing to meet the entry requirements of various countries or airlines. This test involves a polymerase chain reaction (PCR) test for COVID-19, which is considered the gold standard for detecting active infections. At our travel clinic in Leeds, we offer fast and reliable Fit to Fly PCR testing, providing you with an official certificate verifying your negative COVID-19 status. Our process is designed for convenience and accuracy, with quick turnaround times to ensure you receive your results and certificate in time for your departure. Trust our professional and experienced medical team to help you travel safely and compliantly, giving you peace of mind for your journey.www.nxhealthcare.co.uk
Sectional dentures for microstomia patients.pptxSatvikaPrasad
Microstomia, characterized by an abnormally small oral aperture, presents significant challenges in prosthodontic treatment, including limited access for examination, difficulties in impression making, and challenges with prosthesis insertion and removal. To manage these issues, customized impression techniques using sectional trays and elastomeric materials are employed. Prostheses may be designed in segments or with flexible materials to facilitate handling. Minimally invasive procedures and the use of digital technologies can enhance patient comfort. Education and training for patients on prosthesis care and maintenance are crucial for compliance. Regular follow-up and a multidisciplinary approach, involving collaboration with other specialists, ensure comprehensive care and improved quality of life for microstomia patients.
nursing management of patient with Empyema pptblessyjannu21
prepared by Prof. BLESSY THOMAS, SPN
Empyema is a disease of respiratory system It is defines as the accumulation of thick, purulent fluid within the pleural space, often with fibrin development.
Empyema is also called pyothorax or purulent pleuritis.
It’s a condition in which pus gathers in the area between the lungs and the inner surface of the chest wall. This area is known as the pleural space.
Pus is a fluid that’s filled with immune cells, dead cells, and bacteria.
Pus in the pleural space can’t be coughed out. Instead, it needs to be drained by a needle or surgery.
Empyema usually develops after pneumonia, which is an infection of the lung tissue. it is mainly caused due in infectious micro-organisms. It can be treated with medications and other measures.
This particular slides consist of- what is Pneumothorax,what are it's causes and it's effect on body, risk factors, symptoms,complications, diagnosis and role of physiotherapy in it.
This slide is very helpful for physiotherapy students and also for other medical and healthcare students.
Here is a summary of Pneumothorax:
Pneumothorax, also known as a collapsed lung, is a condition that occurs when air leaks into the space between the lung and chest wall. This air buildup puts pressure on the lung, preventing it from expanding fully when you breathe. A pneumothorax can cause a complete or partial collapse of the lung.
NURSING MANAGEMENT OF PATIENT WITH EMPHYSEMA .PPTblessyjannu21
Prepared by Prof. BLESSY THOMAS, VICE PRINCIPAL, FNCON, SPN.
Emphysema is a disease condition of respiratory system.
Emphysema is an abnormal permanent enlargement of the air spaces distal to terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis.
Emphysema of lung is defined as hyper inflation of the lung ais spaces due to obstruction of non respiratory bronchioles as due to loss of elasticity of alveoli.
It is a type of chronic obstructive
pulmonary disease.
It is a progressive disease of lungs.
1. “A Study On The Effect Of Phototherapy On Various Hematological
And Biochemical Parameters In Neonatal Hyperbilirubinemia In A
Tertiary Care Centre”
DEPARTMENT OF PAEDIATRICS
CHIRAYU MEDICAL COLLEGE AND HOSPITAL,BHOPAL (MP)
Principal Investigator: Guide:
Dr. PRIYANSHI SHRIVASTAVA, Dr. Jaishree Ambhore ,
P.G Resident 1st Year, Professor & HOD,
Department of Paediatrics, Department of Paediatrics,
Chirayu Medical College and Hospital,Bhopal Chirayu Medical College and Hospital,
Bhopal Bhopal
2. INTRODUCTION
Neonatal Hyperbilirubinemia is a common clinical problem encountered during
the neonatal period.
It occurs due to excessive formation of unconjugated (indirect bilirubin) and
inability of neonatal liver to rapidly clear it from blood.
3. High serum bilirubin levels can be toxic for central nervous system
development and may cause behavioral and neurological impairment
(Kernicterus) even in term newborns. Pathological jaundice may also lead to
deafness, cerebral palsy and/or mental retardation. [1]
The treatment options for jaundice includes phototherapy , exchange
transfusion, and pharmacological treatment like phenobarbitone, intravenous
immunoglobulins (IVIG), metallo-porphyrins etc.[2]
4. Phototherapy is one of the most effective way available in preventing the
neurotoxic complications of indirect hyperbilirubinemia .It causes change in
the structure of bilirubin and resulting isomers like lumirubin which is the
water soluble form & it radially excreted in bile and urine .Phototherapy is
safe, but is only used when needed (usually for two to three days after which
the baby’s liver takes over).[3]
5. The side effects of phototherapy are loose stools, hyperthermia,
dehydration, fluid loss, skin rash ,photo retinitis, low platelet count,
increased red cell osmotic fragility, bronze baby syndrome, riboflavin
deficiency and DNA damage.[4,5]
6. A lesser known side effect, but potential complication of phototherapy is
electrolyte imbalance like hyponatremia, hypocalcemia, hypokalemia.
Early screening, quality of Neonatal care and timely intervention can improve
outcome of neonatal hyperbilirubinemia in neonates. So the purpose of this
study is to access effect of Phototherapy on various hematological and
biochemical parameters in Neonatal Hyperbilirubinemia[6,7,8,9].
7. RESEARCH QUESTION
Does phototherapy affect biochemical and
hematological parameters of neonates suffering from
hyperbilirubinemia?
8. AIM:
• To Asses the effect of Phototherapy on various
Hematological and biochemical parameters in
Neonatal Hyperbillirubinemia.
9. OBJECTIVE
1.To asses the effect of Phototherapy on various Hematological and Biochemical
parameters in Neonatal Hyperbilirubinemia.
2. To compare the changes in various hematological and biochemical parameters
including complete blood count, total bilirubin, direct bilirubin, indirect
bilirubin, serum electrolyte(sodium, potassium, calcium), urea and creatinine
levels in plasma/serum of pre and post Phototherapy.
10. METHOD/PROCEDURE
1. STUDY DESIGN: Comparitive,Cross Sectional, Descriptive Study.
2. STUDY SETTING: The study will be conducted in Neonatal Intensive Care Unit in the
Department of Paediatrics , Chirayu Medical College and Hospital, Bhopal, Madhya
Pradesh, India, after approval by ethics committee over a period of 18 months.
3. STUDY SIZE: The sample required for the study is 50 neonates admitted in NICU
requiring Phototherapy during a designated study period i.e, March 2023 to August 2024.
The sample size is calculated to be 50 with an estimation at 95% confidence interval &
10% margin of error and taking prevelance 11% from previous study[10].
4. DURATION OF STUDY: 18 months after approval from Institutional Ethics Committee.
11. ❖INCLUSION CRITERIA
1.The study will include all those inborn and outborn neonates who will be
admitted to receive Phototherapy for 24-48 hours duration during study
period paediatric department at Chirayu Medical College and Hospital,
Bhopal, (M.P).
❖EXCLUSION CRITERIA
1. Birth Asphyxia
2. Neonatal Septicemia
3. Respiratory Distress Syndrome
4. Major or Life threatening Congenital Malformation
5. Icterus in the range requiring Exchange Transfusion
6. Conjugated Hyperbilirubinemia
12. METHOD/PROCEDURE:
1.Written Informed consent will be taken from all the parents/guardians of the
neonates delivered in the Institution and out born neonates requiring
Phototherapy for 24 hours duration.
2.The neonates meeting the inclusion criteria will be chosen.
3.The venous sample will be collected aseptically during the course of
phototherapy in Plain and EDTA vial in Neonatal intensive care unit at the
Department of Paediatrics.
13. 5. The sample will be sent for analyses by the department of biochemistry and
pathology respectively.
6. The hematological and biochemical parameters will checked (first sample)
at the start of phototherapy and after discontinuation of phototherapy(second
sample).
14. METHODS:
1. Serum Bilirubin
• Total Bilirubin – Azobilirubin/ Dyphylline method in vitros 250 dry chemistry
analyze.
• Indirect Bilirubin – Dual wavelength spectrophotometric analysis in Vitros 250
• Direct Bilirubin- Direct bilirubin is calculated from total and Indirect Bilirubin in
Vitros 250.
2. Creatinine – Enzymatic method (Creatinine Amidohydrolase) in Vitros 250
15. 3. Sodium /Potassium – I selective electrode direct in electrolyte analyzer.
4. Urea – Calculated from blood urea Nitrogen ( BUN) Urea with Indicator is
method and is estimated in vitros 250
5.CBC- Automated CBC analyzer BC 6000 cell counter
6. Serum calcium-5-Nitro-5;methyl NM BAPTA on COBAS Integra 400 plus
chemistry analyzer.
7. Blood Group- Anti Sera method
16. ❖ANALYSIS AND STATISTICAL ASPECT
• Data will be analyzed using appropriate statistical test of significance
and appropriate statistical software like SPSS software as per
requirement.
• p-value < 0.05 will be taken as statistically significant.
ETHICAL CONSIDERATION
• Study will be started after clearance from the Institutional Ethical
Committee.
• Informed written consent of the patient will be taken.
• Confidentiality of the patients data will be maintained.
18. REFRENCES
1.Kemper AR, Newman TB, Slaughter JL, et al. Clinical practice
guideline revision: Management of hyperbilirubinemia in the
newborn infant 35 or more week Gestation. SO Pediatrics.
2022;150(3)
2. Suneja S, Kumawat R, Saxena R. Effect of phototherapy on
various biochemical parameters in neonatal hyperbilirubinaemia: a
clinical insight. Indian J Neonat Med Res. 2018;6(2):PO13-PO18.
19. 3.Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in neonates: Types,
causes, clinical examinations, preventive measures and treatments: a
narrative review article. Iran J Public Health. 2016;45(5):558-68.
4. Rozario CI, Pillai PS, Ranamol T. Effect of
phototherapy on serum calcium level in term
newborns. Int J Contemp Pediatr. 2017;4:1975-9.
5. Taheri PA, Sajjadian N,Eivazzadeh B. Prevalence of phototherapy induced
hypocalcemia in term neonate. Iran J Pediatr. 2013;23(6):710-1
20. 6. Reddy AT, Bai KV, Shankar SU. Electrolyte changes following
phototherapy in neonatal hyperbilirubinemia. Inter J Sci Res.
2013;6(14):2319-7064.
7. Bezboruah G, Majumder AK. Electrolyte imbalances resulting
from phototherapy in neonatal hyperbilirubinemia. J Dent Med
Sci. 2019;18(8):51-8.
21. 8. Rangaswamy KB, Yeturi D, Gowda ANBL, Krishna C,
Samyuktha. Study of sodium and potassium changes in term
neonates receiving phototherapy. Int J Contemp Pediatr.
2019;6:1076-9.
9.Yadav RK, Sethi RS, Sethi AS, Kumar L, Chaurasia OS. The
evaluation of effect of phototherapy on serum calcium level.
People’s J Sci Res. 2012;5(2):1-4.
22. 10. Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M,
Ebbesen FNeonatal hyperbilirubinemia and Rhesus disease of
the newborn: incidence and impairment estimates for 2010 at
regional and global levels. Pediatr Res, 2013;1: 86–100
23. GANTT CHART
GANTT CHART
TOPIC OF THESIS:" A Study on the Effect of Phototherapy on various Hematological and Biochemical Parameters in Neonatal Hyperbilirubinemia in a Tertiary Care
Centre"
F
e
b
,
2
0
2
3
March
, 2023
April
,
2023
May
,
2023
June
,
2023
July,
2023
Aug,
2023
Sep,
2023
Oct,
2023
Nov,
2023
Dec,
2023
Jan,
2024
Feb,
2024
March
, 2024
April
,
2024
May
,
2024
June
,
2024
July,
2024
A
u
g
,
2
0
2
4
Develop
Research
Proposal
Submit for RAC
& IEC Approval
Review of
Literature
Pilot Study
Data Collection
Data Analysis
Write up for
First Draft
Write up for
Second Draft
Submission of
Dissertation
24. • PARTICIPANT INFORMATION SHEET
• TITLE OF THE STUDY :A Study on the Effect of Phototherapy on various Hematological and
Biochemical Parameters in Neonatal Hyperbilirubinemia in a Tertiary Care Centre : A Descriptive Study.
• PATIENT’s NAME-
• INTRODUCTION TO RESEARCH STUDY: We are inviting participants as we are conducting a study on
effect of phototherapy on various hematological and biochemical parameters in neonatal hyperbilirubinemia in
Neonatal Intensive Care Unit.
• PURPOSE OF THE STUDY: The purpose of the study is to assess effect of phototherapy on various
hematological and biochemical parameters in neonatal hyperbilirubinemia.
• WHO CAN TAKE PART: Any patient fulfilling the inclusion criteria
• WHO WILL BE CONDUCTING THE STUDY: Dr. Priyanshi Shrivastava, PG Resident (1st Year).
• MY ROLE/RESPONSIBILITY IN THE STUDY: If you decide to participate as a participant for this
study, you will be apprised and requested to answer all relevant question listed in the questionnaire.
• PARTICIPATION IS VOLUNTARY: Your participation in the study is entirely voluntary and of your own
volition. You are free to join the study. You will have the freedom to withdraw your participation at any point of
time during study. If you withdraw your participation from the study this decision of yours will not affect your
healthcare benefits from institute
25. • TOTAL STUDY DURATION: The entire duration of study is a period of 18 months i.e.
one year and six months.
• RISKS AND DISCOMFORTS OF THE STUDY: During interview, you have to
disclose only the facts which are related to study and there is no risk to you or your family,
involved in any way.
• BENEFITS OF THE STUDY: The above mentioned study shall benefit in research and
development of medical field by expanding the probability of identifying effect on various
Hematological and Biochemical parameters related to Phototherapy and early intervention.
• PARTICIPATION OF THE STUDY KEPT CONFIDENTIAL : All the information
disclosed during the study will be kept confidential. Your medical records will be only
reviewed by the medical team.
Name of the Principal investigator & Sign- Dr. Priyanshi Shrivastava Date –
PG Resident 1st Year
Department of Paediatrics
Chirayu Medical College and Hospital,Bhopal, M.P.
26. PATIENT CONSENT FORM
I _______________________, am assuring you that I have
all
the knowledge of this medical research and all the doubts
about the research have been resolved to me.
I accept that I have taken part in this research willingly
and I know that if I have any reason I can withdraw from
the research without any lawful liability.
I am aware that they can use my medical history for
another research. I am sure that my identity would be
kept confdential during any research.
I accept that as long as all the information that I have
provided for this research project is used for research
programme, without my objection.
1. Patient’s signature
Date:
Name
27. lwfpr lgefr
fiz; izfrHkkxh]
vkidks ― A Study On The Effect Of Phototherapy On Various Hematological And
Biochemical Parameters In Neonatal Hyperbilirubinemia In A Tertiary Care Centre uked
,d 'kks/k v/;;u esa Hkkx ysus ds fy, dgk tk jgk gSA bl v/;;u esa vkidks ,d
iz'ukoyh Hkjus ds fy, dgk tk,xkA v/;;u esa Hkkx ysus ds fy, vkids fy, dksbZ Kkr
tksf[ke vkSj ykHk ugha gSA lkj tkudkjh xksiuh; rjhds ls fu;af=r dh tk,xhA vkidh
Hkkxhnkjh LoSfPNd gS vkSj vki fcuk fdlh udkjkRed ifj.kk ds v/;;u ls fdlh Hkh le;
okil ys ldrs gSA
lgefr
orZeku esa eSaus i<+k gS vkSj eSa iznku dh xbZ tkudkjh dks le>krk@rh gWwa vkSj iz'uksa dks
iwNus dk volj feyk gSA eSa le>rk @ rh gwWa fd esjh Hkkxhnkjh LoSfPNd gS vkSj eSa fcuk
fdlh dkj.k vkSj ykxr ds fcuk fdlh Hkh le; okil ysus ds fy, Lora= gwWaA esjh mez 18
o"kZ ;k mlls vf/kd gS vkSj eSa bl v/;;u esa Hkkx ysus ds fy, lger gwWaA
izfrHkkxh ds gLrk{kj ----------------------------------------------
fnukad------------------
'kks/kdrkZ ds gLrk{kj -----------------------------------------------
fnukad------------------
28. PROFORMA
S.No. IPD No.
NAME: AGE/SEX
FATHER/MOTHER NAME: ADDRESS:
BIRTH ORDER: CONTACT NUMBER:
DATE AND TIME OF BIRTH: MODE OF DELIVERY:
BIRTH WEIGHT: DATE AND TIME OF EXAMINATION:
GESTATIONAL AGE:
BALLARD:
USG:
APGAR SCORE:
1 MIN:
5 MIN:
10 MIN:
ANTENATAL HISTORY: O/E:
HR:
MOTHER’S AGE RR:
HYPERTENTION[Y/N]: SPO2:
INFANT OF DIABETIC MOTHER[Y/N]: CRT:
H/O DRUG SYSTEMIC EXAMINATION:
H/O TWINS[Y/N]: CVS:
IMMUNISATION STATUS OF MOTHER CNS:
BREASTFEEDING R/S:
NEONATAL HYPERBILIRUBINEMIA P/A:
OTHERS:
INVESTIGATIONS: PRE PHOTOTHERAPY POST PHOTOTHERAPY
HOURS OF LIFE:
SERUM BILIRUBIN
COMPLETE BLOOD COUNT
SERUM CALCIUM
SERUM MAGNESIUM
SERUM POTASSIUM
UREA
CREATININE
BLOOD GROUP
29. DECLARATION AND CHECKLIST
DECLARATION (Please tick as applicable)
I/We certify that the information provided in this application is complete and correct.
I/We confirm that all investigators have approved the submitted version of proposal/related documents.
I/We confirm that this study will be conducted in accordance with the latest ICMR National Ethical Guidelines for Biomedical and
Health Research involving Human Participants and other applicable regulations and guidelines including responsible.
I/We confirm that this study will be conducted in accordance with the Drugs and Cosmetics Act 1940 and its Rules 1945 as amended
from time to time, GCP guidelines and other applicable regulations and guidelines.
I/We will comply with all policies and guidelines of the institute and affiliated/collaborating institutions where this study will be
conducted.
I/We will ensure that personnel performing this study are qualified, appropriately trained and will adhere to the provisions of the EC
approved protocol.
I/We declare that the expenditure in case of injury related to the study will be taken care of.
If applicable,I/We confirm that an undertaking of what will be done with the leftover samples is provided, if applicable.
I/We confirm that we shall submit any protocol amendments, adverse events report, significant deviations from protocols, progress
reports (if required) and a final report and also participate in any audit of the study if needed.
I/We confirm that we will maintain accurate and complete records of all aspects of the study.
I/We will protect the privacy of participants and assure safety and confidentiality of study data and biological samples.
I/We hereby declare that I/any of the investigators, researchers and/or close relative(s), have no conflict of interest (Financial/Non-
Financial) with the sponsor(s) and outcome of study.
I/We have the following conflict of interest (PI/Co-PI):
1.
I/We declare/confirm that all necessary government approvals will be obtained as per requirements wherever applicable.
Name of PI: Dr. Priyanshi Shrivastava Signature; Date- ----------------
Name of Guide: Dr Jaishree Ambhore Signature: Date------------------
Name of HOD: Dr. Jaishree Ambhore Signature: Date-----------------