PreDiRe T1D Symposium - Sonia Chritton, President, Children with Diabetes Research Foundation
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Diabetes Research Institute hosts first PreDiRe T1D Symposium to focus on preventing type 1 diabetes and its recurrence.
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Red meat allergy, also known as alpha-gal allergy, is caused by IgE antibodies to the carbohydrate epitope galactose-alpha-1,3-galactose (alpha-gal) found in mammalian meats. Certain tick bites, such as from the lone star tick, are associated with the production of these IgE antibodies. Reactions to red meat following tick bites are often delayed 3-6 hours after ingestion. The discovery of the alpha-gal allergy has provided insights into regional differences in food allergies and advanced understanding of how environmental exposures can induce novel food allergies.
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Red meat allergy, also known as alpha-gal allergy, is caused by IgE antibodies to the carbohydrate epitope galactose-alpha-1,3-galactose (alpha-gal) found in mammalian meats. Certain tick bites, such as from the lone star tick, are associated with the production of these IgE antibodies. Reactions to red meat following tick bites are often delayed 3-6 hours after ingestion. The discovery of the alpha-gal allergy has provided insights into regional differences in food allergies and advanced understanding of how environmental exposures can induce novel food allergies.
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Chronic spontaneous urticaria (part 1)
1) The document outlines an overview of chronic spontaneous urticaria (CSU), including its epidemiology, clinical presentation, natural history, and pathogenesis.
2) CSU affects approximately 0.5-1% of the general population and is more common in adults than children, with a peak age of onset between 20-40 years.
3) The pathogenesis of CSU is not fully understood but is believed to involve inappropriate activation of mast cells and basophils by autoantibodies, leading to the release of inflammatory mediators that cause wheals and angioedema.
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- Both innate and adaptive immune responses are involved, with dysregulation of cytokines like IL-4, IL-13 and IL-31 contributing to barrier defects.
- Microbes like Staphylococcus aureus can both exacerbate skin inflammation and be exacerbated by skin barrier defects in AD patients.
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- Clinical manifestations ranging from mild oral symptoms to anaphylaxis and factors affecting reactions.
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The document discusses several key points:
1) It questions the common belief that childhood exposure to measles provides immunity and that avoiding it threatens health.
2) It suggests that genetically modified foods and agricultural chemicals may promote disease more than genetics.
3) It warns that mandatory vaccinations could require Americans to accept poor and chronic health. Overall, the document casts doubt on mainstream views of health, immunity, and the role of vaccines and industrialized foods.
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1. It discusses Koch's postulates and how they have been challenged, as bacteria are not always the sole cause of disease and can be effects rather than causes.
2. It emphasizes that the true cause of disease is a weakened immune system, and lists several autoimmune conditions.
3. It discusses how factors like pathogens, adjuvants, vaccines, and aluminum can negatively impact the immune system and potentially cause immune-mediated diseases.
Common variable immunodeficiency
Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, poor response to vaccination, and increased susceptibility to infection. It is the most common symptomatic antibody deficiency disorder. The pathogenesis of CVID involves defects in B cell differentiation and antibody production that can be caused by genetic mutations affecting surface molecules, cytosolic proteins, or nuclear factors involved in B cell development and antibody class switching. While most cases of CVID are sporadic, about 5-25% show familial inheritance in an autosomal dominant pattern.
Glucocorticoids
Here are the key effects of glucocorticoids on inflammatory cells according to the document:
- Eosinophils: Prevent migration to the lung, decrease blood levels after antigen challenge, induce apoptosis but do not affect chemotaxis, adhesion or degranulation.
- Neutrophils: Increase peripheral blood levels by decreasing migration from blood, increasing survival and bone marrow production.
- T cells: Reduce numbers, inhibit activation and inflammatory mediator expression, induce apoptosis. Decrease TH1 cells which mediate delayed-type hypersensitivity reactions. Small increase in IgG and IgM from B cells. Enhance regulatory T cells which express IL-10. Effects on TH17 and NK cells are not well established.
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Hyper IgM syndrome
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Hereditary angioedema
Hereditary angioedema (HAE) is caused by C1 inhibitor deficiency or dysfunction. There are three main types: HAE type I and II involve C1INH mutations, while HAE type III has normal C1INH levels. Symptoms include non-pruritic swelling of the skin or mucosa. Abdominal or laryngeal attacks can be life-threatening. Diagnosis involves evaluating C1INH antigenic and functional levels. Treatment focuses on preventing attacks or treating acute episodes. Acquired angioedema has similar symptoms but later onset and is sometimes associated with lymphoproliferative disorders.
X linked agammaglobulinemia
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3) The pathogenesis of CSU is not fully understood but is believed to involve inappropriate activation of mast cells and basophils by autoantibodies, leading to the release of inflammatory mediators that cause wheals and angioedema.
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The document discusses alpha-gal syndrome, which causes delayed allergic reactions to red meat in some individuals. It may be triggered by tick bites that induce IgE antibodies against the alpha-gal oligosaccharide found in mammalian meat. Patients report generalized hives, swelling, or anaphylaxis hours after eating beef, pork or lamb. The condition is diagnosed by positive tests for alpha-gal IgE antibodies. Management involves strictly avoiding all mammalian meat and organs as well as tick bites. The cause of the delayed reactions and high antibody levels from tick bites remains unknown.
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- AD results from a complex interplay between skin barrier defects and immune dysregulation. Filaggrin gene mutations contribute to barrier defects but are absent in many AD cases.
- Both innate and adaptive immune responses are involved, with dysregulation of cytokines like IL-4, IL-13 and IL-31 contributing to barrier defects.
- Microbes like Staphylococcus aureus can both exacerbate skin inflammation and be exacerbated by skin barrier defects in AD patients.
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This document summarizes information about steroid hypersensitivity. It discusses allergic and nonallergic hypersensitivity reactions to corticosteroids and the factors that influence sensitization. Topical corticosteroids have a prevalence of allergy ranging from 0.2-5%, while systemic corticosteroids have a prevalence of 0.3%. The pathogenesis involves corticosteroids binding covalently to proteins. Cross-reactivity exists within corticosteroid groups based on structural similarities and shared metabolic pathways. Clinical presentation, diagnostic testing, and management of corticosteroid hypersensitivity are also reviewed.
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This document provides an overview of shellfish allergy, including:
- Classification of different types of shellfish such as crustaceans, mollusks, and others.
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- Diagnosis involving patient history, skin prick tests, food challenges and IgE antibody tests to confirm allergy.
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The document discusses several key points:
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3) It warns that mandatory vaccinations could require Americans to accept poor and chronic health. Overall, the document casts doubt on mainstream views of health, immunity, and the role of vaccines and industrialized foods.
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1. It discusses Koch's postulates and how they have been challenged, as bacteria are not always the sole cause of disease and can be effects rather than causes.
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Glucocorticoids
Here are the key effects of glucocorticoids on inflammatory cells according to the document:
- Eosinophils: Prevent migration to the lung, decrease blood levels after antigen challenge, induce apoptosis but do not affect chemotaxis, adhesion or degranulation.
- Neutrophils: Increase peripheral blood levels by decreasing migration from blood, increasing survival and bone marrow production.
- T cells: Reduce numbers, inhibit activation and inflammatory mediator expression, induce apoptosis. Decrease TH1 cells which mediate delayed-type hypersensitivity reactions. Small increase in IgG and IgM from B cells. Enhance regulatory T cells which express IL-10. Effects on TH17 and NK cells are not well established.
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Hyper IgM syndrome
Hyper IgM Syndrome is characterized by immunodeficiency with elevated serum IgM and low or absent other immunoglobulins due to a defect in class switching recombination. The most common form is X-linked Hyper IgM Syndrome caused by mutations in the CD40 ligand gene, affecting approximately 1 in 1,000,000 males. Clinical manifestations include recurrent respiratory and gastrointestinal infections. Treatment involves hematopoietic stem cell transplantation which is curative but has better outcomes when performed at a younger age before organ damage develops.
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Specific antibody deficiency
Specific antibody deficiency is characterized by a failure to respond to polysaccharide antigens, leading to recurrent sinopulmonary infections, despite normal immunoglobulin levels and response to protein antigens. It has a variety of clinical and immunological phenotypes that can be transient or permanent. Diagnosis involves evaluating the pattern of infections and measuring pneumococcal antibody levels before and after vaccination. Management includes immunizations, antibiotic prophylaxis and treatment, and potentially immunoglobulin replacement therapy to prevent organ damage from infections. With proper treatment, the prognosis is generally good, but permanent sequelae can occur if left undiagnosed or untreated.
Hereditary angioedema
Hereditary angioedema (HAE) is caused by C1 inhibitor deficiency or dysfunction. There are three main types: HAE type I and II involve C1INH mutations, while HAE type III has normal C1INH levels. Symptoms include non-pruritic swelling of the skin or mucosa. Abdominal or laryngeal attacks can be life-threatening. Diagnosis involves evaluating C1INH antigenic and functional levels. Treatment focuses on preventing attacks or treating acute episodes. Acquired angioedema has similar symptoms but later onset and is sometimes associated with lymphoproliferative disorders.
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Growing evidence for the benefits of yogurt consumption in preventing type 2 diabetes and other cardiometabolic risk factors. The importance of dairy as part of a balanced and healthy diet is widely recognised by health authorities and scientific experts worldwide. Now, evidence is mounting that consuming yogurt in particular as part of a healthy diet helps to prevent type 2 diabetes and other cardiometabolic risk factors, with one of the most recent studies suggesting that people who regularly eat yogurt are almost 30% less likely to develop type 2 diabetes than those who do not (1). Speaking to public health officials at the III World Congress of Public Health Nutrition in Spain, Dr André Marette from the Heart and Lung Institute of Laval Hospital in Quebec, Canada, said it was time to recognize the all-round health benefits of yogurt and encourage more people to eat yogurt on a daily basis.New Standard of Care
The document discusses establishing a new standard of care for nutrition intervention based on whole food concentrates rather than isolated vitamins and minerals. It outlines the limitations of current recommendations and the growing evidence from clinical studies showing whole food concentrates are more effective at the cellular level in supporting health, healing and reducing oxidative stress. Whole food concentrates have been shown to help conditions like cancer, heart disease, immune function and more in peer-reviewed research. The evidence suggests whole food concentrates should replace multivitamins as the recommended daily standard of care once healthcare professionals are properly educated on the data.
2010-07 HCC Vaccine lecture
This document summarizes concerns about vaccine safety and alternatives to vaccination. It discusses the potential risks of mercury, aluminum, and other components in vaccines on immune and neurological development. While not suggesting abandoning vaccines, it notes the lack of long-term safety studies and the possibility that vaccines may exacerbate underlying immune issues or metabolic disorders in some children.
PREDICT Study ASN Presentation June 2020
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Biblical Revelation On Nutrition
The document discusses biblical revelations about nutrition and health based on passages from the Bible. It states that sickness and disease plague mankind due to a lack of knowledge, and that God's words in the Bible contain the truth about health and disease prevention. It provides examples from the Bible of the types of meat, fat, and plants that are healthy to eat according to biblical teachings.
Probiotics in Health & Disease
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REGULAR YOGURT CONSUMPTION MAY HELP PREVENT CARDIOMETABOLIC DISEASES - Andre ...
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1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
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2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
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PreDiRe T1D Symposium - Sonia Chritton, President, Children with Diabetes Research Foundation
- 1. APRIL 20, 2018 Diabetes Research Institute University Of Miami
- 3. CANDIDATES FOR A CURE CANDIDATES • DHA and/or DHA and EPA blend, combined with Vit D, Nutritional intervention and monitoring • Anti-oxidants (?), pro-biotics (?), aspirin (?) • Nimble approach to allow for innovative interventions for those at highest risk (ie: methyldopa) • Finally, due to “Open Source” Nature of research, verifiability of compliance PAST Oral Insulin, Nasal Insulin, Exclusive Breastfeeding, ITN Drug Studies, BCG, Cord Blood Transplantation, NIP Pilot study PRESENT Lund Study, Molecular Blocking Study, Oral Insulin and ITN studies FUTURE Cocktail Approaches which are Safe, Efficacious and Affordable for all Improved and Expanded Genetic Risk Testing
- 4. CELLULAR (T CELL) AUTOIMMUNITY LOSS OF FIRST PHASE INSULIN RESPONSE (IVGTT) GLUCOSE INTOLERANCE (OGTT) HUMORAL AUTOANTIBODIES (IAA, Anti-GAD65, IA-2Ab, ZnT8, etc.) PUTATIVE ENVIRONMENTAL TRIGGER(S) CLINICAL ONSET Eisenbarth, NEJM 1986 NATURAL HISTORY OF TYPE 1 DIABETES TIME BETACELLMASS DIABETES “PRE”- DIABETES GENETIC PREDISPOSITION INSULITIS BETA CELL INJURY
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- 6. Implicating Inflammation Elimination of Aspirin for Children: Ban due to Reyes Syndrome – American Academy of Pediatrics and FDA Less than 1 in 1 million - 2 cases per year since 1994 O-6 to O-3 Ratio: FDA says eliminate fish during pregnancy and feeding of fish to young children Increase in Trans Fatty Acids Vit D Reduction : from 4500 to 2000 to 400 – blood level rather than dose? Probiotics – increase in use of anti-biotics, increase in gluten BMI and Sugar Intake: Dr. Jill Norris – both can cause inflammation Viral Cause – Stay Nimble and Stay Tuned Translation with Transplantation: What can we learn from each other?
- 7. In the battle to eradicate diabetes, there are “doers” and “viewers”... In an ocean of “viewers”, you are the Poseidon for us!