Temperature is a measure of the thermal state of a substance and determines whether it will give or receive heat. Heat is a form of energy transferred between substances at different temperatures. There are various methods to measure temperature, including liquid expansion thermometers like mercury thermometers, electrical methods like resistance thermometers, and chemical indicators. The human body tightly regulates its core temperature within a narrow range through mechanisms that increase or decrease heat loss and production in response to temperature changes. Temperature monitoring has clinical applications to detect changes in peripheral perfusion, unintentional temperature changes, and hyperthermia or hypothermia.
In this presentation we have discussed about temperature measuring instruments used in industry. Like Mechanical , electrical and non contact types instruments for measuring temperature
Discussing what is temperature. How to calibrate a thermometer. Liquid in glass thermometers. Calibrate a liquid-in-glass thermometer using two fixed points. Characteristics of a quality/ good thermometer.
various types of temperature measuring instrument
1.expansion types
i)bimetallic strips
ii)liquid in gas
2.based on electric resistivity
i)thermocouple
ii)thermistors(most sensitivity)
3.pyrometers
i)mirror types
ii)optical
iii)photon types(not exact names:-based on collection of photon)
and one interesting term include in pyrometers is THERMOPILE:A large number of themocouple connected in series.Hopes so you all will enjoy
Explains the principles underlying all devices used to sense temperature, and how the sensor signals are processed to convert them to indications of temperature. Describes the fundamental concepts of temperature, the Thermodynamic Temperature Scale, and the International Practical Temperature Scale. Covers sensor choice, response characteristics, heat transfer conditions, installation errors, instrumentation compromises, and mechanisms of sensor deterioration.
In this presentation we have discussed about temperature measuring instruments used in industry. Like Mechanical , electrical and non contact types instruments for measuring temperature
Discussing what is temperature. How to calibrate a thermometer. Liquid in glass thermometers. Calibrate a liquid-in-glass thermometer using two fixed points. Characteristics of a quality/ good thermometer.
various types of temperature measuring instrument
1.expansion types
i)bimetallic strips
ii)liquid in gas
2.based on electric resistivity
i)thermocouple
ii)thermistors(most sensitivity)
3.pyrometers
i)mirror types
ii)optical
iii)photon types(not exact names:-based on collection of photon)
and one interesting term include in pyrometers is THERMOPILE:A large number of themocouple connected in series.Hopes so you all will enjoy
Explains the principles underlying all devices used to sense temperature, and how the sensor signals are processed to convert them to indications of temperature. Describes the fundamental concepts of temperature, the Thermodynamic Temperature Scale, and the International Practical Temperature Scale. Covers sensor choice, response characteristics, heat transfer conditions, installation errors, instrumentation compromises, and mechanisms of sensor deterioration.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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3. Temperature &Heat
Temperature :Is the thermal state of a substance that
determines whether it will give heat to another substance
or receive.
Heat :Is a form of energy transferred from a hotter
subset. to a colder one
6. Temperature Measurement
A. Non_electrical Methods
1. Liquid Expansion Thermometers
i. Mercury Thermometers
Advantages :it has linear scale&
cheap
disadv.:
1. unsuitable for remote readings &
for measurement of very low temp.
2. Response time is long (2-3min.)
3. Rigid & made of glass which is
liable to break.
7.
8. Temp.Measurement(cont)
ii. Alcohol thermometers
Adv:
cheaper than mercury
Suitable for use at very low temp
Disadv:
Unsuitable for remote reading or
recording results
Non linear scale
Unsuitable for high temp
9. 2. Dial expansion Thermometers
Bimetallic strip thermometers
i. It is used for measuring air temp.
ii. It depends on 2 dissimilar metals with diff. coefficients
of expansion fixed together as a coil.
iii. temp diff. in length of the 2 metals moving a
pointer on a scale.
Adv: cheap
disadv:not accurate
10.
11. Bourdon gauge thermometers
i. Used for measuring large temp changes e.g.
autoclaves
ii. Small bulb cont. volatile fl. to a small coiled
tube attached to a pointer.
iii. Temp bulb pr. Straighten the coiled
tube moving the pointer on a scale.
Adv:Cheap
Disadv.:not accurate
12.
13. 3.Chemical thermometers
Arise of temperature increases the number
of cells which release the chemical dyes
which appear indicating the temperature
Adv :It detect the change temperature on
the skin
Disadv: It disposable
:It not accurate
:It dose not allow continuous
reading
14. B.Electrical methods
1. Resistance Thermometer;
based on the fact that :the electrical resistance of a
metal increases with the increase of temp.
Adv:- can be used for calibration of other
thermometers accurately
-remote &continuous reading
-linear scale
Disadv.;-long response time
-expensive& fragile
15. 2-thermistor
• The electrical resist. decreases with the
increase of temp.It is formed of a small
bead of metal oxide e.g.zinc oxide.
Adv. :-the bead is of very small size &
diff. shapes,fixed on a needle. very
accurate with remote & continuos
reading.cheap. than platinum resis.therm.
Disadv.the is not linear &resistance
changes with time.
16.
17. 3-Thermocouple
• Based on the seebeck effect,2 diff. metals are
joined to form a circle the potential diff. bet. the 2
junctions is proportional to the diff.in their temps.
• The 2 metals may be copper or iron & constantan.
19. • 4-Transistor thermometer The
voltage across transistor js.is temp.-dependent
&more sensit.than thermocouple
• 5-Optical thermometer objects
emits electro magnetic radiations,the wave lengths
of these radiations are temp. dependent.
Types; a-infrared ear thermometer.
B-tympanic membrane thermometer
20. 6-Liquid crystal thermometer
• temp. organic.comp. from solid to liq.passing
by intermed. State with optically active properties
• Exposure of such material (intermed.state) to light
at certain temp. iridescent colors &the
remaining of light transmitt. By the crystals
• The colors form letters & numbers& black
background.
21. • It consists of a flexible adhesive –backed strip
with plastic-encased liq. Crystals on a black
background.
• To use ,the covering over the adhesive is removed
&the strip placed on the skin.
• Advs.;convenient,non-invasive,easy to
apply&read,unbreakable,disposable&inexpensive.
• Disadvs.;infrared lamps&sun exposure give high
readings &less accurate
22.
23. Clinical Applications
• Humans are homeothermic i.e. control body temp.
within a narrow range despite a wide range of
environmental temp.
• Body temp. :
a-Core temp. i.e.temp. of deeper tissues(2.5 cm
from the skin).It includes brain ,thoracic&
abdominal organs(37˚C).
b-Shell temp.:temp.of tissues within 2.5 cm.from
the skin(32-35˚C).
26. Mechanisms activated by heat
• Increased heat loss
• Cutaneous vasodilation
• Sweating
• Increased respiration
• Decreased heat production
27. Mechanisms activated by cold
• Shivering
• Hunger
• Increased voluntary activity
• Increased secretion of norepinephrine and
epinephrine
• Decreased heat loss
• Cutaneous vasoconstriction
• Curling up
• Horripilation
28. Sites Of Temp. Monitoring
• Core temp.
1. Tympanic memb. Brain temp.
2. Nasopharynx.
3. Oesophagus Cardiac temp.
4. Rectum(risk of perforation)
5. Pulmonary a. catheter
6. Urinary bladder
• Peripheral temp.:at the skin by liq.
Crystal adhesive strip
29. Indication of temp. monitoring
1. Detection of peripheral perfusion (core-
peripheral temp.gradient is 5C )
2. Detection of unintentional hypothermia
3. Detection of elective hypothermia
4. Detection of hyperthermia