Postoperative Pain
Management
Presented by
Tanjina Yeasmin Eva
Intern Doctor,Surgery unit 1,SOMCH
 Pain is the most common postoperative complaint
of surgical patients .About 75% patients complain
of pain in postoperative period.
 Clinicians attending to these patients need to have
better understanding about Effective postoperative
pain control as an essential component of the care
of the surgical patients.
Patient has to be
completely pain free
Target:
What is pain?
• Pain is an unpleasant sensory or emotional
experience associated with actual or potential
tissue damage, or described in terms of such
damage
Ref: The InternationalAssociation for the Study of
Pain (IASP)
HOW DOES
POSTOPERATIVE PAIN
ARISE?
Transduction
Transmission
Modulation
Perception
2
1
3
• Pain involves four physiological processes
4
Pain begins when..
Local tissue damage during surgery
Release of inflammatory substances
(PG,histamines,serotonin, bradykinin, substance P)
Electrical impulse generation ( transduction) at peripheral
nerve endings or niciceptors
Through A-delta or C fibers to spinal cord (Transmission)
Further relay to the higher brain centres can be modified
within the spinal cord (Modulation) before an individual
perceives a painful stimulus (perception)
Ref: Clinical surgery in general(RCS course manual):4th edition
Factors affecting postoperative pain
• The intensity, quality and duration of postoperative
pain is affected mainly by:
 Location, type, and duration of the surgical
procedure
 Extent of the incision and surgical trauma
 Physical and mental state of the patient
including the patient’s personal approach to pain
 Type of anesthesia
Cont..
 Incidence of surgical complications
 Quality of preoperative patient preparation
 Quality of postoperative care
Ref: Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first day after surgery: a prospective cohort study
comparing 179 surgical procedures. Anesthesiology. 2013
Why treating
postoperative pain is
important?
Why treating
postoperative pain is important?
Patient comfort & satisfaction
Early mobilization & rehabilitation
Prevention of pulmonary complications
 Atelectasis and Pneumonia,
Prevention of cardiac complications
 Increased risk of Myocardial Ischaemia in
patients with pre-existing cardiac disease
Cont…
• Reduced risk of DVT
• Faster recovery
• Reduced hospital stay & cost
• Good postoperative analgesia is related to reduced
clinical morbidity
Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first
day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013
? Reasons behind
poor analgesia
Failure to provide good postoperative
analgesia is multifactorial
Insufficient knowledge & lack of
proper counselling
Fear of complications associated
with analgesic drugs
Poor pain assessment
Inadequate stuffing
Methods available to treat
post operative pain
Methods available to treat post operative
pain
Methods
Non-
pharmacological
Pharmacological
Non-pharmacological
Psychological methods:
 Pre-operative
counselling-maybe
beneficial for reducing
patient anxiety and
improve satisfaction with
treatment
 Hypnosis- it can help
reduce anxiety
Cont…
• Physical methods
i. TENS( Transcutanenous electrical nerve stimulation): reduces the
transmission of painful nerve impulses to the higher cortical centres,
thereby theoretically reducing the level of postoperative pain
ii. Acupuncture: number of studies that suggest that it reduces pain &
analgesic consumption after dental and abdominal surgery.
iii. Massage
iv. Application of superficial heat or cold
• **Although there is little evidence to support the effectiveness of unconventional
methods, certain patients do derive some benefit from them, so do not dismiss them
without consideration
Pharmacological
Paracetamol
NSAIDs: Diclofenac, Ibuprofen,Ketorolac
Opioids:
 Mild opioids: Codeine, Tramadol
 Strong opioids: morphine, diamorphine,
fentanyl,oxycodone,pethidine
Adjuvants : Local anesthesia, Epidural
Anesthesia, Patient controlled analgesia
Site of action of common analgesics
• Improving analgesia alone may not be
sufficient to reduce stress response to surgery.
• We must also influence other physiological
processes and restore homeostasis
Paracetamol
First line treatment if no
contraindicaton
Max dose: 4 g / 24 hrs
from all sources
More effective in
severe pain when
combined with other
opioids such as
codeine
Mechanism: thought to
inhibit prostaglandin
synthesis in CNS →
analgesia, antipyretic
Effective for mild to
moderate pain
Contraindicated in Acute
liver disease alcohol-
induced liver disease,
glucose-6-phosphate
dehydrogenase deficiency
NSAIDS
Use
• Moderate pain relief, reduces dose of opoids when
used combined
Adverse effects
• Gastric ulceration,nephrotoxicity,impaired
haemostasis,aspirin induced asthma,high cardiac
risk(COX-II inhibitor)
Contraindications
• Pre-existing PUD, Renal Failure,Asthma,Bleeding
disorder
Also, first-line treatment
 Mechanism -Block cyclooxygenase (COX)
enzyme → ↓ prostaglandin synthesis
Opioids
Route of
administration
• Oral,
• Intramascular
• Intravenous
• Centrally (epidural)
Side effects
• Itching, Sedation, Respiratory depression,
• Nausea and vomiting, Euphoria or dysphoria and
• bladder dysfunction, Dependency
Contraindications • Asthma, Shock, Hypotension
 Centrally acting on opioid receptors
Other…
Local
anesthetic
infiltration
Epidural
anesthesia
Patient
controlled
analgesia
 Local infiltration of
bupivacaine provides
pain relief for first 6
hours
postoperatively
 Affective for day
care surgery
 Extremely
satisfactory method
of ensuring a pain
free early
postoperative period
after major
abdominal or
thorasic surgery
without the sedation
o systemic opoids
 Administration of
intravenous opoids
at a bolus dose
controlled by the
patient where
overdose is
prevented by
lockout devices
Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the
first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013,Frquhanson’s textbook
of Operative general surgery:11th edition;Essential surgical practice:higher surgical training in general surgery,5th edition
NSAIDs vs Opioids
NSAIDs Opioids
Weaker analgesic Strong analgesic
Acts peripherally Acts centrally
Does not Depress CNS depress CNS
No abuse liability High abuse potential
No dependence Can cause physical & mental
dependence
Ref:Ingredient Medical Pharmacology:4th edition
Single drug vs combination drugs
Benefits of using multimodal drugs
Different drugs with different mechanisms/sites of action
along pain pathway
 Each with a lower dose than if used alone Can provide
additive or synergistic effects
Provides better analgesia with less side effects (mainly
opiate related S/E)
Approach to a
postoperative patient
in pain
WHO Analgesic stepladder
• The WHO analgesic stepladder is the best known method
for approaching pain relief .
• it provides a strategy for titrating analgesia, starting with
simple analgesics & working upwards the ladder to strong
opioids.
Clinical assessment of pain
• Post-operative pain can be assessed subjectively &
objectively
Subjective: (history taking)
Ask the patient to grade their pain on a scale
of mild ,moderate or severe & use pain
scoring scales
Take history about the onset of pain, speed of
onset, location, radiation, quality of the pain,
and accompanying symptoms
causative factors – movement, sitting
position, cough, etc.
intensity of the pain at rest, during movement
Quality of sleep
Assessment of the patient’s expectations, personal
approach to pain, stress and pain coping strategies,
analgesic therapy preferences
History of any pre-existing pathology
Pain scoring tools
Cont..
Objective(physical examination):
 Pulse: Tachycardia
 BP: Hypertension
 Respiratory rate: Tachypnea
 Sweating or flushing
 Local area of tenderness
Monitoring
• Regular Assessment of the level of pain,
• Effectiveness & side effects of ongoing analgesic regimen
• Monitoring of sedation & respiration strictly for a patient on
opioids
• Observe patients behavior to assess the outcome of
treatment
Points to be noted
• After thorough assessment of patient create a
individual analgesic regimen for each patient
because pain is a subjective concept and patients’
experience of pain after a similar procedure varies
considerably.
“The good physician treats the
disease;the great physician treats
the patient who has the disease”
-Sir William Osler
Thank you

Postoperative pain management

  • 1.
    Postoperative Pain Management Presented by TanjinaYeasmin Eva Intern Doctor,Surgery unit 1,SOMCH
  • 2.
     Pain isthe most common postoperative complaint of surgical patients .About 75% patients complain of pain in postoperative period.  Clinicians attending to these patients need to have better understanding about Effective postoperative pain control as an essential component of the care of the surgical patients.
  • 3.
    Patient has tobe completely pain free Target:
  • 4.
    What is pain? •Pain is an unpleasant sensory or emotional experience associated with actual or potential tissue damage, or described in terms of such damage Ref: The InternationalAssociation for the Study of Pain (IASP)
  • 5.
  • 6.
  • 7.
    Pain begins when.. Localtissue damage during surgery Release of inflammatory substances (PG,histamines,serotonin, bradykinin, substance P) Electrical impulse generation ( transduction) at peripheral nerve endings or niciceptors Through A-delta or C fibers to spinal cord (Transmission) Further relay to the higher brain centres can be modified within the spinal cord (Modulation) before an individual perceives a painful stimulus (perception) Ref: Clinical surgery in general(RCS course manual):4th edition
  • 9.
    Factors affecting postoperativepain • The intensity, quality and duration of postoperative pain is affected mainly by:  Location, type, and duration of the surgical procedure  Extent of the incision and surgical trauma  Physical and mental state of the patient including the patient’s personal approach to pain  Type of anesthesia
  • 10.
    Cont..  Incidence ofsurgical complications  Quality of preoperative patient preparation  Quality of postoperative care Ref: Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013
  • 11.
  • 12.
    Why treating postoperative painis important? Patient comfort & satisfaction Early mobilization & rehabilitation Prevention of pulmonary complications  Atelectasis and Pneumonia, Prevention of cardiac complications  Increased risk of Myocardial Ischaemia in patients with pre-existing cardiac disease
  • 13.
    Cont… • Reduced riskof DVT • Faster recovery • Reduced hospital stay & cost • Good postoperative analgesia is related to reduced clinical morbidity Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013
  • 14.
    ? Reasons behind pooranalgesia Failure to provide good postoperative analgesia is multifactorial Insufficient knowledge & lack of proper counselling Fear of complications associated with analgesic drugs Poor pain assessment Inadequate stuffing
  • 15.
    Methods available totreat post operative pain
  • 16.
    Methods available totreat post operative pain Methods Non- pharmacological Pharmacological
  • 17.
    Non-pharmacological Psychological methods:  Pre-operative counselling-maybe beneficialfor reducing patient anxiety and improve satisfaction with treatment  Hypnosis- it can help reduce anxiety
  • 18.
    Cont… • Physical methods i.TENS( Transcutanenous electrical nerve stimulation): reduces the transmission of painful nerve impulses to the higher cortical centres, thereby theoretically reducing the level of postoperative pain ii. Acupuncture: number of studies that suggest that it reduces pain & analgesic consumption after dental and abdominal surgery. iii. Massage iv. Application of superficial heat or cold • **Although there is little evidence to support the effectiveness of unconventional methods, certain patients do derive some benefit from them, so do not dismiss them without consideration
  • 19.
    Pharmacological Paracetamol NSAIDs: Diclofenac, Ibuprofen,Ketorolac Opioids: Mild opioids: Codeine, Tramadol  Strong opioids: morphine, diamorphine, fentanyl,oxycodone,pethidine Adjuvants : Local anesthesia, Epidural Anesthesia, Patient controlled analgesia
  • 20.
    Site of actionof common analgesics
  • 22.
    • Improving analgesiaalone may not be sufficient to reduce stress response to surgery. • We must also influence other physiological processes and restore homeostasis
  • 23.
    Paracetamol First line treatmentif no contraindicaton Max dose: 4 g / 24 hrs from all sources More effective in severe pain when combined with other opioids such as codeine Mechanism: thought to inhibit prostaglandin synthesis in CNS → analgesia, antipyretic Effective for mild to moderate pain Contraindicated in Acute liver disease alcohol- induced liver disease, glucose-6-phosphate dehydrogenase deficiency
  • 24.
    NSAIDS Use • Moderate painrelief, reduces dose of opoids when used combined Adverse effects • Gastric ulceration,nephrotoxicity,impaired haemostasis,aspirin induced asthma,high cardiac risk(COX-II inhibitor) Contraindications • Pre-existing PUD, Renal Failure,Asthma,Bleeding disorder Also, first-line treatment  Mechanism -Block cyclooxygenase (COX) enzyme → ↓ prostaglandin synthesis
  • 25.
    Opioids Route of administration • Oral, •Intramascular • Intravenous • Centrally (epidural) Side effects • Itching, Sedation, Respiratory depression, • Nausea and vomiting, Euphoria or dysphoria and • bladder dysfunction, Dependency Contraindications • Asthma, Shock, Hypotension  Centrally acting on opioid receptors
  • 26.
    Other… Local anesthetic infiltration Epidural anesthesia Patient controlled analgesia  Local infiltrationof bupivacaine provides pain relief for first 6 hours postoperatively  Affective for day care surgery  Extremely satisfactory method of ensuring a pain free early postoperative period after major abdominal or thorasic surgery without the sedation o systemic opoids  Administration of intravenous opoids at a bolus dose controlled by the patient where overdose is prevented by lockout devices Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013,Frquhanson’s textbook of Operative general surgery:11th edition;Essential surgical practice:higher surgical training in general surgery,5th edition
  • 27.
    NSAIDs vs Opioids NSAIDsOpioids Weaker analgesic Strong analgesic Acts peripherally Acts centrally Does not Depress CNS depress CNS No abuse liability High abuse potential No dependence Can cause physical & mental dependence Ref:Ingredient Medical Pharmacology:4th edition
  • 28.
    Single drug vscombination drugs
  • 29.
    Benefits of usingmultimodal drugs Different drugs with different mechanisms/sites of action along pain pathway  Each with a lower dose than if used alone Can provide additive or synergistic effects Provides better analgesia with less side effects (mainly opiate related S/E)
  • 30.
  • 31.
    WHO Analgesic stepladder •The WHO analgesic stepladder is the best known method for approaching pain relief . • it provides a strategy for titrating analgesia, starting with simple analgesics & working upwards the ladder to strong opioids.
  • 33.
    Clinical assessment ofpain • Post-operative pain can be assessed subjectively & objectively Subjective: (history taking) Ask the patient to grade their pain on a scale of mild ,moderate or severe & use pain scoring scales Take history about the onset of pain, speed of onset, location, radiation, quality of the pain, and accompanying symptoms causative factors – movement, sitting position, cough, etc.
  • 34.
    intensity of thepain at rest, during movement Quality of sleep Assessment of the patient’s expectations, personal approach to pain, stress and pain coping strategies, analgesic therapy preferences History of any pre-existing pathology
  • 35.
  • 36.
    Cont.. Objective(physical examination):  Pulse:Tachycardia  BP: Hypertension  Respiratory rate: Tachypnea  Sweating or flushing  Local area of tenderness
  • 37.
    Monitoring • Regular Assessmentof the level of pain, • Effectiveness & side effects of ongoing analgesic regimen • Monitoring of sedation & respiration strictly for a patient on opioids • Observe patients behavior to assess the outcome of treatment
  • 38.
    Points to benoted • After thorough assessment of patient create a individual analgesic regimen for each patient because pain is a subjective concept and patients’ experience of pain after a similar procedure varies considerably.
  • 39.
    “The good physiciantreats the disease;the great physician treats the patient who has the disease” -Sir William Osler
  • 40.