Postoperative pain management is an essential component of surgical patient care. About 75% of surgical patients experience pain after a procedure. Effective pain control allows for early mobilization, reduced complications, and faster recovery. Postoperative pain arises from tissue damage during surgery and the subsequent inflammatory response. Both pharmacological and non-pharmacological methods can be used to treat postoperative pain, including opioids, NSAIDs, local anesthetics, and physical therapy. Proper assessment and an individualized treatment plan that utilizes a stepwise multimodal approach can provide pain relief and optimize patient outcomes.
To improving postoperative pain management, we need to;
- Always applies multi-modal analgesia. (get the advantages of multimodal analgesia)
- Implementation of the existing EB regarding the use of non-opioid + opioid on as needed basis.
- Use available specific evidence for optimizing multimodal pain management procedure (PROSPECT Web site).
Post operative pain management has no specific criteria. Lots of methods and procedures are suggested with various types of drugs. It is just a guideline for management of pain after surgery.
Aggressive preemtive multimodal including epidural or nerve block not only produce optimal analgesia but also may prevent the occurrence of chronic pain after surgical
Paracetamol as a single analgesic is only for mild and moderate pain.
However it can be combined with many analgesics to provide strong effect.
So, it can be the basic regiment for Multimodal Analgesia.
To improving postoperative pain management, we need to;
- Always applies multi-modal analgesia. (get the advantages of multimodal analgesia)
- Implementation of the existing EB regarding the use of non-opioid + opioid on as needed basis.
- Use available specific evidence for optimizing multimodal pain management procedure (PROSPECT Web site).
Post operative pain management has no specific criteria. Lots of methods and procedures are suggested with various types of drugs. It is just a guideline for management of pain after surgery.
Aggressive preemtive multimodal including epidural or nerve block not only produce optimal analgesia but also may prevent the occurrence of chronic pain after surgical
Paracetamol as a single analgesic is only for mild and moderate pain.
However it can be combined with many analgesics to provide strong effect.
So, it can be the basic regiment for Multimodal Analgesia.
Preventive analgesia:
Broader definition of preemptive analgesia
Perioperative analgesic regimen that able to control pain-induced sensitization
Not the timing of the analgesic treatment but the duration and efficacy of an analgesic intervention are more important for an effective postoperative pain relief
Adequate preventive analgesia should include multimodal techniques and with a sufficient duration of tretment
Preventive analgesia:
Broader definition of preemptive analgesia
Perioperative analgesic regimen that able to control pain-induced sensitization
Not the timing of the analgesic treatment but the duration and efficacy of an analgesic intervention are more important for an effective postoperative pain relief
Adequate preventive analgesia should include multimodal techniques and with a sufficient duration of tretment
On every Wednesday The department of Otolaryngology & Head neck surgery of Sylhet MAG Osmani Medical College Does Case presentation session by Students and doctors.
this was done by the 5th year medical students (52nd MBBS,F batch 2013-14 session)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Pain is the most common postoperative complaint
of surgical patients .About 75% patients complain
of pain in postoperative period.
Clinicians attending to these patients need to have
better understanding about Effective postoperative
pain control as an essential component of the care
of the surgical patients.
4. What is pain?
• Pain is an unpleasant sensory or emotional
experience associated with actual or potential
tissue damage, or described in terms of such
damage
Ref: The InternationalAssociation for the Study of
Pain (IASP)
7. Pain begins when..
Local tissue damage during surgery
Release of inflammatory substances
(PG,histamines,serotonin, bradykinin, substance P)
Electrical impulse generation ( transduction) at peripheral
nerve endings or niciceptors
Through A-delta or C fibers to spinal cord (Transmission)
Further relay to the higher brain centres can be modified
within the spinal cord (Modulation) before an individual
perceives a painful stimulus (perception)
Ref: Clinical surgery in general(RCS course manual):4th edition
8.
9. Factors affecting postoperative pain
• The intensity, quality and duration of postoperative
pain is affected mainly by:
Location, type, and duration of the surgical
procedure
Extent of the incision and surgical trauma
Physical and mental state of the patient
including the patient’s personal approach to pain
Type of anesthesia
10. Cont..
Incidence of surgical complications
Quality of preoperative patient preparation
Quality of postoperative care
Ref: Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first day after surgery: a prospective cohort study
comparing 179 surgical procedures. Anesthesiology. 2013
12. Why treating
postoperative pain is important?
Patient comfort & satisfaction
Early mobilization & rehabilitation
Prevention of pulmonary complications
Atelectasis and Pneumonia,
Prevention of cardiac complications
Increased risk of Myocardial Ischaemia in
patients with pre-existing cardiac disease
13. Cont…
• Reduced risk of DVT
• Faster recovery
• Reduced hospital stay & cost
• Good postoperative analgesia is related to reduced
clinical morbidity
Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the first
day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013
14. ? Reasons behind
poor analgesia
Failure to provide good postoperative
analgesia is multifactorial
Insufficient knowledge & lack of
proper counselling
Fear of complications associated
with analgesic drugs
Poor pain assessment
Inadequate stuffing
18. Cont…
• Physical methods
i. TENS( Transcutanenous electrical nerve stimulation): reduces the
transmission of painful nerve impulses to the higher cortical centres,
thereby theoretically reducing the level of postoperative pain
ii. Acupuncture: number of studies that suggest that it reduces pain &
analgesic consumption after dental and abdominal surgery.
iii. Massage
iv. Application of superficial heat or cold
• **Although there is little evidence to support the effectiveness of unconventional
methods, certain patients do derive some benefit from them, so do not dismiss them
without consideration
22. • Improving analgesia alone may not be
sufficient to reduce stress response to surgery.
• We must also influence other physiological
processes and restore homeostasis
23. Paracetamol
First line treatment if no
contraindicaton
Max dose: 4 g / 24 hrs
from all sources
More effective in
severe pain when
combined with other
opioids such as
codeine
Mechanism: thought to
inhibit prostaglandin
synthesis in CNS →
analgesia, antipyretic
Effective for mild to
moderate pain
Contraindicated in Acute
liver disease alcohol-
induced liver disease,
glucose-6-phosphate
dehydrogenase deficiency
25. Opioids
Route of
administration
• Oral,
• Intramascular
• Intravenous
• Centrally (epidural)
Side effects
• Itching, Sedation, Respiratory depression,
• Nausea and vomiting, Euphoria or dysphoria and
• bladder dysfunction, Dependency
Contraindications • Asthma, Shock, Hypotension
Centrally acting on opioid receptors
26. Other…
Local
anesthetic
infiltration
Epidural
anesthesia
Patient
controlled
analgesia
Local infiltration of
bupivacaine provides
pain relief for first 6
hours
postoperatively
Affective for day
care surgery
Extremely
satisfactory method
of ensuring a pain
free early
postoperative period
after major
abdominal or
thorasic surgery
without the sedation
o systemic opoids
Administration of
intravenous opoids
at a bolus dose
controlled by the
patient where
overdose is
prevented by
lockout devices
Ref: Clinical surgery in general(RCS course manual):4th edition; Gerbershagen HJ, Aduckathil S, van Wijck AJ et al. Pain intensity on the
first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013,Frquhanson’s textbook
of Operative general surgery:11th edition;Essential surgical practice:higher surgical training in general surgery,5th edition
27. NSAIDs vs Opioids
NSAIDs Opioids
Weaker analgesic Strong analgesic
Acts peripherally Acts centrally
Does not Depress CNS depress CNS
No abuse liability High abuse potential
No dependence Can cause physical & mental
dependence
Ref:Ingredient Medical Pharmacology:4th edition
29. Benefits of using multimodal drugs
Different drugs with different mechanisms/sites of action
along pain pathway
Each with a lower dose than if used alone Can provide
additive or synergistic effects
Provides better analgesia with less side effects (mainly
opiate related S/E)
31. WHO Analgesic stepladder
• The WHO analgesic stepladder is the best known method
for approaching pain relief .
• it provides a strategy for titrating analgesia, starting with
simple analgesics & working upwards the ladder to strong
opioids.
32.
33. Clinical assessment of pain
• Post-operative pain can be assessed subjectively &
objectively
Subjective: (history taking)
Ask the patient to grade their pain on a scale
of mild ,moderate or severe & use pain
scoring scales
Take history about the onset of pain, speed of
onset, location, radiation, quality of the pain,
and accompanying symptoms
causative factors – movement, sitting
position, cough, etc.
34. intensity of the pain at rest, during movement
Quality of sleep
Assessment of the patient’s expectations, personal
approach to pain, stress and pain coping strategies,
analgesic therapy preferences
History of any pre-existing pathology
37. Monitoring
• Regular Assessment of the level of pain,
• Effectiveness & side effects of ongoing analgesic regimen
• Monitoring of sedation & respiration strictly for a patient on
opioids
• Observe patients behavior to assess the outcome of
treatment
38. Points to be noted
• After thorough assessment of patient create a
individual analgesic regimen for each patient
because pain is a subjective concept and patients’
experience of pain after a similar procedure varies
considerably.
39. “The good physician treats the
disease;the great physician treats
the patient who has the disease”
-Sir William Osler