Ethnographic research is one of the many crucial research methodologies in educational research. This well-researched ppt gives a clear picture of the what, how, and why of the research design.
Ethnographic research is one of the many crucial research methodologies in educational research. This well-researched ppt gives a clear picture of the what, how, and why of the research design.
Presentation Title: Citizen Science: Science as if People Mattered
Presenter: Raj Pandya, Director, Spark: UCAR Science Education, University Corporation for Atmospheric Research
Preparing for Genomic Research Among Indigenous People: What Scientists Need to Know – Jeffrey Collmann, PhD; Director, O’Neill Institute for National and Global Health Law, Georgetown University. As presented at Ohio State's Personalized Health Care National Conference.
An overview of citizen science including the diversity of projects and people involved. Includes a nod towards the potential influence citizen scientists may have on policy matters .
Arie Rip of the University of Twente gave a STEPS Centre Manifesto Seminar on February 19 2009 entitles 'Putting the K back in: Knowledge, Research and Innovation Systems'.
Analysis of science, technology and innovation in terms of a national research or innovation system is a starting point for policy making, as well as policy implementation. There is a risk, however, that some national research or innovation systems become a model for other countries. This paper starts by offering a broader analysis of the dynamics of “modern” (i.e. OECD-countries, since 1870) research and innovation systems, which opens up the possibility of other paths of development.
Considering recent changes in “modern” research and innovation systems, as well as actual dynamics and needs of developing countries, it is clear that research captures only part what is important. Knowledge has to be recognized as an integral element, and institutionalized science then becomes one form of knowledge production. The paper argues that in this way, developing countries might actually create centres of excellence & relevance that can compete globally.
Find out more at: http://www.steps-centre.org/manifesto/index.html
Citation: O Riordan, N. 2013. An initial exploration of Citizen Science. NUIG Whitaker Institute Working Paper Series.
A working paper summarising the latest research on citizen science and its relationship with open innovation and the wisdom of crowds. Considers well known cases of citizen science including Galaxy Zoo. Identifies key research questions for future study.
Presentation Title: Citizen Science: Science as if People Mattered
Presenter: Raj Pandya, Director, Spark: UCAR Science Education, University Corporation for Atmospheric Research
Preparing for Genomic Research Among Indigenous People: What Scientists Need to Know – Jeffrey Collmann, PhD; Director, O’Neill Institute for National and Global Health Law, Georgetown University. As presented at Ohio State's Personalized Health Care National Conference.
An overview of citizen science including the diversity of projects and people involved. Includes a nod towards the potential influence citizen scientists may have on policy matters .
Arie Rip of the University of Twente gave a STEPS Centre Manifesto Seminar on February 19 2009 entitles 'Putting the K back in: Knowledge, Research and Innovation Systems'.
Analysis of science, technology and innovation in terms of a national research or innovation system is a starting point for policy making, as well as policy implementation. There is a risk, however, that some national research or innovation systems become a model for other countries. This paper starts by offering a broader analysis of the dynamics of “modern” (i.e. OECD-countries, since 1870) research and innovation systems, which opens up the possibility of other paths of development.
Considering recent changes in “modern” research and innovation systems, as well as actual dynamics and needs of developing countries, it is clear that research captures only part what is important. Knowledge has to be recognized as an integral element, and institutionalized science then becomes one form of knowledge production. The paper argues that in this way, developing countries might actually create centres of excellence & relevance that can compete globally.
Find out more at: http://www.steps-centre.org/manifesto/index.html
Citation: O Riordan, N. 2013. An initial exploration of Citizen Science. NUIG Whitaker Institute Working Paper Series.
A working paper summarising the latest research on citizen science and its relationship with open innovation and the wisdom of crowds. Considers well known cases of citizen science including Galaxy Zoo. Identifies key research questions for future study.
Into the Night - Citizen Science Training day - introduction to citizen scienceMuki Haklay
Setting, running and evaluating - In this session, we will provide a brief overview of the types of citizen science that are relevant in addressing environmental challenges. We will look at classifications of citizen science projects, explore their potential goals, the process of recruitment and retention as well as the need to start project evaluation from an early stage. Participants will have the opportunity to engage in a short exercise to consider how these elements can be used in the design of a citizen science project.
Scientists and Public Communication: A Report on NC State University Research...Jacques Nemo
This report emerges from data collected as part of the master’s thesis work of the author as a
graduate student at North Carolina State University. It also reflects his particular interest in public
communication of science and technology, specifically the views and behavior of scientists
regarding public engagement (PE).
The report is based on data of an online survey of researchers working at North Carolina
State University (NCSU) in Raleigh, NC, United States.
Slides from my talk in the European Citizen Science Conference in Berlin, May 2016. The talk look at issues of participation, citizen science and open science, and a bit about implications. It's about participation inequality and educational attainment of participants
The ECSA Characteristics of Citizen ScienceMargaret Gold
An overview of the work and outcomes on the ECSA Characteristics of Citizen Science - full notes on https://zenodo.org/communities/citscicharacteristics
Similar to Situating Citizen Science in Multiple Social Worlds: The Journalist-Researcher Interaction (20)
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
PRESENTATION ABOUT PRINCIPLE OF COSMATIC EVALUATION
Situating Citizen Science in Multiple Social Worlds: The Journalist-Researcher Interaction
1. Situating Citizen Science in Multiple Social Worlds: The Journalist-Researcher Interaction
Todd Suomela
University of Alberta
Acknowledgements: Suzie Allard, Carol Tenopir, Mark Littmann, Harry Dahms, Adele Suomela
Methods
• Semi-structured interviews were conducted with 10 different people who
were involved with citizen science projecs as researchers, project staff, or
writers/journalists.
• Subjects were purposefully recruited through sources identified during
the initial design of the project. Key web writers and individuals involved
in communication roles for existing citizen science projects were sent re-cruitment
emails. Journalists were identified based on a content analysis
of newspaper and web articles on citizen science.
• Interviews were transcribed and analyzed using NVivo.
• Situational analysis (Clarke, 2005) was used to drive the development of
visual maps of the content and activities of the people involved in citizen
science projects.
References
Clarke, A. (2005). Situational analysis: grounded theory after the postmodern
turn. Thousand Oaks, CA: SAGE Publications.
Demerath, L. “Social Worlds” in Ritzer, G. (2004). Encyclopedia of Social Theory.
SAGE Publications.
Goals and Research Question
Understand the communication frames and information exchanges between
the media and citizen science projects.
• What are the frames for citizen science in different discourse communi-ties?
• How are those frames created?
• Does citizen science alter the relationship between science and the pub-lic?
Social Worlds
“Social worlds are collections of actors with shared understandings and
shared institutionalized arrangements that convene, communicate, and coor-dinate
behaviors on the basis of some shared interest.” (Demerath, 2014) The
social worlds perspective developed during the 1970s in sociology, growing
out of work by Anselm Strauss and other sociologists to enhance symbolic in-teractionism.
Social worlds operate at many levels from the micro to the mac-ro.
They help to manage conflict and negotiate agreements around shared
interests and organizations. The degree of participation in a social world can
range from insiders who are deeply invested in a shared interest to outsiders
who are just observers of the interest. At the same time, individuals may par-ticipate
in multiple social worlds across many temporal and spatial scales.
Sci-entific
articles
are the main form for
communicating the results of
citizen science projects to other
specialists who study the same or sim-ilar
fields. There is a growing number
of scientific articles that reflect upon the
practice of citizen science. These articles
reach other communities interested
in science communication, the sci-ence
of team science, crowd-sourcing,
and other re-search
areas.
Press
releases were an-other
communication tool
used by some citizen science
projects to announce the start of a
new project or to publicize the results
of an ongoing or completed project. Some
interviewees reported that press releases
had been successful for gaining the atten-tion
of journalists. More data is needed
in order to assess the overall factors
that make press releases a useful
outreach tool for citizen sci-ence
projects.
Proj-ect
websites, at
least from the evidence
collected in this study, were not
frequently used by journalists or
writers reporting on citizen science
projects. Outsider journalists were
more likely to rely upon interviews
with volunteers or researchers. Regu-lar
writers on citizen science were
more likely to use project
websites for information
gathering.
In-terviews
were
the primary exchange
mechanism for information be-tween
researchers and journalists,
especially those outside of the social
world of citizen science. Journalists were
also very keen to interview volunteers,
especially when those volunteers repre-sented
a local geographic connection
to a project. For example, interview-ing
a local birder participating
in the Audubon Christmas
Bird Count.
Staff were members of particular research
teams who focused on activities which were
not directly related to the analysis of data
or the production of scientific articles. The
typical staff activity was usually in outreach
to particular communities, such as educa-tors
and teachers. Staff were also involved in
developing websites, supporting long-term
infrastructure, and recruiting volunteers.
Journalists and writers were distributed in
two main groups, both in the public are-na.
Outsiders worked for traditional print
or radio news outlets, and usually had pro-fessional
training in journalism or lengthy
individual experience. Regulars worked for
weblogs or other online sites that collect-ed
and reported on stories related to citizen
science. They were also less likely to have
professional training in journalism but some
had training in other areas, such as science.
Researchers come in two main groups. Pro-fessional
scientists who have training in a
particular subject specialty or researchers
who may have particular technical train-ing
in system design or engineering. In this
study the researchers were distributed along
the spectrum from insiders, to regulars, to
tourists. Insiders either worked as primary
investigators for a citizen science project or
investigated and developed the methods and
tools used by citizen science projects. Reg-ulars
worked as support staff or technology
designers for citizen science projects. Tour-ists
used citizen science methods for their
own research objectives but were not deeply
involved in the citizen science community.
Situational Mapping
The public-science vertical axis represents individuals based on their profes-sional
training and expertise. Scientists usually have advanced degrees in a
particular subject specialty such as ecology, or biology. Members of the pub-lic
usually do not have advanced degrees in a scientific subject, but some of
them may have additional training in professional fields such as journalism or
education.
The horizontal access represents participation in the social world of citizen
science. The amount of participation and investment in the social world of
citizen science increases from outsiders, to tourists, to regulars, to insiders.
According to the social worlds perspective people become increasingly identi-fied
with the goals of a social world as they journey from outsider to insider.
Insiders Regulars Tourists Outsiders
Public
Science
