The document summarizes a study comparing the automated serum protein electrophoresis system V8 from Sysmex to the Capillarys 2 system from Sebia. Over 1,600 patient samples were run on both systems using different buffers on the V8. The concordance between observers and systems for detecting monoclonal components was variable depending on the buffer used. While the V8 performance was similar to Capillarys 2 for monoclonal component detection, the V8 electropherograms had less defined outlines and lower run-to-run reproducibility compared to Capillarys 2.