This document discusses developing cyberinfrastructure to support computational chemistry workflows. It describes the OREChem project which aims to develop infrastructure for scholarly materials in chemistry. It outlines IU's objectives to build pipelines to fetch OREChem data, perform computations on resources like TeraGrid, and store results. It also discusses the GridChem science gateway which supports various chemistry applications and the ParamChem project which automates parameterization of molecular mechanics methods through workflows. Finally, it covers the Open Gateway Computing Environments project and efforts to sustain software through the Apache Software Foundation.