Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, responsible for over 1 million deaths annually. It is the leading cause of bacterial pneumonia. Certain populations are at higher risk of pneumococcal disease, including the elderly, young children, smokers, and those with chronic medical conditions. Pneumococcal infections have seasonal peaks in the winter. Multidrug resistant strains are increasing globally. Guidelines from organizations like the WHO and ACIP recommend pneumococcal vaccination for high risk groups like all adults over 65 and those with chronic lung, heart or liver disease.
Influenza vaccination and prevention of antimicrobial resistance - Slides by ...WAidid
The lecture presented by Professor Susanna Esposito at AMR 2019 on influenza vaccination and abuse of available antimicrobials.
To learn more, please visit www.waidid.org.
Dr vijay pneumococcal disease prevention in older adults 2020vkatbcd
The document provides details about Dr. Vijay K. Agrawal including his credentials and positions held. It also includes two disclosure statements indicating that Dr. Agrawal does not have any financial interests or arrangements that could be perceived as a conflict of interest. The rest of the document appears to be a slide presentation on pneumococcal disease.
Meningococcal carriage in the African meningitis belt and the impact of MenAfriVac: an overview of the MenAfriCar project
http://www.meningitis.org/conference2015
1) The document discusses theories that Western pharmaceutical companies and the US Department of Defense may have played a role in manufacturing and spreading Ebola and other diseases in Africa.
2) It notes that the US began clinical trials of an Ebola vaccine just before the 2014 Ebola outbreak, and that the US has a bioweapons research lab in the town at the epicenter of the outbreak.
3) It argues that vaccine makers are pushing for legal immunity to profit from fast-tracked Ebola vaccines while questioning whether an Ebola vaccine will actually work as intended.
The document discusses the FebriDx rapid point-of-care test that can differentiate between viral and bacterial infections in patients presenting with acute respiratory symptoms. It notes that overprescription of antibiotics for respiratory infections is a major problem, and physicians currently lack tools to determine infection etiology. The FebriDx test measures levels of MxA and CRP proteins to provide results in 10 minutes. Clinical trials found it had high sensitivity and specificity for differentiating between viral and bacterial infections. The test could help reduce unnecessary antibiotic prescribing without adverse events.
Vitamin D and COVID-19
Presentation at the Ancestral Health Symposium (AHS) 2021
by Chris Masterjohn, PhD
Watch the presentation recording, download a PDF version of the slides, and read the written report at https://chrismasterjohnphd.com/vitamind
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patientsijtsrd
Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi
Influenza vaccination and prevention of antimicrobial resistance - Slides by ...WAidid
The lecture presented by Professor Susanna Esposito at AMR 2019 on influenza vaccination and abuse of available antimicrobials.
To learn more, please visit www.waidid.org.
Dr vijay pneumococcal disease prevention in older adults 2020vkatbcd
The document provides details about Dr. Vijay K. Agrawal including his credentials and positions held. It also includes two disclosure statements indicating that Dr. Agrawal does not have any financial interests or arrangements that could be perceived as a conflict of interest. The rest of the document appears to be a slide presentation on pneumococcal disease.
Meningococcal carriage in the African meningitis belt and the impact of MenAfriVac: an overview of the MenAfriCar project
http://www.meningitis.org/conference2015
1) The document discusses theories that Western pharmaceutical companies and the US Department of Defense may have played a role in manufacturing and spreading Ebola and other diseases in Africa.
2) It notes that the US began clinical trials of an Ebola vaccine just before the 2014 Ebola outbreak, and that the US has a bioweapons research lab in the town at the epicenter of the outbreak.
3) It argues that vaccine makers are pushing for legal immunity to profit from fast-tracked Ebola vaccines while questioning whether an Ebola vaccine will actually work as intended.
The document discusses the FebriDx rapid point-of-care test that can differentiate between viral and bacterial infections in patients presenting with acute respiratory symptoms. It notes that overprescription of antibiotics for respiratory infections is a major problem, and physicians currently lack tools to determine infection etiology. The FebriDx test measures levels of MxA and CRP proteins to provide results in 10 minutes. Clinical trials found it had high sensitivity and specificity for differentiating between viral and bacterial infections. The test could help reduce unnecessary antibiotic prescribing without adverse events.
Vitamin D and COVID-19
Presentation at the Ancestral Health Symposium (AHS) 2021
by Chris Masterjohn, PhD
Watch the presentation recording, download a PDF version of the slides, and read the written report at https://chrismasterjohnphd.com/vitamind
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patientsijtsrd
Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi
- 84 of the 201 patients with COVID-19 pneumonia (41.8%) developed acute respiratory distress syndrome (ARDS), and of those 84 patients, 44 (52.4%) died.
- Risk factors for developing ARDS included older age, pre-existing comorbidities like hypertension and diabetes, and signs of disease severity like dyspnea.
- Risk factors for progression from ARDS to death included older age, signs of immune system overactivation and organ dysfunction like neutrophilia and elevated lactate dehydrogenase and D-dimer levels.
- Treatment with the corticosteroid methylprednisolone was associated with decreased risk of death among patients with ARDS.
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
Zyvac TCV - The Indian Typhoid Conjugate VaccineGaurav Gupta
The document discusses a new typhoid conjugate vaccine called Zyvac-TCV developed by Zydus Vaccines. It provides details of a phase II/III clinical trial conducted to evaluate the immunogenicity and safety of Zyvac-TCV compared to another licensed typhoid conjugate vaccine. The results showed that Zyvac-TCV was non-inferior in inducing seroconversion and had a comparable safety profile. No serious adverse events were reported for either vaccine. The document concludes that Zyvac-TCV met the immunogenicity and safety endpoints for efficacy.
Respiratory virus shedding in exhaled breath and efficacy of face masksValentina Corona
1) The study identified seasonal human coronaviruses, influenza viruses, and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness.
2) Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols. There was also a trend toward reduced detection of coronavirus RNA in respiratory droplets.
3) The results indicate that surgical face masks could help prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals.
This document discusses the use of subtractive genomics to identify potential drug targets for pathogenic organisms. Subtractive genomics involves subtracting the sequences between a host and pathogen's proteome to identify proteins essential to the pathogen but not present in the host. This approach has been applied to identify drug targets for multi-drug resistant pathogens like Salmonella typhi and Listeria monocytogenes, as well as pathogens with no existing effective drugs like Leishmania donovani and Clostridium botulinum. Identifying novel drug targets through subtractive genomics can help develop new defenses against antibiotic-resistant pathogens and treat diseases currently lacking effective treatments.
Emerging and reemerging infectious diseasesarijitkundu88
Various emerging and reemerging diseases. Factors contributing to the emergence of infectious diseases. Antibiotic resistance. The global response to control them. Laboratories network in surveillance.
- The study monitored 10 healthy individuals for over 35 years to investigate the duration of protective immunity against reinfection from the four seasonal human coronaviruses (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1).
- A total of 101 coronavirus infection events were detected using serum samples to measure antibody levels against the nucleocapsid protein of each coronavirus.
- Reinfections were frequently observed at around 12 months after the initial infection. Some reinfections occurred within 6-9 months, but no reinfections were seen within the first 3 months during follow-up visits.
- The study suggests that protective immunity against seasonal coronavirus reinfection is
This document discusses a case of a 38-year-old man who presents with fever and cough, and later develops a rash. The physician suspects measles. Measles is highly contagious and was eliminated in the US in 2000, but cases have been increasing since 2016 due to imported cases. Measles presents with fever and rash, and is diagnosed through IgM antibody or PCR testing of specimens. Treatment involves supportive care and vitamin A for severe cases. Prevention relies on two doses of MMR vaccine, which have reduced global measles deaths by over 20 million since 2000. However, outbreaks continue to occur in undervaccinated communities.
Hundred samples viz. urine, blood, wound, pus and sputum collected from different patients were found to harbour Pseudomonas aeruginosa (P. aeruginosa) (27%) with a maximum isolation from wound samples (33.33%) and minimum from blood samples (11.11%). The degree of resistance of P. aeruginosa isolates to different antibiotics like Ceftazidime (30µg), Amikacin (30µg), Imipenem (10µg), Ciprofloxacin (30µg), Tetracycline (30µg), Gentamicin (10µg), Norfloxacin (10µg), Penicillin (30µg), Chloramphenicol (30µg), and Ofloxacin (5µg) varied from 56% to 100%. Antiseptics i.e. Betadine and Dettol were found to be more effective against the MDR strain of P. aeruginosa at the dilutions of 10-1 and 10-2. Duration of the disease and hospitalization duration, evaluated as risk factors for P. aeruginosa colonization were found to be statistically significant while age and gender were found to be statistically non- significant. The incidence of multidrug resistance of P. aeruginosa is increasing fast due to the frequent use of antibiotics and antiseptics, which are used extensively in hospitals and healthcare centers, therefore it is a need to develop alternative antimicrobial agents for the treatment of infectious diseases.
Key-words- Antibiotic, Antiseptic, Betadine and Dettol, Disinfectants, P. aeruginosa
A single low-cost 2.5mg dose of vitamin D was found to boost the immune system's ability to fight tuberculosis (TB) for at least 6 weeks in a randomized controlled trial. Over 90% of TB patients studied in London hospitals had vitamin D deficiency. While vitamin D supplements were commonly used to treat TB before antibiotics, this is the first study to show that vitamin D supplementation can enhance immunity against mycobacteria that cause TB. A single large dose of vitamin D was found to enhance immunity at low cost and with no safety risks, suggesting vitamin D supplements could significantly impact people most at risk for TB.
This document summarizes research on the impacts of respiratory epidemics on healthcare workers. Some key points:
- Acute respiratory infections are very common, estimated to account for half of all acute illnesses. Incidence is highest in young children.
- Morbidity from respiratory illnesses justifies 30-50% absenteeism among adult workers and 60-80% school absences in children.
- Attack rates among healthcare workers during epidemics like SARS and influenza have been estimated as high as 60%.
- Nosocomial outbreaks have resulted in significant psychological and economic impacts with increased mortality, especially in intensive care settings.
- Risk factors for infection among healthcare workers include exposure to aerosol-generating procedures,
Human Coronaviruses (HCoV) exhibit positive single stranded RNA genome with enveloped nucleocapsid. Coronavirus belongs to the family Coronaviridae, originated from avian and mammalian species causes upper respiratory tract infection in humans by novel HCoVs viruses named as HCoV-HKU1, HCoV-NL63 but predominant species is Middle East respiratory syndrome (MERS-CoV) across the world. HCoV-HKU1 sp. is associated with chronic pulmonary disease, while HCoV-NL63 causes upper and lower respiratory tract disease in both children and adults, but most recent one was MERS-CoV, which caused acute pneumonia and occasional renal failure. The novel coronavirus SARS-CoV-2 is a new strain that causes the Coronavirus Disease 2019 (COVID-19) as named by the World Health Organization. According to the recent world statistics report about the COVID-19 cases approx. 101,500 confirmed cases and 3,500 death cases appeared. And mostly, a case of infection with CoV was identified in Wuhan, China. Structurally viral genome constitutes of 2/3rd of replicase gene encoding ORFs regions and rest of the 1/3rd region of genome form the structural proteins. The aim of the study was to understand the viral genetic systems in order to facilitate the genetic manipulation of the viral genome and to know the fundamental mechanism during the viral replication, facilitating the development of antidotes against the virus.
The document discusses concerns about the MMR vaccine and a potential link to autism. It provides details on vaccine ingredients including fetal bovine serum and human fetal cells. It summarizes testimony from a Congressional hearing linking vaccines to autism, including findings of measles virus in the gut and autoimmune responses post-vaccination. The document also discusses the history of measles and implications of vaccination and waning immunity over time.
Man Vs Microbe - Pre-Apocalyptic Phase Failed? in IJAHSPreethi Selvaraj
This document discusses the ongoing battle between humans and microbes. It notes the rise of antibiotic-resistant superbugs like MDR-TB that are difficult to treat. Factors contributing to this include overprescription of antibiotics and patient non-compliance. It also discusses the threat of biological warfare, from small-scale food poisoning to mass attacks. Modern techniques allow biological agents to be easily spread through aerosols, contaminated food/water, and more. Stronger regulations on antibiotic usage and policies to defend against bioterrorism are needed to prevent a potential "apocalypse."
PECULIARITIES OF ANTIBIOTIC-ASSOCIATED DIARRHEA DEVELOPMENT IN CHILDREN WITH ...Alexander Smiyan
ABSTRACT Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR). Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43. Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development. KEY WORDS: Antibiotic associated diarrhea, children
Edward Cachay, MD, MAS
Professor of Medicine
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
Adult Vaccines for Prevention of Pulmonary Infections | Jindal Chest ClinicJindal Chest Clinic
Importance of vaccination in preventing diseases like pneumonia, influenza, and other Pulmonary infections. For more information, please contact us: 9779030507.
This document discusses the management of community-acquired pneumonia (CAP), sinusitis, acute exacerbations of chronic bronchitis (AECB), and pharyngitis. It provides information on common etiologic agents, statistics on CAP in the US, diagnostic probabilities, modifying risk factors, appropriate initial antibiotic therapy, and factors that can improve outcomes.
- 84 of the 201 patients with COVID-19 pneumonia (41.8%) developed acute respiratory distress syndrome (ARDS), and of those 84 patients, 44 (52.4%) died.
- Risk factors for developing ARDS included older age, pre-existing comorbidities like hypertension and diabetes, and signs of disease severity like dyspnea.
- Risk factors for progression from ARDS to death included older age, signs of immune system overactivation and organ dysfunction like neutrophilia and elevated lactate dehydrogenase and D-dimer levels.
- Treatment with the corticosteroid methylprednisolone was associated with decreased risk of death among patients with ARDS.
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
Zyvac TCV - The Indian Typhoid Conjugate VaccineGaurav Gupta
The document discusses a new typhoid conjugate vaccine called Zyvac-TCV developed by Zydus Vaccines. It provides details of a phase II/III clinical trial conducted to evaluate the immunogenicity and safety of Zyvac-TCV compared to another licensed typhoid conjugate vaccine. The results showed that Zyvac-TCV was non-inferior in inducing seroconversion and had a comparable safety profile. No serious adverse events were reported for either vaccine. The document concludes that Zyvac-TCV met the immunogenicity and safety endpoints for efficacy.
Respiratory virus shedding in exhaled breath and efficacy of face masksValentina Corona
1) The study identified seasonal human coronaviruses, influenza viruses, and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness.
2) Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols. There was also a trend toward reduced detection of coronavirus RNA in respiratory droplets.
3) The results indicate that surgical face masks could help prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals.
This document discusses the use of subtractive genomics to identify potential drug targets for pathogenic organisms. Subtractive genomics involves subtracting the sequences between a host and pathogen's proteome to identify proteins essential to the pathogen but not present in the host. This approach has been applied to identify drug targets for multi-drug resistant pathogens like Salmonella typhi and Listeria monocytogenes, as well as pathogens with no existing effective drugs like Leishmania donovani and Clostridium botulinum. Identifying novel drug targets through subtractive genomics can help develop new defenses against antibiotic-resistant pathogens and treat diseases currently lacking effective treatments.
Emerging and reemerging infectious diseasesarijitkundu88
Various emerging and reemerging diseases. Factors contributing to the emergence of infectious diseases. Antibiotic resistance. The global response to control them. Laboratories network in surveillance.
- The study monitored 10 healthy individuals for over 35 years to investigate the duration of protective immunity against reinfection from the four seasonal human coronaviruses (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1).
- A total of 101 coronavirus infection events were detected using serum samples to measure antibody levels against the nucleocapsid protein of each coronavirus.
- Reinfections were frequently observed at around 12 months after the initial infection. Some reinfections occurred within 6-9 months, but no reinfections were seen within the first 3 months during follow-up visits.
- The study suggests that protective immunity against seasonal coronavirus reinfection is
This document discusses a case of a 38-year-old man who presents with fever and cough, and later develops a rash. The physician suspects measles. Measles is highly contagious and was eliminated in the US in 2000, but cases have been increasing since 2016 due to imported cases. Measles presents with fever and rash, and is diagnosed through IgM antibody or PCR testing of specimens. Treatment involves supportive care and vitamin A for severe cases. Prevention relies on two doses of MMR vaccine, which have reduced global measles deaths by over 20 million since 2000. However, outbreaks continue to occur in undervaccinated communities.
Hundred samples viz. urine, blood, wound, pus and sputum collected from different patients were found to harbour Pseudomonas aeruginosa (P. aeruginosa) (27%) with a maximum isolation from wound samples (33.33%) and minimum from blood samples (11.11%). The degree of resistance of P. aeruginosa isolates to different antibiotics like Ceftazidime (30µg), Amikacin (30µg), Imipenem (10µg), Ciprofloxacin (30µg), Tetracycline (30µg), Gentamicin (10µg), Norfloxacin (10µg), Penicillin (30µg), Chloramphenicol (30µg), and Ofloxacin (5µg) varied from 56% to 100%. Antiseptics i.e. Betadine and Dettol were found to be more effective against the MDR strain of P. aeruginosa at the dilutions of 10-1 and 10-2. Duration of the disease and hospitalization duration, evaluated as risk factors for P. aeruginosa colonization were found to be statistically significant while age and gender were found to be statistically non- significant. The incidence of multidrug resistance of P. aeruginosa is increasing fast due to the frequent use of antibiotics and antiseptics, which are used extensively in hospitals and healthcare centers, therefore it is a need to develop alternative antimicrobial agents for the treatment of infectious diseases.
Key-words- Antibiotic, Antiseptic, Betadine and Dettol, Disinfectants, P. aeruginosa
A single low-cost 2.5mg dose of vitamin D was found to boost the immune system's ability to fight tuberculosis (TB) for at least 6 weeks in a randomized controlled trial. Over 90% of TB patients studied in London hospitals had vitamin D deficiency. While vitamin D supplements were commonly used to treat TB before antibiotics, this is the first study to show that vitamin D supplementation can enhance immunity against mycobacteria that cause TB. A single large dose of vitamin D was found to enhance immunity at low cost and with no safety risks, suggesting vitamin D supplements could significantly impact people most at risk for TB.
This document summarizes research on the impacts of respiratory epidemics on healthcare workers. Some key points:
- Acute respiratory infections are very common, estimated to account for half of all acute illnesses. Incidence is highest in young children.
- Morbidity from respiratory illnesses justifies 30-50% absenteeism among adult workers and 60-80% school absences in children.
- Attack rates among healthcare workers during epidemics like SARS and influenza have been estimated as high as 60%.
- Nosocomial outbreaks have resulted in significant psychological and economic impacts with increased mortality, especially in intensive care settings.
- Risk factors for infection among healthcare workers include exposure to aerosol-generating procedures,
Human Coronaviruses (HCoV) exhibit positive single stranded RNA genome with enveloped nucleocapsid. Coronavirus belongs to the family Coronaviridae, originated from avian and mammalian species causes upper respiratory tract infection in humans by novel HCoVs viruses named as HCoV-HKU1, HCoV-NL63 but predominant species is Middle East respiratory syndrome (MERS-CoV) across the world. HCoV-HKU1 sp. is associated with chronic pulmonary disease, while HCoV-NL63 causes upper and lower respiratory tract disease in both children and adults, but most recent one was MERS-CoV, which caused acute pneumonia and occasional renal failure. The novel coronavirus SARS-CoV-2 is a new strain that causes the Coronavirus Disease 2019 (COVID-19) as named by the World Health Organization. According to the recent world statistics report about the COVID-19 cases approx. 101,500 confirmed cases and 3,500 death cases appeared. And mostly, a case of infection with CoV was identified in Wuhan, China. Structurally viral genome constitutes of 2/3rd of replicase gene encoding ORFs regions and rest of the 1/3rd region of genome form the structural proteins. The aim of the study was to understand the viral genetic systems in order to facilitate the genetic manipulation of the viral genome and to know the fundamental mechanism during the viral replication, facilitating the development of antidotes against the virus.
The document discusses concerns about the MMR vaccine and a potential link to autism. It provides details on vaccine ingredients including fetal bovine serum and human fetal cells. It summarizes testimony from a Congressional hearing linking vaccines to autism, including findings of measles virus in the gut and autoimmune responses post-vaccination. The document also discusses the history of measles and implications of vaccination and waning immunity over time.
Man Vs Microbe - Pre-Apocalyptic Phase Failed? in IJAHSPreethi Selvaraj
This document discusses the ongoing battle between humans and microbes. It notes the rise of antibiotic-resistant superbugs like MDR-TB that are difficult to treat. Factors contributing to this include overprescription of antibiotics and patient non-compliance. It also discusses the threat of biological warfare, from small-scale food poisoning to mass attacks. Modern techniques allow biological agents to be easily spread through aerosols, contaminated food/water, and more. Stronger regulations on antibiotic usage and policies to defend against bioterrorism are needed to prevent a potential "apocalypse."
PECULIARITIES OF ANTIBIOTIC-ASSOCIATED DIARRHEA DEVELOPMENT IN CHILDREN WITH ...Alexander Smiyan
ABSTRACT Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR). Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43. Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development. KEY WORDS: Antibiotic associated diarrhea, children
Edward Cachay, MD, MAS
Professor of Medicine
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
Adult Vaccines for Prevention of Pulmonary Infections | Jindal Chest ClinicJindal Chest Clinic
Importance of vaccination in preventing diseases like pneumonia, influenza, and other Pulmonary infections. For more information, please contact us: 9779030507.
This document discusses the management of community-acquired pneumonia (CAP), sinusitis, acute exacerbations of chronic bronchitis (AECB), and pharyngitis. It provides information on common etiologic agents, statistics on CAP in the US, diagnostic probabilities, modifying risk factors, appropriate initial antibiotic therapy, and factors that can improve outcomes.
The document discusses principles of treating infectious illnesses in critical care, with a focus on antibiotic resistance and choice of antibiotics. It covers several topics: the impact of antibiotic use on resistance; choosing initial antibiotics and tailoring treatment based on culture results; applying pharmacology and pharmacodynamics to optimize bacterial killing; and reviewing guidelines for specific infections. It also provides an overview of antibiotic classes, mechanisms of action, considerations for dosing in renal impairment, and highlights specific agents like penicillins, cephalosporins, and vancomycin.
This document discusses factors related to the treatment of community-acquired pneumonia (CAP). It notes that Streptococcus pneumoniae is the leading cause of CAP and risk factors for infection include age over 65, comorbidities, and recent antibiotic use. Mortality is higher in CAP patients with COPD, septic shock, or inappropriate initial antibiotic treatment. Early administration of antibiotics within 4 hours is associated with lower mortality. Combination antibiotic therapy is more effective than monotherapy for pneumococcal bacteremia.
This document outlines Patient Safety Goal 4 to tackle antimicrobial resistance as part of WHO's 3rd Global Patient Safety Challenge. It describes 3 indicators to monitor the incidence of MRSA, ESBL-Klebsiella Pneumoniae, and ESBL-E.coli infections. Data on newly identified multidrug resistant organism cases will be collected and the infection rates calculated monthly. Strategies like implementing antibiotic guidelines, stewardship programs, and national campaigns aim to optimize antibiotic use and contain the spread of antimicrobial resistance.
1) Three studies showed lower mortality for patients with bacteremic pneumococcal pneumonia treated with antibiotic combination therapy compared to monotherapy.
2) Combination therapy including a beta-lactam plus macrolide is recommended for critically ill patients and those with bacteremic pneumococcal pneumonia based on evidence showing lower mortality compared to fluoroquinolone combinations or monotherapy.
3) The optimal duration of combination therapy for bacteremic pneumococcal pneumonia is unclear but guidelines recommend limiting it to 3-5 days once the pathogen is identified.
This document discusses the key elements of DOTS (Directly Observed Treatment, Short-course), which remains the core strategy for tuberculosis control recommended by the WHO. It describes the five elements of DOTS: 1) Political commitment and sustained financing, 2) Case detection through quality-assured bacteriology, 3) Standardized treatment regimen for all cases of TB, 4) A regular drug supply and management system, 5) Monitoring and evaluation system and impact measurement. It focuses on the importance of political commitment, funding, strengthening laboratory networks, ensuring access to quality diagnostics, and establishing competent human resources for effective TB control.
Pneumococcal disease is caused by Streptococcus pneumoniae and remains a serious global health problem. It can cause infections like pneumonia, bacteremia, and meningitis. There are over 90 known serotypes of S. pneumoniae. Pneumonia is the most common clinical syndrome and a leading cause of death. Pneumococcal disease disproportionately affects young children, older adults, and those with underlying medical conditions. Vaccines provide an important strategy for prevention.
This document discusses antibiotic use and resistance in the ICU. It notes that 30-40% of ICU patients have or develop nosocomial infections, with antibiotics commonly used empirically, definitively, or prophylactically. While appropriate antibiotic choice and timing can reduce mortality from infection, clinical trials have not proven this due to flaws in study design. Widespread antibiotic use leads to increased resistance, seen most prominently in India with extended-spectrum beta-lactamase producing bacteria. The document advocates for more responsible antibiotic use through early culture and de-escalation of therapy once pathogens are identified, in order to curb rising antibiotic resistance in the ICU.
Characteristic and outcomes of patients with ptb requiring icu careEArl Copina
This document summarizes a study of 58 patients with active pulmonary tuberculosis who required admission to an intensive care unit. The mean age was 48 years and 37.9% required mechanical ventilation. The in-hospital mortality rate was 25.9% with a mean survival of 53.6 days for those who died. Factors independently associated with increased mortality included acute renal failure, need for mechanical ventilation, chronic pancreatitis, sepsis, acute respiratory distress syndrome, and hospital-acquired pneumonia. The study identified risk factors for high mortality rates in tuberculosis patients requiring intensive care.
Mitigation strategies for the protection of health care workers and first res...Omar Ha-Redeye
Mitigation strategies for protecting health care workers and first responders from swine flu are discussed. Key points include using personal protective equipment like masks and gowns, isolating confirmed cases, contact tracing, and treating symptomatic individuals and exposed health care workers with antiviral drugs. Stockpiles of antiviral drugs and personal protective equipment have been increased in many countries to prepare for a potential pandemic. There is ongoing debate around certain strategies like the use of masks and social distancing policies.
This document reviews the association between atopic conditions like asthma, allergic rhinitis, and atopic dermatitis with an increased risk of respiratory and non-respiratory tract infections. It discusses several potential mechanisms for this association, including dysfunction in innate immunity, humoral immunity, and cell-mediated immunity in atopic individuals. Specific examples are provided of impaired responses to pathogens like bacteria and viruses in those with asthma or allergies. The role of corticosteroid use and asthma severity/control in modifying infection risk is also examined.
This document summarizes a study of 60 cases of bacteremic pneumococcal pneumonia that occurred between 2005-2010 at a hospital in Chile. The main findings were:
1) The mean age was 72.1 years old and over 80% of cases were in patients over 60 years of age.
2) 22 pneumococcal serotypes were identified among 59 strains, with serotypes 14, 7f, 9v, 12f and 22f being the most common.
3) Only one strain showed intermediate resistance to penicillin.
4) The in-hospital mortality rate was high at 33.3%. Three independent factors associated with death were identified: a CAP PIRO score >
Common antibiotics prescribed for acute respiratory tract infected children i...iosrphr_editor
Background: Acute respiratory infection is a common disease in children. Most cases were due to upper respiratory tract infection. Early intervention and prompt treatment of acute respiratory infections are the easiest ways to prevent complications. Objective of the study: to determine the indications, frequency, and types of antibiotics used in hospitalized paediatric patients Messellata General Hospital , Messellata, Libya and to evaluate whether the prescribed antibiotics were based on the isolation of organism and their sensitivity. Study Design: Descriptive observational hospital based study. Results and discussion: A total of 200 child patients were included over 6 months of study period, in whom antibiotics were prescribed at the time of admission. The majority were between < 2 and 8 years of age. Fever was the commonest symptom. Out of 200 encounters for patients with various acute respiratory infections, acute pharyngotonsillits were (62.5%), followed by acute laringitis (26.5%). Acute pneumonia represented by (11%) of the total acute respiratory infection cases. Penicillins were the most commonly prescribed antibiotics for acute pharyngotonsillitis among children patients (40.8% of prescriptions), followed by cephalosporins (36.0%) and aminoglycosides (23.2%). A high percentage (59.1%) of children patients diagnosed with acute pneumonia was treated with cephalosporins, whereas (27.3%) of children patients with acute pneumonia were treated with penicillins. However, only (13.6%) of children patients with acute pneumonia often treated with aminoglycosides antibiotics. In case of acute laryngitis, the antibiotic prescription rates were as follow: Penicillins (58.5%), Cephalosporis (30.2%) and aminoglycosides (11.3%).
Common antibiotics prescribed for acute respiratory tract infected children i...iosrphr_editor
Background: Acute respiratory infection is a common disease in children. Most cases were due to upper respiratory tract infection. Early intervention and prompt treatment of acute respiratory infections are the easiest ways to prevent complications. Objective of the study: to determine the indications, frequency, and types of antibiotics used in hospitalized paediatric patients Messellata General Hospital , Messellata, Libya and to evaluate whether the prescribed antibiotics were based on the isolation of organism and their sensitivity. Study Design: Descriptive observational hospital based study. Results and discussion: A total of 200 child patients were included over 6 months of study period, in whom antibiotics were prescribed at the time of admission. The majority were between < 2 and 8 years of age. Fever was the commonest symptom. Out of 200 encounters for patients with various acute respiratory infections, acute pharyngotonsillits were (62.5%), followed by acute laringitis (26.5%). Acute pneumonia represented by (11%) of the total acute respiratory infection cases. Penicillins were the most commonly prescribed antibiotics for acute pharyngotonsillitis among children patients (40.8% of prescriptions), followed by cephalosporins (36.0%) and aminoglycosides (23.2%). A high percentage (59.1%) of children patients diagnosed with acute pneumonia was treated with cephalosporins, whereas (27.3%) of children patients with acute pneumonia were treated with penicillins. However, only (13.6%) of children patients with acute pneumonia often treated with aminoglycosides antibiotics. In case of acute laryngitis, the antibiotic prescription rates were as follow: Penicillins (58.5%), Cephalosporis (30.2%) and aminoglycosides (11.3%).
1) Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a major healthcare problem with high mortality rates, especially septic shock which has mortality rates of 50-60%.
2) The new Sepsis-3 definition defines sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection represented by an increase of two or more points in the SOFA score.
3) Early goal-directed therapy (EGDT) is a protocol-based approach for initial resuscitation of sepsis patients. It aims to achieve specific goals for central venous pressure, mean arterial pressure, ScvO2, and other parameters within 6 hours and
Clinical Mycology U F Medical Students 12 05 07 Final2raj kumar
The document discusses several key points about fungal infections:
1) Fungi are common in nature but relatively few cause disease in humans, usually superficial infections or allergies. Major disease-causing fungi include Candida, Aspergillus, and Zygomycetes.
2) Risk factors for invasive fungal infections include surgery, immunosuppression, and broad-spectrum antibiotic use. Candida infections are the most common cause of healthcare-associated bloodstream infections.
3) Early diagnosis and treatment of invasive fungal infections is important, as mortality can be high. Removing intravascular catheters and restoring immune function are also important aspects of management.
Seasonal influenza - current perspective with special reference to India - au...Gaurav Gupta
This document discusses influenza disease and vaccination, with a focus on India. It provides an overview of influenza viruses and infection, influenza outbreaks and pandemics throughout history, and an analysis of the 2009 H1N1 pandemic. It defines populations at high risk of influenza complications and analyzes influenza vaccine data from Chandigarh, India. Recommendations for influenza vaccines for the 2010-2011 and 2011-2012 seasons in India are also presented. Clinical studies on the effectiveness of influenza vaccines in reducing influenza-like illness among children in India are summarized.
Challenges in the management of HAP-VAP include multidrug-resistant pathogens becoming more common. Combination antibiotic therapy is recommended for patients with risk factors for multidrug-resistant infections or septic shock. Newer beta-lactam/beta-lactamase inhibitor combinations such as ceftolozane-tazobactam and ceftazidime-avibactam show promise in treating resistant gram-negative bacteria including ESBL, AmpC, KPC, and OXA-48 producers.
Community Acquired Pneumonia is an inflammatory lung condition caused by infection. It is defined as pneumonia occurring outside of a hospital setting. Respiratory infections are the leading cause of doctor visits. Streptococcus pneumoniae is the most common pathogen identified, causing around 46% of cases. Risk factors include older age, smoking, lung disease, and conditions that impair immunity or clearance of secretions. Diagnosis involves assessing severity, likely pathogens, and testing sputum, blood, or urine depending on the suspected germ. Most cases are treated initially with antibiotics at home or in the hospital depending on severity. Vaccines can help prevent many types of community acquired pneumonia.
Similar to Pneumococcal Disease - Epidemiology & Resistance (20)
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
3. Estimated Annual
Disease Burden Worldwide
Pneumococcal infections are a major cause of morbidity and
mortality worldwide
Streptococcus pneumoniae is the #1 cause of bacterial
pneumonia and a leading cause of otitis media
Pneumococcal infections cause >1 million annual deaths
worldwide
Most deaths occur in developing countries
Even in developed countries, invasive pneumococcal disease carries
high mortality in certain population groups (ie, elderly people,
especially those living in institutions, and patients with chronic organ
failure, diabetes, nephrotic syndrome, and immunodeficiencies)
Adapted from World Health Organization. Weekly Epidemiological Record. 2003;78(14):97-120; Beers MH, et al. The Merck Manual
of Diagnosis and Therapy. 18th edition. 2006.
4. The Primary Causes of Vaccine-Preventable
Deaths in All Age Groups Worldwide
Hib = Haemophilus influenzae type b.
WHO Official Mortality Rates, 2003, cited in and adapted from Global Alliance for Vaccines & Immunization. Speeding access to new, life-
saving vaccines: GAVI’s pneumococcal and rotavirus ADIPs. Available at:
http://www.who.int/vaccine_research/about/gvrf/Levine_Orin.pdf. Accessed October 23, 2006. Used with permission.
Vaccine-Preventable Deaths by Cause (WHO data), June 2003
0
200,000
400,000
600,000
800,000
1,000,000
1,200,000
1,400,000
1,600,000
<5 Years of Age ≥5 Years of Age Total
NumberofDeaths
Pneumococci
Measles
Hepatitis B
Rotavirus
Hib
Pertussis
Tetanus
Yellow Fever
Meningitis AC
Diphtheria
Polio
5. Estimated Annual Burden of Invasive
Pneumococcal Disease in Defined Populations
in the US According to Age, 1998–2005 (CDC
Data)
CDC = Centers for Disease Control and Prevention.
Adapted from Active Bacterial Core Surveillance Report, 1998. Available at: http://www.cdc.gov/ncidod/dbmd/abcs/survreports/spneu98.pdf. Accessed
October 24, 2006; ABCs Report, 2001. Available at: http://www.cdc.gov/ncidod/dbmd/abcs/survreports/spneu01.pdf. Accessed October 24, 2006; ABCs
Report, 2005. Available at: http://www.cdc.gov/ncidod/dbmd/abcs/survreports/spneu05prelim.pdf. Accessed October 24, 2006.
0
50
100
150
200
250
<1 1 2–4 5–17 18–34 35–49 50–64 65+ Total
Age (years)
1998 (N = 17,383,935)
2001 (N = 22,479,308)
2005 (N = 27,419,898)
Casesper100,000
6. Epidemiology of Pneumococcal
Pneumonia (US CDC Data)
Total cases per year
500,000
Hospitalized cases per year
175,000
Case fatality rate
5%–7% (higher in elderly)
Responsible for:
Up to 36% of adult community-acquired pneumonia
Up to 50% of adult hospital-acquired pneumonia
CDC = Centers for Disease Control and Prevention.
Adapted from CDC. Epidemiology & Prevention of Vaccine-Preventable Diseases: The Pink Book. 9th edition; CDC. MMWR.
2005;54(RR-05):1-9.
7. Epidemiology of Pneumococcal
Bacteremia (US CDC Data)
Cases per year
>50,000
Case fatality rate
20% (up to 60% in elderly)
Incidence in patients with pneumococcal
pneumonia
25%–30%
CDC = Centers for Disease Control and Prevention.
Adapted from CDC. Epidemiology & Prevention of Vaccine-Preventable Diseases: The Pink Book. 9th edition.
8. Epidemiology of Pneumococcal
Meningitis (US CDC Data)
Cases per year
3,000–6,000
Case fatality rate
~30% (up to 80% in elderly)
Responsible for 13%–19% of all cases of
bacterial meningitis
CDC = Centers for Disease Control and Prevention.
Adapted from CDC. Epidemiology & Prevention of Vaccine-Preventable Diseases: The Pink Book. 9th edition.
9. Temporal Incidence Patterns of
Invasive Pneumococcal Disease
Pneumococcal infections occur year-round, with seasonal peaks in winter
Monthly Rates of Invasive Pneumococcal Disease in Adults and Children in
Defined Populations in Australia, 2004 (N = 2,375) Based on a Surveillance
Study
Adapted from Roche P, et al. Commun Dis Intell. 2006;30(1):80-92. Used with permission.
Jan Feb Mar Apr May Jun Jul Aug Sept Oct Nov Dec
400
350
300
250
200
150
100
50
0
Notifications
Month
Total Cases
<5 years
≥5 years
10. Incidence of Invasive Pneumococcal
Disease in Viral Season (US CDC
Data)
Viral season
MeanWeeklyFrequency
ofPneumococcalDisease
*P < 0.05; †
P < 0.01.
CDC ABCs = Centers for Disease Control and Prevention Active Bacterial Core Surveillance.
Adapted from Talbot TR, et al. Am J Med. 2005;118(3):285-291. Figure used with permission; McCullers JA. Clin Microbiol Rev. 2006;19(3):571-582.
0
20
15
10
5
25
Early
1995
1995-
1996
1996-
1997
1997-
1998
1998-
1999
1999-
2000
2000-
2001
2001-
2002
Year (July 1–June 30)
†
†
†
†
† †
*
Nonviral season
Viral respiratory infections increase the risk of pneumococcal disease
Surveillance Study Conducted in Tennessee, US by CDC
ABCs; Total Population of Surveillance Area N = 2,283,929
†
12. Populations at Risk of
Pneumococcal Disease
Certain age groups
ie, persons ≥65 years of age and young children
Cigarette smokers
People living in crowded environments
People with chronic diseases
Immunodeficient individuals
Members of certain racial and ethnic groups
ie, African Americans, Alaskan Natives, and American
Indians
Adapted from Whitney CG, et al. Clin Infect Dis. 2001;33:662–675; Ortqvist A, et al. Semin Respir Crit Care Med. 2005;26(6):563-574; Fletcher MA, et
al. Int J Pract. 2006;60(4):450-456; CDC. Epidemiology & Prevention of Vaccine-Preventable Diseases: The Pink Book. 9th edition.
14. Epidemiology of Pneumococcal
Disease In India
CAP = community-acquired pneumonia.
*Pseudomonas species, Enterobacter species, Citrobacter species, Acinetobacter species.
Adapted from Bansal S, et al. Indian I Chest Dis Allied Sci. 2004;46:17-22. Used with permission.
S
pneum
oniae
K
pneum
oniae
S
aureus
M
pneum
oniae
E
coli
B
eta-hem
olytic
streptococci
O
therG
ram
-negative
bacilli*
0
5
10
15
20
25
30
35
40
%ofIsolates
Microbiologic Diagnoses in Patients >15 Years of Age
Presenting With CAP March 2000–February 2001 at an
Academic Hospital in Shimla, India (n = 70)
Based on a Surveillance Study
15. Streptococcus pneumoniae:
The Bacterium
Gram-positive
Polysaccharide
capsule important
virulence factor
>90 known capsular
types
Type-specific
antibody is protective
S pneumoniae and the associated
pneumococcal capsular
polysaccharide
CDC. Epidemiology & Prevention of Vaccine-Preventable Diseases: The Pink
Book. 9th edition; Ho CF, Lin TY. Chang Gung Med J. 2005;28(11):765-772.
Adapted from Jones C. An Acad Bras Cienc. 2005;77(2):293-
324. Epub 2005. Used with permission.
17. Drug Resistance Complicates
Management of Pneumococcal Disease
Multidrug-resistant pneumococci are common
and increasing
Up to 35% of pneumococcal isolates in some areas are
penicillin-resistant
There are multiple consequences of pneumococcal
antibiotic resistance
Treatment failures
The need for expensive alternative antimicrobial agents
Prolonged hospitalization
Increased medical costs
Adapted from Whitney CG, et al. N Engl J Med. 2000;343:1917-1924; Whitney CG, et al. Clin Infect Dis. 2001;33:662–675;
Schrag SJ, et al. Resistant Pneumococcal Infections. WHO, 2001; CDC. MMWR. 1997;46(RR-08):1-24.
18. Factors Associated With
Pneumococcal Antibiotic Resistance
Young age
Setting: day-care centers and hospitals
HIV infection
Certain infective serotypes (6, 9, 14, 19, and 23)
Aspects of community/individual antibiotic use:
Ongoing, recent, repeated, frequent, and/or
prophylactic use
Recent use of trimethoprim-sulfa
Adapted from Kristinsson KG. Microb Drug Resist. 1997;3(2):117-123; Schrag SJ, et al. Resistant Pneumococcal Infections. WHO,
2001.
19. Penicillin Resistance in Asia
ANSORP = Asian Network for Surveillance of Resistant Pathogens; MIC = minimum inhibitory concentrations.
*According to the National Committee for Clinical Laboratory Standards (NCCLS) guidelines for breakpoints.
Adapted from Song JH, et al. Antimicrob Agents Chemother. 2004;48(6):2101-2107.
0
20
40
60
80
100
C
hina
(n
=
111)
Taiw
an
(n
=
57)
K
orea
(n
=
31)
SriLanka
(n
=
42)
Singapore
(n
=
35)
M
alaysia
(n
=
44)
Vietnam
(n
=
64)
Philippines
(n
=
22)
H
ong
K
ong
(n
=
112)
%ofIsolates
Resistant (MIC >2 mg/L) Intermediately resistant (MIC 0.12-1 mg/L)
India
(n
=
77)
SaudiArabia
(n
=
39)
Resistance* to Penicillin of 111 S pneumoniae Isolates in
ANSORP, 2000–2001
21. Organizations That Have Issued
Guidelines for Pneumococcal
Vaccination
World Health Organization (International)
Advisory Committee on Immunization Practices
(US)
American Thoracic Society
Canadian Medical Association
United Kingdom Department of Health
National Health and Medical Research Council
(Australia)
Adapted from World Health Organization. Weekly Epidemiological Record. 2003;78(14):97-120; Centers for Disease Control
and Prevention. MMWR. 1997;46(RR-08):1–24; National Advisory Committee on Immunization. Canadian Immunization
Guide, 2002; United Kingdom Department of Health: The pneumococcal immunisation programme for older people and risk
groups, 2005; National Health and Medical Research Council: The Australian Immunisation Handbook, 8th Edition, 2003.
23. US ACIP* Recommendations for
Pneumococcal Polysaccharide Vaccination:
Overview of Candidates
High-risk patients who have not received prior
immunization or whose prior vaccination status is
unknown
All persons ≥65 years of age
Persons 2–64 years with underlying medical
conditions
Immunocompromised persons >2 years of age
*US ACIP=United States Advisory Committee on Immunization Practices.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
24. US ACIP* Recommendations for Pneumococcal
Polysaccharide Vaccination in Persons >2
Years With Underlying Medical Conditions
Chronic cardiovascular disease
Chronic pulmonary disease
Diabetes mellitus
Alcoholism
Chronic liver disease
Cerebrospinal fluid leaks
Functional or anatomic asplenia
*US ACIP=United States Advisory Committee on Immunization Practices.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
25. US ACIP* Recommendations for Pneumococcal
Polysaccharide Vaccination in
Immunocompromised Persons ≥2 Years of Age
HIV† infection
Leukemia
Hodgkin’s disease
Lymphoma
Multiple myeloma
Generalized malignancy
Chronic renal failure
Nephrotic syndrome
Immunosuppressive chemotherapy/ Organ or bone marrow
transplant
*US ACIP=United States Advisory Committee on Immunization Practices.
†
HIV=human immunodeficiency virus.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
26. US ACIP* Recommendations for
Pneumococcal Polysaccharide
Vaccination if Vaccination Status Is
Unknown
The ACIP recommends administration of the
pneumococcal vaccine for all immunocompromised
persons if prior vaccination status is unknown
*US ACIP=United States Advisory Committee on Immunization Practices.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
27. US ACIP* Recommendations for
Pneumococcal Polysaccharide Revaccination
for Immunocompetent Persons
Group Special Considerations
Persons aged >65 years If patient received vaccine ≥5
years previously and was <65
years of age at time of initial
vaccination, revaccinate
Persons 2–64 years with functional or
anatomic asplenia†
If patient is >10 years of age,
administer single revaccination ≥5
years after previous dose
If patient is <10 years of age,
consider revaccination 3 years
after previous dose
*US ACIP=United States Advisory Committee on Immunization Practices.
†
Including sickle cell disease and splenectomy.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
28. US ACIP* Recommendations for
Pneumococcal Polysaccharide Revaccination
for Immunocompromised Persons
Group Special Considerations
Persons ≥2 years of age with:
HIV infection
Leukemia, lymphoma, Hodgkin’s
disease, multiple myeloma,
generalized malignancy
Chronic renal failure, nephrotic
syndrome
Immunosuppressive
chemotherapy (including long-
term systemic corticosteroids)
Organ or bone marrow
transplantation
Single revaccination ≥5 years
after previous dose
In patients ≤10 years of age:
single revaccination 3 years after
previous dose
*US ACIP=United States Advisory Committee on Immunization Practices.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
29. US ACIP* Recommendations for
Revaccination of Immunocompetent
Persons
Group Special Considerations
Persons aged >65 years If patient received vaccine ≥5
years previously and was <65
years of age at time of initial
vaccination, revaccinate
Persons 2–64 years with functional or
anatomic asplenia†
If patient is >10 years of age,
administer single revaccination ≥5
years after previous dose
If patient is <10 years of age,
consider revaccination 3 years
after previous dose
*US ACIP=United States Advisory Committee on Immunization Practices.
†
Including sickle cell disease and splenectomy.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
30. US ACIP* Recommendations for
Revaccination of
Immunocompromised Persons
Group Special Considerations
Persons ≥2 years of age with:
HIV infection
Leukemia, lymphoma, Hodgkin’s
disease, multiple myeloma,
generalized malignancy
Chronic renal failure, nephrotic
syndrome
Immunosuppressive chemotherapy
(including long-term systemic
corticosteroids)
Organ or bone marrow
transplantation
If ≥5 years have elapsed since
previous dose: single
revaccination
In patients ≤10 years of age:
consider single revaccination 3
years after previous dose
*US ACIP=United States Advisory Committee on Immunization Practices.
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
31. American Thoracic Society-Guidelines
23 Valent pneumococcal polysaccharide
vaccine is recommended for persons >65 yr of
age & for those with selected high-risk
concurrent diseases (strong recommendations;
level II evidence)
Smoking cessation should be a gial for persons
hospitalized with CAP who smoke( Moderate
recommendations, level III evidence)
34. US Pneumococcal Vaccination Rates
According to CDC* vs. Healthy People 2010
Goals
Adult vaccination rates in the US in 2002 and 2003 were
far below Healthy People 2010 goals
* Data for persons >65 years of age from US Behavioral Risk Factor Surveillance System, 2003; data for high-risk persons 18-64 years of age from US
National Health Interview Survey, 2002
**Persons with one or more risk factors for pneumococcal disease
Adapted from Centers for Disease Control and Prevention. Healthy People 2010: Immunization and Infectious Diseases. Available at:
http://www.healthypeople.gov/Document/pdf/Volume1/14Immunization.pdf. Accessed February 12, 2007; CDC MMWR. 2005;54(RR-5):1–13; CDC
MMWR. 2004;53(43):1007–1012.
Healthy People
2010 Goal: 90%
Healthy People
2010 Goal: 60%
19.1
64.2
0
10
20
30
40
50
60
70
80
90
100
Individuals
>65 Years of Age
(2003)
High-Risk Individuals**
18-64 Years of Age
(2002)
%ofadultsvaccinated
36. Protective Efficacy of 6- and 13-Valent
Vaccines in Healthy Young Males*
*Combined results of 3 controlled clinical studies in 12,000 young adult males, mostly from Malawi and Mozambique, who were randomized to receive
pneumococcal vaccine (containing serotypes 1,3,4,7,8, and 12 in Trial 1 and serotypes 1,2, 3, 4, 6, 7, 8, 9, 12,14, 18,19, and 25 in Trials 2 and 3), Group A
meningococcal vaccine, or saline placebo.
Adapted from Austrian R, et al. Trans Assoc Am Phys. 1976;89(7):184-194.
Protective Efficacy Against Pneumococcal Bacteremic Pneumonia
82.3%
78.5%
76
77
78
79
80
81
82
83
3 Trials of 6-Valent or
13-Valent Vaccine
(N=12,000)
2 Trials of 13-Valent
Vaccine
(N=4,500)
%protectiveefficacy
37. Combined Protective Efficacy of 6- and 12-
Valent Vaccines in South African Gold
Miners*
*Two separate controlled clinical studies in 4,694 South African gold miners conducted In the 1970s In which subjects were randomized to receive
pneumococcal vaccine (6-valent in one study and 12-valent in the other), Group A meningococcal vaccine, or placebo
**vs meningococcal vaccine and placebo
Protective Efficacy Against Pneumococcal Pneumonia in 2 Separate Trials:
Pneumococcal Pneumonia Cases ≥14 Days After Vaccination
Protective
Efficacy
76%
p<0.001**
Protective
Efficacy
92%
p<0.004**
Trial of 6-Valent Pneumococcal Vaccine Trial of 12-Valent Pneumococcal Vaccine
9.2
1.8
38.1
15.4
38.6
29
0
5
10
15
20
25
30
35
40
45
Pneumococcus
(n=983)
Meningococcus
(n=1051)
Placebo
(n=985)
Pneumococcus
(n=540)
Meningococcus
(n=585)
Placebo
(n=550)
Rate/1,000patients
38. Protective Efficacy in Prospective Trials
(Meta-Analysis)*
*Meta-analysis of 14 prospective, randomized trials in which the 6-, 12-, 13-, 14-, or 23-valent pneumococcal polysaccharide vaccine was administered to a
total of 48,837 immunocompetent adults.
Note: There was no significance identified in the subgroup of patients >55 years of age, probably due to lack of statistical power.
CI=confidence interval
Adapted from Cornu C, et al. Vaccine. 2001;19(32):4780-4790.
Protective
Efficacy
40%
(CI: 0.60–0.96)
Protective
Efficacy
71%
(CI: 0.2–0.42)
Definite Pneumococcal Pneumonia
(6 Trials)
Presumptive Pneumococcal Pneumonia
(8 Trials)
5.5
22
19
34
0
5
10
15
20
25
30
35
40
Pneumococcal Vaccine
(n=6689)
Control
(n=6441)
Pneumococcal Vaccine
(n=11945)
Control
(n=13714)
rate/1,000patients
39. Timing of Antibody Response
(Seroconversion)
Antibody titers develop by the third week
following vaccination
40. Duration of Protection
Following pneumococcal vaccination, serotype-
specific antibody levels decline after 5–10 years
A more rapid decline in antibody levels may occur in
some groups (eg, children, the elderly)
The results of one epidemiologic study suggest that
vaccination may provide protection for at least
9 years after receipt of the initial dose
42. Indications
PNEUMOVAX ®
23 is indicated for vaccination
against pneumococcal disease caused by those
pneumococcal types included in the vaccine
Effectiveness of the vaccine in the prevention of
pneumococcal pneumonia and pneumococcal
bacteremia has been demonstrated in controlled
trials in South Africa and France and in case-
controlled studies
PNEUMOVAX® 23 is a registered trademark of Merck & Co., Inc. Whitehouse Station, NJ, USA
43. Indications for Immunocompetent
Persons
Vaccination with PNEUMOVAX ®
23 is recommended
for selected immunocompetent individuals as follows:
Routine vaccination for persons aged ≥50 years
Persons aged ≥2 years with chronic cardiovascular
disease, chronic pulmonary disease, diabetes mellitus,
alcoholism, chronic liver disease, cerebrospinal fluid
leaks, functional asplenia, or anatomic asplenia
Persons aged ≥2 years living in special environments or
social settings
44. Indications for Immunocompromised
Persons
Vaccination with PNEUMOVAX ®
23 is recommended
for selected immunocompromised persons aged ≥2
years as follows:
Persons with HIV infection, leukemia, lymphoma,
Hodgkin’s disease, multiple myeloma, generalized
malignancy, chronic renal failure, nephrotic syndrome
Persons receiving immunosuppressive chemotherapy
(including corticosteroids)
Persons who have received an organ or bone marrow
transplant
45. Contraindications
PNEUMOVAX ®
23 is contraindicated in
individuals who are hypersensitive to any
component of the vaccine
Epinephrine injection (1:1000) must be available
immediately should an acute anaphylactoid
reaction occur due to any component of the
vaccine
47. Precautions—General
If PNEUMOVAX ®
23 is used in persons receiving
immunosuppressive therapy, the expected serum antibody response
may not be obtained and potential impairment of future immune
responses to pneumococcal antigens may occur
Intradermal administration may cause severe local reactions
Caution and appropriate care should be exercised in administering
PNEUMOVAX ®
23 to individuals with severely compromised
cardiovascular and/or pulmonary function in whom a systemic
reaction would pose a significant risk
Any febrile respiratory illness or other active infection is reason for
delaying use of PNEUMOVAX ®
23, except when, in the opinion of the
physician, withholding the agent entails even greater risk
In patients who require penicillin (or other antibiotic) prophylaxis
against pneumococcal infection, such prophylaxis should not be
discontinued after vaccination with PNEUMOVAX ®
23
48. Precautions—Special
Populations
Pregnant Women Nursing Mothers
Children
<2 years of age
• It is not known
whether
PNEUMOVAX ®
23
can cause fetal harm
or can affect
reproduction capacity
when administered to
a pregnant woman
• PNEUMOVAX ®
23
should be given to
pregnant women only
if clearly needed
• It is not known
whether
PNEUMOVAX ®
23 is
excreted in human
milk
• Caution should be
exercised when
PNEUMOVAX ®
23 is
administered to a
nursing mother
• PNEUMOVAX ®
23 is
not recommended in
this age group
49. Adverse Reactions
In clinical trials and/or postmarketing experience
with PNEUMOVAX ®
23, the following adverse
experiences were reported:
Injection-site reactions (including soreness,
erythema, warmth, swelling, local induration,
decreased limb mobility, and peripheral edema in
the injected extremity), fever (≤38.8º C/102º F), and
increases in lab values for C-reactive protein
Cellulitis-like reactions (very rare)
50. Dosage and Administration
Inspect product visually for particulate matter and discoloration prior
to administration. PNEUMOVAX ®
23 is a clear, colorless solution
Withdraw 0.5 mL from the vial using a sterile needle and syringe free
of preservatives, antiseptics, and detergents
Administer a single 0.5 mL dose of PNEUMOVAX ®
23
subcutaneously or intramuscularly (preferably in the deltoid muscle or
lateral mid-thigh), with appropriate precautions to avoid intravascular
administration
Use a separate sterile syringe and needle for each individual patient
to prevent transmission of infectious agents from one person to
another
Store unopened and opened vials at 2°–8° C/35.6°–46.4° F. Use the
vaccine directly as supplied, without dilution or reconstitution. Phenol
0.25% is added as a preservative. Discard all vaccine after the
expiration date
51. Vaccine Schedule for Special
Populations
Pneumococcal vaccine should be given at least 2 weeks
before elective splenectomy, if possible
For patients planning cancer chemotherapy or other
immunosuppressive therapy, the interval between
vaccination and initiation of immunosuppressive therapy
should be at least 2 weeks
Vaccination during chemotherapy or radiation therapy
should be avoided
Pneumococcal vaccine may be given several months
following completion of chemotherapy or radiation therapy
for neoplastic disease
52. Vaccine Schedule for Special
Populations, continued
In patients with Hodgkin’s disease, immune response to
vaccination may be suboptimal for 2 years or longer after
intensive chemotherapy (with or without radiation)
For some patients, during the 2 years following the completion
of chemotherapy or other immunosuppressive therapy (with or
without radiation), significant improvement in antibody
response has been observed, particularly as the interval
between the end of treatment and pneumococcal vaccination
increased
Persons with asymptomatic or symptomatic HIV infection
should be vaccinated as soon as possible after their diagnosis
is confirmed
53. Use With Other Vaccines
The ACIP recommends that pneumococcal vaccine be
administered at the same time as influenza vaccine
Concomitant administration of the pneumococcal and
influenza vaccines does not increase side effects or
decrease the antibody response to either vaccine
Influenza vaccine is recommended annually for
appropriate populations
Pneumococcal vaccine is not given annually
ACIP=Advisory Committee on Immunization Practices
Adapted from CDC. MMWR. 1997;46(RR-08):1–24.
Pneumococcal infections are a major cause of morbidity and mortality worldwide.1
The most common pneumococcal infections are the least serious; that is, sinusitis, bronchitis, and otitis media are more common but less serious than pneumonia, bacteremia, and meningitis.1
The pathogen that causes pneumococcal infections, Streptococcus pneumoniae, is the most common identifiable cause of bacterial pneumonia and a leading cause of otitis media.2
Annually, pneumococcal infections cause more than 1 million deaths worldwide. While most of these deaths occur in developing countries, invasive pneumococcal disease carries high mortality in certain population groups (ie, elderly people, especially those living in institutions, and patients with chronic organ failure, diabetes, nephrotic syndrome, and immunodeficiencies) even in developed countries.1
Despite the importance of pneumococcal disease, information on disease burden is scarce in developing countries,1 particularly in adults.
Pneumococcal disease is a major cause of death worldwide.1
Using official mortality rates compiled by the World Health Organization (WHO) in 2003, the Global Alliance for Vaccines & Immunization (GAVI) determined that pneumococcal disease was the leading cause of death in all age groups analyzed.1
~700,000 deaths in persons younger than 5 years of age
~900,000 deaths in persons 5 years of age and older
~1.6 million deaths in both age groups combined
US data collected by Active Bacterial Core Surveillance between 1998 and 2005 in defined populations in 8 states showed progressive declines in the rates of invasive pneumococcal disease in each age group in the years 2001 and 2005.1-3
These data correspond with the documented increase in the rate of pneumococcal vaccination among persons 65 years of age and older between 1998 and 2002.4
Pneumococcal pneumonia is one of the major clinical syndromes of pneumococcal disease.1
According to the CDC, approximately 500,000 cases of pneumococcal pneumonia are estimated to occur annually in the US,2 resulting in approximately 175,000 hospitalizations.1
The case-fatality rate is approximately 5%–7% and may be much higher in the elderly.1
Pneumococci are responsible for up to 36% of cases of community-acquired pneumonia and up to 50% of cases of hospital-acquired pneumonia in adults.1
Bacteremia is one of the major clinical syndromes of pneumococcal disease.1
According to the CDC, over 50,000 cases of pneumococcal bacteremia are estimated to occur annually in the US.1
The case-fatality rate is approximately 20% and may be up to 60% in the elderly.1
Bacteremia is a common sequelae of pneumococcal pneumonia, occurring in approximately 25%–30% of patients with pneumococcal pneumonia.1
Meningitis is one of the major clinical syndromes of pneumococcal disease.1
According to the CDC, approximately 3,000–6,000 cases of pneumococcal meningitis are estimated to occur annually in the US.1
The case-fatality rate is approximately 30% and may be as high as 80% in the elderly.1
Pneumococci are responsible for 13%–19% of all cases of bacterial meningitis.1
An analysis of data collected by the National Notifiable Diseases Surveillance System in Australia examined the incidence of invasive pneumococcal disease among children younger than 5 years in Australian Capital Territory, New South Wales, Queensland, South Australia, and Victoria; adults older than 50 years in New South Wales; adults older than 64 years in South Australia and Victoria; and all ages in Northern Territory, North Queensland, Tasmania, and Western Australia during a 1-year period in 2004.1
During the study period, there were 2,375 notifications of invasive pneumococcal disease.1
As shown on the slide, pneumococcal infections occurred year-round, with a seasonal peak in the winter months (July, August, and September).1
The incidence of invasive pneumococcal infections follows a distinct seasonal pattern that coincides with the incidence of influenza and respiratory syncytial virus (RSV), indicating that viral respiratory infections increase the risk of pneumococcal disease.1,2
As shown on the slide, a 7-year surveillance study among residents of 5 urban counties in Tennessee, US (N = 2,283,929) by the CDC ABC Surveillance program showed that the mean weekly frequency of invasive pneumococcal disease was significantly higher during the winter virus seasons (when influenza and RSV circulated concurrently) than in the nonviral seasons each year from 1995 to 2002 (P &lt; 0.05 for early 1995; P &lt; 0.01 for all other years).1
An epidemiology study conducted in Sweden from January 1994 to March 2004 attributed up to 20% of cases of invasive pneumococcal disease to prior influenza infection.2
The weight of clinical and pathological evidence indicates that virus-induced changes in the respiratory tract prime the upper airways and lungs for subsequent bacterial infection.3
Damage to the epithelial layer exposes extracellular matrix molecules and basement membrane elements to bacterial adhesion.
Changes in eustachian tube or pulmonary function may promote bacterial superinfections.
Changes in bacterial receptors may allow access of bacteria to normally sterile sites.
Several population groups have been identified as being at high risk for pneumococcal disease. These include:
Certain age groups (ie, persons ≥65 years of age, and young children)1,2
Cigarette smokers1
People living in crowded environments, such as long-term care facilities, correctional facilities, and military barracks1,3,4
People with chronic diseases, such as alcoholism, congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and end-stage renal disease1,5
Immunosuppressed individuals, such as people with HIV/AIDS or asplenia2
Members of certain racial and ethnic groups (ie, African Americans, Alaskan Natives, and American Indians)1
A study was conducted to determine the clinical profile and etiology of community-acquired pneumonia among patients older than 15 years of age presenting to the outpatient department of an academic hospital in Shimla, a northwestern Himalayan region of India.1
The study population consisted of 70 patients age 17 to 93 years (mean age, 52.77 years).1
In this study, S pneumoniae was the most common cause of community-acquired pneumonia in this patient population, identified in 35.8% of isolates.1
Streptococcus pneumoniae is a gram-positive, lancet-shaped, facultative anaerobic bacterium.1
Some pneumococci are encapsulated, with a surface composed of complex polysaccharides, labeled as “6” on the slide. These encapsulated organisms are pathogenic; the polysaccharide capsules are antigenic and form the basis for classifying pneumococci by serotype.1
To date, more than 90 known serotypes have been identified, based on their reaction to type-specific antisera.1
Type-specific antibodies provide protection against the capsular polysaccharide by interacting with complement to opsonize pneumococci, which helps to facilitate phagocytosis and clearance of the organism.1
Multicenter surveillance projects have revealed that multidrug-resistant pneumococci are common and increasing.1-3
In fact, up to 35% of pneumococcal isolates in some areas are penicillin-resistant.1
The consequences of pneumococcal antibiotic resistance are manifold.
Treatment failures
Worldwide, pneumococcal resistance represents the principal cause of treatment failures for acute respiratory infections and meningitis.4
The need for expensive alternative antimicrobial agents5
Prolonged hospitalization5
Increased medical costs5
Antibiotic resistance to pneumococci is spread primarily via clonal amplification rather than repeated de novo generation.1
Several factors are associated with the development and spread of pneumococcal resistance, including:
Young age2
Certain settings: day-care centers and hospitals2
HIV infection2
Certain infective serotypes (ie, 6, 9, 14, 19, and 23)1
Patterns of antibiotic use in the community or individual level of use (ie, ongoing, recent, repeated, frequent, and/or prophylactic use, and the recent use of trimethoprim-sulfa)1,2
Of all of these factors, antibiotic use is the major driving force.2
Several organizations worldwide have issued guidelines for pneumococcal vaccination, including:
The World Health Organization (WHO)1
The Advisory Committee on Immunization Practices in the US2
The National Advisory Committee on Immunization of the Canadian Medical Association3
The United Kingdom Department of Health4
The National Health and Medical Research Council in Australia5
The United States Advisory Committee on Immunization Practices (ACIP) has issued recommendations for pneumococcal polysaccharide vaccination among certain high-risk groups.1 These recommendations have been endorsed by the American Academy of Family Physicians, the American College of Physicians, the American Academy of Pediatrics, the Canadian Task Force on the Periodic Health Examination, and the US Preventive Services Task Force.2
The ACIP recommends administration of the pneumococcal polysaccharide vaccine for the patients in the following high-risk groups who have not received prior immunization or whose prior vaccination status is unknown:
All immunocompetent persons ≥65 years of age
Persons 2-64 years with underlying medical conditions (discussed in the next few slides)
Immunocompromised persons ≥2 years of age
The ACIP recommends pneumococcal polysaccharide vaccination of individuals 2-64 years of age with underlying medical conditions, including chronic cardiovascular disease (including congestive heart failure and cardiomyopathies), chronic pulmonary disease (including chronic obstructive pulmonary disease and emphysema), diabetes mellitus, alcoholism, chronic liver disease (including cirrhosis), cerebrospinal fluid leaks, and functional or anatomic asplenia (including sickle cell disease and splenectomy).1
The ACIP recommends immunization with the pneumococcal polysaccharide vaccine for immunocompromised people ≥2 years of age, including those with HIV infection, leukemia, lymphoma, Hodgkin’s disease, multiple myeloma, generalized malignancy, chronic renal failure, nephrotic syndrome, those receiving immunosuppressive chemotherapy (including corticosteroids), and those who have received an organ or bone marrow transplant.1
This group of patients should receive pneumococcal vaccine if earlier vaccination status is unknown.1
The ACIP recommends administration of the pneumococcal polysaccharide vaccine for all immunocompromised persons.1
Providing an immunization card can help establish a record of your patients’ vaccination status.
The ACIP recommends revaccination with the pneumococcal polysaccharide vaccine for immunocompetent persons in two special groups.
Revaccination is recommended for persons 65 years of age and older if the patient received the initial vaccine 5 or more years previously and was younger than 65 years of age at the time of initial vaccination.1
Revaccination is recommended for persons 2-64 years of age with functional or anatomic asplenia (including sickle cell disease and splenectomy).
If the patient is older than 10 years of age, revaccination should be considered 5 years after the previous dose.
If the patient is 10 years of age or younger, a single revaccination is recommended 3 or more years after the previous dose.
The ACIP recommends pneumococcal polysaccharide revaccination of immunocompromised patients 2 years of age and older, including those with:1
HIV infection
Leukemia, lymphoma, Hodgkin’s disease, multiple myeloma, generalized malignancy
Chronic renal failure, nephrotic syndrome
Immunosuppressive chemotherapy (including long-term systemic corticosteroids)
Organ or bone marrow transplantation
If 5 or more years have elapsed since the first dose was administered, single revaccination is recommended.
If the patient is 10 years of age or younger, revaccination should be considered 3 years after the previous dose.1
The ACIP recommends revaccination with the pneumococcal polysaccharide vaccine for immunocompetent persons in two special groups.
Revaccination is recommended for persons 65 years of age and older if the patient received the initial vaccine 5 or more years previously and was younger than 65 years of age at the time of initial vaccination.1
Revaccination is recommended for persons 2-64 years of age with functional or anatomic asplenia (including sickle cell disease and splenectomy).
If the patient is older than ten years of age, a single revaccination is recommended 5 or more years after the previous dose.
If the patient is 10 years of age or younger, revaccination should be considered 3 years after the previous dose.
The ACIP recommends pneumococcal polysaccharide revaccination of immunocompromised patients 2 years of age and older, including those with:1
HIV infection
Leukemia, lymphoma, Hodgkin’s disease, multiple myeloma, generalized malignancy
Chronic renal failure, nephrotic syndrome
Immunosuppressive chemotherapy (including long-term systemic corticosteroids)
Organ or bone marrow transplantation
If 5 or more years have elapsed since the first dose was administered, single revaccination is recommended.
If the patient is 10 years of age or younger, revaccination should be considered 3 years after the previous dose.1
Level 1 (High): Evidence from well conducted, randomized controlled trails
Level 2 (Moderate): Evidence from well designed controlled trails without randomization including any large case series in which systemic analysis of disease patterns was conducted.
Level 3 (Low): Evidence from case studies and expert opinion.
&quot;Healthy People“ is an initiative founded under the auspices of the US Centers for Disease Control and Prevention whose overall purpose is to prevent disease, disability, and death from infectious diseases, including vaccine-preventable diseases. The Healthy People goals for vaccination against pneumococcal disease are to achieve 90% vaccination rates among adults older than 65 years of age and 60% among high-risk adults (that is, people with heart disease, diabetes, and/or chronic respiratory disease, or people living in institutional settings) 18 to 64 years of age by the year 2010.1
Data from the US Behavioral Risk Factor Surveillance System showed that in 2003, 64.2% of adults older than 65 years of age had received pneumococcal polysaccharide vaccination.2 Data from the US National Health Interview Survey showed that in 2002, 19.1% of high-risk (with one or more risk factors for pneumococcal disease) adults 18 to 64 years of age had been vaccinated.3
These rates were far below the Healthy People 2010 goals.1
In the 1970s, trials were conducted of vaccines containing 6, 12, or 13 capsular polysaccharides.1,2
Three controlled clinical trials of 6- and 13-valent pneumococcal vaccines were conducted in 12,000 healthy, young adult males, mostly from Malawi and Mozambique, where pneumonia was epidemic.1
Subjects were randomized to receive pneumococcal vaccine (containing serotypes 1, 3, 4, 7, 8, and 12 in Trial 1 and serotypes 1, 2, 3, 4, 6, 7, 8, 9, 12, 14, 18,19, and 25 in Trials 2 and 3), Group A meningococcal vaccine, or saline placebo.1
The combined protective efficacy of the 6-valent and 13-valent vaccine against pneumococcal bacteremic pneumonia from all three trials was 82.3%.1
The combined protective efficacy of the 13-valent vaccine from Trials 2 and 3 was 78.5%.1
In the 1970s, the protective efficacy of 6- and 12-valent pneumococcal capsular polysaccharide vaccines was evaluated in two separate controlled clinical studies in a total of 4,694 South African gold miners.1
In one trial, the 6-valent pneumococcal vaccine was administered to 983 subjects, the Group A meningococcal vaccine was administered for 1,051 subjects, and placebo was administered to 985 subjects.1
In the other trial, the 12-valent pneumococcal vaccine was administered to 540 subjects, the Group A meningococcal vaccine was administered for 585 subjects, and placebo was administered to 550 subjects.1
The incidence of pneumococcal pneumonia was significantly reduced by both the 12-valent vaccine (protective efficacy, 92%; P&lt;0.004) and the 6-valent vaccine (protective efficacy, 76%; P&lt;0.001) versus the combined comparator groups.1
A meta-analysis examined the results of 14 prospective, randomized trials in which the 6-, 12-, 13-, 14-, or 23-valent pneumococcal polysaccharide vaccine was administered to a total of 48,837 immunocompetent adults.1
In 6 trials in which 6683 patients received the pneumococcal vaccine and 6441 patients received placebo, the pneumococcal polysaccharide vaccine significantly (based on confidence intervals [CIs]) reduced the incidence of definite pneumococcal pneumonia (clinically and radiographically confirmed pneumonia with Streptococcus pneumoniae isolated from a culture of blood or any other usual sterile fluid) by 71% (CI, 0.2–0.42).1
In 8 trials in which 11,945 patients received the pneumococcal vaccine and 13,714 patients received placebo, the pneumococcal polysaccharide vaccine significantly (based on CIs) reduced the incidence of presumptive pneumococcal pneumonia by 40% (CI 0.37–0.96).1
Subgroup analysis of patients older than 55 years of age showed no significant protective effects, mainly because of low statistical power due to the low number of events for each endpoint.1
Protective capsular type-specific antibody levels generally develop by the third week following vaccination.
Following pneumococcal vaccination, serotype-specific antibody levels decline after 5–10 years.
A more rapid decline in antibody levels may occur in some groups (eg, children, the elderly).
The results of one epidemiologic study suggest that vaccination may provide protection for at least 9 years after receipt of the initial dose.
PNEUMOVAX® 23(pneumococcal vaccine, polyvalent, MSD) is indicated for vaccination against pneumococcal disease caused by those pneumococcal types included in the vaccine.
Effectiveness of the vaccine in the prevention of pneumococcal pneumonia and pneumococcal bacteremia has been demonstrated in controlled trials in South Africa and France and in case-controlled studies.
Vaccination with PNEUMOVAX® 23(pneumococcal vaccine, polyvalent, MSD) is recommended for selected immunocompetent individuals as follows:
Routine vaccination for persons ≥50 years of age
Persons aged ≥2 years with chronic cardiovascular disease, chronic pulmonary disease, diabetes mellitus, alcoholism, chronic liver disease, cerebrospinal fluid leaks, functional asplenia, or anatomic asplenia
Persons aged ≥2 years living in special environments or social settings (including Alaskan Natives and certain American Indian populations)
Vaccination with PNEUMOVAX® 23 (pneumococcal vaccine, polyvalent, MSD) is recommended for selected immunocompromised persons aged &gt;2 years as follows:
Persons with HIV infection, leukemia, lymphoma, Hodgkin’s disease, multiple myeloma, generalized malignancy, chronic renal failure, nephrotic syndrome
Persons receiving immunosuppressive chemotherapy (including corticosteroids)
Persons who have received an organ or bone marrow transplant
PNEUMOVAX® 23(pneumococcal vaccine, polyvalent, MSD) is contraindicated in individuals who are hypersensitive to any component of the vaccine.
Epinephrine injection (1:1000) must be available immediately should an acute anaphylactoid reaction occur due to any component of the vaccine.
If PNEUMOVAX® 23 (pneumococcal vaccine, polyvalent, MSD) is used in persons receiving immunosuppressive therapy, the expected serum antibody response may not be obtained and potential impairment of future immune responses to pneumococcal antigens may occur.
Intradermal administration may cause severe local reactions.
Caution and appropriate care should be exercised in administering PNEUMOVAX 23 to individuals with severely compromised cardiovascular and/or pulmonary function in whom a systemic reaction would pose a significant risk.
Any febrile respiratory illness or other active infection is reasons for delaying use of PNEUMOVAX 23, except when, in the opinion of the physician, withholding the agent entails even greater risk.
In patients who require penicillin (or other antibiotic) prophylaxis against pneumococcal infection, such prophylaxis should not be discontinued after vaccination with PNEUMOVAX 23.
Pregnant Women
It is not known whether PNEUMOVAX® 23 (pneumococcal vaccine, polyvalent, MSD) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity
PNEUMOVAX 23 should be given to pregnant women only if clearly needed
Nursing Mothers
It is not known whether PNEUMOVAX 23 is excreted in human milk
Caution should be exercised when PNEUMOVAX 23 is administered to a nursing mother
Children &lt;2 years of age
PNEUMOVAX 23 is not recommended in this age group
In clinical trials and/or postmarketing experience with PNEUMOVAX® 23 (pneumococcal vaccine, polyvalent, MSD) , the following adverse experiences were reported: injection site reactions (including soreness, erythema, warmth, swelling, local induration, decreased limb mobility, and peripheral edema in the injected extremity), fever (≤38.8º C/102º F), increases in lab values for C-reactive protein, and very rarely, cellulitis-like reactions.
Other adverse experiences reported in clinical trials and/or post-marketing experience included:
Asthenia
Fever
Chills
Malaise
Nausea
Vomiting
Lymphadenitis
Lymphadenopathy
Thrombocytopenia*
Hemolytic anemia†
Anaphylactoid reactions
Serum sickness
Angioneurotic edema
Arthralgia
Arthritis
Myalgia
Headache
Paresthesia
Radiculoneuropathy
Guillain-Barré Syndrome
Rash
Urticaria
*In patients with stabilized idiopathic thrombocytopenic purpura
†In patients who had had other hematologic disorders
Inspect product visually for particulate matter and discoloration prior to administration. PNEUMOVAX® 23 (pneumococcal vaccine, polyvalent, MSD) is a clear, colorless solution.
Withdraw 0.5 mL from the vial using a sterile needle and syringe free of preservatives, antiseptics, and detergents.
Administer a single 0.5 mL dose of PNEUMOVAX 23 subcutaneously or intramuscularly (preferably in the deltoid muscle or lateral mid-thigh), with appropriate precautions to avoid intravascular administration.
Use a separate sterile syringe and needle for each individual patient to prevent transmission of infectious agents from one person to another.
Store unopened and opened vials at 2–8° C/35.6–46.4° F. Use the vaccine directly as supplied, without dilution or reconstitution. Phenol 0.25% is added as a preservative. Discard all vaccine after the expiration date.
Do not inject PNEUMOVAX 23 intravenously or intradermally.
Pneumococcal vaccine should be given at least 2 weeks before elective splenectomy, if possible.
For patients planning cancer chemotherapy or other immunosuppressive therapy, the interval between vaccination and initiation of immunosuppressive therapy should be at least 2 weeks.
Vaccination during chemotherapy or radiation therapy should be avoided.
Pneumococcal vaccine may be given several months following completion of chemotherapy or radiation therapy for neoplastic disease.
In patients with Hodgkin’s disease, immune response to vaccination may be suboptimal for two years or longer after intensive chemotherapy (with or without radiation).
For some patients, during the two years following the completion of chemotherapy or other immunosuppressive therapy (with or without radiation), significant improvement in antibody response has been observed, particularly as the interval between the end of treatment and pneumococcal vaccination increased.
Persons with asymptomatic or symptomatic HIV infection should be vaccinated as soon as possible after their diagnosis is confirmed.
The ACIP recommends that pneumococcal vaccine be administered at the same time as influenza vaccine.1
Concomitant administration of the pneumococcal and influenza vaccines does not increase side effects or decrease the antibody response to either vaccine.1
Influenza vaccine is recommended annually for appropriate populations.
Pneumococcal vaccine is not given annually.