Detecting, analysing and interpreting diagnostic devicesWalt Whitman
Novarum DX provides smartphone-based readers and image analysis technology that can interpret various diagnostic tests performed outside clinical laboratories. Their technology supports monitoring of chronic/autoimmune diseases and infectious disease testing. They have CE marked products for inflammatory bowel disease in Europe and Canada, and expect FDA approval in the US. Their technology prevents errors and ensures accurate results by guiding users through sample preparation and incubation times. It allows decentralized healthcare by enabling at-home testing and sharing results securely online.
The Food and Drug Administration (FDA) released Clinical Trial Imaging Endpoint Process Standards guidance for clinical trials industry. Why? To standardize. To automate. To move closer to zero-delay clinical trials. Read AG Mednet's perspective on this FDA guidance.
The document discusses the Implantable Miniature Telescope (IMT), an FDA approved implant for patients over 75 with macular degeneration. The IMT requires patients to undergo training and show a five letter improvement on an eye chart with an external telescope. The FDA created detailed labeling and agreements patients must complete acknowledging risks. While the IMT has potential to improve vision, there are risks like corneal endothelial cell loss and some patients required explantation. Patients undergo a 3 month rehabilitation program after the 35 minute surgery.
The De-Identification of a Large Electronic Medical Records Database for Seco...Luk Arbuckle
Over the last decade Canada has seen extensive reforms, investments, and innovations in primary health care. The Canadian Working Group for Primary Healthcare Improvement recommended that performance reporting be a strategic priority in moving towards transforming the primary health care system. To enable scalable and sustainable performance measurement and reporting, automated data collection from electronic medical records (EMR) will be necessary. EMR data can also play an important role in adverse drug event detection and public health surveillance.
Paul Coplan, VP, Johnson & Johnson_mHealth IsraelLevi Shapiro
Pesentation, October 19th, 2021: What’s Next in RWE for Medical Devices: The Art of the Possible. Presented by Paul Coplan, ScD, MBA, FISPE, Vice President, Med Device Epidemiology and RWD Sciences, Johnson & Johnson; Adjunct Professor, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Perelman School of Medicine; Fellow of the International Society of Pharmacoepidemiology
- Why RWE is Important for Medical Devices: Challenges with Clinical Trials of Medical Devices (Blinding, Surgeon skill/technique, Hospital process, Product modifications, Long term Follow up, Enrolment challenges)
- Types of Real-World Data Sources (Complaints like MAUDE, Eudramed and Company Databases, Hospital Databases, Electronic Health Records, Claims, Registries, Patient surveys, Surgeon surveys, PROs, Patient Preferences, wearables, sensors, social media, Surgical videos, device generated data, radiographic images)
- FDA CDRH Report on RWE Examples for Regulatory Decisions
- J&J Med Device Epidemiology & Real-World Data Sciences
- US National Evaluation System for Health Technology (NEST)
- RWE for Safety Assessments: Cobalt in Implants and at Work and Risk of Cancer
- Summary of Cobalt Exposure and All-Site Cancer Risk, by Study Type
- Comparative Effectiveness Studies Using RWE
- Summary
a. Use of RWE is important to benefit patients globally and enhance the safety and innovation of medical devices
b. Regulators are interested in using RWE for regulatory decisions but data quality and evidence needs to be regulatory grade
c. NEST has been a useful forum to advance the use of RWE for regulatory decisions in the US
d. RWE can be used for safety assessments, regulatory decisions, comparative effectiveness research, and R&D of products
This document discusses the rising costs of medical imaging and strategies to reduce costs. It notes that diagnostic imaging is the fastest growing component of healthcare costs, with up to a third of procedures being inappropriate. Digital imaging technologies can reduce costs compared to conventional methods when accounting for long-term costs. However, overuse of imaging from increased physician requests and patient demands contributes to higher costs. Promoting the appropriate use of diagnostic imaging through guidelines and reducing unnecessary procedures can help lower costs while maintaining quality of care.
The document discusses the IRIS Registry, the nation's first comprehensive eye disease clinical database created by the American Academy of Ophthalmology. The IRIS Registry collects data directly from electronic health records to improve care delivery, meet federal reporting requirements, advance medical research, and provide physicians with analytics on their performance. It has integrated with 39 EHR systems and collected data on over 60 million patient visits. The registry contains valuable clinical data that can be used for research studies, clinical trials, and monitoring treatment outcomes and patterns of care.
Detecting, analysing and interpreting diagnostic devicesWalt Whitman
Novarum DX provides smartphone-based readers and image analysis technology that can interpret various diagnostic tests performed outside clinical laboratories. Their technology supports monitoring of chronic/autoimmune diseases and infectious disease testing. They have CE marked products for inflammatory bowel disease in Europe and Canada, and expect FDA approval in the US. Their technology prevents errors and ensures accurate results by guiding users through sample preparation and incubation times. It allows decentralized healthcare by enabling at-home testing and sharing results securely online.
The Food and Drug Administration (FDA) released Clinical Trial Imaging Endpoint Process Standards guidance for clinical trials industry. Why? To standardize. To automate. To move closer to zero-delay clinical trials. Read AG Mednet's perspective on this FDA guidance.
The document discusses the Implantable Miniature Telescope (IMT), an FDA approved implant for patients over 75 with macular degeneration. The IMT requires patients to undergo training and show a five letter improvement on an eye chart with an external telescope. The FDA created detailed labeling and agreements patients must complete acknowledging risks. While the IMT has potential to improve vision, there are risks like corneal endothelial cell loss and some patients required explantation. Patients undergo a 3 month rehabilitation program after the 35 minute surgery.
The De-Identification of a Large Electronic Medical Records Database for Seco...Luk Arbuckle
Over the last decade Canada has seen extensive reforms, investments, and innovations in primary health care. The Canadian Working Group for Primary Healthcare Improvement recommended that performance reporting be a strategic priority in moving towards transforming the primary health care system. To enable scalable and sustainable performance measurement and reporting, automated data collection from electronic medical records (EMR) will be necessary. EMR data can also play an important role in adverse drug event detection and public health surveillance.
Paul Coplan, VP, Johnson & Johnson_mHealth IsraelLevi Shapiro
Pesentation, October 19th, 2021: What’s Next in RWE for Medical Devices: The Art of the Possible. Presented by Paul Coplan, ScD, MBA, FISPE, Vice President, Med Device Epidemiology and RWD Sciences, Johnson & Johnson; Adjunct Professor, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Perelman School of Medicine; Fellow of the International Society of Pharmacoepidemiology
- Why RWE is Important for Medical Devices: Challenges with Clinical Trials of Medical Devices (Blinding, Surgeon skill/technique, Hospital process, Product modifications, Long term Follow up, Enrolment challenges)
- Types of Real-World Data Sources (Complaints like MAUDE, Eudramed and Company Databases, Hospital Databases, Electronic Health Records, Claims, Registries, Patient surveys, Surgeon surveys, PROs, Patient Preferences, wearables, sensors, social media, Surgical videos, device generated data, radiographic images)
- FDA CDRH Report on RWE Examples for Regulatory Decisions
- J&J Med Device Epidemiology & Real-World Data Sciences
- US National Evaluation System for Health Technology (NEST)
- RWE for Safety Assessments: Cobalt in Implants and at Work and Risk of Cancer
- Summary of Cobalt Exposure and All-Site Cancer Risk, by Study Type
- Comparative Effectiveness Studies Using RWE
- Summary
a. Use of RWE is important to benefit patients globally and enhance the safety and innovation of medical devices
b. Regulators are interested in using RWE for regulatory decisions but data quality and evidence needs to be regulatory grade
c. NEST has been a useful forum to advance the use of RWE for regulatory decisions in the US
d. RWE can be used for safety assessments, regulatory decisions, comparative effectiveness research, and R&D of products
This document discusses the rising costs of medical imaging and strategies to reduce costs. It notes that diagnostic imaging is the fastest growing component of healthcare costs, with up to a third of procedures being inappropriate. Digital imaging technologies can reduce costs compared to conventional methods when accounting for long-term costs. However, overuse of imaging from increased physician requests and patient demands contributes to higher costs. Promoting the appropriate use of diagnostic imaging through guidelines and reducing unnecessary procedures can help lower costs while maintaining quality of care.
The document discusses the IRIS Registry, the nation's first comprehensive eye disease clinical database created by the American Academy of Ophthalmology. The IRIS Registry collects data directly from electronic health records to improve care delivery, meet federal reporting requirements, advance medical research, and provide physicians with analytics on their performance. It has integrated with 39 EHR systems and collected data on over 60 million patient visits. The registry contains valuable clinical data that can be used for research studies, clinical trials, and monitoring treatment outcomes and patterns of care.
Posterior Segment Company Showcase - AGTCHealthegy
Posterior Segment Company Showcase - AGTC at OIS@AAO 2016.
Presenter:
Sue Washer, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
This document discusses the regulatory pathway for MIGS devices in the United States. It outlines how the requirements for MIGS device approval through the PMA process have evolved over time based on learnings from early studies. Specifically, it notes that sample sizes, follow-up periods, clinical endpoints, and trial methodology have all increased in rigor. This includes moving primary endpoints from 12 to 24 months, requiring terminal washout periods, and measuring diurnal intraocular pressure. The document emphasizes that achieving level 1 clinical evidence for approval requires significant effort and collaboration between industry and the FDA over many years.
Acr mr equipment evaluation summary form and safety checklist with hilights★Jordi Rius Bonjorn
This document is an MRI safety checklist that assesses whether a site has written policies addressing 19 safety items related to screening patients and personnel, designating equipment safety status, access restrictions, training, and incident reporting. It also checks if 3 additional criteria from the American College of Radiology are met. An evaluator reviews the policies and documentation, and determines an overall pass/fail assessment of the site's MRI safety program.
This document discusses various aspects of genomic sequencing and its clinical translation process. It describes how sequencing output is analyzed through IT processing and human expertise to identify putative mutations and their potential functions and clinical effects. It also discusses challenges around genome assembly, computational analysis, and integrating genetic information with a person's medical condition and protein function through a user-friendly interface. Several diagrams and figures are also included to illustrate the flow of data to information to knowledge in clinical genomics.
Protek Healthcare provides healthcare IT solutions including PACS/RIS systems, hospital information systems, and teleradiology services. They focus on research and development to create user-friendly, multi-platform medical software. Their teleradiology service allows clients to access radiology reports within 24 hours through an online platform and experienced radiologists. Protek also offers NAPHIS and NAPPACS, which are patient management and PACS solutions to streamline processes like registration, viewing patient history, and generating reports.
Making clinical AI and decision support a reality through adaptive user inter...Alcidion Corporation
The document discusses the need for adaptive user interfaces and clinical decision support systems in healthcare. It notes that while large investments have been made in electronic medical records, healthcare outcomes and clinician workload have not significantly improved. Adaptive user interfaces that tailor information display based on user context could help integrate clinical decision support and artificial intelligence into clinical workflows. This would allow local specialty and role-based customization to support new models of care and help sustain the healthcare system by better supporting clinicians and patients. The company discussed in the document, Alcidion, provides an adaptive platform that uses contextual data and decision engines to generate customized, real-time user interfaces.
The document discusses predictions for the future of laboratory medicine in 3 key areas:
1) Laboratory organization and staffing will consolidate into large regional centers and networks, with reduced numbers of laboratories and increased outsourcing. Staff will focus more on consultative services and quality control.
2) Automation and robotics will continue to increase to make laboratories more cost efficient, though they still have limitations, especially in specialized areas like microbiology.
3) Point-of-care testing is predicted to become more common, integrated into patient care, and allow for more home testing using portable devices. Genomics and proteomics are also expected to be the basis for many new diagnostic tests in the future.
Real-World Data – What’s Next? by Michael Seewald, AstraZeneca for mHealth Is...Levi Shapiro
Presentation by Michael Seewald, Michael Seewald, Ph.D.
Global Head Evidence, AstraZeneca Biopharmaceuticals for mHealth Israel, October 19th, 2021.
Real-World Data is able to uncover local unmet medical need – Call to action to build Learning Healthcare Systems. Significant Variations in Care and Large Potential for Improvement. Real-World Data helps to benchmark efficient use of resources and detect “waste”. Healthcare systems need to address the problem of waste. But fundamental change is hard, and progress slow. Outcomes Transparency Improves ComplianceExample: Swedish myocardial infarction registry. Outcomes Transparency Improves Compliance. Example: Swedish myocardial infarction registry. Improving Outcomes and Creating Value will continue to guide Learning Healthcare Systems- enabled by RWD. Four technological trends as accelerators on our path. Empowered patients- Molecular screening and 24/7 monitoring driving a step change in diagnosis. Algorithmic decision-making: Artificial intelligence supports physician intelligence. Evidence-generating healthcare systemsLive insights on clinical efficacy from digital monitoring. 360° care delivery. Home replaces hospital via digital therapeutics and on-demand remote support. AstraZeneca Areas of Partnering Interest: (https://www.astrazeneca.com/partnering/our-areas-of-partnering-interest.html).
Presentation investing-in-medical-device-safetyTGA Australia
The document discusses the importance of having a functional Quality Management System (QMS) for medical device companies. It notes that over 5000 medical device incident reports are filed each year, with most incidents being rooted in quality system deficiencies. The Therapeutic Goods Administration (TGA) regulates medical devices in Australia and may get involved when investigations into incidents find insufficient clarity or corrective actions from companies. A case study highlights how the TGA intervened when a company failed to adequately address increased failure rates in a patient monitoring device. The key takeaway is that companies should invest in quality control processes and actively maintain their QMS to avoid safety issues.
Computerized physician order entry (CPOE)Norah Alfayez
This document provides an overview of computerized physician order entry (CPOE) systems. It defines CPOE and describes its key features and functions, including ordering, decision support, safety checks, and improved documentation. The document discusses common CPOE hardware and software and examines legal/ethical issues. It outlines both the advantages of CPOE in reducing errors and costs and the disadvantages such as high implementation costs. The document also reviews studies on CPOE's impact on patient safety and productivity issues during implementation.
The document discusses careers in clinical research, which involves ensuring the safety and efficacy of medications, devices, and treatments intended for human use. It outlines several career paths in clinical operations, pharmacovigilance, clinical data management, medical/regulatory affairs, and managerial positions. The document encourages the reader to consider a rewarding career as a clinical research professional.
Presentation from OIS@ASCRS 2016
Moderator:
Elizabeth Yeu, MD
Participants:
David Chang, MD
Eric Donnenfeld, MD
Sherman Reeves, MD, MPH
Denise Visco, MD
Video Presentation:
https://www.youtube.com/watch?v=GTiBOslQYlI&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=37
[P.D.F] Laboratory and Diagnostic Tests with Nursing Implications For Kindlecabimeci121
LABORATORY AND DIAGNOSTIC TESTS WITH NURSING IMPLICATIONS, 9/e brings together current information on more than 420 modern laboratory and diagnostic tests, together with their corresponding nursing implications. For each test, it presents reference values/normal findings, descriptions, purpose(s), clinical problems, procedures, factors affecting results, and nursing implications with rationales, including client teaching. This edition contains new, rewritten, or updated coverage of dozens of tests, including IgE, arsenic, blood smear, chromosomal analysis, CBC, cyanide, cytokines, heroin, HIV, influenza, macular degeneration risk analysis, SCID, sexual assault/attack, ABG, bilirubin tests, C-reactive protein (hs CRP) and glucose, cardiac catheterization, echocardiography, colonoscopy, ERCP, CT, MRI, and many others. An updated section on Therapeutic Drug Monitoring now covers HIV drugs, and revised appendices address everything from abbreviations to test values.
Ivantis is developing the Hydrus Microstent, a minimally invasive implant designed to dilate and scaffold the natural outflow path of the eye to treat glaucoma. It has raised $107 million and conducted clinical trials involving over 2,000 patients in 21 countries. A recent randomized controlled trial found that 74% of patients who received the Hydrus Microstent in addition to cataract surgery experienced at least a 20% reduction in eye pressure without medication, compared to 46% for cataract surgery alone, demonstrating the Hydrus' increasing treatment effect over time. Ivantis is pursuing US FDA approval for the Hydrus Microstent based on these promising clinical results.
Computerized physician order entry (CPOE), sometimes referred to as computerized provider order entry or computerized provider order management (CPOM), is a process of electronic entry of medical practitioner instructions for the treatment of patients (particularly hospitalized patients) under his or her care.
How digital technologies can improve diagnosticsKoen De Lombaert
A talk I gave at IDWeek 2014. I am making the case for the smartphone (mobile, connectivity, sensors, and computing) as the ultimate enabler of remote diagnostics. Use cases, examples of products, and the (possible) future of remote diagnosis.
Presentation from OIS@ASCRS 2016
James Brandt, MD, Principal Investigator
Video Presentation:
https://www.youtube.com/watch?v=jvIozhPMSQ8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=30
Getting Right with The Joint Commission's Communication GoalSpok
In pursuit of its mission, The Joint Commission audits and accredits more than 21,000 healthcare organizations and programs for clinical excellence and patient safety. The organization also publishes an annual list of National Patient Safety Goals (NPSG) highlighting specific areas of focus for improvement within the healthcare environment. Improving communications is included in the list as a high priority because communication delays and errors can have serious consequences, for patients as well as hospitals.This webinar explores some of the communication challenges hospitals face and how technology can help them comply with The Joint Commission’s communication goal (NPSG 2).
Presentation from OIS@ASCRS 2016
Mark Packer, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=CWwqmEDJOhM&index=20&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Creating commercial value out of the consumerization of medical devicesKoen De Lombaert
A talk I gave at the MEDevice San Diego conference. Consumer medical devices as beautiful devices connected to smartphones with a focus on wellness instead of disease blurring the line between tracking and diagnosis. Devices that consumers want to buy and use as opposed to their clunky, clinical counterparts. I argue that the consumerization of medical devices is the second wave after consumer medical information such as WebMD and Everyday Health in the empowerment of the “patient”. Let’s see when the term “patient” completely disappears
This document discusses health analytics and Pera Health. It provides background on how much healthcare data is generated and the need for more data scientists. It then summarizes Pera Health's product called the Rothman Index, which analyzes patient data to generate a acuity score to detect deterioration. The document also discusses a case study on using the Rothman Index to predict ICU readmissions and provides some success stories and challenges of healthcare analytics.
Posterior Segment Company Showcase - AGTCHealthegy
Posterior Segment Company Showcase - AGTC at OIS@AAO 2016.
Presenter:
Sue Washer, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
This document discusses the regulatory pathway for MIGS devices in the United States. It outlines how the requirements for MIGS device approval through the PMA process have evolved over time based on learnings from early studies. Specifically, it notes that sample sizes, follow-up periods, clinical endpoints, and trial methodology have all increased in rigor. This includes moving primary endpoints from 12 to 24 months, requiring terminal washout periods, and measuring diurnal intraocular pressure. The document emphasizes that achieving level 1 clinical evidence for approval requires significant effort and collaboration between industry and the FDA over many years.
Acr mr equipment evaluation summary form and safety checklist with hilights★Jordi Rius Bonjorn
This document is an MRI safety checklist that assesses whether a site has written policies addressing 19 safety items related to screening patients and personnel, designating equipment safety status, access restrictions, training, and incident reporting. It also checks if 3 additional criteria from the American College of Radiology are met. An evaluator reviews the policies and documentation, and determines an overall pass/fail assessment of the site's MRI safety program.
This document discusses various aspects of genomic sequencing and its clinical translation process. It describes how sequencing output is analyzed through IT processing and human expertise to identify putative mutations and their potential functions and clinical effects. It also discusses challenges around genome assembly, computational analysis, and integrating genetic information with a person's medical condition and protein function through a user-friendly interface. Several diagrams and figures are also included to illustrate the flow of data to information to knowledge in clinical genomics.
Protek Healthcare provides healthcare IT solutions including PACS/RIS systems, hospital information systems, and teleradiology services. They focus on research and development to create user-friendly, multi-platform medical software. Their teleradiology service allows clients to access radiology reports within 24 hours through an online platform and experienced radiologists. Protek also offers NAPHIS and NAPPACS, which are patient management and PACS solutions to streamline processes like registration, viewing patient history, and generating reports.
Making clinical AI and decision support a reality through adaptive user inter...Alcidion Corporation
The document discusses the need for adaptive user interfaces and clinical decision support systems in healthcare. It notes that while large investments have been made in electronic medical records, healthcare outcomes and clinician workload have not significantly improved. Adaptive user interfaces that tailor information display based on user context could help integrate clinical decision support and artificial intelligence into clinical workflows. This would allow local specialty and role-based customization to support new models of care and help sustain the healthcare system by better supporting clinicians and patients. The company discussed in the document, Alcidion, provides an adaptive platform that uses contextual data and decision engines to generate customized, real-time user interfaces.
The document discusses predictions for the future of laboratory medicine in 3 key areas:
1) Laboratory organization and staffing will consolidate into large regional centers and networks, with reduced numbers of laboratories and increased outsourcing. Staff will focus more on consultative services and quality control.
2) Automation and robotics will continue to increase to make laboratories more cost efficient, though they still have limitations, especially in specialized areas like microbiology.
3) Point-of-care testing is predicted to become more common, integrated into patient care, and allow for more home testing using portable devices. Genomics and proteomics are also expected to be the basis for many new diagnostic tests in the future.
Real-World Data – What’s Next? by Michael Seewald, AstraZeneca for mHealth Is...Levi Shapiro
Presentation by Michael Seewald, Michael Seewald, Ph.D.
Global Head Evidence, AstraZeneca Biopharmaceuticals for mHealth Israel, October 19th, 2021.
Real-World Data is able to uncover local unmet medical need – Call to action to build Learning Healthcare Systems. Significant Variations in Care and Large Potential for Improvement. Real-World Data helps to benchmark efficient use of resources and detect “waste”. Healthcare systems need to address the problem of waste. But fundamental change is hard, and progress slow. Outcomes Transparency Improves ComplianceExample: Swedish myocardial infarction registry. Outcomes Transparency Improves Compliance. Example: Swedish myocardial infarction registry. Improving Outcomes and Creating Value will continue to guide Learning Healthcare Systems- enabled by RWD. Four technological trends as accelerators on our path. Empowered patients- Molecular screening and 24/7 monitoring driving a step change in diagnosis. Algorithmic decision-making: Artificial intelligence supports physician intelligence. Evidence-generating healthcare systemsLive insights on clinical efficacy from digital monitoring. 360° care delivery. Home replaces hospital via digital therapeutics and on-demand remote support. AstraZeneca Areas of Partnering Interest: (https://www.astrazeneca.com/partnering/our-areas-of-partnering-interest.html).
Presentation investing-in-medical-device-safetyTGA Australia
The document discusses the importance of having a functional Quality Management System (QMS) for medical device companies. It notes that over 5000 medical device incident reports are filed each year, with most incidents being rooted in quality system deficiencies. The Therapeutic Goods Administration (TGA) regulates medical devices in Australia and may get involved when investigations into incidents find insufficient clarity or corrective actions from companies. A case study highlights how the TGA intervened when a company failed to adequately address increased failure rates in a patient monitoring device. The key takeaway is that companies should invest in quality control processes and actively maintain their QMS to avoid safety issues.
Computerized physician order entry (CPOE)Norah Alfayez
This document provides an overview of computerized physician order entry (CPOE) systems. It defines CPOE and describes its key features and functions, including ordering, decision support, safety checks, and improved documentation. The document discusses common CPOE hardware and software and examines legal/ethical issues. It outlines both the advantages of CPOE in reducing errors and costs and the disadvantages such as high implementation costs. The document also reviews studies on CPOE's impact on patient safety and productivity issues during implementation.
The document discusses careers in clinical research, which involves ensuring the safety and efficacy of medications, devices, and treatments intended for human use. It outlines several career paths in clinical operations, pharmacovigilance, clinical data management, medical/regulatory affairs, and managerial positions. The document encourages the reader to consider a rewarding career as a clinical research professional.
Presentation from OIS@ASCRS 2016
Moderator:
Elizabeth Yeu, MD
Participants:
David Chang, MD
Eric Donnenfeld, MD
Sherman Reeves, MD, MPH
Denise Visco, MD
Video Presentation:
https://www.youtube.com/watch?v=GTiBOslQYlI&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=37
[P.D.F] Laboratory and Diagnostic Tests with Nursing Implications For Kindlecabimeci121
LABORATORY AND DIAGNOSTIC TESTS WITH NURSING IMPLICATIONS, 9/e brings together current information on more than 420 modern laboratory and diagnostic tests, together with their corresponding nursing implications. For each test, it presents reference values/normal findings, descriptions, purpose(s), clinical problems, procedures, factors affecting results, and nursing implications with rationales, including client teaching. This edition contains new, rewritten, or updated coverage of dozens of tests, including IgE, arsenic, blood smear, chromosomal analysis, CBC, cyanide, cytokines, heroin, HIV, influenza, macular degeneration risk analysis, SCID, sexual assault/attack, ABG, bilirubin tests, C-reactive protein (hs CRP) and glucose, cardiac catheterization, echocardiography, colonoscopy, ERCP, CT, MRI, and many others. An updated section on Therapeutic Drug Monitoring now covers HIV drugs, and revised appendices address everything from abbreviations to test values.
Ivantis is developing the Hydrus Microstent, a minimally invasive implant designed to dilate and scaffold the natural outflow path of the eye to treat glaucoma. It has raised $107 million and conducted clinical trials involving over 2,000 patients in 21 countries. A recent randomized controlled trial found that 74% of patients who received the Hydrus Microstent in addition to cataract surgery experienced at least a 20% reduction in eye pressure without medication, compared to 46% for cataract surgery alone, demonstrating the Hydrus' increasing treatment effect over time. Ivantis is pursuing US FDA approval for the Hydrus Microstent based on these promising clinical results.
Computerized physician order entry (CPOE), sometimes referred to as computerized provider order entry or computerized provider order management (CPOM), is a process of electronic entry of medical practitioner instructions for the treatment of patients (particularly hospitalized patients) under his or her care.
How digital technologies can improve diagnosticsKoen De Lombaert
A talk I gave at IDWeek 2014. I am making the case for the smartphone (mobile, connectivity, sensors, and computing) as the ultimate enabler of remote diagnostics. Use cases, examples of products, and the (possible) future of remote diagnosis.
Presentation from OIS@ASCRS 2016
James Brandt, MD, Principal Investigator
Video Presentation:
https://www.youtube.com/watch?v=jvIozhPMSQ8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=30
Getting Right with The Joint Commission's Communication GoalSpok
In pursuit of its mission, The Joint Commission audits and accredits more than 21,000 healthcare organizations and programs for clinical excellence and patient safety. The organization also publishes an annual list of National Patient Safety Goals (NPSG) highlighting specific areas of focus for improvement within the healthcare environment. Improving communications is included in the list as a high priority because communication delays and errors can have serious consequences, for patients as well as hospitals.This webinar explores some of the communication challenges hospitals face and how technology can help them comply with The Joint Commission’s communication goal (NPSG 2).
Presentation from OIS@ASCRS 2016
Mark Packer, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=CWwqmEDJOhM&index=20&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Creating commercial value out of the consumerization of medical devicesKoen De Lombaert
A talk I gave at the MEDevice San Diego conference. Consumer medical devices as beautiful devices connected to smartphones with a focus on wellness instead of disease blurring the line between tracking and diagnosis. Devices that consumers want to buy and use as opposed to their clunky, clinical counterparts. I argue that the consumerization of medical devices is the second wave after consumer medical information such as WebMD and Everyday Health in the empowerment of the “patient”. Let’s see when the term “patient” completely disappears
This document discusses health analytics and Pera Health. It provides background on how much healthcare data is generated and the need for more data scientists. It then summarizes Pera Health's product called the Rothman Index, which analyzes patient data to generate a acuity score to detect deterioration. The document also discusses a case study on using the Rothman Index to predict ICU readmissions and provides some success stories and challenges of healthcare analytics.
This document discusses patient generated data (PGD) and how mobile health (mHealth) technologies can be used to capture it. PGD includes data recorded by patients about their health symptoms, medication adherence, biometric data from wearables, and patient reported outcomes. The document outlines how PGD can help with clinical trials and care by providing more comprehensive real-world data. Challenges with PGD like data quality, privacy and regulatory issues are discussed. The document provides examples of how the Aparito platform captures different types of PGD through mobile apps and connected devices to improve disease understanding and drug development.
Connected Health & Me - Matic Meglic - Nov 24th 2014ipposi
This document discusses how data sharing is changing healthcare by empowering patients. It outlines a shift from a traditional care model, where patients are passive recipients of care, to one where patients are engaged and empowered through access to their own health data and contextual knowledge. Key drivers of this change include affordable technology, the quantified self-movement, big data, and empowered patients. The document discusses how patient registries and personalized medicine can utilize data to better understand treatment efficacy for similar patients and provide personalized care plans. It also notes challenges around data privacy and the need for guidelines. Overall, the document advocates for empowering patients through access to their own health data while using data and technology to coordinate and improve healthcare.
Overview of Patient Reported Outcomes in SAFTINet Marion Sills
This document discusses patient-reported outcomes (PROs) in the SAFTINet and PEC studies. It defines a PRO as a questionnaire collected directly from patients in clinical trials or settings. PROs can measure disease control and be used for screening, monitoring, feedback, decision-making, communication, and evaluating quality. The document outlines upcoming agenda items for meetings discussing how partners currently collect and use PROs, barriers to implementation, and potential use cases for an asthma PRO measure.
How to Use Data to Improve Patient Safety: A Two-Part DiscussionHealth Catalyst
As healthcare organizations continue to experience expenses growing faster than revenues, value based care, and consumer transparency of costs and quality, patient safety will be an important determinant of success. This session will describe the sociotechnical attributes of a safe system, the challenges, the barriers and opportunities, and how to use data and your culture of safety as a powerful tool to drive down adverse events.
Attendees will learn:
Why patient safety and quality are important.
How data can help improve patient safety.
The history of patient safety and where we are today.
What components make up a safety analytics culture.
How the internal safety culture directly impacts patient safety metrics.
To describe basic guidelines for improving a safety culture with analytics.
Attached is a view on the importance of Automation & appropriate technology in the collection of Adverse Event data, and how this data can be used to the benefit of the patient population.
Using Digital Innovation to Establish Authentic Reporter DialogueSophia Ahrel FCIM
Digital solutions that put patients at forefront of safety processes
Capture relevant, essential and complete data at first interaction
Maximise the value of initial contact and reduce low value follow up
Solutions that ensure REMS and RMP commitments are met and are future proofed
The document discusses the potential for mobile health (mHealth) technologies and small data sensing. It describes how sensors in smartphones can be used to monitor health metrics and manage chronic diseases. Some examples discussed include using phone sensors and microphones to monitor lung function for conditions like asthma. Challenges around compliance, cost, and data reliability are also covered. The future of mHealth is predicted to involve integrating more sensors directly into phones and greater involvement of regulatory agencies like the FDA.
Is it self-tracking? We are only beginning to understand the power of self-tracking be it due to the quantified self movement or because of the increasing number of connected medical devices. A real opportunity is in understanding how mobile devices will play a key role in the future of our personal health. Medical Devices, sensors, big data, cloud computing are and will continue to enable continuous monitoring of people and patients.
The Pegwin Insights software platform is used by caregivers at the point of care to measure and monitor a patient’s risk profile and receive early insight into a patient’s deterioration so that timely intervention and preventive action can be taken to avoid post-operative complications. Pegwin Insights is the only evidence-based Machine Learning and AI solution to assist caregivers with better-than-human accuracy in real-time.
Information technology refers to hardware and software used to store, process, transmit, and securely retrieve information. Computers are reshaping healthcare by connecting different departments and enabling storage and retrieval of clinical and statistical data. Some key applications of computers in nursing include computerized hospital information systems, clinical decision support, electronic medical records, and medication administration records.
Big Data and Analytic Strategy for Clinical ResearchBBCR Consulting
This document discusses how big data and analytics can help simplify clinical research and make trials more cost-effective. It begins by providing context on how Henry Ford revolutionized car manufacturing using specialized machinery and standardized processes. Similarly, big data is creating a radical shift in how research is conducted by enabling the analysis of large and complex datasets. The rest of the document outlines opportunities in areas like personalized medicine, challenges like dealing with diverse and fast-changing data, and how innovation in clinical research design can help address these challenges to develop more targeted treatments.
This document discusses how integrated computing and data can lead to improved healthcare outcomes through precision medicine. It provides examples of how large healthcare data sets from various sources can be analyzed using machine learning to better predict and treat conditions like heart failure. Penn Medicine is highlighted as successfully using patients' electronic medical records, medications, and other data to improve predictive models for re-hospitalization risk. The document also introduces the Trusted Analytics Platform and Intel's Collaborative Cancer Cloud initiative for enabling genomic research through distributed analytics. Finally, it describes how natural language processing of clinical records could help identify cancer patients for clinical trials more quickly.
This document discusses how integrated computing and data can lead to improved healthcare outcomes through precision medicine. It provides examples of how large healthcare systems like Penn Medicine are using machine learning on patient data to better predict and treat conditions like heart failure. The document also introduces the Trusted Analytics Platform and Intel's Collaborative Cancer Cloud which aim to accelerate big data analytics for medical research. Finally, it discusses how natural language processing of clinical records through the ConSoRe project could help oncologists more quickly identify patient cohorts for clinical trials and research.
Pharma challenges - Patient Centricity and Digital CapabilitiesJoana Santos Silva
Today pharma's business model is being challenged. The industry needs to rethink how it creates value. In particular, it needs to connect to patients and caregivers in a meaningful way. It many cases this connection can be guaranteed through digital tools and strategies. This presentation focuses on these challenges and showcases some best practices that are already available in the marketplace.
This is a presentation from 2011 highlighting the possibilities of IT in private cardiology practice. It is of historical value but touches on early fundamental concepts of digitalization of a private practice in the field of cardiology.
Theranos presented to investors with the goal of becoming the standard for improving drug therapies. Its initial market is phase IV clinical trials, using a product platform of cartridges, readers, and informatics services. Founded in 2003 with 50 employees, Theranos aims to generate $120-300M in revenue over 1.5 years through deals with pharmaceutical companies. The company's system allows for simultaneous quantitative measurement of drugs and biomarkers from small blood samples, returning results comparable to gold standards within 30 minutes. Theranos' value proposition is improving drug labels and safety by enabling real-time pharmacokinetic and pharmacodynamic monitoring during trials and treatment.
Ontology-Driven Clinical Intelligence: A Path from the Biobank to Cross-Disea...Remedy Informatics
The discovery of clinical insights through effective management and reuse of data requires several conditions to be optimized: Data need to be digital, data need to be structured, and data need to be standardized in terms of metadata and ontology. This presentation describes a bioinformatics system that combines a next-generation biobank management model mapped to applicable international standards and guidelines with a master ontology that controls all input and output and is able to add unique properties to meet the specialized needs of clinicians for cross-disease research.
Similar to PMED: APPM Workshop: Personalized Patient Vital Sign Monitoring in Home, Hospital & Clinical Settings - Christopher McCann, March 14, 2019 (20)
Recently, the machine learning community has expressed strong interest in applying latent variable modeling strategies to causal inference problems with unobserved confounding. Here, I discuss one of the big debates that occurred over the past year, and how we can move forward. I will focus specifically on the failure of point identification in this setting, and discuss how this can be used to design flexible sensitivity analyses that cleanly separate identified and unidentified components of the causal model.
I will discuss paradigmatic statistical models of inference and learning from high dimensional data, such as sparse PCA and the perceptron neural network, in the sub-linear sparsity regime. In this limit the underlying hidden signal, i.e., the low-rank matrix in PCA or the neural network weights, has a number of non-zero components that scales sub-linearly with the total dimension of the vector. I will provide explicit low-dimensional variational formulas for the asymptotic mutual information between the signal and the data in suitable sparse limits. In the setting of support recovery these formulas imply sharp 0-1 phase transitions for the asymptotic minimum mean-square-error (or generalization error in the neural network setting). A similar phase transition was analyzed recently in the context of sparse high-dimensional linear regression by Reeves et al.
Many different measurement techniques are used to record neural activity in the brains of different organisms, including fMRI, EEG, MEG, lightsheet microscopy and direct recordings with electrodes. Each of these measurement modes have their advantages and disadvantages concerning the resolution of the data in space and time, the directness of measurement of the neural activity and which organisms they can be applied to. For some of these modes and for some organisms, significant amounts of data are now available in large standardized open-source datasets. I will report on our efforts to apply causal discovery algorithms to, among others, fMRI data from the Human Connectome Project, and to lightsheet microscopy data from zebrafish larvae. In particular, I will focus on the challenges we have faced both in terms of the nature of the data and the computational features of the discovery algorithms, as well as the modeling of experimental interventions.
1) The document presents a statistical modeling approach called targeted smooth Bayesian causal forests (tsbcf) to smoothly estimate heterogeneous treatment effects over gestational age using observational data from early medical abortion regimens.
2) The tsbcf method extends Bayesian additive regression trees (BART) to estimate treatment effects that evolve smoothly over gestational age, while allowing for heterogeneous effects across patient subgroups.
3) The tsbcf analysis of early medical abortion regimen data found the simultaneous administration to be similarly effective overall to the interval administration, but identified some patient subgroups where effectiveness may vary more over gestational age.
Difference-in-differences is a widely used evaluation strategy that draws causal inference from observational panel data. Its causal identification relies on the assumption of parallel trends, which is scale-dependent and may be questionable in some applications. A common alternative is a regression model that adjusts for the lagged dependent variable, which rests on the assumption of ignorability conditional on past outcomes. In the context of linear models, Angrist and Pischke (2009) show that the difference-in-differences and lagged-dependent-variable regression estimates have a bracketing relationship. Namely, for a true positive effect, if ignorability is correct, then mistakenly assuming parallel trends will overestimate the effect; in contrast, if the parallel trends assumption is correct, then mistakenly assuming ignorability will underestimate the effect. We show that the same bracketing relationship holds in general nonparametric (model-free) settings. We also extend the result to semiparametric estimation based on inverse probability weighting.
We develop sensitivity analyses for weak nulls in matched observational studies while allowing unit-level treatment effects to vary. In contrast to randomized experiments and paired observational studies, we show for general matched designs that over a large class of test statistics, any valid sensitivity analysis for the weak null must be unnecessarily conservative if Fisher's sharp null of no treatment effect for any individual also holds. We present a sensitivity analysis valid for the weak null, and illustrate why it is conservative if the sharp null holds through connections to inverse probability weighted estimators. An alternative procedure is presented that is asymptotically sharp if treatment effects are constant, and is valid for the weak null under additional assumptions which may be deemed reasonable by practitioners. The methods may be applied to matched observational studies constructed using any optimal without-replacement matching algorithm, allowing practitioners to assess robustness to hidden bias while allowing for treatment effect heterogeneity.
This document discusses difference-in-differences (DiD) analysis, a quasi-experimental method used to estimate treatment effects. The author notes that while widely applicable, DiD relies on strong assumptions about the counterfactual. She recommends approaches like matching on observed variables between similar populations, thoughtfully specifying regression models to adjust for confounding factors, testing for parallel pre-treatment trends under different assumptions, and considering more complex models that allow for different types of changes over time. The overall message is that DiD requires careful consideration and testing of its underlying assumptions to draw valid causal conclusions.
We present recent advances and statistical developments for evaluating Dynamic Treatment Regimes (DTR), which allow the treatment to be dynamically tailored according to evolving subject-level data. Identification of an optimal DTR is a key component for precision medicine and personalized health care. Specific topics covered in this talk include several recent projects with robust and flexible methods developed for the above research area. We will first introduce a dynamic statistical learning method, adaptive contrast weighted learning (ACWL), which combines doubly robust semiparametric regression estimators with flexible machine learning methods. We will further develop a tree-based reinforcement learning (T-RL) method, which builds an unsupervised decision tree that maintains the nature of batch-mode reinforcement learning. Unlike ACWL, T-RL handles the optimization problem with multiple treatment comparisons directly through a purity measure constructed with augmented inverse probability weighted estimators. T-RL is robust, efficient and easy to interpret for the identification of optimal DTRs. However, ACWL seems more robust against tree-type misspecification than T-RL when the true optimal DTR is non-tree-type. At the end of this talk, we will also present a new Stochastic-Tree Search method called ST-RL for evaluating optimal DTRs.
A fundamental feature of evaluating causal health effects of air quality regulations is that air pollution moves through space, rendering health outcomes at a particular population location dependent upon regulatory actions taken at multiple, possibly distant, pollution sources. Motivated by studies of the public-health impacts of power plant regulations in the U.S., this talk introduces the novel setting of bipartite causal inference with interference, which arises when 1) treatments are defined on observational units that are distinct from those at which outcomes are measured and 2) there is interference between units in the sense that outcomes for some units depend on the treatments assigned to many other units. Interference in this setting arises due to complex exposure patterns dictated by physical-chemical atmospheric processes of pollution transport, with intervention effects framed as propagating across a bipartite network of power plants and residential zip codes. New causal estimands are introduced for the bipartite setting, along with an estimation approach based on generalized propensity scores for treatments on a network. The new methods are deployed to estimate how emission-reduction technologies implemented at coal-fired power plants causally affect health outcomes among Medicare beneficiaries in the U.S.
Laine Thomas presented information about how causal inference is being used to determine the cost/benefit of the two most common surgical surgical treatments for women - hysterectomy and myomectomy.
We provide an overview of some recent developments in machine learning tools for dynamic treatment regime discovery in precision medicine. The first development is a new off-policy reinforcement learning tool for continual learning in mobile health to enable patients with type 1 diabetes to exercise safely. The second development is a new inverse reinforcement learning tools which enables use of observational data to learn how clinicians balance competing priorities for treating depression and mania in patients with bipolar disorder. Both practical and technical challenges are discussed.
The method of differences-in-differences (DID) is widely used to estimate causal effects. The primary advantage of DID is that it can account for time-invariant bias from unobserved confounders. However, the standard DID estimator will be biased if there is an interaction between history in the after period and the groups. That is, bias will be present if an event besides the treatment occurs at the same time and affects the treated group in a differential fashion. We present a method of bounds based on DID that accounts for an unmeasured confounder that has a differential effect in the post-treatment time period. These DID bracketing bounds are simple to implement and only require partitioning the controls into two separate groups. We also develop two key extensions for DID bracketing bounds. First, we develop a new falsification test to probe the key assumption that is necessary for the bounds estimator to provide consistent estimates of the treatment effect. Next, we develop a method of sensitivity analysis that adjusts the bounds for possible bias based on differences between the treated and control units from the pretreatment period. We apply these DID bracketing bounds and the new methods we develop to an application on the effect of voter identification laws on turnout. Specifically, we focus estimating whether the enactment of voter identification laws in Georgia and Indiana had an effect on voter turnout.
This document summarizes a simulation study evaluating causal inference methods for assessing the effects of opioid and gun policies. The study used real US state-level data to simulate the adoption of policies by some states and estimated the effects using different statistical models. It found that with fewer adopting states, type 1 error rates were too high, and most models lacked power. It recommends using cluster-robust standard errors and lagged outcomes to improve model performance. The study aims to help identify best practices for policy evaluation studies.
We study experimental design in large-scale stochastic systems with substantial uncertainty and structured cross-unit interference. We consider the problem of a platform that seeks to optimize supply-side payments p in a centralized marketplace where different suppliers interact via their effects on the overall supply-demand equilibrium, and propose a class of local experimentation schemes that can be used to optimize these payments without perturbing the overall market equilibrium. We show that, as the system size grows, our scheme can estimate the gradient of the platform’s utility with respect to p while perturbing the overall market equilibrium by only a vanishingly small amount. We can then use these gradient estimates to optimize p via any stochastic first-order optimization method. These results stem from the insight that, while the system involves a large number of interacting units, any interference can only be channeled through a small number of key statistics, and this structure allows us to accurately predict feedback effects that arise from global system changes using only information collected while remaining in equilibrium.
We discuss a general roadmap for generating causal inference based on observational studies used to general real world evidence. We review targeted minimum loss estimation (TMLE), which provides a general template for the construction of asymptotically efficient plug-in estimators of a target estimand for realistic (i.e, infinite dimensional) statistical models. TMLE is a two stage procedure that first involves using ensemble machine learning termed super-learning to estimate the relevant stochastic relations between the treatment, censoring, covariates and outcome of interest. The super-learner allows one to fully utilize all the advances in machine learning (in addition to more conventional parametric model based estimators) to build a single most powerful ensemble machine learning algorithm. We present Highly Adaptive Lasso as an important machine learning algorithm to include.
In the second step, the TMLE involves maximizing a parametric likelihood along a so-called least favorable parametric model through the super-learner fit of the relevant stochastic relations in the observed data. This second step bridges the state of the art in machine learning to estimators of target estimands for which statistical inference is available (i.e, confidence intervals, p-values etc). We also review recent advances in collaborative TMLE in which the fit of the treatment and censoring mechanism is tailored w.r.t. performance of TMLE. We also discuss asymptotically valid bootstrap based inference. Simulations and data analyses are provided as demonstrations.
We describe different approaches for specifying models and prior distributions for estimating heterogeneous treatment effects using Bayesian nonparametric models. We make an affirmative case for direct, informative (or partially informative) prior distributions on heterogeneous treatment effects, especially when treatment effect size and treatment effect variation is small relative to other sources of variability. We also consider how to provide scientifically meaningful summaries of complicated, high-dimensional posterior distributions over heterogeneous treatment effects with appropriate measures of uncertainty.
Climate change mitigation has traditionally been analyzed as some version of a public goods game (PGG) in which a group is most successful if everybody contributes, but players are best off individually by not contributing anything (i.e., “free-riding”)—thereby creating a social dilemma. Analysis of climate change using the PGG and its variants has helped explain why global cooperation on GHG reductions is so difficult, as nations have an incentive to free-ride on the reductions of others. Rather than inspire collective action, it seems that the lack of progress in addressing the climate crisis is driving the search for a “quick fix” technological solution that circumvents the need for cooperation.
This document discusses various types of academic writing and provides tips for effective academic writing. It outlines common academic writing formats such as journal papers, books, and reports. It also lists writing necessities like having a clear purpose, understanding your audience, using proper grammar and being concise. The document cautions against plagiarism and not proofreading. It provides additional dos and don'ts for writing, such as using simple language and avoiding filler words. Overall, the key message is that academic writing requires selling your ideas effectively to the reader.
Machine learning (including deep and reinforcement learning) and blockchain are two of the most noticeable technologies in recent years. The first one is the foundation of artificial intelligence and big data, and the second one has significantly disrupted the financial industry. Both technologies are data-driven, and thus there are rapidly growing interests in integrating them for more secure and efficient data sharing and analysis. In this paper, we review the research on combining blockchain and machine learning technologies and demonstrate that they can collaborate efficiently and effectively. In the end, we point out some future directions and expect more researches on deeper integration of the two promising technologies.
In this talk, we discuss QuTrack, a Blockchain-based approach to track experiment and model changes primarily for AI and ML models. In addition, we discuss how change analytics can be used for process improvement and to enhance the model development and deployment processes.
More from The Statistical and Applied Mathematical Sciences Institute (20)
This presentation was provided by Rebecca Benner, Ph.D., of the American Society of Anesthesiologists, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.
Chapter wise All Notes of First year Basic Civil Engineering.pptxDenish Jangid
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.pptHenry Hollis
The History of NZ 1870-1900.
Making of a Nation.
From the NZ Wars to Liberals,
Richard Seddon, George Grey,
Social Laboratory, New Zealand,
Confiscations, Kotahitanga, Kingitanga, Parliament, Suffrage, Repudiation, Economic Change, Agriculture, Gold Mining, Timber, Flax, Sheep, Dairying,
🔥🔥🔥🔥🔥🔥🔥🔥🔥
إضغ بين إيديكم من أقوى الملازم التي صممتها
ملزمة تشريح الجهاز الهيكلي (نظري 3)
💀💀💀💀💀💀💀💀💀💀
تتميز هذهِ الملزمة بعِدة مُميزات :
1- مُترجمة ترجمة تُناسب جميع المستويات
2- تحتوي على 78 رسم توضيحي لكل كلمة موجودة بالملزمة (لكل كلمة !!!!)
#فهم_ماكو_درخ
3- دقة الكتابة والصور عالية جداً جداً جداً
4- هُنالك بعض المعلومات تم توضيحها بشكل تفصيلي جداً (تُعتبر لدى الطالب أو الطالبة بإنها معلومات مُبهمة ومع ذلك تم توضيح هذهِ المعلومات المُبهمة بشكل تفصيلي جداً
5- الملزمة تشرح نفسها ب نفسها بس تكلك تعال اقراني
6- تحتوي الملزمة في اول سلايد على خارطة تتضمن جميع تفرُعات معلومات الجهاز الهيكلي المذكورة في هذهِ الملزمة
واخيراً هذهِ الملزمة حلالٌ عليكم وإتمنى منكم إن تدعولي بالخير والصحة والعافية فقط
كل التوفيق زملائي وزميلاتي ، زميلكم محمد الذهبي 💊💊
🔥🔥🔥🔥🔥🔥🔥🔥🔥
A Visual Guide to 1 Samuel | A Tale of Two HeartsSteve Thomason
These slides walk through the story of 1 Samuel. Samuel is the last judge of Israel. The people reject God and want a king. Saul is anointed as the first king, but he is not a good king. David, the shepherd boy is anointed and Saul is envious of him. David shows honor while Saul continues to self destruct.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
PMED: APPM Workshop: Personalized Patient Vital Sign Monitoring in Home, Hospital & Clinical Settings - Christopher McCann, March 14, 2019
1. Personalized Patient Vital Sign
Monitoring in Home, Hospital,
and Clinical Trial Settings
Christopher McCann
CEO Current Health
Contact Information
www.currenthealth.com
Twitter: @heycurrent
LinkedIn: https://www.linkedin.com/company/currenthealth
Email: hello@currenthealth.com
Facebook: www.facebook.com/heycurrenthealth
14. Challenges in Monitoring
Data Quality:
Patient-Specific Ranges
The “average”
patient’s data
is anomalous to
large portions
of the patient
population
18. Concluding Remarks
• Working at the confluence of
software engineers and data
scientists.
• Many of these methods are
technically simple.
• Imperative to acquire high-
quality personalized data
• Strong building blocks for more
sophisticated data analysis