The document summarizes two scientific studies that provide new insights into ribosome assembly and cell division. The first study identified steps in ribosome assembly that could help understand defects linked to cancer. The second study discovered a protein called Lem4 that acts as a "traffic officer" to regulate proteins tagging another protein during cell division, a process critical for human and worm cells. Understanding these molecular mechanisms could help develop new drugs to treat diseases.

1. John Sebastián Henao Espinosa
Medical Student
July 16,2012

4. •Ribosomes, site of
research to find cure for
cancer
• ARN, the language of
the life
•Phosphate, the new traffic
officer found.
• It is the same mechanism for
all!
•how is the beginning of our life?
Look at the cell division process

5. Study sheds light on the
assembly of ribosome
“Scientists from the Florida
campus of The Scripps
Research Institute have
identified a series of intricate
biochemical steps that lead to
the successful production of
proteins, the basic working
units of any cell”
News Medical
(July 6, 2012 )

6. Study sheds light on the assembly of
ribosome
The study gave new
insights about the
essambly of the ribosomes
it is seen like a promising
area of research because There are well-established
of the importance of the links between defects in
ribosome function for cell ribosome assembly
growth and cancer

7. Study sheds light on the assembly of
ribosome
At translation, the
ribosome decodes
information carried in
mRNA to produce a
chain of aminoacids
If the translation
to producing functional process acts on the
ribosome there are two steps: subunits prematurely,
1) in the nucleolus, a protein- would be found a
nucleic acid structure inside production of
the nucleus . incorrectly assembled
2) in the cytoplasm, the basic proteins.
cellular stew where protein
translation occurs.

8. Study sheds light on the assembly of
ribosome
“Does the conversion of
inactive assembly
intermediates into mature Said
ribosomes require
checkpoints to assure that Karbstein
subunits are functional?”
They showed that during
this translation-like cycle the
newly made ribosome subunit
joins with its complementary
preexisting subunit to form a
much larger complex
“What is important here is
that the test cycle involves
the same translational
factors that are involved in Final
normal translation” Conclusion

9. Thanks to this study, scientists can
learn more about the different
process of the RNA with the end of
attempt to find different ways to
repair the problems with the
assembly of the ribosomes and
beforehand, finding new drugs that
could combat strong diseases like
cancer. In addition, I think its
fascinating to see this mechanism is
conserved in creatures ranging from
one-celled organisms to humans .

10. Stop and Go: „Traffic
Officer‟ Protein Directs
Crucial Step in Cell Division
“The EMBL scientists discovered a new
molecule, Lem4, which acts as a traffic
officer, stopping one protein from adding
phosphate tags to BAF and bringing in
another protein to remove the existing
tags.
“This happens in both human cells and in
the worm C. elegans, so it seems to be a
strategy which evolved long ago," says Iain
Mattaj, director general of EMBL”
Science Daily
( July 6, 2012 )

11. Stop and Go: „Traffic Officer‟ Protein Directs
Crucial Step in Cell Division
the nuclear envelope - has to
The cells divides to give rise
be broken down and later
to two cell
rebuilt
a protein called BAF The availability of phosphate
performs this function Tags can involve regulating
throught phosphates the activity of proteins that
removed add phosphate an proteins
that remove phosphate.

12. Stop and Go: „Traffic Officer‟ Protein Directs
Crucial Step in Cell Division
Lm4
Why is it called like traffic
officer?
Because they Stop
one protein
AND?
TheyAdd They remove
phosphate tags to
BAF

13. Stop and Go: „Traffic Officer‟ Protein Directs
Crucial Step in Cell Division
•Although the human version of Lem4 is
different that the worm version, both
perform the same funciton at the final of
the cell division
•Now, there is to investigate which is the
need of Lem4 to start its double-action at
the right moment

14. In my opinion, is a greatest form
of deepen at the subject of
molecular biology, knowing about
it and looking for the form of
learning each day more.
The discovery of Lem4 is the best
opportunities to understand the
mechanism of cell division, and
find possible cures to new
diseases.

15.  Ribosomes can be used like molecular target
drugs.
 Learning new ways to attack several diseases
like cancer

16. MEDICAL UTILITY
study sheds light on the assemby
of ribosoma
 Knowing about the role of ARN at the
transcripition process with the end of
understand how is the structural, enzymatic
and conveyor operation of the new proteins.

17. MEDICAL UTILITY
Stop and Go: ‘Traffic Officer’ Protein
Directs Crucial Step in Cell Division
 Knowing perfectly the cell division process and
the form like it is regulated by this new
molecule. It´s important for future research
where some types of diseases can be found by
researches .

18. Stop and Go: ‘Traffic Officer’ Protein
Directs Crucial Step in Cell Division
 By knowing new cell cycle regulator
molecules, the health team can find new
targets for producing antibiotics and
medicines for discover and prevent new
diseases.

19.  · Martinez S, Lina Maria. Biología Molecular. 5 ed
Medellín: UPB. Fac Medicina
 . Study sheds light on the aNews medical .(July
6, 2012)
 · Stop and Go: ‘Traffic Officer’ Protein Directs
Crucial Step in Cell Division. Science Daily. (July
6,2012)