MOLLECULAR SWITCHES: FROMTHE RNA WORLD TO THEMODERN PROTEIN WORLD ANDCHEMISTS DEVELOP MOREEFFICIENT PROTEIN LABELING Sara Guzmán Restrepo Medicine Student, 3rd Semestrer Teacher: Lina María Martinez Molecular Biology
INTRODUCTION• is important to know the new advances in science to diagnose, prevent or cure a disease• The study’s function of new molecules, may change previous theories
MOLLECULAR SWITCHES:FROM THE RNA WORLD TOTHE MODERN PROTEINWORLD.
MOLLECULAR SWITCHES: FROM THE RNA WORLD TO THE MODERN PROTEIN WORLD. They are described as molecular switches that oscillate between on and off, regulated by effectors.
MOLLECULAR SWITCHES: FROM THE RNAWORLD TO THE MODERN PROTEIN WORLD. The G protein FlhF, together with a signal sequence binding protein (SRP54) and its receptor (FtsY), constitutes the ancient family of SRP-GTPases
MOLLECULAR SWITCHES: FROM THE RNA WORLD TO THE MODERN PROTEIN WORLD. it was recently demonstrated that the protein SRP54 and the receptor FtsY interact with the SRP RNA in a way reminiscent of FlhF and its newly discovered effector.
COMMENTIs important to understand the function and structure of the effectors because from these you can create an inhibitor for the same molecule, if a disease requires.
Chemists Develop MoreEfficIent Protein labeling beling
Chemists Develop More EfficIent Protein labeling beling Protein labeling is used by researchers in a variety of fields to help them understand how these important molecules affect the normal functioning of cells
Chemists Develop More EfficIent Protein labeling beling Deiters and Chin developed a special 21st amino acid that they added to cells that were specially engineered to incorporate this amino acid into the protein they wanted to study This 21st amino acid has a “chemical handle” that only reacts with a specifically designed fluorophore, but not any cellular components
Chemists Develop More EfficIent Protein labeling beling they found that their approach gave them a higher yield of labeled proteins and that the binding reaction was 50 times faster than with current methods
COMMENTthis discovery is really important tounderstand the movement and therole of one of the most importantmolecules in the body, through asignaling method much more effective
MEDICAL UTILITY Everything that isdiscovered about the manhelps us understand howto make it through difficult processes, makes this great body?
MEDICAL UTILITY The importance of knowing these molecules has led to a detailed study, so that the proteins have provided much information about the discovery of the treatment and cure of many diseases
MEDICAL UTILITY modern medicine andscience has limits, every day we discover a new disease, the important thing is thatwith the help of these studies may be possible to understand and treat
BIBLIOGRAPHY• “Cellular Switches: From the RNA World to the Modern Protein World”, ScienceDaily journal, internet edition,February. 9, 2012 http://www.sciencedaily.com/releases/2012/02/120209101607. htm• “Chemists Develop More Efficient Protein Labeling” ScienceDaily journal, internet edition,Feruary. 5, 2012, http://www.sciencedaily.com/releases/2012/02/1202051637 16.htm