The aim of this knowledge transfer session is to describe our research on a series of population-based indicators using data available at the NB-IRDT. These indicators can identify New Brunswick communities and citizens that may be more vulnerable to negative consequences of COVID-19 or provide evidence to support planning for targeted intervention and resource allocation. This session will describe the six high-level indicators in each of the 33 health council communities and will provide a more in-depth look at specific vulnerabilities. For example, seniors who live alone, individuals with COVID-19 relevant physical health conditions or those with diagnosed mental health disorders. Population-based risk indicators such as these can inform regional efforts to limit spread and exacerbation of infection in those most at-risk, and in helping to identify the at-risk groups likely impacted by measures to combat the spread of COVID-19.