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In Research and Development
October 15th
Machine Learning
Why Machine Learning?
We want the machine to do something:
1. we can’t do
2. we prefer not to do
3. we can’t do at scale
2
Machine Learning Use Cases
3
Counting
Parasites
Classifying
Documents
Coding Doctors
Notes
Use Case 1 - Counting Parasites
4
The Problem
Counting the parasites for our animal
health products is labor-intensive,
tedious, cumbersome and error-prone
1. Evaluate the practical feasibility of endo-parasites (worms) counting from videos
2. Create a prototype of a model that will count worms from a video of a single
segment of a Petri dish with at least 90% precision
Our Goal
• Detected between 70% - 95% of parasites across different petri dish segments
• Additional work required to move and count the entire petri dish
• Did not detect dead worms
Initial Results
Use Case 2 – Classifying Clinical Documents
5
The Problem
Building the Trial Master File (TMF) is a
laborious task that requires a lot of
time and manpower. Mislabeled
documents may take time to locate
during auditing
Evaluate the feasibility of machine learning for classifying and labeling documents,
especially when documents are scanned and partially handwritten
Our Goal
• Accurately classified 90% of documents to their labels after applying OCR
• Additional work required to integrate the machine learning model with the product
we use for TMF
Initial Results
Use Case 3 – Coding Doctor’s Notes
6
The Problem
Creating population health metrics
from certain global EMR systems is
difficult since they are not coded and
only have unstructured doctors notes
1. Evaluate the feasibility of mapping unstructured doctors notes to ICD-10 codes
2. Achieve > 95% accuracy that can be verified by physicians and specialists
Our Goal
• Initial machine learning approach achieved very poor results
• 75% - 95% accuracy was achieved through a rules-based approach with regular
expressions.
Initial Results
Chief Complaint:
Agitation
The patient complains of
feeling agitated most of
time. Associated symptoms
include anxiety.
Patient is not currently
medication.
Lessons Learned
• Finding your Precision vs Recall needs
• Language Handling
• Durability of results
• Trust & Confidence in results
• Vendor software integration
7

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Pistoia Alliance USA Conference 2016

  • 1. In Research and Development October 15th Machine Learning
  • 2. Why Machine Learning? We want the machine to do something: 1. we can’t do 2. we prefer not to do 3. we can’t do at scale 2
  • 3. Machine Learning Use Cases 3 Counting Parasites Classifying Documents Coding Doctors Notes
  • 4. Use Case 1 - Counting Parasites 4 The Problem Counting the parasites for our animal health products is labor-intensive, tedious, cumbersome and error-prone 1. Evaluate the practical feasibility of endo-parasites (worms) counting from videos 2. Create a prototype of a model that will count worms from a video of a single segment of a Petri dish with at least 90% precision Our Goal • Detected between 70% - 95% of parasites across different petri dish segments • Additional work required to move and count the entire petri dish • Did not detect dead worms Initial Results
  • 5. Use Case 2 – Classifying Clinical Documents 5 The Problem Building the Trial Master File (TMF) is a laborious task that requires a lot of time and manpower. Mislabeled documents may take time to locate during auditing Evaluate the feasibility of machine learning for classifying and labeling documents, especially when documents are scanned and partially handwritten Our Goal • Accurately classified 90% of documents to their labels after applying OCR • Additional work required to integrate the machine learning model with the product we use for TMF Initial Results
  • 6. Use Case 3 – Coding Doctor’s Notes 6 The Problem Creating population health metrics from certain global EMR systems is difficult since they are not coded and only have unstructured doctors notes 1. Evaluate the feasibility of mapping unstructured doctors notes to ICD-10 codes 2. Achieve > 95% accuracy that can be verified by physicians and specialists Our Goal • Initial machine learning approach achieved very poor results • 75% - 95% accuracy was achieved through a rules-based approach with regular expressions. Initial Results Chief Complaint: Agitation The patient complains of feeling agitated most of time. Associated symptoms include anxiety. Patient is not currently medication.
  • 7. Lessons Learned • Finding your Precision vs Recall needs • Language Handling • Durability of results • Trust & Confidence in results • Vendor software integration 7

Editor's Notes

  1. Counting Parasites Classifying Documents Coding Doctor Notes Parasite detection in videos of petri dishes Document Categorization for clinical trials EMR Doctors Note translation
  2. More features