Phytochemical Profiling of Ruta graveolens L. a Vital Medicinal Plant Using Gas Chromatography-Mass Spectrometry
http://dx.doi.org/10.21276/SSR-IIJLS.2020.6.3.2
GC-MS Analysis of Bio-Active Compounds in Aqueous Extract of Boerhaavia Diffu...ijtsrd
Medicinal plants have had a crucial role in human culture and civilization. The present study deals with the Gas Chromatography Mass Spectroscopy analysis of Boerhaavia diffusa, Euphorbia hirta and Amaranthus polygonoides, which have various medicinal properties. The aim of this study was to investigate and characterize the chemical composition of the different crude aqueous extracts of these plant samples using PerkinElmer Gas Chromatography'Mass Spectrometry. Our results show that the compounds in the extract revealed by GC MS were the same as recorded in the National Institute of Standards and Technology NIST library. The identity and quantity of the measured active compounds was correlated with the expected therapeutic effects. The content of active principles was determined. The quantity of the active principles in the plants was also determined. R. Ezhilarasi | Dr. B. Senthilkumar | Dr. K. Devi "GC-MS Analysis of Bio-Active Compounds in Aqueous Extract of Boerhaavia Diffusa, Euphorbia Hirta and Amaranthus Polygonoides" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29436.pdfPaper URL: https://www.ijtsrd.com/biological-science/zoology/29436/gc-ms-analysis-of-bio-active-compounds-in-aqueous-extract-of-boerhaavia-diffusa-euphorbia-hirta-and-amaranthus-polygonoides/r-ezhilarasi
Pixe for Elemental Analysis of Domestic Medicinal Plants in Bangladeshijrap
The medicinal plants are a source of biologically important elements which are necessary both for animals
and plants. Present study investigates the concentration of elemental constituents of seven selected
medicinally important plants of Bangladesh, namely Terminalia bellirica, Centella asiatica, Pleurotus
ostreatus, Curcuma longa, Bombax ceiba and Trigonella foenum-graecum. Appropriately desiccated
samples (pellets) of these medicinal plants were bombarded with accelerated proton beam with the help of
3 MV Van de Graff accelerator at accelerator Facilities Division, Atomic Energy Center, Dhaka. Eleven
different elements- P, S, K, Ca, Sc, Ti, V, Mn, Fe, Cd and I were detected by collecting the harvested X-rays
with [Si(Li)] detector. Data collection and analysis were performed using Maestro-32 and GUPIX
software
Comparative Analysis of Phytochemical compounds in Normal and root gall of Ok...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Unraveling the potential phytochemical compounds of gymnema sylvestre through...University of Pretoria
ABSTRACT
Objective: To profile the chemical composition of ethanolic extract of Gymnema sylvestre through Gas Chromatography-Mass Spectrometry technique.
Methods: The chemical compositions of the plant leaf extracts of G. sylvestre were investigated using Gas Chromatography–Mass Spectroscopy (Scion 436-GC Bruker model coupled with a Triple, quadruple mass spectrophotometer) and NIST-MS library.
Results: GC-MS analysis of leaf extracts revealed the existence of Terpenes, alcohols, fatty acids, amine and sterols. The highest % Peak area is hexadecanoic acid, α-Santoline alcohol, recorded the next highest % peak area of 9.05. Major of the compounds belongs to terpeneoid group, namely 6-Octen-1-ol, 3,7-dimethyl, Isophytol, Squalene, Nerolidol, β-Amyrin and Cedrene-V6 which constitutes 30.7% of the peak area. The presence of α-Tocopherol-β-D-mannoside and Vitamin E also identified through this study.
Conclusion: From the above finding we can interpret that the G. sylvestre contained a considerable amount of phytoconstituents especially terpenoids. In future, this study will be helpful for the quantitative analysis of phytochemicals as well as formulation studies.
Comprehensive study on pharmacognostic, physico and phytochemical evaluation ...Uploadworld
Terminalia arjuna Roxb. (Family-Combretaceae) is commonly known as Arjun tree and valued for its medicinal uses. In the present investigation, the detailed pharmacognostic study of T. arjuna stem bark (TASB) is carried out to lay down the standards which could be useful in forthcoming experimental studies.
Structural Characterization and Antimicrobial Activity of Cocculus hirsutus L...BRNSS Publication Hub
Many number of the plant species including Cocculus hirsutus L. is being used as the sources of herbal
medicine. Present work was mainly focused with the identification of the therapeutic properties of
C. hirsutus L. leaf extracts. The leaf extracts of methanol, aqueous, chloroform, and benzene showed
solvent dependent qualitative and quantitative phytochemical presence as well as antimicrobial activity.
Whereas the leaf extracts of methanol and chloroform showed significantly high antimicrobial activity
than water and benzene extracts. Further methanol leaf extract of C. hirsutus performed to liquid
chromato y-mass spectroscopy (LC-MS) for identification of active antimicrobial compound structure.
LC-MS studies give 26 structural compounds. Docking (annotating) studies revealed that among 26
compounds the Compound-5 (Hexadecanoic acid - (1R, 2R, 3S, 4R, 6S)-4, 6-diamino-2, 3-dihydroxy
cyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside) showed highest docking fitness score with
the bacterial membrane protein sortase-A. Our data suggest that methanol extract of C. hirsutus leaf
possess medicinally significant antimicrobial compounds and thus justify the use of this leaf as folklore
medicine for preventing human microbial related diseases.
GC-MS Analysis of Bio-Active Compounds in Aqueous Extract of Boerhaavia Diffu...ijtsrd
Medicinal plants have had a crucial role in human culture and civilization. The present study deals with the Gas Chromatography Mass Spectroscopy analysis of Boerhaavia diffusa, Euphorbia hirta and Amaranthus polygonoides, which have various medicinal properties. The aim of this study was to investigate and characterize the chemical composition of the different crude aqueous extracts of these plant samples using PerkinElmer Gas Chromatography'Mass Spectrometry. Our results show that the compounds in the extract revealed by GC MS were the same as recorded in the National Institute of Standards and Technology NIST library. The identity and quantity of the measured active compounds was correlated with the expected therapeutic effects. The content of active principles was determined. The quantity of the active principles in the plants was also determined. R. Ezhilarasi | Dr. B. Senthilkumar | Dr. K. Devi "GC-MS Analysis of Bio-Active Compounds in Aqueous Extract of Boerhaavia Diffusa, Euphorbia Hirta and Amaranthus Polygonoides" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29436.pdfPaper URL: https://www.ijtsrd.com/biological-science/zoology/29436/gc-ms-analysis-of-bio-active-compounds-in-aqueous-extract-of-boerhaavia-diffusa-euphorbia-hirta-and-amaranthus-polygonoides/r-ezhilarasi
Pixe for Elemental Analysis of Domestic Medicinal Plants in Bangladeshijrap
The medicinal plants are a source of biologically important elements which are necessary both for animals
and plants. Present study investigates the concentration of elemental constituents of seven selected
medicinally important plants of Bangladesh, namely Terminalia bellirica, Centella asiatica, Pleurotus
ostreatus, Curcuma longa, Bombax ceiba and Trigonella foenum-graecum. Appropriately desiccated
samples (pellets) of these medicinal plants were bombarded with accelerated proton beam with the help of
3 MV Van de Graff accelerator at accelerator Facilities Division, Atomic Energy Center, Dhaka. Eleven
different elements- P, S, K, Ca, Sc, Ti, V, Mn, Fe, Cd and I were detected by collecting the harvested X-rays
with [Si(Li)] detector. Data collection and analysis were performed using Maestro-32 and GUPIX
software
Comparative Analysis of Phytochemical compounds in Normal and root gall of Ok...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Unraveling the potential phytochemical compounds of gymnema sylvestre through...University of Pretoria
ABSTRACT
Objective: To profile the chemical composition of ethanolic extract of Gymnema sylvestre through Gas Chromatography-Mass Spectrometry technique.
Methods: The chemical compositions of the plant leaf extracts of G. sylvestre were investigated using Gas Chromatography–Mass Spectroscopy (Scion 436-GC Bruker model coupled with a Triple, quadruple mass spectrophotometer) and NIST-MS library.
Results: GC-MS analysis of leaf extracts revealed the existence of Terpenes, alcohols, fatty acids, amine and sterols. The highest % Peak area is hexadecanoic acid, α-Santoline alcohol, recorded the next highest % peak area of 9.05. Major of the compounds belongs to terpeneoid group, namely 6-Octen-1-ol, 3,7-dimethyl, Isophytol, Squalene, Nerolidol, β-Amyrin and Cedrene-V6 which constitutes 30.7% of the peak area. The presence of α-Tocopherol-β-D-mannoside and Vitamin E also identified through this study.
Conclusion: From the above finding we can interpret that the G. sylvestre contained a considerable amount of phytoconstituents especially terpenoids. In future, this study will be helpful for the quantitative analysis of phytochemicals as well as formulation studies.
Comprehensive study on pharmacognostic, physico and phytochemical evaluation ...Uploadworld
Terminalia arjuna Roxb. (Family-Combretaceae) is commonly known as Arjun tree and valued for its medicinal uses. In the present investigation, the detailed pharmacognostic study of T. arjuna stem bark (TASB) is carried out to lay down the standards which could be useful in forthcoming experimental studies.
Structural Characterization and Antimicrobial Activity of Cocculus hirsutus L...BRNSS Publication Hub
Many number of the plant species including Cocculus hirsutus L. is being used as the sources of herbal
medicine. Present work was mainly focused with the identification of the therapeutic properties of
C. hirsutus L. leaf extracts. The leaf extracts of methanol, aqueous, chloroform, and benzene showed
solvent dependent qualitative and quantitative phytochemical presence as well as antimicrobial activity.
Whereas the leaf extracts of methanol and chloroform showed significantly high antimicrobial activity
than water and benzene extracts. Further methanol leaf extract of C. hirsutus performed to liquid
chromato y-mass spectroscopy (LC-MS) for identification of active antimicrobial compound structure.
LC-MS studies give 26 structural compounds. Docking (annotating) studies revealed that among 26
compounds the Compound-5 (Hexadecanoic acid - (1R, 2R, 3S, 4R, 6S)-4, 6-diamino-2, 3-dihydroxy
cyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside) showed highest docking fitness score with
the bacterial membrane protein sortase-A. Our data suggest that methanol extract of C. hirsutus leaf
possess medicinally significant antimicrobial compounds and thus justify the use of this leaf as folklore
medicine for preventing human microbial related diseases.
Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane SteroidRatnakaram Venkata Nadh
Phytochemical screening of Caralluma lasiantha was carried out and one C21 pregnane steroid was isolated from chloroform extract. Based on spectroscopic studies (IR, 1H NMR, 13C NMR and ESI-MS) the isolated compound is 3b,14b-dihydroxy-14b-pregn-5-en-20-one which was earlier isolated from other species.
In-vitro antioxidant and GC-MS analysis ethanolic extract of poly herbal drugSkyfox Publishing Group
Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against
infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe
therapeutics. Poly herbal drugs is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism
of pharmacological actions, antioxidant properties of the Poly herbal drugs extract were tested using standard in vitro models. The
ethanolic extract of Poly herbal drugs exhibited strong scavenging effect on superoxide, nitric oxide radical and reducing power radical
scavenging assay. The free radical scavenging effect of Poly herbal drugs extract was comparable with that of the reference antioxidants.
The data obtained in the present study suggests that the extract of Poly herbal drugs have potent Invitro antioxidant and Anti Diabetic
activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.
Pharmacokinetic Properties of Biomass-extracted Substances Isolated by Green ...Michal Jablonsky
According to the literature, approximately 41 nutraceutical compounds have been isolated from different types of biomass using green solvents. It is important to collect information on the pharmacokinetic properties of the nutraceutical substances from biomass isolated according to the published papers. The pharmacokinetic properties of the bioactive substances extracted by green solvents, such as the molecular weight, logP, AlogP, H-bond acceptor, H-bond donor, total polar surface area, atom molar refractivity, number of rotatable bonds, number of atoms, rotatable bond count, number of rigid bonds, number of atom rings, and number of H-bonds, were calculated with a drug-likeness tool. In practical terms, the original and most well-known Lipinski's Rule of Five (Ro5) was applied to 28 substances, namely 3-hydroxytyrosol; apigenin; artemisinin; bergapten; bilobalide; biochanin A; caffeic Acid; caffeoylmalic acid; catechins; cinnamic acid; curcumin; daidzei; daidzin; epicatechin; gallic acid; genistein; ginkgolide A; ginkgolide B; levofloxacin; luteolin; naringenin; p-coumaric acid; protocatechuic acid; psoralen; quercetin; trans-ferulic acid; tyrosol, and vanillin.
GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Uloth...IOSRJPBS
The determination of phytochemical constituents, total phenol, flavonoid contents and antioxidant assays of methanol extract of Ulothrix flacca and its main constituent dimethyl sulfone was studied. The mass spectra of the compounds were matched with the NIST library. The GC-MS analysis of methanol extracts of Ulothrix flacca showed sixteen peaks. Of all the sixteen chemical compounds revealed from the GC-MS analysis of Ulothrix flacca, Dimethyl Sulfone (C2H6O2S) (RT-8.9), 4-Bromobenzoic Acid, 2-Chlorophenyl Ester (C13H8BrClO2) (RT-12.642), Tetradecanoic Acid, 10,13-Dimethyl-, Methyl Ester (C17H34O2) (RT-18.669) are the three major components. The methanol extracts of Ulothrix flacca possess phenolic and flavonoid content of (5.74 ± 0.45mg Gallic acid equivalent (GAE)/g Wt, and 12.58 ± 1.52mg quercetin eq/g wt) respectively. Antioxidant activity was determined using 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical, for evaluating free radicle scavenging activity, ABTS radical cation scavenging activity, Ferric reducing antioxidant power (FRAP) assay, Phosphomolybdenum assay and Metal chelating activity using BHT, Rutin and Quercetin. The highest radicle scavenging activity was shown by dimethyl sulfone (15.156mg/ml), which is higher than the BHT and Rutin. In vitro antioxidant activity of methanolic extract of Ulothrix flacca and Dimethyl sulfone showed an increase with increasing concentration indicating positive association with the total phenolic and flavonoid contents of the extract, which could be considered for future applications in medicine, dietary supplements ,cosmetics or food industries.
HPTLC determination of carotenoid profile in the leaf and bark samples of lor...Jing Zang
Influence of host plants on the carotenoid profile of Loranthus longiflorus leaf and bark samples collected from Casuarina equisetifolia and Ficus religiosa host trees were determined by HPTLC method. The methanol extract of L. longiflorus leaf samples obtained from C. equisetifolia host trees showed 9 compounds while it was 8 compounds in the leaf samples collected from F. religiosa host tree. Among the compounds, 5 and 3 compound in each sample, respectively, was identified as carotinoids while the others were unknown. Four compounds from each leaf samples collected from C. equisetifolia (peak no. 4- 6 & 8) and F. religiosa (peak no. 1-3 & 6) host trees showed similar Rf values (0.15, 0.19, 0.23 & 0.53, respectively). Similarly, the methanol extract of L. longiflorus bark sample collected from C. equisetifolia and F. religiosa host trees contained 8 compounds each. Of these compounds only 3 from each sample was identified as carotenoids whereas others were unknown and none of these compounds showed any similar Rf values. One compound from leaf and park samples of L. longiflorus collected from C. equisetifolia (peak no. 6 & 4) and F. religiosa (peak no. 4 & 3) showed similar Rf values (0.23 & 0.26), respectively.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
A STUDY TO EVALUATE THE IN VITRO ANTIMICROBIAL ACTIVITY AND ANTIANDROGENIC E...Dr. Pradeep mitharwal
The present paper deals with synthesis and characterization
of some new chromium (III) Schiff base complexes using microwave irradiation
technique as well as conventional heating. The S∩N donor benzothiazolines, 1-
(2-furanyl) ethanone benzothiazoline (Bzt1N
∩
SH), 1-(2-thienyl) ethanone
benzothiazoline (Bzt2N
∩
SH) and 1-(2-pyridyl) ethanone benzothiazoline
(Bzt3N
∩
SH) were prepared by the condensation of ortho-aminothiophenol with
respective ketones in ethanol.
Assessment of Asymptomatic Urinary Tract Infection and Susceptibility of Anti...BRNSS Publication Hub
Urinary tract infection (UTI) is a common and serious health problem affecting many people each year around the world especially females. Therapy of UTI relies on the predictability of the agents causing UTI and knowledge of their antimicrobial susceptibility patterns. A retrospective cross-sectional study was conducted in two major hospitals of Western Nepal. Tools for data collection were a data collection form. A total of 400 patient’s file with suspected UTI were reviewed, out of which 173 (43.3%) of the suspected samples showed the presence of potential pathogens causing UTI. UTI was most prevalent in females of age group of 21–30 years. Escherichia coli was the predominant (65.1%) bacterial pathogen. Amikacin was found to be the most sensitive antimicrobial followed by nitrofurantoin and gentamicin. Ampicillin showed a higher percentage of resistant, compared to other antimicrobials. As drug resistance among bacterial pathogens is an evolving process, regular surveillance and monitoring are necessary to provide effective treatment of UTIs.
Antibacterial and Antifungal Activities of Essential Oils of Crude Extracts o...lukeman Joseph Ade shittu
Concern about the rising prevalence of antibiotics-resistant strains of pathogenic microorganisms has been expressed in the last three decades. However, intensive studies on extracts and biologically-active compounds isolated from medicinal plants have also doubled in the last decade. As a result of paucity of knowledge and folkloric claim on the leaves effectiveness in infectious disease treatments, we aimed to determine the antimicrobial activity of essential oils and lignans present in the crude Sesame radiatum leaves extracts. Ethanolic, Methanolic and Aqueous extracts of Sesame radiatum leaves were studied for their in-vitro antimicrobial activity against both Gram positive and Gram negative micro-organisms and Yeast using Agar diffusion method. The GC-MS phytochemical screening of methanolic extract showed the presence of carboxylic acids and phenolic groups in essential oils especially some of the most potent antioxidants like Sesamol, Sesamolin and Sesamin. Both the methanolic and ethanolic extracts have broad spectrum antimicrobial effect against all the tested micro-organisms except Streptococcus pneumoniae, Candida albicans and Staphylococcus aureus respectively, while the aqueous extract exhibited no inhibitory effect on Staphylococcus aureus and Streptococcus pneumoniae except on Candida albicans. The result confirmed the folkloric claims of the antimicrobial effectiveness of locally consumed Sesame leaves extracts especially against bacterial and common skin infection in many areas of the Country (Nigeria).
Physical and Structural Characterization of Biofield Treated Imidazole Deriva...albertdivis
The Aim of present study was to evaluate the impact of biofield treatment on two imidazole derivatives (i.e., imidazole and 2-methylimidazole) by various analytical methods.
The use of agrochemicals has increased considerably in recent years, and consequently, there has been increased exposure of ecosystems and human populations to these highly toxic compounds. The study and development of methodologies to detect these substances with greater sensitivity has become extremely relevant. This article describes, for the first time, the use of atomic force spectroscopy (AFS) in the detection of enzyme-inhibiting herbicides. A nanobiosensor based on an atomic force microscopy (AFM) tip functionalised with the acetolactate synthase (ALS) enzyme was developed and characterised. The herbicide metsulfuron-methyl, an ALS inhibitor, was successfully detected through the acquisition of force curves using this biosensor. The adhesion force values were considerably higher when the biosensor was used. An increase of ~250% was achieved relative to the adhesion force using an unfunctionalised AFM tip. This considerable increase was the result of a specific interaction between the enzyme and the herbicide, which was primarily responsible for the efficiency of the nanobiosensor. These results indicate that this methodology is promising for the detection of herbicides, pesticides, and other environmental contaminants.
Background: Cancer is a disease caused when cells divide uncontrollably and spread into the surrounding tissue. Changes to DNA cause cancer. It is one of the most common and largest killer diseases in the world. It usually affects physically, and the disease can alter one’s perspective on life and personality. Many treatment options are there to treat cancer. Among them, chemotherapy treatment may have more side effects like lethargy, esophagitis, nausea, vomiting, Fatigue, and insomnia, the most common problems among chemotherapy patients in India. Methods: A quasi-experimental study with a sample size of 60, out of which 30 subjects were in the experimental group and 30 were in the control group. A convenient sampling method was used to select the subjects. A structured questionnaire tool was used to collect the data. Result: The result of the study showed that, during pre-test in the study group, among 30 subjects 3(10%) had moderate Fatigue, 22(73.33%) had severe Fatigue, 5(16.67%) had worst Fatigue and 12(40%) had moderate insomnia, 18(60%) had severe insomnia and in control group among 30 subjects, 6(20%) had moderate Fatigue, 13(43.33%) had severe Fatigue, 11(36.67%) had a worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. With post-test, in experimental group, 14(46.67%) had no fatigue, 16(53.33%) had mild fatigue, 14(46.67%) had no insomnia, 16(53.33%) had mild insomnia, and in control group, 6(20%) had moderate fatigue, 13(43.33%) had extreme fatigue, 11(36.67%) had worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. Conclusion: The study concluded that clients who were receiving chemotherapy had fatigue and insomnia problems. The Warm water foot bath therapy is very effective in clients undergoing chemotherapy in reducing Fatigue and insomnia. A positive correlation between pre-test and post-test was found by using the Mann-Whitney test.
Key-words: Cancer, Chemotherapy, Foot bath, Health, Warm water
Background: Alcohol has long been a global social and medical issue. According to W.H.O report. Total 3.3 million people die from
alcohol abuse annually. Alcoholic liver disease (A.L.D.) ranges from steatosis to liver cirrhosis. Chronic heavy drinkers get hepatitis
or cirrhosis 15 20% of the time
Methods: This study was c onducted in the general medicine inpatient department at PGIMER & C . in Bhubaneswar, Odisha,
Indi a. All hospitali z ed patients with liver illness who had previously t aken alcohol were screened. Each patient's alcohol
consumption, including native alcoholic beverages, was recorded. To support the diagnosis, all standard and extra examination s
were carri ed out. The modified Kuppuswamy scale was used to determine s s ocioeconomic class.
Results: The study comprised 186 participants with a median age of 46. The gender ratio was 3:1, with 139 (74.7%) men. Urban
populations have a greater prevalence of alcohol ic liver disease (60.75%) than rural populations (39.24%). The l ower
s ocioeconomic c lass (50.53%) has the highest rate of alcoholic liver disease. Men drink more (>700 gm/wk) and married people
drink more. A woman who drinks 140 280 grams per week for 10 1 5 years is more likely to develop alcoholic liver disease than a
man who drinks >700 grams per week for 15 years.
Conclusions: In this study, we conclude d that the prevalence of A .L. about S .E. is of utmost importance in developing
population based st r ategies that effectively educate individuals on the need to modify their drinking habits. This is crucial to
mitigate the occurrence of alcohol consumption and its associated repercussions.
Key-words: Socioeconomic status, Hospitalized Patients, Alcoholic Liver Disease
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Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane SteroidRatnakaram Venkata Nadh
Phytochemical screening of Caralluma lasiantha was carried out and one C21 pregnane steroid was isolated from chloroform extract. Based on spectroscopic studies (IR, 1H NMR, 13C NMR and ESI-MS) the isolated compound is 3b,14b-dihydroxy-14b-pregn-5-en-20-one which was earlier isolated from other species.
In-vitro antioxidant and GC-MS analysis ethanolic extract of poly herbal drugSkyfox Publishing Group
Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against
infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe
therapeutics. Poly herbal drugs is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism
of pharmacological actions, antioxidant properties of the Poly herbal drugs extract were tested using standard in vitro models. The
ethanolic extract of Poly herbal drugs exhibited strong scavenging effect on superoxide, nitric oxide radical and reducing power radical
scavenging assay. The free radical scavenging effect of Poly herbal drugs extract was comparable with that of the reference antioxidants.
The data obtained in the present study suggests that the extract of Poly herbal drugs have potent Invitro antioxidant and Anti Diabetic
activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.
Pharmacokinetic Properties of Biomass-extracted Substances Isolated by Green ...Michal Jablonsky
According to the literature, approximately 41 nutraceutical compounds have been isolated from different types of biomass using green solvents. It is important to collect information on the pharmacokinetic properties of the nutraceutical substances from biomass isolated according to the published papers. The pharmacokinetic properties of the bioactive substances extracted by green solvents, such as the molecular weight, logP, AlogP, H-bond acceptor, H-bond donor, total polar surface area, atom molar refractivity, number of rotatable bonds, number of atoms, rotatable bond count, number of rigid bonds, number of atom rings, and number of H-bonds, were calculated with a drug-likeness tool. In practical terms, the original and most well-known Lipinski's Rule of Five (Ro5) was applied to 28 substances, namely 3-hydroxytyrosol; apigenin; artemisinin; bergapten; bilobalide; biochanin A; caffeic Acid; caffeoylmalic acid; catechins; cinnamic acid; curcumin; daidzei; daidzin; epicatechin; gallic acid; genistein; ginkgolide A; ginkgolide B; levofloxacin; luteolin; naringenin; p-coumaric acid; protocatechuic acid; psoralen; quercetin; trans-ferulic acid; tyrosol, and vanillin.
GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Uloth...IOSRJPBS
The determination of phytochemical constituents, total phenol, flavonoid contents and antioxidant assays of methanol extract of Ulothrix flacca and its main constituent dimethyl sulfone was studied. The mass spectra of the compounds were matched with the NIST library. The GC-MS analysis of methanol extracts of Ulothrix flacca showed sixteen peaks. Of all the sixteen chemical compounds revealed from the GC-MS analysis of Ulothrix flacca, Dimethyl Sulfone (C2H6O2S) (RT-8.9), 4-Bromobenzoic Acid, 2-Chlorophenyl Ester (C13H8BrClO2) (RT-12.642), Tetradecanoic Acid, 10,13-Dimethyl-, Methyl Ester (C17H34O2) (RT-18.669) are the three major components. The methanol extracts of Ulothrix flacca possess phenolic and flavonoid content of (5.74 ± 0.45mg Gallic acid equivalent (GAE)/g Wt, and 12.58 ± 1.52mg quercetin eq/g wt) respectively. Antioxidant activity was determined using 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical, for evaluating free radicle scavenging activity, ABTS radical cation scavenging activity, Ferric reducing antioxidant power (FRAP) assay, Phosphomolybdenum assay and Metal chelating activity using BHT, Rutin and Quercetin. The highest radicle scavenging activity was shown by dimethyl sulfone (15.156mg/ml), which is higher than the BHT and Rutin. In vitro antioxidant activity of methanolic extract of Ulothrix flacca and Dimethyl sulfone showed an increase with increasing concentration indicating positive association with the total phenolic and flavonoid contents of the extract, which could be considered for future applications in medicine, dietary supplements ,cosmetics or food industries.
HPTLC determination of carotenoid profile in the leaf and bark samples of lor...Jing Zang
Influence of host plants on the carotenoid profile of Loranthus longiflorus leaf and bark samples collected from Casuarina equisetifolia and Ficus religiosa host trees were determined by HPTLC method. The methanol extract of L. longiflorus leaf samples obtained from C. equisetifolia host trees showed 9 compounds while it was 8 compounds in the leaf samples collected from F. religiosa host tree. Among the compounds, 5 and 3 compound in each sample, respectively, was identified as carotinoids while the others were unknown. Four compounds from each leaf samples collected from C. equisetifolia (peak no. 4- 6 & 8) and F. religiosa (peak no. 1-3 & 6) host trees showed similar Rf values (0.15, 0.19, 0.23 & 0.53, respectively). Similarly, the methanol extract of L. longiflorus bark sample collected from C. equisetifolia and F. religiosa host trees contained 8 compounds each. Of these compounds only 3 from each sample was identified as carotenoids whereas others were unknown and none of these compounds showed any similar Rf values. One compound from leaf and park samples of L. longiflorus collected from C. equisetifolia (peak no. 6 & 4) and F. religiosa (peak no. 4 & 3) showed similar Rf values (0.23 & 0.26), respectively.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
A STUDY TO EVALUATE THE IN VITRO ANTIMICROBIAL ACTIVITY AND ANTIANDROGENIC E...Dr. Pradeep mitharwal
The present paper deals with synthesis and characterization
of some new chromium (III) Schiff base complexes using microwave irradiation
technique as well as conventional heating. The S∩N donor benzothiazolines, 1-
(2-furanyl) ethanone benzothiazoline (Bzt1N
∩
SH), 1-(2-thienyl) ethanone
benzothiazoline (Bzt2N
∩
SH) and 1-(2-pyridyl) ethanone benzothiazoline
(Bzt3N
∩
SH) were prepared by the condensation of ortho-aminothiophenol with
respective ketones in ethanol.
Assessment of Asymptomatic Urinary Tract Infection and Susceptibility of Anti...BRNSS Publication Hub
Urinary tract infection (UTI) is a common and serious health problem affecting many people each year around the world especially females. Therapy of UTI relies on the predictability of the agents causing UTI and knowledge of their antimicrobial susceptibility patterns. A retrospective cross-sectional study was conducted in two major hospitals of Western Nepal. Tools for data collection were a data collection form. A total of 400 patient’s file with suspected UTI were reviewed, out of which 173 (43.3%) of the suspected samples showed the presence of potential pathogens causing UTI. UTI was most prevalent in females of age group of 21–30 years. Escherichia coli was the predominant (65.1%) bacterial pathogen. Amikacin was found to be the most sensitive antimicrobial followed by nitrofurantoin and gentamicin. Ampicillin showed a higher percentage of resistant, compared to other antimicrobials. As drug resistance among bacterial pathogens is an evolving process, regular surveillance and monitoring are necessary to provide effective treatment of UTIs.
Antibacterial and Antifungal Activities of Essential Oils of Crude Extracts o...lukeman Joseph Ade shittu
Concern about the rising prevalence of antibiotics-resistant strains of pathogenic microorganisms has been expressed in the last three decades. However, intensive studies on extracts and biologically-active compounds isolated from medicinal plants have also doubled in the last decade. As a result of paucity of knowledge and folkloric claim on the leaves effectiveness in infectious disease treatments, we aimed to determine the antimicrobial activity of essential oils and lignans present in the crude Sesame radiatum leaves extracts. Ethanolic, Methanolic and Aqueous extracts of Sesame radiatum leaves were studied for their in-vitro antimicrobial activity against both Gram positive and Gram negative micro-organisms and Yeast using Agar diffusion method. The GC-MS phytochemical screening of methanolic extract showed the presence of carboxylic acids and phenolic groups in essential oils especially some of the most potent antioxidants like Sesamol, Sesamolin and Sesamin. Both the methanolic and ethanolic extracts have broad spectrum antimicrobial effect against all the tested micro-organisms except Streptococcus pneumoniae, Candida albicans and Staphylococcus aureus respectively, while the aqueous extract exhibited no inhibitory effect on Staphylococcus aureus and Streptococcus pneumoniae except on Candida albicans. The result confirmed the folkloric claims of the antimicrobial effectiveness of locally consumed Sesame leaves extracts especially against bacterial and common skin infection in many areas of the Country (Nigeria).
Physical and Structural Characterization of Biofield Treated Imidazole Deriva...albertdivis
The Aim of present study was to evaluate the impact of biofield treatment on two imidazole derivatives (i.e., imidazole and 2-methylimidazole) by various analytical methods.
The use of agrochemicals has increased considerably in recent years, and consequently, there has been increased exposure of ecosystems and human populations to these highly toxic compounds. The study and development of methodologies to detect these substances with greater sensitivity has become extremely relevant. This article describes, for the first time, the use of atomic force spectroscopy (AFS) in the detection of enzyme-inhibiting herbicides. A nanobiosensor based on an atomic force microscopy (AFM) tip functionalised with the acetolactate synthase (ALS) enzyme was developed and characterised. The herbicide metsulfuron-methyl, an ALS inhibitor, was successfully detected through the acquisition of force curves using this biosensor. The adhesion force values were considerably higher when the biosensor was used. An increase of ~250% was achieved relative to the adhesion force using an unfunctionalised AFM tip. This considerable increase was the result of a specific interaction between the enzyme and the herbicide, which was primarily responsible for the efficiency of the nanobiosensor. These results indicate that this methodology is promising for the detection of herbicides, pesticides, and other environmental contaminants.
Background: Cancer is a disease caused when cells divide uncontrollably and spread into the surrounding tissue. Changes to DNA cause cancer. It is one of the most common and largest killer diseases in the world. It usually affects physically, and the disease can alter one’s perspective on life and personality. Many treatment options are there to treat cancer. Among them, chemotherapy treatment may have more side effects like lethargy, esophagitis, nausea, vomiting, Fatigue, and insomnia, the most common problems among chemotherapy patients in India. Methods: A quasi-experimental study with a sample size of 60, out of which 30 subjects were in the experimental group and 30 were in the control group. A convenient sampling method was used to select the subjects. A structured questionnaire tool was used to collect the data. Result: The result of the study showed that, during pre-test in the study group, among 30 subjects 3(10%) had moderate Fatigue, 22(73.33%) had severe Fatigue, 5(16.67%) had worst Fatigue and 12(40%) had moderate insomnia, 18(60%) had severe insomnia and in control group among 30 subjects, 6(20%) had moderate Fatigue, 13(43.33%) had severe Fatigue, 11(36.67%) had a worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. With post-test, in experimental group, 14(46.67%) had no fatigue, 16(53.33%) had mild fatigue, 14(46.67%) had no insomnia, 16(53.33%) had mild insomnia, and in control group, 6(20%) had moderate fatigue, 13(43.33%) had extreme fatigue, 11(36.67%) had worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. Conclusion: The study concluded that clients who were receiving chemotherapy had fatigue and insomnia problems. The Warm water foot bath therapy is very effective in clients undergoing chemotherapy in reducing Fatigue and insomnia. A positive correlation between pre-test and post-test was found by using the Mann-Whitney test.
Key-words: Cancer, Chemotherapy, Foot bath, Health, Warm water
Background: Alcohol has long been a global social and medical issue. According to W.H.O report. Total 3.3 million people die from
alcohol abuse annually. Alcoholic liver disease (A.L.D.) ranges from steatosis to liver cirrhosis. Chronic heavy drinkers get hepatitis
or cirrhosis 15 20% of the time
Methods: This study was c onducted in the general medicine inpatient department at PGIMER & C . in Bhubaneswar, Odisha,
Indi a. All hospitali z ed patients with liver illness who had previously t aken alcohol were screened. Each patient's alcohol
consumption, including native alcoholic beverages, was recorded. To support the diagnosis, all standard and extra examination s
were carri ed out. The modified Kuppuswamy scale was used to determine s s ocioeconomic class.
Results: The study comprised 186 participants with a median age of 46. The gender ratio was 3:1, with 139 (74.7%) men. Urban
populations have a greater prevalence of alcohol ic liver disease (60.75%) than rural populations (39.24%). The l ower
s ocioeconomic c lass (50.53%) has the highest rate of alcoholic liver disease. Men drink more (>700 gm/wk) and married people
drink more. A woman who drinks 140 280 grams per week for 10 1 5 years is more likely to develop alcoholic liver disease than a
man who drinks >700 grams per week for 15 years.
Conclusions: In this study, we conclude d that the prevalence of A .L. about S .E. is of utmost importance in developing
population based st r ategies that effectively educate individuals on the need to modify their drinking habits. This is crucial to
mitigate the occurrence of alcohol consumption and its associated repercussions.
Key-words: Socioeconomic status, Hospitalized Patients, Alcoholic Liver Disease
Background: One of the most common disorders in this age group, abnormal uterine bleeding (AUB), is the primary cause of most gynaecological problems in adolescents. Unfortunately, epidemiological data on AUB in teenagers is scarce, especially in the Indian subcontinent. The PALM-COEIN classification, where PALM stands for structural reasons and COEIN for functional causes, was employed in this single-center prospective observational study to evaluate the relative contributions of several etiological factors in AUB. To comprehend the etiological, dermographic, and therapeutic factors affecting menorrhagia in patients going through adolescence. Methods: Enrollment for females with AUB between 10 and 19 occurred between January and December 2022. A thorough history, physical examination, and laboratory evaluation, which in every case comprised standard testing, hormone analysis, and abdominal and pelvic ultrasonography were used to determine the cause of AUB. MRIs and CT scans were performed when needed. Results: There were 190 patients enrolled in total. Functional factors comprised the predominant aetiology of AUB among adolescent females: Adenomyosis=01 (0.52%), Polyp=1 (0.52%). Coagulopathy=2 (1.05%), Leomyoma=01 (0.52%), Malignancy=1 (0.52%), and PALM=4 (2.11%). COEIN=186 (97.89%), ovulation disorder=175 (92.15%), endometrial=01 (0.52%), iatrogenic=6 (3.15%), non-specified=2 (1.05%), and iatrogenic=6 (3.15%). Conclusion: The most frequent cause of AUB in the adolescent population is ovulatory abnormalities. Even though they are extremely rare, structural factors must be ruled out. A helpful technique for evaluating patients with AUB systematically is the PALM-COEIN classification.
Key-words: PALM-COEIN, Leiomyoma, AUB, Polycystic ovarian syndrome, Hormonal therapy
Derived from the bacterium Proteus vulgaris , chondroitin ABC lyase is an enzyme that can be used in treating proteoglycans that
affect neural activity (communication, plasticity). Chondroitinase can be used for vision abnormalities and spinal injuries. The
biological activity of chondroitinase is due to its ability to act on chondroitin sulfate proteoglycans (CSPGs) which are required for
normal functioning. Th is study aim s to examine various types and routes of administration of Chondr oitina se e n zymes. There is an
increasing application of chondro itin sulfate proteoglycans in spinal cord injury, vit reous attachment, and the management of
various carcinogenic conditions. Research must be done to create an effective chondroitinase delivery mech anism so that the
pharmacological activity seen in vitro and in preclinical research may be applied in the clinic. More studies are required to widen
the application of chondroitinase in therapeutics. In this review, chondroitinase ABC, B, and C are all di scuss ed. T he routes of
administration like caudal or ros tral, intracerebroventricular, hydrogels, and intrath ecal have been detailed. The current review
article highlights the different medical uses for chondroitinase, drug delivery methods for the enzym e, and chondroitinase
dispersion across bacteria. In conclusion, this study can reduce the chance of edema by the intracerebroventric ular route.
However, it is not effective for people due to the gyrencephalic anatomy of brain
Key-words: Chondroitinase, Chondroitin, Chondroitin Sulfate Proteoglycans, Spinal Injuries, Ocular Abnormalities, Proteoglycans
Background: Maturing is a widespread peculiarity. Advanced age is not in itself a sickness however is an ordinary piece of human existence length. A guardian, like wise called a career, home wellbeing assistant or individual consideration assistant, is the individual answerable for furnishing their clients with day-to-day private consideration and help with exercises. Methods: Exploration approach: unmistakable methodology research plan: graphic study research plan. The setting of the review: provincial areas of Bagalkot region. Information assortment strategy: organized polls test. The example was chosen by an arbitrary inspecting procedure. The analyst arbitrarily chose Shirur town as a provincial setting and was chosen for enrolment of subjects. Results: The information score of guardians was 41.06%, with mean and SD of 12.32±3.925. These discoveries uncover those guardians had normal information for advanced-age medical conditions. The mentality score of guardians was 73.73%, with a mean and SD of 110.6±11.008. These discoveries uncovers that parental figures have concur capable demeanour in regards to the advanced age medical conditions. Conclusion: At last, a critical co-connection between the information and demeanour at 0.001 the discoveries uncovers that there is a moderate positive relationship between the information and disposition of the advanced age medical issues.
Key-words: Assess, Care Giver, Health Problems, Knowledge, Old Age
Background: Adolescent is one of the most rapid phases of human development. Anemia is a deficiency in the number of RBC in your body. RBC carry oxygen around your body using a particular protein called hemoglobin. Normal hemoglobin level in adolescent girls 13-15 g/dl. According to WHO, the hemoglobin level 10- 11.9 g/dl is considered mild anemia, 7-9 g/dl is considered moderate, and less than 7 g/dl is called severe anemia. Methods: The present study is pre-experimental among 60 adolescent girls, using a disproportional stratified random technique. One experimental group of clients was selected without randomization and no control group was used. The data was collected by using the structured close-ended knowledge questionnaire. The data was analyzed using descriptive and inferential statistics regarding mean, frequency distribution, percentage, paired table t-test and chi-square test. Results: The overall findings reveal that the post-test knowledge mean score 26.24% with SD±5.94, which was 72% of the total score was more when compared to the pre-test knowledge mean score 12.98 with SD 5.94, which was 36.83% of total score. The calculated t-value of 24.91 was much higher than the table t-value 1.96 for the hypothesis. Conclusion: The study provides that VATP on knowledge regarding the preparation and use of moringa juice in managing anemia among adolescent girls was the scientific, logical and cost-effective strategy.
Key-words: Adolescent girls, Knowledge, VATP, Effectiveness, Socio-demographic variables.
Background: The research demonstrates that water birth comports and loosens mothers actually and intellectually. The buoyance lessens body weight and permits free development and situating to the mother. Buoyance and warm water upgrade uterine withdrawal and better blood flow, which builds uterine muscles' oxygenation, diminishes the mother's torment and increases maternal oxygenation of the child. Submersion of water assists with decreasing circulatory strain and additionally gives security, which hinders uneasiness or dread. Methods: The current review pre-trial study with 50, 4th-year B.Sc. Nursing is chosen through basic arbitrary methods. One gathering pre-test without control bunch configuration was utilized. Information was gathered through a self-directed, organized, shut, finished information survey. Data was examined by involving distinct and inferential measurements concerning mean rate by conveyance, matched "t" test, and Chi-square test for affiliation. Results: The pre-test reveals that out of 50 BSc 4th-year nursing students, the highest pre-test (62%) of BSc 4th-year nursing students had poor knowledge. Overall, the post-test knowledge score (22.6±4.19), 70.62% of the total score, was more than the pre-test knowledge score (8.76±3.95), 23.3%. The effectiveness of the assisted teaching programme, in this area, the mean knowledge score was 13.84 with SD±0.24, which was 43.25% of the total score. Hence, it indicates that the video-assisted teaching program effectively enhanced the knowledge of BSc 4th-year nursing students. Conclusion: This study concluded that video-assisted teaching programmes on knowledge regarding waterbirth among B.Sc 4th year Nursing students was the scientific, logical and cost-effective strategy.
Key-words: Effectiveness, Fourth year B.Sc. Nursing students, Knowledge, VATP, Water birth
Background: Post-menopausal women experience many physical, emotional, and mental symptoms during the post-menopausal period, and reflexology has grown into a complex therapeutic modality and has a range of effects. Reflexology will help put hormones back into a normal state and act like a process of emotional cleansing, relieving stress and restoring harmony to the body and soul. Hence, foot reflexology seems to be effective in treating post-menopausal symptoms. Methods: In the present study, pre-experimental i.e. one group pretest-posttest design, was adopted. The study was conducted on 30 post-menopausal women to assess their knowledge regarding foot reflexology. Samples were selected by using a convenient sampling technique. Data was collected using a structured knowledge questionnaire and analyzed using descriptive and inferential statistics. Results: The mean percentage of the pre-test score was 28%, and the post-test score was 76.65%. The mean and the standard deviation of the pre-test score were 5.60±1.71, and the mean and the standard deviation of the post-test score were 15.33±1.15. The total mean and standard deviation are 9.73±2.07 by comparing the pre-test and post-test scores. Hence, it was found that there is a significant difference between pre-test and post-test knowledge scores of post-menopausal women regarding foot reflexology. No significant association was found between post-test knowledge scores and socio-demographic variables on foot reflexology. Conclusion: The study concluded that a planned teaching program on knowledge regarding foot reflexology for post-menopausal women was a scientific, logical, and cost-effective strategy to reduce post-menopausal symptoms.
Key-words: Effectiveness, Foot reflexology, Post-menopausal women, Planned teaching program, Socio-demographic variables
Background: A 51-year-old woman had left lower abdomen pain for 18 hours with nausea and vomiting. Prior CT scans suggested pelvic neoplasms. Our hospital's emergency CT showed an enlarged uterus with cystic shadows, right adnexal cysts, and stomach fluid. Physical examination revealed left lower abdomen discomfort. A gynaecological examination revealed a painful, firm pelvic mass of 151210 cm. Further diagnosis is underway. Method: The patient underwent emergency exploratory laparotomy, discovering a twisted, swollen left ovary with a 540° rotation, classified as a benign cyst. It was found that the patient had congenital upper vaginal atresia and bilateral initial uteri. Pain was reduced after surgery, thanks to symptomatic treatment. An abnormal karyotype of 46, XX,1qh+ was found during genetic testing. Result: Fallopian tubes, uterus, and vagina develop from the embryonic accessory mesonephric duct. MRKH syndrome is caused by bilateral accessory mesonephric duct dysplasia and disappearance of the uterus or vagina. MRKH has three types, with Type 1 lacking uterus or vagina. Due to ovarian cyst torsion, this Type 1 MRKH with double initial uterus and upper vaginal atresia needed left adnexa resection. Genetic testing showed a typical female karyotype. MRKH's complex aetiology incorporates chromosomal abnormalities, emphasizing early cytogenetic evaluation for personalized treatment and fertility assistance. Conclusion: Early cytogenetic testing for MRKH syndrome patients is crucial for determining the underlying cause and guiding personalized treatment plans to restore reproductive function and improve quality of life.
Key-words: Double primordial uterus; MRKH syndrome; Upper vaginal atresia; Torsion of left ovarian cyst pedicle
Background: Cell phones have advanced to the degree of becoming a necessary piece of individuals' lives. Cell phones are utilised for correspondence, diversion, efficiency, interpersonal interaction, and gaming. In addition to supplanting the conventional cells, cell phones have likewise supplanted personal computers and numerous other comparative gadgets. Individuals these days feel indistinguishable from their cell phones. In lined with the rising improvement of innovation and excessive utilisation of cell phones, one of the significant issues that scientists have noticed and are chipping away at is cell phone addiction. Methods: It was a graphic study directed among 100 nursing students aged 19-22 in B.V.V.S. Institute of Nursing Sciences Bagalkot. Information was gathered utilising a structured knowledge questionnaire to survey socio-demographic information. The Stanford Sleepiness Scale (Alertness Test) was utilised to evaluate the classroom alertness of the nursing students and the Cell phone Addiction Scale-Short Version (SAS-SV) was utilised to assess the cell addiction of the nursing students. Results: An association was found between the year of studying and the classroom alertness of students (χ2 =3.9102) p<0.05. There was a significant negative correlation between cell phone addiction and classroom alertness of the nursing students, p<0.05. The r-value obtained was 0.80. Thus, the correlation between the two factors is seen as statistically significant. Conclusion In the wake of acquiring the consequences of the current work the scientist s saw a negati ve relationship between cell
pho ne addiction and the class room alertness of the students.
Key-words: Addiction, Alertness, Cell phone, Classroom, Phone addiction
Background: Chemical changes occur in the epididymis when the testicular sperm grows. When sperm and seminal fluids mix during ejaculation, a substance called semen is formed. The cervical mucus of a fertilized egg screens out the best possible sperm. For infertility, Intra Cytoplasmic Sperm Injection (ICSI) can be necessary. Test sperm that are DNA efficient, normal, and motile using Swim Up. Sperm could be damaged by reactive oxygen species that are produced during centrifugation. All infertility treatments should take these factors into account. Methods: The in vitro fertilization (ICSI) procedure was administered to fifty male patients who were 35 years old or younger and tested positive for normozoospermia, asthenozoospermia, and oligozoospermia. After obtaining informed consent, a Swim-Up was performed using both the full semen and a washed pellet. With sperm obtained from both methods, six Metaphase-2 stages of oocytes (MII oocytes) were implanted in each patient. A Tri-gas Bench-top incubator was used to put each injected oocyte in its 37°C setting. Results: The study showed that the age differences were insignificant (p=0.722), but significant variations emerged in sperm concentration before processing (p=1.030) and after (p=1.064). Sperm morphology differences were evident before processing (p=0.004) and after (p=0.002). No significant differences were noted in the number of Day 3 cleavage stage embryos. Conclusion: The study concluded that there is no significant difference between the two techniques regarding sperm washing efficiency.
Key-words: Sperm preparation methods, Swim-up, Centrifugation, ICSI, Fertilization, Day 3 Embryo
Background: The third most common musculoskeletal symptom in orthopaedic clinical practice is a sore shoulder, which can cause significant morbidity. It has been reported that 7–27% of the general population has it, and 36–66% of overhead arm athletes have it. Pathophysiology includes functional, degenerative, and mechanical factors. Most shoulder pain is subacromial pain syndrome (SAPS), often known as ‘shoulder impingement syndrome’. Impingement hypothesis: shoulder joint structures mechanically clash. SAPS accounts for 36–48% of shoulder discomfort. Methods: This observational study was conducted in the Department of Orthopaedics, MKCG Medical College and Hospital, Berhampur, among Eastern Indian outpatients. The study included adult patients (ages 18–75) of both sexes who presented to MKCG Medical College and Hospital's OPD with shoulder pain from December 2020 to November 2022 and were diagnosed with Shoulder Impingement Syndrome (SIS). Thorough histories and clinical exams were done. The Department of Radiology, MKCG Medical College and Hospital, Berhampur, performed conventional shoulder MRIs on the selected participants. Results: Most cases and controls were Type-II (43.3%), followed by Type-I (28.3% and 30%, 29.2% of the total group). The study's least common acromial shape was type-IV, seen in 5% of cases and 10% of controls (7.5% of the sample). Fisher's exact test showed no significant connection between subacromial impingement and acromial shape (p=0.65). With a p-value of 0.045, cases had a significantly greater acromial width (8.12±2.16 mm) than controls (7.51±0.81 mm). Conclusion: Sub-acromial impingement was unrelated to acromion morphology. There was no correlation between acromial morphology and rotator cuff injuries.
Key-words: Shoulder Impingement Syndrome, Acromion Morphology, MRI
Impact of Acceptance and Mindfulness-Based Intervention as an Add-on Treatment for Skin Diseases-Acne, Eczema and Psoriasis
http://dx.doi.org/10.21276/SSR-IIJLS.2020.6.5.2
Seasonal Incidence and Varietal Response of Gram against Helicoverpa armigera (Hubner) at Talwandi Sabo, Punjab
http://dx.doi.org/10.21276/SSR-IIJLS.2020.6.4.3
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Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
The Evolution of Science Education PraxiLabs’ Vision- Presentation (2).pdfmediapraxi
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💥 Let’s dive into the future of science and shed light on PraxiLabs’ crucial role in transforming this field!
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
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What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
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Toxic effects of heavy metals : Lead and Arsenicsanjana502982
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Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
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