Physiological changes in pregnancy are due to hormonal changes and fetal growth. Systems affected include respiratory (increased lung volumes), cardiovascular (increased cardiac output and stroke volume), hematologic (hemodilution), gastrointestinal (delayed gastric emptying), and renal (increased glomerular filtration rate). These changes result in implications for anesthesia like rapid denitrogenation and hypoxia during apnea due to decreased functional residual capacity. Spinal and epidural requirements are lower due to neural sensitivity changes. Changes revert to pre-pregnancy levels postpartum, generally within 6-12 weeks.
The second stage of labor begins when the cervix is completely dilated (open), and ends with the birth of your baby. Contractions push the baby down the birth canal, and you may feel intense pressure, similar to an urge to have a bowel movement. Your health care provider may ask you to push with each contraction.
The second stage of labor begins when the cervix is completely dilated (open), and ends with the birth of your baby. Contractions push the baby down the birth canal, and you may feel intense pressure, similar to an urge to have a bowel movement. Your health care provider may ask you to push with each contraction.
Threatened abortion by dr alka mukherjee dr apurva mukherjee nagpur m.s.alka mukherjee
Threatened abortion is associated with bleeding and/or uterine cramping while the cervix is closed. This stage of abortion may progress to spontaneous incomplete or complete abortion. While this event may be considered a part of the quality control process in human reproduction, it is important to know the possible etiologies and when therapy might prevent pregnancy loss. The World Health Organization estimated that 15% of all clinically recognizable pregnancies and in spontaneous abortion, 50-60% of which are due to chromosomal abnormalities. Apart from the fetal factors, several maternal and probably paternal factors contribute to the causes of spontaneous abortion. The maternal factors that may be responsible for abortion include both local and systemic conditions such as infections, maternal disease states, genital tract abnormalities, endocrine factors and other miscellaneous causes (antiphospholipid antibodies, maternal-fetal histocompatibility, excessive smoking and other environmental toxicants, etc.). This review focuses on the management of threatened abortion, but it should be emphasized that the management to maintain pregnancy is reasonable only in those cases, in which the fetus is not seriously affected. It would not be beneficial to provide treatment that would permit chromosomally and anatomically abnormal embryos to survive to term. Treatment is feasible first of all in cases with maternal factors. Surgical procedures may precede pregnancy (correction of septate uterus, removal of a submucous leiomyomata) or may be performed usually in the second trimester (cervical cerclage). Maternal general diseases (diabetes, hypothyroidism) and infections should be treated accordingly. The most common entity to be treated in this category is luteal phase deficiency. Progesterone is the most important hormone for the maintenance of an early human pregnancy. Besides progesterone administration, human chorionic gonadotropin (hCG) also is the logical endocrine treatment of choice. In the pregnant woman hCG stimulates and optimizes hormonal production in the corpus luteum and may also influence the fetoplacental unit. The contribution of environmental, physical and chemical agents to the incidence of spontaneous abortion is controversial. They may be abortifacient even if they are not teratogenic. Exposure to environmental toxicants should be avoided. Paternal leukocyte immunotherapy has been associated with successful outcome in patients with unexplained repeated spontaneous abortion. This therapeutic approach is considered experimental, as there may be some significant risks. Associating maternal antiphospholipid antibodies with reproductive failure is a rapidly developing field. Administration of corticosteroids with low doses of aspirin has resulted in fetal salvage in women in whom antiphospholipid antibodies are present.
Threatened abortion by dr alka mukherjee dr apurva mukherjee nagpur m.s.alka mukherjee
Threatened abortion is associated with bleeding and/or uterine cramping while the cervix is closed. This stage of abortion may progress to spontaneous incomplete or complete abortion. While this event may be considered a part of the quality control process in human reproduction, it is important to know the possible etiologies and when therapy might prevent pregnancy loss. The World Health Organization estimated that 15% of all clinically recognizable pregnancies and in spontaneous abortion, 50-60% of which are due to chromosomal abnormalities. Apart from the fetal factors, several maternal and probably paternal factors contribute to the causes of spontaneous abortion. The maternal factors that may be responsible for abortion include both local and systemic conditions such as infections, maternal disease states, genital tract abnormalities, endocrine factors and other miscellaneous causes (antiphospholipid antibodies, maternal-fetal histocompatibility, excessive smoking and other environmental toxicants, etc.). This review focuses on the management of threatened abortion, but it should be emphasized that the management to maintain pregnancy is reasonable only in those cases, in which the fetus is not seriously affected. It would not be beneficial to provide treatment that would permit chromosomally and anatomically abnormal embryos to survive to term. Treatment is feasible first of all in cases with maternal factors. Surgical procedures may precede pregnancy (correction of septate uterus, removal of a submucous leiomyomata) or may be performed usually in the second trimester (cervical cerclage). Maternal general diseases (diabetes, hypothyroidism) and infections should be treated accordingly. The most common entity to be treated in this category is luteal phase deficiency. Progesterone is the most important hormone for the maintenance of an early human pregnancy. Besides progesterone administration, human chorionic gonadotropin (hCG) also is the logical endocrine treatment of choice. In the pregnant woman hCG stimulates and optimizes hormonal production in the corpus luteum and may also influence the fetoplacental unit. The contribution of environmental, physical and chemical agents to the incidence of spontaneous abortion is controversial. They may be abortifacient even if they are not teratogenic. Exposure to environmental toxicants should be avoided. Paternal leukocyte immunotherapy has been associated with successful outcome in patients with unexplained repeated spontaneous abortion. This therapeutic approach is considered experimental, as there may be some significant risks. Associating maternal antiphospholipid antibodies with reproductive failure is a rapidly developing field. Administration of corticosteroids with low doses of aspirin has resulted in fetal salvage in women in whom antiphospholipid antibodies are present.
Detailed account of the various changes that occur in maternal anatomy, physiology, and metabolism of pregnant women. These physiological changes are often very precise, and deviations of physiological responses can be a prelude to possible disease/infectious states. In this second part of Labor, we will examine the various systems of the human body,its altered states during pregnancy, and how those changes affect the woman preparing for delivery. Special care is imperative in properly determining the needs of an expecting mother, so developing an intimate, trusting relationship between the mother and fully understanding her physiological output will lead to the best chances of a successful delivery.
Anaesthesia challenges in neonatal emergencies-1.pptxsouravdash24
Neonatal emergencies present unique challenges in anesthesia, requiring specialized knowledge and skills to ensure safe and effective care for these vulnerable patients. This presentation delves into the intricacies of providing anesthesia to neonates in emergency situations, discussing physiological differences, equipment considerations, medication dosages, and monitoring techniques tailored to this population. Explore essential strategies and best practices for managing airway, ventilation, and hemodynamic stability in neonatal emergencies, aiming to optimize outcomes and mitigate risks. Whether you're a seasoned anesthesiologist or a healthcare professional seeking insight into neonatal anesthesia, this presentation offers valuable insights into navigating the complexities of neonatal emergencies with confidence and expertise.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
3. www.anaesthesia.co.in
Introduction
Changes occur in pregnancy to
1. Support the foetus
2. Prepare mother for delivery
Changes are due to
1. Hormonal changes
2. Increasing size of uterus and foetus
3. Anatomical changes
4. Why study these changes?
1.
2.
3.
4.
To differentiate normal from abnormal
To understand its anaesthetic implications
To make the process of delivery smooth
To anticipate and manage complications
www.anaesthesia.co.in
5. Systems affected
Body wt & metabolism
Respiratory
Cardiovascular
Hematopoietic
Gastrointestinal
CNS
Hepatobiliary
Renal
Endocrine
Pharmacological
6. Body wt. & metabolism
Wt GAIN = 17%
= 12 kg
T1 = 1-2 kg
T2 = 5-6 kg
T3 = 5-6 kg
BMR +15% at term
O2 consumption +35% (↑needs of fetus, uterus, placenta)
+ 40% in stage I of labour
+ 75% in stage II of labour
7. Respiratory
1. Anatomical
a) Rib cage and breast enlargement- laryngoscopy
difficult
b) Diaphragm pushed cranially- changes in lung vol
c) ↑ mucosal engorgement
nasal – epistaxis
nasal intubation difficult
oropharyngeal – smaller ETT
↑mallampatti score
d) ↓Chest wall compliance (lung compliance unaffected)
e) Subglottic airway dilatation (progesterone, cortisone,
S
relaxin) →↓pulmonary resistance (-50%)
8.
9. Changes in lung vol and capacities
PARAMETER
CHANGE
1. TV
+45%
2. FRC
-20%
3. ERV
-25%
4. Dead space
+45%
5. RR
No change/+
6. MV
+45%
7. Alveolar ventilation
+45%
Note: change in MV is solely due to ↑in TV and not RR
11. Continued…
2. Physiological changes
1. ↑MV → ↑ TV (RR unchanged)
1. Progesterone (↑CNS sensitivity to CO2)
2.↑CO2 production
alkalosis (compensatory but incomplete↓HCO3- →↑pH
.
by 0.02-0.06)
2. Breathing diaphragmatic > thoracic - advantage during
high regional blockade
www.anaesthesia.co.in
12. Continued…
3. Blood gases
a) Paco2_- ↓to 30 mm Hg by 30 wk, no further change
b) ∆ Paco2_- ETco2 = 0 (because no. of unperfused
alveoli i.e. DS ↓ due to ↑CO)
c) ↑ PaO2 to 107 mmHg but ↓when supine
d) ∆ AV O2
early gestation: ↑CO > ↑O2 consumption → ↑ ∆ AV O2
late gestation: ↑CO < ↑O2 consumption → ↓ ∆ AV O2
e) FRC < closing capacity → small airways close
during normal tidal ventilation → predisposes to hypoxia
13. Anaesthetic implications
PARAMETER
CONSEQUENCE
1. MV ↑
Faster denitrogenation
2. ↓FRC + ↑O2 consumption
Rapid hypoxia during
apnoea
3. ↑MV + ↓FRC
4. Mucosal engorgement
Faster inhalational induction
Faster emergence
Faster changes in depth
Difficult airway
5. Predominant
diaphragmatic breathing
High spinal does not affect
MV & PaCO2 much
14. Circulatory changes
Examination- 1.Apical impulse in 4th ICS & laterally
2.Loud S1
3.A2P2 changes less with respiration
4.S3 in 16% cases
5.Grade I - II early mid-diastolic murmur at
left sternal border.
6. Asymptomatic pericardial effusion
ECG – 1.Sinus tachycardia ( ↓PR & QT interval)
2.ST depression & T inversion in left precordial
leads
3.Left axis deviation (false)
15. Continued…
ECHO – 1. Enlargement of chambers
2. LVH
3. Annular dilatation of all valves except Aortic
(regurgitation)
4. ↑ LVEDV but no change in filling P(PCWP/CVP)
(because of cardiac dilatation & hypertrophy)
5. LVESV-unchanged
↑EF
Chest X Ray – 1. Apparent cardiomegaly
2. ↑ LA (lateral view)
3. ↑ vascular markings
4. Straightening of left heart border
5. Pleural effusion
18. Continued…
Blood pressure
Position
max. in supine
min. in lateral
Age
↑with age
Parity
nullipara> multipara
SV(↑)
SBP
SBP unaffected
vsl distensibility(↑compliance)
BP
↓PP
DBP
SVR(↓)
DBP ↓
19. Continued…
Aortocaval compression : starts at 13-16 wk
1.Concealed caval compression.
In supine position gravid uterus compresses IVC & ↓CO
without fall in the blood pressure.
Why no fall in blood pressure ?
1.Reflex vasoconstriction
2.Diversion of blood through paravertebral &
epidural venous plexus, ovarian veins – maintains
VR
20. Continued…
2.Overt caval compression (supine hypotensive
syndrome)
Hypotension, sweating, bradycardia, pallor, nausea,
vomiting.
Due to uncompensated ↓VR
Prevention of SHS: (aim is to displace the uterus)
1.Providing left lateral tilt 15 degrees beyond 28wk
2.Placing wedge under the right buttock
3. Oxford position
21. Compression of aorta & IVC in supine & lateral tilt position
www.anaesthesia.co.in
22. Anaesthetic implications
PARAMETER
1. ↓RA filling
CONSEQUENCE
↓SV & CO (25%)
2. Chronic partial IVC
Venous stasis, phlebitis,
obstruction
edema in lower limbs
Note: Adverse hemodynamic ↓ed spinal LA requirement
3. Epidural plexus engorged effects ↓ed after engagement of
fetal head.
4. Systemic hypotension +
Compromised uteroplacental
blood flow
↑ Uterine venous P
24. BV (%∆ from prepregnancy)
Table showing % change in RBC and plasma volume
Plasma
RBC
T1
T2
T3
1hr
1wk
6wk
Note: 1. Hemodilution - patency of uteroplacental vascular bed
2. Facilitates exchange of resp. gases, nutrients & metabolites
3. Reduces impact of maternal blood loss at delivery
25. Continued…
Plasma proteins:
1. ↓Total proteins - ↑unbound ( active) drug
2. ↓cholinesterase conc. (25%) but no change in duration
of action of Sch.
Immunity:
1. Leukocytosis – mainly PMN but function is impaired
(↓chemotaxis & adherence)
a) ↑ Infection
b) diagnosis difficult
c) ↓ s/s of autoimmune disorders
2. ↓Antibody titers to HSV, Measles, Influenza A
27. Gastrointestinal system
Anatomical
1. ↑Angle of GE junction
2. Cephalad displacement of
stomach & intestine
3. Vertical rather than horizontal
stomach
Physiological
1. Relaxed LES (progesterone)
↓barrier P.
2. Delayed gastric emptying
(narcotics, anticholinergics,
pain of labour)
28. Anaesthetic implications
Risk of aspiration pneumonitis
1. Ph < 2.5 (nearly all)
2. Gastric vol > 25 ml ( 60%)
3. ↓ LES tone + ↑ intragastric P + ↓ gastric emptying
4. Recent food intake prior to labour/ surgery
1. Consider gravida as FULL STOMACH beyond 1st trimester
2. Give aspiration prophylaxis
3. Regional anaesthesia / inhalational analgesia preferred
4. Plan RSI
29. Nervous system
Vertebral column
1. ↑ Lumbar lordosis - ↓vertebral interspinous distance
2. Distended epidural veins & ↓ CSF volume
3. Positive Lumbar epidural P (difficult identification)
4. CSF P unaffected (↑ during uterine contraction)
30. Continued…
1. ↑ pain threshold at term & ↑ endogenous neuropeptides
labour
2. ↓ MAC / ED95
1.Sedative effect of
progesterone
2. ↑ CNS serotonergic
activity
3.+ of endorphin system
Dependence on sympathetic nervous system ↑ progressively
a) counteracts adverse effects of aortocaval compresion
b) greater preloading during neuraxial blockade
c) pharmacological sympathectomy can cause marked ↓
in BP
31. Continued…
↓Spinal anaesthetic dose requirement
(25%)
1.↑ Neural suseptibility to LA
2. Epidural plexus engorgement
3. CSF changes a)↓CSF protein (↑unbound drug)
b)↑ CSF pH (↑ unionised drug)
4. Pelvic widening & resultant head down tilt in
lateral position
5. Apex of thoracic kyphosis higher
33. Anaesthetic implications
SPINAL
EPIDURAL
1. ↓ Segmental dose
S
1. ↑ Dural puncture
2. Rapid onset & longer
duration
2.↓Sensitivity of hanging
drop technique (+epidural P)
3. Requirement normalise at 3.Unintentional i.v. injection
3.
24-48 hr PP
4. ↑ Rostral spread (esp.
during uterine contraction)
4. ↓Segmental dose (small
doses) (↑neural sensitivity)
5. Same spread with large
doses (unaltered
extravascular epidural vol)
34. Hepatobiliary system
Progesterone →↓ cholecystokinin→↓GB emptying
Altered bile composition
Serum bilirubin & liver enzymes
↑upto upper limit of normal range
Gall
stones
35. Renal
Progesterone + estrogen → +RAAS → Na & H2O retention
CHANGE
CONSEQUENCE
1. Renal plasma flow↑(70%)
GFR ↑
+
Plasma expansion
Renal indices < normal
(creatinine ↓0.5-0.6)
BUN ↓ 8-9)
2. ↑GFR + ↓absorption
threshold
Mild glycosuria(1-10g/dl)
Proteinuria(<300mg/d)
3. Ureter & renal pelvis dilate
Pyelonephritis
36. Continued…
↑ Kidney size → normal at 6 wk postpartum
↑ creatinine clearance →normal at 8-12 wk postpartum
↑ frequency of micturition6-8wk → resetting of osmoregulation (polyuria + polydipsia)
late pregnancy → P on bladder by presenting part
40. Pharmacological
1. Sch. - ↓pseudocholinesterase (-25%) but no effect on
duration of action
2. NDMR - Rapid & prolonged effect
3. ↓Chronotropic response to isoproterenol & epinephrine
(downregulation of β rec. )
4. Pressor response – inconsistent
refractory
5. LA toxicity – unaffected
41. Changes during labour
RESPIRATORY SYSTEM
Stage I
MV
Stage II
+75-150% +150-300%
O2 need +40%
+75%
O2 requirement > consumption → Anaerobic metabolism
45. www.anaesthesia.co.in
Continued…
600 ml –vaginal
delivery
1L – caesarean
section
Same for RA/GA
1st wk = 25%
6-9 wk = +10%
Hb
6 wk
Protein
Blood loss
PREPREGNANT AT
BV
Hematological
PARAMETER
6 wk
TLC
D-1 = 15000
6 wk >prepreg.
Fibrinolysis
Immediate postpartum
Clotting
+ at placental
separation
Fibrinogen & platelet
count
↑ D3 – D5
Thrombosis
46. www.anaesthesia.co.in
References
1. Obstetric anaesthesia – principles and practiceDavid H Chestnut
2. Anaesthesia & Co-existing diseases-Stoelting
3. Millers anaesthesia
4. Short Practice of Anaesthesia – Churchill Davidson
5. Textbook of obstetrics- DC Dutta