1. The document discusses phospholipases A2, enzymes that hydrolyze phospholipids and release fatty acids and lysophospholipids. These molecules participate in inflammation and diseases like cancer and multiple sclerosis. Phospholipase inhibitors could lead to new anti-inflammatory and anticancer drugs. 2. Specifically, it focuses on cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2 (iPLA2), which have roles in diseases of the brain, nervous system, and cancer. The synthesis and testing of novel 2-oxoamide and polyfluoroketone inhibitors of iPLA2 is described. 3. Testing showed some 2-oxo