This presentation covers the Introduction to Healthcare & different Products, Role of Pharmaceutical in Healthcare, Drug Details, What a drug is made of ?, Classification of drugs, Product Life Cycle of a Drug, Drug Development Phases, Regulatory Framework & various Regulatory Bodies
DRA (Drug Regulatory Affairs) , RA (Regulatory Affairs)Naman Ruhela
A Brief Introduction about the Regulatory Affairs / Drug Regulatory Affairs (DRA). Introduction to Drug Regulatory Affairs. Why Drug Regulatory Affairs?. Role of Regulatory Affairs Experts. Types of the company hiring RA professionals. RA professional can get employment. Regulatory Bodies.
The India Pharmaceutical Industry is developing, producing and marketing drugs.
The pharmaceutical companies are generally dealing in generic or brand medications and medical device.
Indian Pharmaceutical Industry today is in the front rank of India’s science-based industries with wide ranging capabilities in the complex field of drug manufacture and technology.
India enjoys a important position in the global pharmaceutical market. The Indian pharmaceuticals market is the third largest in terms of volume and thirteenth largest in terms of value.
It ranks very high in the third world, in terms of technology, quality and range of medicines manufactured.
complete description about pharmaceutical industry how it work how it is operated both at micro as well as macro level. it also include leading pharma firms in market. in simple words if we say it is an industry analysis.
This presentation explores some of the underlying issues responsible for declining pharma R&D productivity, and provides a new, fully integrated approach to reverse this trend by navigating R&D projects and portfolios through the risk-return landscape in real time.
A case study demonstrates how this system can be used in practice to improve the risk-return profile of a Phase 2 development project according to risk appetite.
This presentation focuses on R&D in the pharmaceutical industry, however the approach can be used to manage and optimize the risk-return profile of any business asset at any stage of its lifecycle, at any level, in any industry.
Pharmaceutical Industry Departments roles and responsibilities manasa life sc...ManasaLifeSciencesMa
Pharmaceutical Industry Departments and its roles and responsibilities were discussed. Product selection, Development, Manufacturing, Product approval, Marketing
Pharmaceutical, Bulk Drugs and Medicine Manufacturing Industry (Production, F...Ajjay Kumar Gupta
Quality control and quality assurance are vital in this industry. Many production workers are assigned full time to quality control and quality assurance functions, whereas other employees may devote part of their time to these functions. For example, although pharmaceutical company sales representatives, often called detailers, work primarily in marketing, they engage in quality control when they assist pharmacists in checking for outdated products.
Advances in manufacturing processes are also impacting the industry. While pharmaceutical manufacturers have long devoted resources to new drug development as a source for future profits, firms are increasingly realizing that improvements throughout the drug pipeline are needed to stay competitive.
See more
http://goo.gl/1sQLwS
http://goo.gl/jajeNa
http://goo.gl/0tvlst
http://www.entrepreneurindia.co/
Tags
Pharmaceutical Technology Books, Essentials of Pharmaceutical Technology, Pharmaceutical Technology, Pharmaceutical books, Science, Technology & Medicine Books, Drugs technology books, Drug and Pharmaceuticals technology book, Best small and cottage scale industries, Bulk Drugs Formulation, Bulk Drugs Manufacturing Industry, Business consultancy, Business consultant, Business guidance for Pharmaceutical industry, Business guidance to clients, Business Plan for a Startup Business, Creating a Pharma Start-up, Drug formulation manual, Formulation of Antibiotics, Formulation of Paracetamol, Formulation of Tablets, Great Opportunity for Startup, How to Start a Medicines manufacturing business?, How to start a pharmaceutical company, How to Start a Pharmaceutical Product Business, How to Start a Pharmaceutical Production Business, How to start a pharmacy business, How to start a successful drugs making business, How to start Antibiotics manufacturing business, How to start drugs pharmaceutical business, How to start medicine business, How to Start Medicine Manufacturing Industry in India, How to start medicine manufacturing, How to start Paracetamol production business, How to Start Pharmaceutical Manufacturing Company in India, Invest to setup a pharmaceutical business, Manufacturing of medicinal products- Pharmaceutical industry, Medicine Manufacturing Industry, Medicines Making Small Business Manufacturing, Modern small and cottage scale industries, Most Profitable Bulk Drugs production Business Ideas, New small scale ideas in Pharmaceutical industry, Pharma Manufacturing, Pharmaceutical and Medicines production Business, Pharmaceutical Based Profitable Projects, Pharmaceutical Based Small Scale Industries Projects, Pharmaceutical Drug Formulation, Pharmaceutical Drug Manufacturing Business, Pharmaceutical formulation guidelines, Pharmaceutical formulation, Pharmaceutical industry in India, Pharmaceutical industry, Pharmaceutical manufacturing Industry in India, Pharmaceutical Manufacturing Industry, Pharmaceutical Projects,
(This is an extract from the lecture delivered by Shyamsunder Panchavati on 2nd September 2010 at Hyderabad)
Human being lives in whirlpool of Industries. All the industries revolve around the living beings specially the human beings. One industry or profession that keeps the human being fit enough to wither the whirlpool and keeps the industry going is the Medical Profession. Hence the Medical Profession occupies the high pedestal in this world.
View the abstract at
http://capacitybuildingdevelopment.blogspot.com/2010/09/pharmaceutical-industry-overview_06.html
This document gives detailed information regarding the processes followed in a Pharma Manufacturing Company.
It also includes graphical representation, for easy understanding.
DRA (Drug Regulatory Affairs) , RA (Regulatory Affairs)Naman Ruhela
A Brief Introduction about the Regulatory Affairs / Drug Regulatory Affairs (DRA). Introduction to Drug Regulatory Affairs. Why Drug Regulatory Affairs?. Role of Regulatory Affairs Experts. Types of the company hiring RA professionals. RA professional can get employment. Regulatory Bodies.
The India Pharmaceutical Industry is developing, producing and marketing drugs.
The pharmaceutical companies are generally dealing in generic or brand medications and medical device.
Indian Pharmaceutical Industry today is in the front rank of India’s science-based industries with wide ranging capabilities in the complex field of drug manufacture and technology.
India enjoys a important position in the global pharmaceutical market. The Indian pharmaceuticals market is the third largest in terms of volume and thirteenth largest in terms of value.
It ranks very high in the third world, in terms of technology, quality and range of medicines manufactured.
complete description about pharmaceutical industry how it work how it is operated both at micro as well as macro level. it also include leading pharma firms in market. in simple words if we say it is an industry analysis.
This presentation explores some of the underlying issues responsible for declining pharma R&D productivity, and provides a new, fully integrated approach to reverse this trend by navigating R&D projects and portfolios through the risk-return landscape in real time.
A case study demonstrates how this system can be used in practice to improve the risk-return profile of a Phase 2 development project according to risk appetite.
This presentation focuses on R&D in the pharmaceutical industry, however the approach can be used to manage and optimize the risk-return profile of any business asset at any stage of its lifecycle, at any level, in any industry.
Pharmaceutical Industry Departments roles and responsibilities manasa life sc...ManasaLifeSciencesMa
Pharmaceutical Industry Departments and its roles and responsibilities were discussed. Product selection, Development, Manufacturing, Product approval, Marketing
Pharmaceutical, Bulk Drugs and Medicine Manufacturing Industry (Production, F...Ajjay Kumar Gupta
Quality control and quality assurance are vital in this industry. Many production workers are assigned full time to quality control and quality assurance functions, whereas other employees may devote part of their time to these functions. For example, although pharmaceutical company sales representatives, often called detailers, work primarily in marketing, they engage in quality control when they assist pharmacists in checking for outdated products.
Advances in manufacturing processes are also impacting the industry. While pharmaceutical manufacturers have long devoted resources to new drug development as a source for future profits, firms are increasingly realizing that improvements throughout the drug pipeline are needed to stay competitive.
See more
http://goo.gl/1sQLwS
http://goo.gl/jajeNa
http://goo.gl/0tvlst
http://www.entrepreneurindia.co/
Tags
Pharmaceutical Technology Books, Essentials of Pharmaceutical Technology, Pharmaceutical Technology, Pharmaceutical books, Science, Technology & Medicine Books, Drugs technology books, Drug and Pharmaceuticals technology book, Best small and cottage scale industries, Bulk Drugs Formulation, Bulk Drugs Manufacturing Industry, Business consultancy, Business consultant, Business guidance for Pharmaceutical industry, Business guidance to clients, Business Plan for a Startup Business, Creating a Pharma Start-up, Drug formulation manual, Formulation of Antibiotics, Formulation of Paracetamol, Formulation of Tablets, Great Opportunity for Startup, How to Start a Medicines manufacturing business?, How to start a pharmaceutical company, How to Start a Pharmaceutical Product Business, How to Start a Pharmaceutical Production Business, How to start a pharmacy business, How to start a successful drugs making business, How to start Antibiotics manufacturing business, How to start drugs pharmaceutical business, How to start medicine business, How to Start Medicine Manufacturing Industry in India, How to start medicine manufacturing, How to start Paracetamol production business, How to Start Pharmaceutical Manufacturing Company in India, Invest to setup a pharmaceutical business, Manufacturing of medicinal products- Pharmaceutical industry, Medicine Manufacturing Industry, Medicines Making Small Business Manufacturing, Modern small and cottage scale industries, Most Profitable Bulk Drugs production Business Ideas, New small scale ideas in Pharmaceutical industry, Pharma Manufacturing, Pharmaceutical and Medicines production Business, Pharmaceutical Based Profitable Projects, Pharmaceutical Based Small Scale Industries Projects, Pharmaceutical Drug Formulation, Pharmaceutical Drug Manufacturing Business, Pharmaceutical formulation guidelines, Pharmaceutical formulation, Pharmaceutical industry in India, Pharmaceutical industry, Pharmaceutical manufacturing Industry in India, Pharmaceutical Manufacturing Industry, Pharmaceutical Projects,
(This is an extract from the lecture delivered by Shyamsunder Panchavati on 2nd September 2010 at Hyderabad)
Human being lives in whirlpool of Industries. All the industries revolve around the living beings specially the human beings. One industry or profession that keeps the human being fit enough to wither the whirlpool and keeps the industry going is the Medical Profession. Hence the Medical Profession occupies the high pedestal in this world.
View the abstract at
http://capacitybuildingdevelopment.blogspot.com/2010/09/pharmaceutical-industry-overview_06.html
This document gives detailed information regarding the processes followed in a Pharma Manufacturing Company.
It also includes graphical representation, for easy understanding.
Indian Pharma Market - April 2017 HighlightsAnup Soans
IPM posted a growth of 8.3%, which is faster as compared to April 2016 (5.5% growth).
Major segments like Anti-diabetic and Derma have grown by double digit and Anti Infective segment has not de-grown for the month.
FDC related market show a de-growth of -18.4% while the Non FDC market is growing at 8.9%
Indian cos showed a de-growth of -7.8% while MNCs showed a de-growth of -39.2% in the FDC segment
IPM registered sales worth INR 9474 crs for the month of April 2017
Indian Pharmaceutical Export Market - Top Export Destinations for Indian Phar...Irish Pereira
By Mr. Irish Pereira. The report present snapshot of Indian Pharmaceutical industry in both domestic as well as export market. It is collation of facts pertaining to Indian pharma exports and explore key emerging trends pertaining to pharma export market. It describes key players of Indian pharma market and their export orientation as in their target export destinations, their focus therapies etc.
Fact sheet:
1) Indian Pharma Market size 2015
2) Indian pharmaceutical market segments by value
3)Patented (Innovator) Vs Generics Scenario
4)Growth drivers of Indian pharmaceutical industry
5) Indian Pharmaceutical sector – SWOT Analysis
6)PHARMEXCIL – Facilitating agency for Indian Pharma Exports
7) Indian Pharmaceutical Exports (USD bn)
8)Formulations share in Total Pharma Exports (2014-15)
9) Top 25 destination countries of India’s pharmaceutical exports during 2013-14 (INR mn)
10) Major Indian Pharma Companies (By Revenue-USD mn)
11) Pharma players and their export destinations
Sun Pharma,Dr. Reddy’s Lab,
CIPLA, Lupin, Aurobindo, Cadila Healthcare, Torrent Pharma, Wockhardt,
12) Emerging trends in Indian Pharma Market
indian Pharmaceutical industry export import overviewbipindapin
Pharmaceutical Industry-EXPORT IMPORT INDIA
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices
Indian Pharma Market - IPM Overview June 2015Anup Soans
Major Highlights for Month of June 2015:
...................................................................
Indian Pharma Market (IPM) clocked 7928 Crs in June 2015
........................................................................
IPM grew at 14.8% for the month of June 2015
...................................................................................
Companies:
For the month of June 2015, among the top 10, Sun* grew by 27.9% followed by Pfizer at 20.2% & Abbott* at 19.0%
.........................................................................................................
23 companies crossed the growth of IPM for the month of June 2015 among top 50
...............................................................................................
Among the top 50, Wockhardt has the highest growth of 36.2% followed by AstraZeneca at 35.4% & Glenmark at 34.5 %
..................................................................................................
27 Co's showed growths more than 10% among the top 50
............................................................................................
Among the 11-20 ranked, Glenmark has the highest growth of 34.5% followed by Torrent at 28.3% & USV at 27.1%
..................................................................................................
Among the 21-30 ranked, Wockhardt has the highest growth at 36.2% followed by MSD* 31.6% & Unichem at 20.5% & Novo Nordisk at 18.9%
......................................................................................................
Among the 31-40 ranked, AstraZeneca has the highest growth at 35.4% followed by Akumentis at 33.4% & JBCPL at 27.0%
....................................................................................................
Among the 41-50 ranked, Hetero has the highest growth at 21.0% followed by Fourrts at 17.9% & Allergan at 17.8%
..............................................................................................
Among the 51-60 ranked, Boehringer grew at 79.1% followed by Eli Lilly at 39.9% & Troikaa at 38.4%
..............................................................................................
Among the 61-70 ranked, Fresenius Kabi grew at 38.8% followed by RPG at by 36.1% followed by TTK at 26.3%
..............................................
AstraZeneca enters the 500 Cr Club, Hetero 400 Crs, Troikaa 300 Crs, Tablets India 200 Crs on MAT Basis
Indian pharmaceutical industry organisational structure & strategiesPankaj Gaurav
Strategic Implementation & control Project Report on organizational structure and strategies adopted by prominent players in Indian pharmaceutical industry
This presentation provides a comprehensive overview of the current pharmaceutical industry. It begins with a look at some of the changes facing the industry and then moves into a discussion on digital technology and its impact on pharmaceutical companies. From there, the deck explores two digital trends, mobile and eDetailing. The presentation wraps up with some examples of pharmaceutical companies their digital presence.
Clinical research is a branch of healthcare science that determines the safety and effectiveness (efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use.
Regulatory requirements for drug approval - industrial pharmacy IIJafarali Masi
Regulatory requirements for drug approval - industrial pharmacy IIDrug Development Teams, Non-Clinical Drug Development, Pharmacology, Drug Metabolism and Toxicology, General considerations of Investigational New Drug (IND) Application, Investigator’s Brochure (IB) and New Drug Application (NDA), Clinical research / BE studies, Clinical Research Protocols, Biostatistics in Pharmaceutical Product Development, Data Presentation for FDA Submissions, Management of Clinical Studies.
Sending a resume to a HR in the company in most cases has to be done through email. This presentation covers the basics of how the email has to be structured so that it gives a professional look to the email that is sent.
Mindqjobs.com : Interview Body LanguageSudeep DSouza
This presentation covers the importance of body language and what it can convey in an interview. Also covered are good body posture, position of hands, movements during the interview and how to handle nervousness in the interview.
Having the right behavior at an interview can go a long way in ensuring that there is a positive first impression made. Some important tips on how to shake hands, introducing oneself and taking leave can help one in making a good connection with the interviewer. Dressing right for an interview is very important to send the right signals.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Summary
• Introduction to Healthcare & different Products
• Role of Pharmaceutical in Healthcare
• Drug Details
What a drug is made of ?
Classification of drugs
Product Life Cycle of a Drug
• Drug Development Phases
• Regulatory Framework & various Regulatory Bodies
3. Introduction to Healthcare
• One of the world's largest and fastest-growing industries
• Also called medical industry
• Provides goods & services to treat patients with curative, preventive,
rehabilitative & palliative care
4. Different Healthcare Products
Products Description
Pharmaceutical Medicine/vaccines for human use, may have a trademark, may be prescribed or
over the counter
Diagnostics Equipment & Supplies used in screening, detecting, diagnostics
Medical Devices Advanced instrumentation & appliances used for medical therapy e.g. joint
replacements, pacemakers, syringes, infusion pumps
Medical Supplies E.g. surgical gowns and gloves
Durable Medical Equipment Reusable products e.g. walkers, wheelchairs, oxygen equipment
5. Role of Pharmaceutical in Healthcare
• Socially important
• Varied use from Out patient (self-administered) to Inpatient (professionally
administered)
• Spectrum of Care Settings
Home based Care
Primary Care
Secondary Care
Tertiary Care
End Stage Care
6. Drug Details
1) Drug Definition/ Drug Category
Drug Definition
Any substance that produces a physical /psychological change
Under FFDCA – Any substance intended for use in diagnosis, cure, mitigation, treatment
or prevention of a disease
Examples :
Aspirin , antibiotics, products contained in food – caffeine & others like fluoride
Drug Category
7. Drug Details (cont.)
2) What are Drugs Made of ?
7
• (API) Active Pharmaceutical Ingredient – Used in drug manufacture. API – mainly fall into
2 categories:
Chemical - Small molecule products (manufactured by chemical process)
Biological– Large molecule products (manufactured from living materials –
humans/plants/micro-organisms
• Biological Division :
Genetically Engineered (recombinant)
Non Recombinant
8. Drug Details (cont.)
3) Drug Classification
8
Classification based on
Therapeutic Categories
Target Customers
Novelty
Market Potential
Access Rights
9. Drug Development Life Cycle
9
Discovery
Development
Launch & Growth
Maturity
Generic Erosion
Commodity/ Obsolete Product
10. Drug Development Life Cycle
Discovery Phase
10
• Represents first stage
• Is the process by which drugs are discovered and/or designed
• To understand how disease and infection are controlled at the molecular and
physiological level and to target specific entities based on this knowledge
• Identify cellular and genetic factors that play a role in specific diseases
11. Drug Development Life Cycle
Drug Discovery - A Closer Look
11
Disease and Target Selection
Select the disease targets
TPP
Lead Identification
Search for one or more lead compounds
Compound screening, Molecular Modeling, Simulation
Lead Series and Lead Optimization
Means of identifying promising compounds
Involves testing
Discovery Phase goes till 2-4 years
12. Drug Development Life Cycle
Discovery Phase – Patent Protection
12
Patent Protection
A truly promising set of lead compounds – need to be protected
Primary means of protection – is called PATENT
Also called as “Composition of Matter”
Undiscovered molecule is called (NCE)/ (NME)
Patent is given by a regulatory body and issued for 20 years
Patent Authority of India
The Patent Controller of India
13. Importance of Regulatory Framework
13
Regulations are designed to:
Protect public welfare
Ensure that critical new therapies reach market quickly & safely
Some of the Regulatory bodies :
FDA – Food and Drug Administration, US
CDSCO - Central Drugs Standard Control Organization, India
PMDA - Pharmaceuticals and Medical Devices Agency, Japan
EMA - European Medicines Agency, European Union agency
14. Drug Development Life Cycle
Development Phase
14
Phase where promising compound is transformed into a marketable product/shelved
Process of taking a new chemical lead through the stages necessary to allow it to be
tested in human clinical trials
Development Phase goes till 12-13 years
15. Drug Development Life Cycle
Development Phase - A Closer Look
Development Phase is further divided into
15
16. Drug Development Life Cycle
Preclinical Development
16
“FIRST LINE OF DEFENSE”
Establish initial parameters for safety and efficiency
Bioavailability
Effectiveness of the compound in terms of - ADME (Absorption, distribution, metabolism and
excretion)
Toxicology/Pharmacology
Develop initial formulation and manufacturing plan
Perform both in vitro and in vivo studies
Key milestone – submission of IND to FDA
17. Drug Development Life Cycle
Investigational New Drug (IND)
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The application filed by pharmaceutical company to obtain
permission for sending the new (or experimental) drug for
clinical trial studies
Information contained in IND:
Composition & source of drug
Manufacturing information
ALL preclinical data
Protocols for clinical studies
Names & qualifications of physicians conducting the trials
18. D Drug Development Life Cycle
Clinical Trials
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• Process of testing a drug in human subjects
• The trial may be carried out in a clinic or other medical facility
• First 3 phases termed as – Regisrational or label enabling
• PHASE I : Human Pharmacology
• PHASE II : Initial Clinical Trials
• PHASE III : Comparative Clinical Trials
• PHASE IV : Controlled Marketing
19. Development Life Cycle
Phase I, II
19
Phase
Name
Activities Goal
Phase 1 • First administration to humans
• Testing on a limited population of healthy
volunteers
• To establish – safe dosage range
• To demonstrate that drug
is safe to be tested with
target disease
Phase 2 • Establish EFFICACY & appropriate dosage
• First set of test of the drug for patients who have
disease/condition
• Small scale trails of patients with the target disease
(100-200)
• To generate POC
• To establish min & max
effective dosage
• To look for side effects
20. Drug Development Life Cycle
Phase III, IV
20
Phase
Name
Activities Goal
Phase 3 • Extensive, multiple sites, clinical trials
• Testing on a large scale randomized blinded,
placebo- controlled trials in app 1,000-5,000
subjects with the target disease
• Elaborate design
• Represents largest investment in terms of
money and time
• To provide basis for a New
Drug Application (NDA)
Phase 4 • Post-Marketing Surveillance/Post Approval
• Occurs after FDA issues an NDA Approval and
under controlled marketing
• Addition explorations
• Additional safety studies
• To generate additional data
base to demonstrate the
efficiency and safety of