Peter libby, md
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Dr. Peter Libby earned his medical degree from the University of California, San Diego and completed his training in internal medicine and cardiology at Brigham and Women's Hospital. He is currently the Mallinckrodt Professor of Medicine at Harvard Medical School and Chief of the Cardiovascular Division at Brigham and Women's Hospital. Dr. Libby's research focuses on the role of inflammation in vascular diseases like atherosclerosis. He has published extensively on cardiovascular medicine and atherosclerosis in journals like Circulation and The New England Journal of Medicine.
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This document summarizes guidelines developed by the Task Force on Hypertension in Pregnancy for the diagnosis and management of hypertensive disorders during pregnancy. The guidelines are intended to be adapted based on local needs and resources. Variations are encouraged to improve patient care. The guidelines provide a framework on which local standards of care can be built. They aim to help healthcare providers diagnose and treat conditions like preeclampsia and eclampsia according to current best practices and translate recent research findings into clinical practice.
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Dr. Helmut Schreiber has been a pioneer in bariatric surgery for over 30 years. When he began in 1975, bariatric surgery was a little-known and barely respected specialty. Now, it is one of the fastest growing fields in medicine due to the obesity epidemic. As medical director at St. Vincent Charity Hospital, Dr. Schreiber performs around 100 bariatric surgeries per month and helped establish a comprehensive support system for patients. Validation of bariatric surgery has grown as studies show it significantly reduces obesity-related health risks and hormones like ghrelin that cause hunger. Dr. Schreiber's dedication to helping obese patients transform their lives through bariatric surgery has earned
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The document summarizes an invitation and agenda for the Atlanta Summit on Global Health in Latin America and the Caribbean held on June 1, 2015. The summit, organized by CARE, the World Affairs Council of Atlanta, and the Center for Strategic and International Studies, brought together experts and leaders to discuss health issues affecting Latin America and the Caribbean, including access to healthcare, chronic diseases, drug policy reform, and partnerships to improve public health. The all-day event included panel discussions on these topics with leaders from government, non-profits, and private organizations.
Candid assessment of u.s. response to the ebola crisis at home and abroad
FEATURING REPRESENTATIVES FROM GLOBAL SCIENTIFIC; COMMUNITIES, US POLITICIANS, INVENTORS, ECONOMISTS,CIVIL SOCIETY, CARE GIVERS, PHYSICIANS, MEMBERS OF THE PRESS, EBOLA SURVIVORS, AND REPRESENTATIVES FROM AFRICAN COMMUNITIES.
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(AVTELEFORUM) | African Community Public Health Coalition | Diaspora Liberian Emergency Response Task Force on the Ebola Crisis
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AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
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This document discusses developing an artificial intelligence system to predict short-term cardiovascular disease (CVD) events. The goal is to eradicate unexpected heart attacks by predicting risk similar to hurricane forecasts. Existing studies are cited that show over 50% of heart attacks are first symptoms of underlying disease. The document outlines previous work by SHAPE to define vulnerable patients and release guidelines. It proposes using machine learning on existing cohort data to develop algorithms predicting heart attacks within 12 months, and validate the system. The hope is this can trigger preventative actions and add over 10 years to life expectancy. Funding is needed to implement the proposed "Machine Learning Vulnerable Patient Project".AHA SHAPE Symposium 2017 Dr. Kloner Presentation
Triggers of cardiovascular events can include physical and emotional stress. Stress from events like earthquakes, blizzards, intense sporting games, and overexertion from activities like snow shoveling have been shown to increase the risk of acute cardiovascular outcomes like myocardial infarction. While modern therapies have improved cardiovascular health, research continues to show temporary increases in cardiovascular mortality associated with highly emotional sporting events even in recent years. Managing risk factors, reducing stress, and utilizing preventative therapies may help reduce the impact of triggers on cardiovascular health.
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
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The document introduces the All of Us Research Program, which aims to collect health data from one million Americans to advance precision medicine research. It was announced by President Obama in 2015. The program receives funding from the federal government and private partners. It collects various types of health data from participants through surveys, health records, samples, and devices. The data is stored and shared securely while protecting privacy. The goal is to generate new medical discoveries and more personalized healthcare through collaboration between researchers and participants.AHA SHAPE Symposium 2017 Dr. Yen Presentation
A machine learning model outperformed the ACC/AHA Pooled Cohort Equations Risk Calculator in detecting high-risk asymptomatic individuals and recommending statin treatment for cardiovascular disease prevention in the Multi-Ethnic Study of Atherosclerosis. The machine learning model used support vector machines and data augmentation to derive a CVD risk predictor from nine variables in the MESA study population. It demonstrated higher sensitivity, specificity, and AUC compared to the ACC/AHA risk calculator, recommending statin treatment for fewer individuals while missing fewer cardiovascular events.
AHA SHAPE Symposium 2017 Dr. Slomka Presentation
This document discusses machine learning applications in cardiac imaging presented by Piotr Slomka. It describes how machine learning can improve image analysis, diagnosis, and risk prediction. Machine learning combines multiple data points like imaging and clinical data to predict outcomes. Deep learning can perform tasks like image segmentation. Machine learning provides quantitative scores that predict disease, need for intervention, or patient outcomes to help clinicians. The goal is to integrate machine learning into clinical decision making.
Vu lplaque1 pasterkamp
This document summarizes a post-mortem study examining the prevalence of inflammatory cells in non-ruptured atherosclerotic plaques. The study found that moderate or heavy staining for macrophages was present in 45% of femoral artery cross-sections and 84% of femoral arteries had at least one cross-section with moderate/heavy inflammation. There was no observed relationship between the degree of inflammation in the left and right coronary arteries within individuals, indicating the level of local inflammation is locally determined with little predictive value for other arteries.
Vulnerable plaque vulnerable patient
The document provides guidelines for defining vulnerable plaque and vulnerable patients from the Association for Eradication of Heart Attack. It outlines major and minor histopathological and clinical criteria for vulnerable plaque including active inflammation, thin fibrous cap with large lipid core, endothelial denudation, and stenosis. Potential screening and diagnostic methods are discussed at the plaque, systemic, and blood levels ranging from non-invasive imaging to intravascular techniques. Different types of vulnerable plaque that can cause acute coronary events are also categorized.
Vulnerable plaque overview
Vulnerable plaque refers to dangerous forms of atherosclerotic plaques that can rupture or induce thrombosis, disrupting blood flow. The document discusses the history and research around vulnerable plaque, including pioneers in the field and emerging techniques to detect vulnerable plaque such as intravascular ultrasound, optical coherence tomography, and magnetic resonance imaging. It summarizes that vulnerable plaques are typically characterized by a thin fibrous cap, large lipid core, and presence of macrophages.
Vulnerable patient talk in poland
The document summarizes research on vulnerable plaques and markers of vulnerability. It finds that ruptured plaques are the most common type of culprit lesion, accounting for around 70% of cases. Major criteria for defining vulnerable plaque include outward remodeling, endothelial dysfunction, and a thin fibrous cap with a large lipid core. Both plaque morphology and activity need to be assessed to identify vulnerability.
Vulnerable patient mar 04
This document discusses triggers for sudden cardiac arrest (SCA) and death (SCD). It notes that over 2/3 of SCD cases are unable to be predicted due to a lack of well-established risk factors. While population risk factors can identify at-risk groups, they cannot predict risk for individuals. The document explores various biological, anatomical, and environmental factors that can precipitate fatal arrhythmias and discusses how the timing of transient initiating events is critical for the development of ventricular tachyarrhythmias. It emphasizes that myocardial electrophysiological processes likely determine the onset or lack of VT/VF/SCD and that immediate access to automated external defibrillators is needed to save lives.
Vulnerable (thrombogenic blood
This document summarizes presentations from symposia on vulnerable plaque and discusses the relationship between plaque, blood, and patients in atherothrombosis. It notes that multiple factors like diabetes, smoking, and hyperlipidemia can make blood more thrombogenic and moderate the severity of acute events after plaque rupture. Statins, aspirin, and other drugs that target tissue factor or thrombin pathways may be promising antithrombotic agents by inhibiting thrombosis initiation and propagation.
Vuln plaque poster burke
1) The study examined 92 hearts from patients with severe coronary artery disease who died suddenly. The hearts were sectioned and plaque types were classified.
2) The number of "vulnerable" plaques, particularly thin cap atheromas, was highest in hearts of patients who died from acute plaque rupture and lowest in those with incidental disease.
3) Thin cap atheromas and other unstable plaque types were concentrated in the proximal coronary segments, similar to the distribution of plaque ruptures. The study suggests vulnerable plaques contribute to acute coronary syndromes and are non-uniformly distributed within the coronary arteries.
Vp watch editorial_slide 25short-
1) Drug-coated stents, particularly those coated with sirolimus, have shown promise in reducing restenosis compared to bare metal stents. Sirolimus inhibits cell proliferation and has been shown in studies to reduce intimal hyperplasia and restenosis in animal models by 50% or more.
2) A study by Suzuki et al. found that a sirolimus-coated stent reduced restenosis by 50% through inhibiting cellular proliferation in a dose-dependent manner compared to a bare metal stent. Adding dexamethasone to the coating did not provide additional benefit.
3) If results of the RAVEL clinical trial showing "zero" restenosis out to 5 years
Vp watch editorial_slide25short-
1) Drug-coated stents, particularly those coated with sirolimus, have shown promise in reducing restenosis compared to bare metal stents. Sirolimus inhibits cell proliferation and has been shown in studies to reduce intimal hyperplasia and restenosis in animal models by 50% or more.
2) A study by Suzuki et al. found that a sirolimus-coated stent reduced restenosis by 50% through inhibiting cellular proliferation in a dose-dependent manner compared to a bare metal stent. Adding dexamethasone to the coating did not provide additional benefit.
3) If results of the RAVEL clinical trial showing "zero" restenosis out to 5 years
Vp watch2002
I. This document discusses various animal models that have been used to study atherosclerosis and plaque rupture, including quail, pigeons, chickens, dogs, monkeys, pigs, rats, rabbits, and mice. It provides details on the types of lesions developed and similarities to human disease for each model.
II. The double knockout LDL/apoE mice are highlighted as offering improvements in studying clinical complications of atherosclerosis like human heart disease. However, it is unclear how closely they model vulnerable plaques.
III. Questions are raised about how closely the coagulation systems of these animal models resemble humans and whether any model fully captures repeated plaque ruptures and the role of aging in natural history as seen in humans.
Vp symposium31602
Trans-Blood Vision is a patented infrared technique that uses short-wave infrared wavelengths to see directly through blood. It has the potential to find vulnerable plaque lesions without first entering them, determine their size and surface characteristics in high resolution, and look at their material constituents both on and below the surface. While it cannot provide direct visual guidance for therapy or penetrate as deeply as ultrasound, combining it with augmentative technologies could allow for real-time multi-mode detection, analysis, and therapy guidance of vulnerable plaque lesions. The document concludes that Trans-Blood Vision warrants significant investigation, possibly in combination with other emerging technologies.
Vpschoenhagen
This study used intravascular ultrasound to examine arterial remodeling and plaque characteristics in 131 patients with either stable angina or recent unstable symptoms. Patients with unstable presentations had greater plaque burden at the culprit lesion despite similar luminal narrowing, and a greater extent of positive arterial remodeling compared to those with stable angina. The culprit lesions in unstable patients also showed a higher rate of echolucent plaque morphology. This suggests that bulky, remodeled plaques may be more vulnerable to rupture, leading to acute coronary syndromes. Further prospective study is needed to better understand the relationship between clinical presentation and plaque features.
Vp meeting orlando2003_new template
The document discusses ways to improve prediction of coronary events beyond the traditional Framingham Risk Score (FRS). It finds that adding C-reactive protein (CRP) measurement to the FRS results in a better model that significantly improves risk prediction, especially for those at intermediate risk. Measuring coronary artery calcium via scanning also seems to enhance prediction over the FRS alone. However, these findings require replication in other patient populations before firmly concluding CRP and calcium scoring can modify physician interpretation of patient risk based on the FRS.
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The document discusses magnetic resonance imaging (MRI) studies of atherosclerosis in human carotid arteries. It summarizes several studies examining features of carotid plaques such as calcified regions, neovasculature and necrotic cores, reproducibility of measurements, appearance of intraplaque hemorrhage, and MRI appearance of thick fibrous caps. The document includes MRI images and photomicrographs comparing MRI findings to histology.
Vp.org cimit harvard
This document provides an overview of the new VP.org website and its goals of promoting research on vulnerable plaque (VP). Key points:
1) The website will include an online library called "Atheroline" with medical literature and multimedia about atherosclerosis and VP.
2) A toolbar will provide one-click access to VP-related information resources.
3) Members can customize "Personal VP Watch" alerts on new science, patents, and industry news.
4) An upcoming VP symposium is announced to bring together researchers and industry. The overall aim is to accelerate VP detection and treatment to ultimately eradicate heart attacks.
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Peter libby, md
- 1. Peter Libby, MDPeter Libby, MD The 3Rd Vulnerable Plaque Lifetime Achievement Award
- 2. Dr. Libby earned his medical degree at theDr. Libby earned his medical degree at the University of California, San Diego andUniversity of California, San Diego and completed his training in internal medicinecompleted his training in internal medicine and cardiology at the Peter Bent Brighamand cardiology at the Peter Bent Brigham Hospital (currently Brigham and Women’sHospital (currently Brigham and Women’s Hospital).Hospital). He also holds an honorary Master of ArtsHe also holds an honorary Master of Arts Degree from Harvard University.Degree from Harvard University.
- 3. Dr. Libby's rise in the world of academic medicine andDr. Libby's rise in the world of academic medicine and research has been meteoric, culminating in hisresearch has been meteoric, culminating in his appointment as Chief of the Cardiovascular Division ofappointment as Chief of the Cardiovascular Division of the Department of Medicine at Brigham and Women'sthe Department of Medicine at Brigham and Women's Hospital.Hospital. He also serves as the Mallinckrodt Professor of MedicineHe also serves as the Mallinckrodt Professor of Medicine at Harvard Medical School.at Harvard Medical School.
- 4. Dr. Libby’s current major research focus isDr. Libby’s current major research focus is the role of inflammation in vascularthe role of inflammation in vascular diseases especially atherosclerosis.diseases especially atherosclerosis. He has received numerous awards andHe has received numerous awards and recognitions for his researchrecognitions for his research accomplishments. His areas of clinicalaccomplishments. His areas of clinical expertise include general and preventiveexpertise include general and preventive cardiology.cardiology.
- 5. Dr. Libby is married to Dr. Beryl Benacerraf, aDr. Libby is married to Dr. Beryl Benacerraf, a distinguished clinical professor of obstetrics,distinguished clinical professor of obstetrics, gynecology and reproductive biology at Harvardgynecology and reproductive biology at Harvard Medical School and Brigham and Women'sMedical School and Brigham and Women's Hospital.Hospital. She is the daughter of Dr. Baruj Benacerraf, whoShe is the daughter of Dr. Baruj Benacerraf, who won the Nobel Prize in 1980 for his pioneeringwon the Nobel Prize in 1980 for his pioneering work on the major histocompatibility complexwork on the major histocompatibility complex and genetic control of immune response.and genetic control of immune response.
- 6. An extensive author and lecturer on cardiovascularAn extensive author and lecturer on cardiovascular medicine and atherosclerosis, Dr. Libby has publishedmedicine and atherosclerosis, Dr. Libby has published numerous research articles in medical journalsnumerous research articles in medical journals includingincluding Circulation, The Journal of ClinicalCirculation, The Journal of Clinical Investigation, The Proceedings of the NationalInvestigation, The Proceedings of the National Academy of SciencesAcademy of Sciences,, The New England Journal ofThe New England Journal of Medicine,Medicine, andand NatureNature..
- 7. He is co-editor of Braunwald'sHe is co-editor of Braunwald's Heart DiseaseHeart Disease,, Edition 6. Dr. Libby also contributed theEdition 6. Dr. Libby also contributed the chapters on the pathogenesis, treatment, andchapters on the pathogenesis, treatment, and prevention of atherosclerosis to the 15thprevention of atherosclerosis to the 15th edition of Harrison’sedition of Harrison’s Principles of InternalPrinciples of Internal MedicineMedicine.. He has held numerous Visiting ProfessorshipsHe has held numerous Visiting Professorships and has been selected to deliver namedand has been selected to deliver named Lectures throughout the world on manyLectures throughout the world on many occasions.occasions.
- 8. Dr. Libby is a member of the Association of AmericanDr. Libby is a member of the Association of American Physicians and the American Society for ClinicalPhysicians and the American Society for Clinical Investigation.Investigation. He has served in many roles as a volunteer for theHe has served in many roles as a volunteer for the American Heart Association, including Chairmanship ofAmerican Heart Association, including Chairmanship of several research committees and membership in theseveral research committees and membership in the Executive Committees of the Councils on Arteriosclerosis,Executive Committees of the Councils on Arteriosclerosis, Circulation, and Basic Science.Circulation, and Basic Science. He has also served as a frequent consultant to theHe has also served as a frequent consultant to the National Heart, Lung and Blood Institute, and has recentlyNational Heart, Lung and Blood Institute, and has recently completed a five-year term on the Board of Scientificcompleted a five-year term on the Board of Scientific Councilors. He is the recipient of a MERIT Award from theCouncilors. He is the recipient of a MERIT Award from the Institute.Institute.