This document summarizes the efforts of a multidisciplinary team at New England Baptist Hospital to reduce surgical site infections (SSIs) through identifying issues, implementing action plans, and tracking outcomes from 2003-2010. The team addressed operating room environment and processes, patient risk factors, and use of innovative technologies like chlorhexidine and antibacterial sutures. SSIs decreased over time, including a reduction in MRSA/MSSA infections after implementing a decolonization protocol in 2006.