Pathophysiology Acute inflammation of the upper genital tract – the uterus or adnexa – from an ascending infection – usually chlamydia or gonorrhea (25%). May lead to epithelial damage thus allowing further pathogen entry. Involves any combination of endometritis, salpingitis, tubo-ovarian abscess, or pelvic peritonitis. Rarer causes: Gardnerella vaginalis, H. influenzae, Strep agalactiae (Group B Strep), CMV. Often no pathogen is found. Signs and symptoms Symptoms: Varies from asymptomatic to severe. Pain: lower abdominal (often bilateral), lower back, and deep dyspareunia. Systemic: fever, nausea and vomiting. Discharge and bleeding: cervical or vaginal mucopurulent discharge, postcoital or intermenstrual bleeding. On bimanual examination, tenderness in the uterus, adnexa, and cervix ('cervical excitation').